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Enriching the library of axial superlattice nanowires

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Science China Materials 2021年第10期64卷 2627-2628页

作者： li Zhai zijian li Hua Zhang Department of Chemistry City University of Hong KongKowloonHong KongChina Hong Kong Branch of National Precious Metals Material Engineering Research Center(NPMM) City University of Hong KongHong KongChina Shenzhen Research Institute City University of Hong KongShenzhen 518057China

Integrating functional materials to form heterostructures with novel,sophisticated architectures has attracted extensive interest in chemistry and materials science^([1]).Heterostructures are expected to exhibit superior electrical,thermal,optical and magnetic properties due to the synergistic effect of their different ***,the rational design and preparation of heterostructures with controlled compositions,dimensions.

关键词： nanowires axial rational

Bile acids and coronavirus disease 2019

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Acta Pharmaceutica Sinica B 2024年第5期14卷 1939-1950页

作者： Xiaoru Huang Xuening liu zijian li Department of Pharmacy Peking University Third HospitalBeijing 100191China Department of Pharmaceutical Management and Clinical Pharmacy College of PharmacyPeking UniversityBeijing 100191China Department of Cardiology and Institute of Vascular Medicine Peking University Third HospitalBeijing Key Laboratory of Cardiovascular Receptors ResearchKey Laboratory of Cardiovascular Molecular Biology and Regulatory PeptidesMinistry of HealthState Key Laboratory of Vascular Homeostasis and RemodelingPeking UniversityBeijing 100191China

The coronavirus disease 2019(COVID-19)pandemic,caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has been significantly ***,long-term health effects and prevention strategy remain ***,it is essential to explore the pathophysiological mechanisms and intervention for SARS-CoV-2 *** research indicates a link between COVID-19 and bile acids,traditionally known for facilitating dietary fat *** bile acid ursodeoxycholic acid potentially protects against SARS-CoV-2 infection by inhibiting the farnesoid X receptor,a bile acid nuclear *** activation of G-protein-coupled bile acid receptor,another membrane receptor for bile acids,has also been found to regulate the expression of angiotensin-converting enzyme 2,the receptor through which the virus enters human ***,we review the latest basic and clinical evidence linking bile acids to SARS-CoV-2,and reveal their complicated pathophysiological mechanisms.

关键词： Bile acids COVID-19 Farnesoid X receptor G-protein-coupled bile acid receptor SARS-CoV-2 Angiotensin-converting enzyme 2 Ursodeoxycholic acid Chenodeoxycholic acid

Corpus Augmentation for Improving Neural Machine Translation

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Computers, Materials & Continua 2020年第7期64卷 637-650页

作者： zijian li Chengying Chi Yunyun Zhan University of Science and Technology liaoning Anshan114031China College of Science&Health Technological University DublinDublinD08 X622Ireland

The translation quality of neural machine translation(NMT)systems depends largely on the quality of large-scale bilingual parallel corpora *** shows that under the condition of limited resources,the performance of NMT is greatly reduced,and a large amount of high-quality bilingual parallel data is needed to train a competitive translation ***,not all languages have large-scale and high-quality bilingual corpus resources *** these cases,improving the quality of the corpora has become the main focus to increase the accuracy of the NMT *** paper proposes a new method to improve the quality of data by using data cleaning,data expansion,and other measures to expand the data at the word and sentence-level,thus improving the richness of the bilingual *** long short-term memory(LSTM)language model is also used to ensure the smoothness of sentence construction in the process of sentence *** the same time,it uses a variety of processing methods to improve the quality of the bilingual *** using three standard test sets are conducted to validate the proposed method;the most advanced fairseq-transformer NMT system is used in the *** results show that the proposed method has worked well on improving the translation *** with the state-of-the-art methods,the BLEU value of our method is increased by 2.34 compared with that of the baseline.

关键词： Neural machine translation corpus argumentation model improvement deep learning data cleaning

Quantitative analysis of impact of green stormwater infrastructures on combined sewer overflow control and urban flooding control

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Frontiers of Environmental Science & Engineering 2017年第4期11卷 93-104页

作者： Jinsong Tao zijian li Xinlai Peng Gaoxiang Ying State Key Laboratory of Pulp and Paper Engineering South China University of Technology Guangzhou 510640 China Department of Civil Engineering Case Western Reserve University Cleveland OH 44106 USA Unified Investigations & Sciences. Fort Lauderdale FL 33071 USA Office of Watersheds Philadelphia Water 1101 Market Street 4th Floor Philadelphia PA 19107 USA

Stimulated by the recent USEPA＇s green stormwater infrastructure （GSI） guidance and policies, GS1 systems have been widely implemented in the municipal area to control the combined sewer overflows （CSOs）, also known as low impact development （liD） approaches. To quantitatively evaluate the performance of GSI systems on CSO and urban flooding control, USEPA-Stormwater Management Model （SWMM） model was adopted in this study to simulate the behaviors of GSI systems in a well- developed urban drainage area, PSW45, under different circumstances. The impact of different percentages of stormwater runoff transported from impervious surfaces to the GSI systems on CSO and urban flooding control has also been investigated. Results show that with current buildup, GSI systems in PSW45 have the best performance for low intensity and short duration events on both volume and peak flow reductions, and have the worst pertbrmance tor high intensity and long durataon events. Since the low intensity and short duration events are dominant from a long-term perspective, utilizing GSI systems is considered as an effective measure of CSO control to meet the long-term controlstrategy for PSW45 watershed. However, GSI systems are not suitable for the flooding control purpose in PSW45 due to the high occurrence possibility of urban flooding during or after high intensity events where GSI systems have relatively poor performance no matter for a short or long duration event,

关键词： Green stormwater infrastructure (GSI) Combined sewer overflows (CSOs) Urban flooding Low impact development (liD) Stormwater Management Model (SWMM)

Tsai Chiao:The founder of physiology and aviation,aerospace and navigation medicine in China

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Protein & Cell 2022年第11期13卷 779-784页

作者： Yalan Wang zijian li Yanyan Qian Benyu Guo Psychology College Nanjing Normal UniversityNanjing 210097China Social and Behavioural Sciences Faculty Leiden University2333 AK LeidenNetherlands

On February 16th,2019,Tsai Academician Museum held a launch ceremony of a minor planet(207681)'s settling in Jieyang County,Guangdong *** minor planet was given a new name Cai Qiao(Fig.1)on October 14th,*** Qiao was discovered at Xu Yi Station in the Purple Hills Observatory of the Chinese Academy of Sciences on August 16th,*** who is the planet named after?

关键词： Academician planet aviation

A novel β_(2)-AR agonist,Higenamine,induces β-arrestin-biased signaling

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Science China(life Sciences) 2022年第7期65卷 1357-1368页

作者： Nana Zhang Haibo Zhu zijian li Erdan Dong State Key Laboratory for Bioactive Substances and Functions of Natural Medicines/Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study/Institute of Materia Medica Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China Department of Cardiology and Institute of Vascular Medicine Peking University Third Hospital/Key Laboratory of Cardiovascular Receptors ResearchBeijing/Key Laboratory of Molecular Cardiovascular SciencesMinistry of Education/Key Laboratory of Cardiovascular Molecular Biology and Regulatory PeptidesMinistry of HealthBeijing 100191China

The biased ligands in G protein-coupled receptors(GPCRs)have opened new avenues for developing safer and more effective ***,the identification of such biased ligands as drug candidates is highly ***,we report that Higenamine,a compound isolated from a Chinese herb,functions as a novel β-arrestin-biased ligand of the β_(2)-adrenergic receptor(β_(2)-AR).The radioligand binding assays demonstrated that Higenamine was the ligand of β_(2)-*** induced phosphorylation of extracellular signal-regulated kinase 1/2(ERK1/2),which can be blocked by propranolol,an inhibitor of β_(2)-*** Gi protein inhibitor,pertussis toxin,had no effect on the phosphorylation of ERK1/2 induced by ***,Higenamine induced ERK1/2 phosphorylation through transactivation of Epithelial growth factor receptor(EGFR).We also found that Higenamine-induced-ERK1/2 phosphorylation is dependent on β-arrestin1/2,and HG inhibits Doxorubicin-induced cardiomyocyte *** results identify Higenamine as a novel biased ligand via the β-arrestin-dependent *** findings give us a better understanding of Higenamine’s potential role in designing diagnostic and therapeutic strategies.

关键词： Higenamine β_(2)-adrenergic receptor β-arrestin-biased signaling extracellular signal-regulated kinase 1/2

Uncertainty Analysis Method of Casing Extrusion Load for Ultra-Deep Wells

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Computer Modeling in Engineering & Sciences 2017年第4期113卷 475-495页

作者： Meng li Kanhua Su zijian li Dongjie li lifu Wan School of Petroleum Chongqing University of Science and TechnologyChongqing401331China Memorial University of Newfoundland St.John'sA1C5S7Canada Engineering Technology Research Institute PetroChina Huabei Oilfield CompanyRenqiu062552China

With the consideration of the randomness of complex geologic parameters for ultra-deep wells,an uncertainty analysis method is presented for the extrusion load on casing in ultra-deep wells through complex formation at a certain confidence *** on the extrusion load model for casing in ultra-deep wells and the prerequisite of integrity of formation-cement ring-casing,the probability and statistics theory are introduced and the sensitivity analysis on the uncertainty of extrusion load on casing is *** distribution types of each formation parameters are determined *** distribution type and distribution function of the extrusion load on casing are ***,the uncertainty analysis of the extrusion load on casing is carried out on several ultra-deep wells in Shanqian block as case *** conclusions are made regarding to the field trial *** randomness of formation elasticity modulus and formation Poisson’s ratio are the main influence *** equivalent density profile of extrusion load on casing in ultra-deep wells is a confidence interval with a certain confidence level,rather than a single curve;the higher the confidence level is,the larger the bandwidth of the confidence interval of equivalent density profile becomes,and the larger the range of uncertainty interval *** with the result of uncertainty analysis,an error exists in the result of traditional single valued calculation *** error varies with different casing program and can be either positive or *** application of uncertainty analysis of extrusion load on casing provides proof for the accurate determination of casing collapse safety ***,the over engineering design or under engineering design as a result of tradition casing design will be avoided.

关键词： Ultra-deep well formation parameters uncertainty extrusion load confidence interval

Microcapsule-enabled self-healing concrete:A bibliometric analysis

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Frontiers of Structural and Civil Engineering 2023年第11期17卷 1611-1629页

作者： Shuai ZHOU zijian li Kai li Yue JIA Chong WANG Xiaoying ZHUANG College of Materials Science and Engineering Chongqing UniversityChongqing 400045China Department of Mathematics and Physics Leibniz Universität HannoverHannover 30167Germany Department of Geotechnical Engineering College of Civil EngineeringTongji UniversityShanghai 200092China

With the development of self-healing technology, the overall properties of the microcapsule-enabled selfhealingconcrete have taken a giant leap. In this research, a detailed assessment of current research on the microcapsuleenabledself-healing concrete is conducted, together with bibliometric analysis. In the bibliometric analysis, variousindicators are considered. The current state of progress regarding self-healing concrete is assessed, and an analysis of thetemporal distribution of documents, organizations and countries of literature is conducted. Later, a discussion of thecitations is analyzed. The research summarizes the improvements of microcapsule-enabled self-healing cementitiouscomposites and provides a concise background overview.

关键词： microcapsule self-healing concrete bibliographic analysis

Applications of nanotechnology in biomedicine

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Chinese Science Bulletin 2013年第35期58卷 4515-4518页

作者： WU JiMin li zijian Institute of Vascular Medicine Peking University Third Hospital Key Laboratory of Cardiovascular Molecular Biology and Regulatory PeptidesMinistry of Health Key Laboratory of Molecular Cardiovascular Sciences Ministry of Education and Beijing Key Laboratory of Cardiovascular Receptors Research

Nanomedicine is the application of nanotechnology in treatment,diagnosis,monitoring and control of biological systems,and is at the leading-edge of clinical medicine and preclinical *** attention has been paid to the application of nanotechnology in medicine recently(Figure 1).Nanotechnology means the control of matter and processes at a nanoscale(1–100 nm)in one or more dimen-

关键词：纳米技术生物医学应用临床医学纳米医学生物系统