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Cochlear and Vestibular Functional Study in Patients with Sudden Deafness and Lyme Disease

International Journal of Otolaryngology and Head & Neck Surgery 2014年第1期3卷 46-50页

作者： ziane selmani Ilmari Pyykko Health Centre of Aava KeravaFinland Department of Otolaryngology University Hospital of TampereUniversity of TampereTampereFinland

Lyme disease (LD) and idiopathic sudden deafness (ISD) are supposed to be different diseases with different aetiologies. In an attempt to confirm this assumption, 10 patients with confirmed LD and 12 patients with ISD were consecutively included into the study. Further to the laboratory and audio logical investigation, a low frequency sound (LFS) stimulation on posturography was performed and evaluated. Patients with ISD had higher pure tone average (PTA) than patients with LD (PTA ISD/LD was 72 decibel (dB)/23 dB). There was no difference of vertigo between LD and ISD patients. Patients with ISD have more body sway velocity during the first stimulation than patients with LD. We conclude that the cochlear organ is more affected in ISD patients than in patients with LD. However, the vestibular organ seems to be affected in both diseases. ISD and LD are two different disease entities with different aetiologies but with common otological clinical signs.

关键词： Idiopathic Sudden Deafness Lyme Disease Low Frequency Sound Stimulation

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Is Meniere Disease Caused by a Pathological Immune Response?

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International Journal of Otolaryngology and Head & Neck Surgery 2014年第2期3卷 106-112页

作者： ziane selmani Ilmari Pyykko Nureddin Ashammakhi Department of Otolaryngology Helsinki University HospitalHelsinkiFinland Department of Otolaryngology Tampere University HospitalTampereFinland Department of Surgery Oulu University HospitalOuluFinland

The etiology of Meniere disease (MD) is unknown. Among the several factors which can provoke the disease is a pathological immune response. Objective: To investigate whether MD is due to a pathological immune reaction. Materials and methods: Immunological assay (IA) was evaluated in a consecutive study on 159 patients with MD (mean age 47.8. years) and the results compared with those from 26 patients operated on because of vestibular schwannoma (VS, mean age 54.1 years), who served as a control group. In cases of MD, transtympanic electrocochleography (ECoG) and hearing threshold were measured. Results: The average hearing level (HL) in the affected ears of patients with MD was 30 dB. Evidence of abnormal plasma protein pattern was found in 127 MD patients (80%). Elevations were found in β1-globulin (54.5%), β2-globulin (26.5%), a2-globulin (34.3%), g-globulin (17.3%), complement (CH100, 36.4%) and antinuclear antibodies (ANA, 43.4%). The onset of the disease did not correlate with the level of the plasma protein neither with the level of IgG titers. Conclusion: Elevated certain plasma proteins in patients with Meniere’s disease could be a sign that Meniere’s disease is a consequence of pathological immune reaction.

关键词： Circulating Immune Complex(Circulating IC) Electrocochleography(ECoG)

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