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Recent advances in magnetic targeting based on high magnetic field and magnetic particles

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High Voltage 2017年第4期2卷 220-232页

作者： zili zhang Ping He Jinyan zhang Yikui Li Qiuliang Wang Institute of Electrical Engineering Chinese Academy SciencesBeijing 100190People's Republic of China Xiyuan Hospital of China Academy of Chinese Medical Sciences Beijing 100019People's Republic of China

In the past few decades,the multifunctional magnetic drug carrier based on the magnetic nanoparticles and high magnetic field has been intensively *** magnetic drug carrier can be targeted to the tumour area not only by the chemical protocol but also by the physical one(external field).In this review,the authors first briefly discuss the fabrication process of magnetic drug carriers,which includes the synthesis of magnetic nanoparticles,fabrication of magnetic drug carriers and conjugation of anti-tumour *** different targeted protocols have been summarised,including passive targeting,biochemical active targeting and biophysical active targeting namely magnetic targeting(MT).Multiple MT results both in vitro and in vivo are introduced,in which two unconventional cases are emphasised and *** first MT clinical research with 14 peoples was performed in the last century.A 0.5–0.8 T permanent magnet was attached to the tumour area when magnetic particles conjugated with epirubicin were *** side effect of epirubicin had been decreased,and the four patients showed the decreasing of a tumour which proved the feasibility of *** from other targeting protocols,MT needs an extra external magnetic *** various types of MT instruments have been shown in the final part of this review,including a single strong magnetic field,homemade electronic solenoid coil assay and commercial magnetic resonance imaging.

关键词： magnetic field high

Cumulus cloud modeling from images based on VAE-GAN

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Virtual Reality & Intelligent Hardware 2021年第2期3卷 171-181页

作者： zili zhang Yunchi CEN Fan zhang Xiaohui LIANG State Key Laboratory of Virtual Reality Technology and Systems Beihang UniversityBeijing 100191China Department of Computer Science and Engineering Shijiazhuang UniversityShijiazhuang 050035China

Background Cumulus clouds are important elements in creating virtual outdoor *** cumulus clouds that have a specific shape is difficult owing to the fluid nature of the ***-based modeling is an efficient method to solve this *** of the complexity of cloud shapes,the task of modeling the cloud from a single image remains in the development *** In this study,a deep learning-based method was developed to address the problem of modeling 3D cumulus clouds from a single *** method employs a three-dimensional autoencoder network that combines the variational autoencoder and the generative adversarial ***,a 3D cloud shape is mapped into a unique hidden space using the proposed ***,the parameters of the decoder are fixed.A shape reconstruction network is proposed for use instead of the encoder part,and it is trained with rendered *** train the presented models,we constructed a 3D cumulus dataset that included 2003D cumulus *** cumulus clouds were rendered under different lighting *** The qualitative experiments showed that the proposed autoencoder method can learn more structural details of 3D cumulus shapes than existing ***,some modeling experiments on rendering images demonstrated the effectiveness of the reconstruction *** The proposed autoencoder network learns the latent space of 3D cumulus cloud *** presented reconstruction architecture models a cloud from a single *** demonstrated the effectiveness of the two models.

关键词： 3D cloud model 3D autoencoder network Generative adversarial network

黑龙江省旅游业绿色低碳转型的现状及发展路径

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学术交流 2024年第7期 127-139页

作者：张自立赵宸悉乔朋华哈尔滨工业大学经济与管理学院哈尔滨150001 昆明理工大学管理与经济学院昆明650500

发展低碳旅游是践行生态文明理念、响应国家绿色低碳发展要求的必然趋势。黑龙江省拥有丰富的旅游文化资源和独特的自然生态条件,但在低碳旅游法律法规和碳排放监管体系、绿色低碳基础设施、低碳技术研发等方面存在不足,制约了黑龙江省... 详细信息

发展低碳旅游是践行生态文明理念、响应国家绿色低碳发展要求的必然趋势。黑龙江省拥有丰富的旅游文化资源和独特的自然生态条件,但在低碳旅游法律法规和碳排放监管体系、绿色低碳基础设施、低碳技术研发等方面存在不足,制约了黑龙江省旅游业向绿色低碳化的方向转型。黑龙江省旅游业在向绿色低碳化方向转型的过程中,在政府层面上健全绿色低碳旅游的法律法规和标准规范、加强旅游业碳排放测算监管与统计、推进低碳旅游示范区建设、完善低碳技术人才的培养与引进机制,在产业层面上引进绿色低碳基础设施和绿色新型材料能源技术、创新低碳旅游经营管理服务模式、构建低碳旅游产业结构体系、推进低碳旅游产业协同融合发展,在游客和从业人员层面上引导并规范游客的低碳旅游行为、树立绿色低碳旅游理念,推动黑龙江省实现旅游业的绿色低碳转型和可持续发展。

关键词：旅游业绿色低碳转型发展路径黑龙江省

乙型肝炎病毒抑制M1巨噬细胞TLR4、NLRP3及下游因子促进免疫逃逸

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中国免疫学杂志 2024年第9期40卷 1808-1814页

作者：张自力刘佳敏曾蓉余玲叶青徐旭潘万龙川北医学院基础医学与法医学院南充637000 川北医学院附属医院南充637000

目的:探讨乙型肝炎病毒(HBV)抑制M1巨噬细胞促进免疫逃逸的机制,为抗病毒治疗提供靶点和策略。方法:人单核细胞系THP-1以PMA+LPS+IFN-γ诱导为M1巨噬细胞。通过细胞形态,流式细胞术及RT-qPCR检测CD68、CD86、HLA-DR及M1巨噬细胞功能性分... 详细信息

目的:探讨乙型肝炎病毒(HBV)抑制M1巨噬细胞促进免疫逃逸的机制,为抗病毒治疗提供靶点和策略。方法:人单核细胞系THP-1以PMA+LPS+IFN-γ诱导为M1巨噬细胞。通过细胞形态,流式细胞术及RT-qPCR检测CD68、CD86、HLA-DR及M1巨噬细胞功能性分子IL-1β、IL-6、TNF-α表达,以鉴定M1巨噬细胞。HBV稳定复制细胞系HepG2.2.15与M1巨噬细胞共培养,qPCR检测HBV-DNA的表达;流式细胞术检测CD68、CD86与HLA-DR表达;RT-qPCR与Western blot测定M1巨噬细胞功能相关分子TLR4、NLRP3、Caspase-1、pro-caspase-1、caspase-1 p20、IL-1β、IL-18的表达;流式细胞术检测细胞凋亡率,Western blot测定凋亡相关蛋白cleaved-caspase-3的表达。结果:成功诱导THP-1分化为M1巨噬细胞;M1巨噬细胞抑制HBV复制(P<0.05);HBV抑制M1巨噬细胞的CD68、CD86与HLA-DR的表达(P<0.01);HBV抑制M1巨噬细胞的TLR4、NLRP3,Cas-pase-1,caspase-1 p20、IL-1β、IL-18的表达(P<0.01);HBV诱导M1巨噬细胞凋亡(P<0.05)。结论:HBV通过抑制M1巨噬细胞及其功能分子TLR4、NLRP3及下游因子,减少炎症因子合成及分泌,诱导凋亡,进而促进免疫逃逸,造成HBV在体内持续存在并复制。

关键词： HBV TLR4 NLRP3 M1巨噬细胞免疫逃逸

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四川盆地及周缘前震旦系裂谷特征与油气地质意义

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天然气工业 2024年第1期44卷 26-39,I0001页

作者：文龙周刚孙峥严威卞从胜汪泽成张本健张亚张自力刘伟曾旭李传新田兴旺谢忱中国石油西南油气田公司中国石油西南油气田公司勘探开发研究院中国石油勘探开发研究院赵文智院士工作室中国石油勘探开发研究院中国地质大学(北京)能源学院

四川盆地及周缘已被证实发育较大规模的前震旦系裂谷,但其在盆地内部的展布及发育特征尚不明确,因此在一定程度上制约了对盆地深部构造格局的认识。为此,在前人研究的基础上,利用最新的重磁电资料,通过联合解译和小子域滤波等新技术对... 详细信息

四川盆地及周缘已被证实发育较大规模的前震旦系裂谷,但其在盆地内部的展布及发育特征尚不明确,因此在一定程度上制约了对盆地深部构造格局的认识。为此,在前人研究的基础上,利用最新的重磁电资料,通过联合解译和小子域滤波等新技术对新元古界构造形态进行了研究,同时结合区域地震大剖面的精细解释并辅以航磁资料进行验证,分析了新元古代裂谷的特征及其对上覆地层的沉积控制作用。研究结果表明:①盆地内部自西北至东南共发育3条近乎平行的前震旦系裂谷,其中以川中裂谷规模最大;②裂谷内部发育一系列与裂谷走向近平行的次级正断层,将裂谷内部结构复杂化,形成一系列断陷;③裂谷内断层在平面上呈平行/斜列式、相向/相背平行式及同向平行式组合,对应在剖面上呈阶梯式、垒堑式、地堑式及铲式半地堑式等组合特征;④盆地东北部盆缘露头揭示南华系—陡山沱组在裂谷内发育冰期—间冰期交互沉积,主要为三角洲、陆棚与斜坡盆地相碎屑岩和冰碛岩。结论认为,应用重磁联合解译+井震资料修订+露头剖面验证的新方法,证实四川盆地前震旦系裂谷的存在,且南华纪裂谷边界(主干)断裂控制了上覆地层沉积古地理格局和坡折带的发育,部分裂谷控制了寒武系或早古生界沉积中心的分布,并对后期沉降中心、构造圈闭的形成以及含油气系统有着极为重要的影响。

关键词：四川盆地新元古代前震旦系冰期—间冰期沉积超深层勘探重磁解译构造样式裂谷分布

“超预测”:蕴含动态因果系统的股债相关性研究

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金融市场研究 2024年第4期 31-40页

作者：杜思臻张自力赵学军北京大学光华管理学院嘉实基金管理有限公司

文章从因果视角提出了一个新的股债相关性分析和预测框架。首先,考虑到股票和债券之间存在高度复杂的非线性关系且并不满足可分离性,文章采用收敛交叉映射方法进行因果检验。结果表明,股票价格和债券价格存在双向因果关系。文章进一步通... 详细信息

文章从因果视角提出了一个新的股债相关性分析和预测框架。首先,考虑到股票和债券之间存在高度复杂的非线性关系且并不满足可分离性,文章采用收敛交叉映射方法进行因果检验。结果表明,股票价格和债券价格存在双向因果关系。文章进一步通过S-map方法量化因果强度,并通过实证分析发现股债因果关系是驱动股债相关性变化的重要因素。在传统股债相关系数预测模型基础上,引入因果强度能够显著提升预测模型的表现,进而提升股票和债券资产配置效率。

关键词：相关性因果性资产配置

A garnet-electrolyte based molten Li-I_(2) battery with high performance

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Nano Research 2022年第5期15卷 4076-4082页

作者： Bin Sun Panpan Wang Jing Xu Qianzheng Jin zili zhang Hui Wu Yang Jin Research Center of Grid Energy Storage and Battery Application School of Electrical EngineeringZhengzhou UniversityZhengzhou 450001China School of Physics and Optoelectronic Engineering Xiangtan universityXiangtan 411105China School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China

Lithium-iodine(Li-I_(2))battery exhibits high potential to match with high-rate property and large energy ***,problems of the system,such as evident sublimation of iodine elements,dissolution of iodine species in electrolyte,and lithium anode corrosion,prevent the practical use of rechargeable Li-I_(2)*** this work,a molten Li-I_(2)typical cell design which has distinct advantages based on the solid-state garnet electrolyte with the eutectic iodate cathode is firstly *** U-shaped ceramic electrolyte tube can separate Li anode from the eutectic iodate cathode,so as to better tackle the above-mentioned inherent challenges for the liquid electrolyte *** self-discharging and lithium anode corrosion,this solid-state battery system demonstrates high safety margin and excellent electrochemical ***,the simple battery structure also indicates the easy assembly process and recycling of electrode *** the cathode loading of 593 mg in a single cell,an energy density of~506.7 Wh·kg^(-1)was achieved at 1 C and a long-term cycling life for 2,000 cycles also displays negligible capacity decay.

关键词： garnet electrolyte molten eutectic salt cathode safety

Terahertz frequency characterization of anisotropic structure of tourmaline

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Frontiers of Optoelectronics 2017年第4期10卷 409-413页

作者： Weichong TANG zili zhang Ke XIAO Changchun ZHAO Zhiyuan ZHENG School of Science China University of Geosciences Beijing 100083 China

The absorption coefficient and refractive index of tourmaline in different directions were characterized for the first time using terahertz time-domain spectroscopy. Results show that the absorption and refractive index of terahertz frequency are related to the structure of tourma- line. Absorption along the optical axis direction is more sensitive than that along the vertical direction. This result indicates that the identification and characterization of crystals as well as minerals can be realized by the terahertz method.

关键词： tourmaline optical properties terahertz spectroscopy

Influence of welding parameters on interface evolution and mechanical properties of FSW Al/Ti lap joints

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Journal of Materials Science & Technology 2019年第8期35卷 1543-1554页

作者： Mingrun Yu Hongyun Zhao Zhihua Jiang zili zhang Fei Xu Li Zhou Xiaoguo Song State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin 150001 China Shandong Provincial Key Laboratory of Special Welding Technology Harbin Institute of Technology at WeihaiWeihai 264209 China

Friction stir welding(FSW)was performed to produce Al/Ti lap joints under various welding *** heat was generated when rotational rate increased or traversing rate *** types of Al/Ti interfaces–mixed interface and diffusive interface–were formed under different welding *** diffusive interface was formed with low heat input,and the mixed interface was formed more *** grains at the mixed interface were larger than those at the diffusive interface because of the higher heat ***,the microstructure of the mixed interface had a lower texture intensity compared with that of the diffusive interface,which was attributed to the enhanced continuous dynamic recrystallization(CDRX).TiAl3 was formed at the diffusive *** the interface varied to the mixed interface as heat input increased,TiAl was fomed within the Al/Ti mixture following the formation of *** addition,TiAl3 precipitates were observed in the diffusion *** hardness value of the mixed interface was higher than 350 HV,due to the larger amount of intermetallic compounds(IMCs).The lap shear strength reached a maximum value of 147 MPa with medium heat input and an interface that exits in a critical state between diffusive and mixed *** the specimens fractured at the interface,which was attributed to the presence of IMCs.

关键词： FSW Al/Ti lap joint Interfacial characteristics Mechanical properties