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Endothelial Nitric Oxyde Synthase Gene Polymorphisms in a Tunisian Deep Vein Thrombosis Group

Journal of Biosciences and Medicines 2016年第9期4卷 33-41页

作者： Nedra Grira Nadia Ben Abdelhafidh Manel Ayoub Rihab Sendesni Bochra Adib Najla Stambouli Salah Othmani zied aouni Chakib Mazigh Research Unit Biochemistry Department Military Hospital of Tunis Montfleury Tunisia Internal Medicine Department Military Hospital of Tunis Montfleury Tunisia

Deep vein thrombosis (DVT) is a multi-factorial disease involving both genetic and acquired risk factors. The objective of this study was to determine the frequencies of endothelial nitric oxide synthase (eNOS) gene polymorphisms G894T (rs1799983) and T-786C (rs2070744) to assess the role of these polymorphisms as a potential risk factor in the development of DVT. Methods: In this case-control study, we included 32 patients with deep vein thrombosis (DVT) and 31 healthy control subjects. Clinical characteristics were collected. Lipids plasma concentrations were determined by the colorimetric method. Genotyping for the polymorphisms was performed by restriction fragment length polymorphism (PCR-RFLP) method. Results: We had found that the eNos G894T genotype G/T was significantly increasing the risk of DTV (P = 0.042, OR = 3.9;95% CI = 1.09 to 13.92). But no association of the eNOS T-786C variant and DVT was found. For the eNOs T-786C polymorphism, the frequency of the T/T genotype was 87.5% in patients (with an allelic frequency of T Allele equal to 91%). No significant difference was noted between the two groups (P > 0.05). Conclusion: The eNOs G894T polymorphism seems to be in association with DVT and may be considered as a risk factor, but this is not the case for the T-786C polymorphism.

关键词： Deep Vein Hrombosis eNOS NO G894T Polymorphism T-786C Polymorphism

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Correlation between Dietary Intake and Inflammatory Biomarkers in a Tunisian Obese Group

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Journal of Biosciences and Medicines 2015年第11期3卷 108-113页

作者： Manel Ayoub Chedia Zouaoui Nedra Grira Radhia Kochkar Nejla Stambouli Chaker Bouguerra Borni Zidi Ezzedine Ghazouani Chakib Mazigh zied aouni Biochemistry Department Research Unit Military Hospital of Tunis Tunis Tunisia Endocrinology Department Research Unit Military Hospital of Tunis Tunis Tunisia Immunology Department Military Hospital of Tunis Tunis Tunisia Epidemiology Department Research Unit Military Hospital of Tunis Tunis Tunisia

Aims: This study aims to determine the inflammatory status and evaluate the correlation between dietary intake and inflammatory biomarkers in a Tunisian obese group. Material and Methods: This is an open cross-sectional study that includes 81 individuals divided into two groups: a group of 42 obese patients recruited from the endocrinology department and a control group of 39 non-obese healthy subjects. All participants received a food survey, anthropometric measurements and blood sampling. Pro-inflammatory cytokines (IL-6, IL-8, TNF-α), and hs-CRP were measured in patients and controls. Results: Dietary data revealed significant increases in food intake in obese patients compared to controls. The results of the laboratory parameters showed a statistically significant increase in IL-8, TNF-α and blood glucose in obese compared to controls. The analysis of correlations among the parameters studied showed that the plasma level of IL-6 was positively correlated with dietary fat intake (r = 0.70;p -3) and carbohydrate (r = 0.54;p = 0.03) and the dietary intake expressed in calories (r = 0.64;p -3). Conclusion: dietary imbalances in obese were observed and characterized by an excessive intake of calories, fat and carbohydrates. The excessive carbohydrate and fat intake is associated with increased IL-6 and TNF-α plasma levels.

关键词： Obesity Dietary Intake Inflammatory Biomarkers

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Evaluation of Cardiovascular Risk Factors in a Young Adults Tunisian Group

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Journal of Biosciences and Medicines 2018年第3期6卷 1-14页

作者： Lamine Oussama Aboulkacem Sana Grira Nedra Ayoub Manel Sendesni Rihab El Oudi Mabrouka Stambouli Nejla Mazigh Chakib aouni zied Biochemistry Department Military Hospital of Tunis Tunis Tunisia

Introduction: Cardiovascular diseases have become more common in young adults. Their emergence is due to the prevalence of cardiovascular risk factors. The aim of this study is to determine the prevalence of cardiovascular risk factors in a Tunisian young adult group. Material and methods: This is an epidemiological study of 705 Tunisians volunteers, free from any cardiovascular pathology;who are recruited at the Military Hospital of Tunis. Besides the classical cardiovascular risk factors (obesity, dyslipidemia, smoking, alcohol…), we evaluate the level of homocysteinemia and determined the C677T mutation of the methylenetetrahydrofolate reductase (MTHFR) gene by PCR-RFLP method. Results and conclusions: The mean age of our population is 28.25 ± 9.08 with a male majority (83.8%). We have 43.8% obese subject or overweight, 54.3% smokers and 12.9% alcoholics. The lipid profile showed that 12.6% of the population had hypercholesterolemia and 39.5% had hypoHDLemia, 7.9% had a high lipoprotein(a) concentration. In our study population we found that 10.9% of subjects had an hs-CRP concentration greater than 3 mg/L. Genotyping of the MTHFR gene revealed that 34% of young adults had a mutated genome (CT). The results showed a significant correlation between different factors, such as cholesterolemia and obesity. The prevalence of these risk factors showed the severity of our young people’s health status and imposes a change in the way of Tunisians life.

关键词： Young Adult Dyslipidemia Cardiovascular Risk Cholesterolemia

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