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Hepatitis B Surface Antigen and Hepatitis C Virus Antibodies among Drug Users in Burkina Faso

Advances in Microbiology 2024年第1期14卷 92-104页

作者： sylvie zida Kadari Cissé Odette Ky-Zerbo Dinanibè Kambiré Serge Théophile Soubeiga Simon Tiendrebéogo Fatou Sissoko Issa Sory Célestine Ki-Toé Solange Dioma Djeneba Zorom Adama Ouédraogo Cedric Dimitri Axon Hien Mahamoudou Sanou Seni Kouanda Henri Gautier Ouédraogo Institut de Recherche en Sciences de la Santé Ouagadougou Burkina Faso Dé partement de G&eacuteographie Universit&eacute Norbert ZONGO Koudougou Burkina Faso Secré tariat permanent du Conseil national de lutte contre le Sida et les IST (SP/CNLS-IST) Ouagadougou Burkina Faso Initiative Privé e et Communautaire pour la Sant&eacute et la Riposte au VIH/SIDA au Burkina Faso (IPC/BF) Ouagadougou Burkina Faso Unité de Formation et de Recherche en Sciences de la Sant&eacute (UFR-SDS) Universit&eacute Joseph KI-ZERBO Ouagadougou Burkina Faso

Introduction: The epidemiology of both hepatitis B virus (HBV) and hepatitis C virus (HCV) infections among drug users (DUs) is little known in West Africa. The study aimed to assess the prevalence of hepatitis B and C viruses among drug users in Burkina Faso. Methodology: This was a cross-sectional biological and behavioral survey conducted between June and August 2022, among drug users in Ouagadougou and Bobo Dioulasso, the two main cities of Burkina Faso. A respondent-driven sampling (RDS) was used to recruit drug users. Hepatitis B surface antigen was determined using lateral flow rapid test kits and antibodies to hepatitis C virus in serum determined using an Enzyme-Linked Immunosorbent Assay. Data were entered and analyzed using Stata 17 software. Weighted binary logistic regression was used to identify the associated factors of hepatitis B and C infections and a p-value Results: A total of 323 drug users were recruited with 97.5% males. The mean age was 32.7 years old. The inhaled or smoked mode was the most used by drug users. The adjusted hepatitis B and hepatitis C prevalence among study participants were 11.1% and 2.3% respectively. The marital status (p = 0.001), and the nationality (p = 0.011) were significantly associated with hepatitis B infection. The type of drug used was not significantly associated with hepatitis B infection or hepatitis C infection. Conclusion: The prevalence of HBsAg and anti-HCV antibodies among DUs are comparable to those reported in the general population in Burkina Faso. This result suggests that the main routes of contamination by HBV and HCV among DUs are similar to those in the population, and could be explained by the low use of the injectable route by DUs in Burkina Faso.

关键词： Drug Users Hepatitis C Hepatitis B Prevalence Burkina Faso

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Bacteriological Profile of Effusion Fluids Infections at Charles De Gaulle University Pediatric Hospital from 2017 to 2020

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Open Journal of Medical Microbiology 2024年第2期14卷 146-163页

作者： Kambiré Dinanibè Ouédraogo Oumarou Tiendrebéogo Salam Tondé Issa Tamboura Mamadou zida sylvie Kpoda Dissinviel Sagna Tani Compaoré T. Rebeca Zouré Abdou-Azaque Soubeiga R. Serge Théophile Sawadogo Stanislas Ilboudo Maïmouna Rouamba Hortense Ouédraogo Wenkouni Henri Gautier Ouédraogo-Traoré Rasmata Sanou Mahamoudou Institut de Recherche en Sciences de la Sant Ouagadougou Burkina Faso Centre Hospitalier Universitaire Pdiatrique Charles De Gaulle Ouagadougou Burkina Faso Centre Universitaire de Ziniar Ziniar Burkina Faso Universit Joseph Ki-Zerbo Ouagadougou Burkina Faso Universit Ouaga 3S Ouagadougou Burkina Faso Centre Mdical Urbain de Samandin Ouagadougou Burkina Faso

Introduction: Microbiology of effusion fluids in children in Burkina Faso is characterized by the scarcity of data. This work aimed to study the bacteriological and antibiotics susceptibility profile of bacteria involved in effusion fluid infections in paediatrics in order to improve the choice of probabilistic antibiotics therapy. Methods: A cross-sectional, descriptive study was used in children aged 0 to 15 years from 2017 to 2020 at the Charles De Gaulle Pediatric University Hospital Center (CHUP-CDG) in Ouagadougou. Classical bacteriology methods such as macroscopy, Gram staining, identification galleries and antibiotics susceptibility testing were used. Results: Of 231 samples, 64 bacteria were isolated. The most common bacterial strains of pleural fluid were Staphylococcus aureus (25%) and 40% for Enterobacteriaceae. Of the peritoneal fluid, 77% were Enterobacteriaceae with 57% Escherichia coli;and from joint fluid, 33% were S. aureus and 22% for P. aeruginosa. The overall susceptibility profile showed 29% extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL), 10% methicillin-resistant S. aureus (MRSA), and 8% carbapenemases. Conclusion: Bacteriological profile is characterized by ESBL-producing Enterobacteriaceae and MRSA. The most active antibiotics were macrolides, aminoglycosides, and cefoxitin (methicillin) for Gram-positive cocci, carbapenems, and aminoglycosides for Gram-negative bacilli. Then, the monitoring of antibiotics resistance must be permanent.

关键词： Bacteriological Profile Effusion Fluid Infections

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Herpes Simplex Virus Type 2 (HSV-2) and HTLV-1 &2 among Female Sex Workers in Ouagadougou, Burkina Faso

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Open Journal of Medical Microbiology 2022年第2期12卷 56-69页

作者： Henri Gautier Ouédraogo Dinanibè Kambiré Tani Sagna Tegwinde Rebeca Compaore Oumarou Ouédraogo Abdou Azaque Zouré Serge Théophile Soubeiga sylvie zida Danielle Belemsaga/Yugbaré Samadoulougou Benoît Cesaire Odette Ky-Zerbo Yves Traoré Nicolas Barro Seni Kouanda Institut de Recherche en Sciences de la Santé (IRSS) Centre National de la Recherche Scientifique et Technologique (CNRST) Ouagadougou Burkina Faso Sécrétariat Permanent du Conseil National de Lutte contre le Sida et les Infections Sexuellement Transmissibles (SP/CNLS-IST) Ouagadougou Burkina Faso Unité de Formation et de Recherche en Sciences de la Santé (UFR-SDS) Université Joseph Ki Zerbo Ouagadougou Burkina Faso

Background: Herpes Simplex Virus type-2 (HSV-2) infection is one of the most common worldwide sexually transmitted and female sex workers are most at risk for these infections. Beside HSV-2, Human T-lymphotropic virus (HTLV) is one of these infections with a high risk of sexual transmission. HTLV-1 causes T-cell leukaemia and myelopathy. Little is known about the HSV-2, HTLV-1 and HTLV-2 infections among female sex workers in West Africa in general, and particularly in Burkina Faso. The aim of this study aimed to estimate HSV-2 and HTLV-1/2 seroprevalence among female sex workers, in Ouagadougou in order to inform HIV prevention programs. Methods: Archived sera samples of a biological and behavioral cross-sectional study among female sex workers (FSWs) in Ouagadougou were tested for HSV-2 and HTLV-1/2. Sera samples collected from February to May 2013 were previously tested for HIV and syphilis and stored with participants’ additional consent for further infection testing. Antibodies against HSV-2 and HTLV-1/2 detection tests were performed using Enzyme-Linked Immuno-Sorbent Assay (ELISA) methods. Results: HSV-2 seroprevalence was approximately 75.7% (95% CI: 70.8-79.9) among FSWs. It ranged from 69.3% among FSWs under 24 years of age, to 88.5% among those who were at least 30 years old. Furthermore, HSV-2 seroprevalence was high among FSW with no formal education (87.7%) and decreased significantly among those with at least primary education (76.0%) and others with secondary education and above (64.9%). Regarding HTLV-1/2, 11.2% (95% CI: 8.3 - 15.1) of FSWs were positive. By age group, 11.8% were positive among FSWs under 25 years of age;15.2% among those 25 to 29 years of age, and 5.8% among those over 30 years of age. Conclusion: HSV-2 and HTLV-1&2 infections are common among FSWs, which confirms the need for effective and preventive interventions such as sex education and early screening.

关键词： HSV-2 HTLV-1/2 Seroprevalence Female Sex Workers FSWs

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Helicobacter pylori Virulence Genes cagA, babA2, and vacA Detection in Dyspeptic Patients from Burkina Faso

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American Journal of Molecular Biology 2023年第3期13卷 141-155页

作者： Tegwinde Rebeca Compaore Kalifou Traore Nômawendé Ines Compaore Lassina Traore sylvie zida Serge Theophile Soubeiga Dinanibe Kambire Jean Claude R. P. Ouedraogo Aminata Dickel Sidibe Yasmine Astrid Sana Tani Sagna Wendkuuni Florencia Djigma Henri Gautier Ouedraogo Jacques Simpore Département Biomédical et Santee Publique Institut de Recherche en Sciences de la Santé (IRSS) Ouagadougou Burkina Faso Centre de Recherche Biomoléculaire Pietro Annigoni (CERBA) Ouagadougou Burkina Faso Laboratoire de Biologie et de Génétique Moléculaire (LABIOGENE) Université Joseph KI-ZERBO Ouagadougou Burkina Faso Clinique El Fateh-Suka Service de médecine et de spécialités médicales Ouagadougou Burkina Faso Département de Médecine et de Pharmacopée Traditionnelle Institut de Recherche en Sciences de la Santé (IRSS) Ouagadougou Burkina Faso

The diverse clinical presentation of Helicobacter pylori (H. pylori) infection results from the interaction between bacterial virulence, host genetics, socio-demographic and environmental factors. This study aimed to characterize Helicobacter pylori virulence genes and the associated behavioral factors among dyspeptic patients in Burkina Faso. Two hundred and fifty (250) stool samples were collected from patients with dyspepsia seen at health centers in Ouagadougou, Burkina Faso. Bacterial deoxyribonucleic acid (DNA) was extracted using a commercial kit. Virulence genes were detected using conventional multiplex Polymerase Chain Reaction with specific primers. The overall prevalence of Helicobacter pylori of the 250 participants was 91.20%. CagA virulence gene was present among 20.19% of individuals, while babA2 and vacA were detected respectively among 9.65% and 67.54% of the population positive for Helicobacter pylori. Among vacA subtypes, vacAs1 was the most frequent, with 39.04%, followed by vacAi1 (19.74%), vacAi2 (17.54%), and vacAs2 with 10.96%. Regarding vacAm1 and vacAm2, they were less frequent at 6.14% each. “Handwashing three times or less per day” significantly increased the risk of having vacAi2 allele and H. pylori rRNA16s, with p-values of 0.013 and 0.020, respectively. The consumption of non-tap water increases the risk of carrying the cagA virulence gene. Additionally, H. pylori-positive patients living with more than four (4) people in their household had about two times the risk of having the vacAs1 allele. The present study shows the detection of Helicobacter pylori cagA, vacA subtypes, and babA2 by stool a PCR method in Burkina Faso. The strong association between sanitary habits and virulence factors depicts the composite interaction between ecological factors, gastric mucosa, and bacteria. Therefore, the synergic action of these factors should be considered when aiming for bacterial eradication and gastric pathology cure.

关键词： Helicobacter pylori Stool cagA babA2 vacA

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ST of Streptococcus pneumonia Circulating in Burkina Faso before the Introduction of PCV-13, 2013

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Advances in Microbiology 2023年第5期13卷 237-248页

作者： Kambiré Dinanibè Tamboura Mamadou Ouédraogo Oumarou Tondé Issa Ouédraogo W. H. Gautier Sanou Mahamoudou Zouré Abdou Azaque Compaoré Rebeca Sagna Tani Soubeiga R. S. Théophile zida sylvie Aké Flavien Abdoul-Salam Ouédraogo Sangaré Lassana Méda Isaïe Kouanda Séni Ouédraogo-Traoré Rasmata Centre Hospitalier Universitaire Pédiatrique Charles De Gaulle Ouagadougou Burkina Faso Institut de Recherche en Sciences de la Santé Ouagadougou Burkina Faso Davycas International Ouagadougou Burkina Faso Centre Hospitalier Universitaire Yalgado Ouédraogo Ouagadougou Burkina Faso Centre Hospitalier Universitaire Sanon Sourô Bobo-Dioulasso Burkina Faso Direction Générale de la Santé Publique Ouagadougou Burkina Faso

Introduction: Burkina Faso experiences regular cases of Streptococcus pneumoniae meningitis. As part of the strategy to reduce cases of meningitis, the 13-valent pneumococcal conjugate vaccine (PCV-13) has been introduced in the Expanded Programme on Immunisation (EPI). Despite these efforts, there are some cases of pneumococcal meningitis including both vaccine and non-vaccine serotypes. The objective of this study was to describe the pneumococcal sequence types (ST) circulating in Burkina Faso before the introduction of the 13-valent pneumococcal conjugate vaccine (PCV-13). Methods: It was a descriptive cross-sectional study that took place from 27th October 2013 to 7th January 2014. S. pneumoniae strains were collected in Burkina Faso and Multi Locus Sequence Typing (MLST) was performed at the Pneumococcal Laboratory at the Centers for Disease Control and Prevention (CDC) in the USA (United States of America). MLST consists of 4 steps: amplification, purification, sequencing and interpretative reading of the results. The amplification used 7 primers consisting of sequences of aroe, gdh, gki, recP, spi, xpt, ddl genes. Results: Of 37 strains tested, 10 serotypes were identified. Serotype 1 was prevalent in 48.7% (18/37) followed by serotype 25F in 10.8% (4/37). Serotypes 5 and 12F/12A/12B/44/46 were 8.1% (3/37) each. Serotype 1 contained 5 STs including ST303 24.3% (9/37), ST217 8.1% (3/37) and ST618 8.1% (3/37);followed by serotype 25F with ST105 10.8% (4/37), serotype 5 with ST289 8.1% (3/37) and serogroup 12F/12A/12B/44/46 with ST 989 8.1% (3/37). Conclusion: Pneumococci are characterised by their great variability both in number of serotypes and in ST within the same serotype. Thus, 10 serotypes have been identified. Also, within serotype 1, 5 different STs have been described. These data indicate the complexity of the pneumococcus which is strongly involved in purulent bacterial meningitis at national level. This requires continuous surveillance of pneumococc

关键词： Streptococcus pneumoniae Burkina Faso PCV-13 Sequence Types

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Meningitis Outbreak Caused by Neisseria meningitidis Serogroup C ST 10217 in 2019 in Diapaga, Burkina Faso

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Advances in Infectious Diseases 2023年第1期13卷 66-76页

作者： Kambiré Dinanibè Tondé Issa Ouédraogo W. H. Gautier Sanou Mahamoudou Ouédraogo L. S. L. Wilfrid Savadogo Mahamoudou Tamboura Mamadou Zongo Moumouni Ouédraogo Oumarou Zouré Abdou Azaque Compaoré Rebeca Sagna Tani zida sylvie Soubeiga R. S. Théophile Aké Flavien Sangaré Lassana Méda Isaïe Kouanda Séni Ouédraogo-Traoré Rasmata Centre Hospitalier Pédiatrique Universitaire Charles De Gaulle Ouagadougou Burkina Faso Institut de Recherche en Sciences de la Santé Ouagadougou Burkina Faso Direction de la protection de la Santé de la Population Ouagadougou Burkina Faso Centre Hospitalier Universitaire Yalgado Ouédraogo Ouagadougou Burkina Faso Davycas International Ouagadougou Burkina Faso Direction Générale de la Santé Publique Ouagadougou Burkina Faso

Introduction: Meningitis caused by Neisseria meningitidis constitutes a burden for the countries in the meningitis belt of sub-Saharan in general and particularly for Burkina Faso. In 2019 the Diapaga health district experienced a meningitis epidemic due to N. meningitidis serogroup C. Methods: This is a cross-sectional study with a descriptive aim in the health district of Diapaga where all cases of meningitis were included in this work. Rapid diagnostic tests (RDTs), culture as well as real-time PCR were used for the biological analysis of cerebral spinal fluid (CSF) samples. Results: Of 155 CSF samples analysed, 42% (65/155) were tested positve. Of them, N. meningitidis C accounted for 83% of all positive cases. Likewise, all thirteen (13) NmC strains were susceptible to oxacillin, ceftriaxone, penicillin and chloramphenicol. All strains of NmC belonged to the sequence type (ST) 10 217 and to the clonal complex (CC) 10 217. These CCs belonged to the same variant PorA type: P1.21-15.16;FetA type: F1-7;PorB type: 3-463. Conclusion: Burkina Faso had known an epidemic of meningitis caused by NmC in 2019 in the health district of Diapaga. This outbreak was contained in time due to the performance of the epidemiological surveillance system which made it possible to investigate on time and introduce the vaccine against the pathogen NmC.

关键词： Meningitis Neisseria meningitidis VS Diapaga Burkina Faso

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Helicobacter pylori Virulence Genes cagA,babA2, and vacA Detection in Dyspeptic Patients from Burkina Faso

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American Journal of Molecular Biology 2023年第3期

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Meningitis Outbreak Caused by Neisseria meningitidis Serogroup C ST 10217 in 2019 in Diapaga, Burkina Faso

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Advances in Infectious Diseases 2023年第1期

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