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Petroleum Science 2022年第5期19卷 2431-2447页

作者： Yan Wu zi-yuan cui Hai Lin Yu-Fei Wang Xiao Feng School of Chemical Engineering and Environment China University of Petroleum(Beijing)18 Fuxue RoadChangpingBeijing102249China School of Chemical Engineering and Technology Xi'an Jiaotong University28 Xianning West RoadXi'anShaanxi710049China

Shale gas gathering systems are of great importance in gas fields for the efficient and reliable transportation of *** traditional design methods,pipeline layouts are optimized only from an economic point of view,where reliability is evaluated after ***,reliability can be enhanced by spare pipelines so that both economic and reliable aspects are evaluated *** on the idea of enhancing reliability,this research proposes a methodology for optimizing the pipeline layout problem including well clustering,stations site selecting,and *** topology arrangements and spare pipelines are investigated to enhance the production efficiency and reliability of the pipeline network under earthquake-related *** evaluation is converted into an economic one so that the objective of this work is to minimize the total annual *** solve such a complex problem,genetic algorithm,K-means algorithm,Geo Steiner algorithm,Kruskal algorithm,linear programming and Monte Carlo simulations are combined.A real-world case study illustrates the effectiveness of the proposed methodology and shows a 36.53%reduction in the total annual cost compared with the initial scheme.

关键词： Shale gas Gathering system Network topology Reliability Uncertainty

Glaucomatous retinal ganglion cells:death and protection

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International Journal of Ophthalmology(English edition) 2025年第1期18卷 160-167页

作者： Na cui Jun Jia yuan He Department of Ophthalmology the Second Affiliated Hospital of Xi’an Medical UniversityXi’an 710038Shaanxi ProvinceChina Xi’an Key Laboratory for the Prevention and Treatment of Eye and Brain Neurological Related Diseases Xi’an 710038Shaanxi ProvinceChina

Glaucoma is a group of diseases characterized by progressive optic nerve degeneration,with the characteristic pathological change being death of retinal ganglion cells(RGCs),which ultimately causes visual field loss and irreversible *** intraocular pressure(IOP)remains the most important risk factor for glaucoma,but the exact mechanism responsible for the death of RGCs is currently *** factor deficiency,impaired mitochondrial structure and function,disrupted axonal transport,disturbed Ca2+homeostasis,and activation of apoptotic and autophagic pathways play important roles in RGC death in *** review was conducted using Web of Science,PubMed,Project,and other databases to summarize the relevant mechanisms of death of RGCs in glaucoma,in addition to outlining protective treatments to improve the degradation of RGCs.

关键词： glaucoma retinal ganglion cells neuroprotection progressive death axonal deletion

Effect of lanthanum on microstructure of a nickel-based single crystal superalloy

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China Foundry 2025年第1期22卷 55-64页

作者： Hong Gao Kai Guan Ren-jie cui Jian-chao Qin zi-han Zhao Zhao-hui Huang Science and Technology on Advanced High Temperature Structural Materials Laboratory Beijing Institute of Aeronautical MaterialsBeijing 100095China

To enhance the high-temperature oxidation resistance and mechanical properties of a secondgeneration nickel-based superalloy,various concentrations of lanthanum(La)ranging from 5.0×10^(-5)wt.%to 3.4×10^(-4)wt.%are added to the *** microstructure of the nickel-based single crystal superalloy with trace of La was examined by means of SEM,EDS and *** show the addition of La decreases the segregation of elements and increases the amount ofγ/γ′eutectics of the as-cast alloy,and in the interdendritic region,the growth of eutectics is accompanied by the growth of strip clusters composed of Ni_(5)La and Ni_(3)*** the La content in the alloy increases,the proportion of Ni_(5)La in the cluster *** heat treatment,incipient melting occurs in the cluster regions,leading to an increase in microporosity compared to the original as-cast ***,the heat treatment alters the shape of the clusters from a strip morphology to an elliptical one,and it changes their composition from Ni_(5)La and Ni_(3)Ta to a combination of Ni_(5)La,Ni_(3)Ta,and MC carbides.

关键词： single crystal superalloy lanthanum microstructure heat-treatment precipitate phase

The gut microbiome modulate response to immunotherapy in cancer

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Science China(Life Sciences) 2025年第2期68卷 381-396页

作者： Shan-Shan Jiang zi-Ran Kang Ying-Xuan Chen Jing-yuan Fang Division of Gastroenterologyand Hepatology Shanghai Instituteof Digestive DiseaseNHC KeyLaboratoryof Digestive DiseasesState KeyLaboratoryfor Oncogenesand Related GenesRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200001China

Gut microbiota have been reported to play an important role in the occurrence and development of malignant ***,clinical studies have identified specific gut microbiota and its metabolites associated with efficacy of immunotherapy in multiple types of *** investigations have elucidated that gut microbiota modulate the antitumor immunity and affect the efficacy of cancer *** microbiota and its metabolites may favorably remodel the tumor microenvironment by engaging innate and/or adaptive immune *** how the gut microbiome interacts with cancer immunotherapy opens new avenues for improving treatment *** microbial transplants,probiotics,dietary interventions,and other strategies targeting the microbiota have shown promise in preclinical studies to enhance the *** clinical trials are evaluating these *** review presents the recent advancements in understanding the dynamic interplay among the host immunity,the microbiome,and cancer immunotherapy,as well as strategies for modulating the microbiome,with a view to translating into clinical applications.

关键词： cancer immunotherapy gut microbiota intratumoral microbiota microbiota-derived metabolites innate and adaptive immunity

TKN3 affects cell expansion to regulate fruit development in tomato

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Horticultural Plant Journal 2025年第1期11卷 251-263页

作者： Shuai Sun Yaqin yuan Meng Xu Zhiqiang Liu Xiaowei yuan Xingsheng Li Ren Li Xia cui Key Laboratory of Biology and Genetic Improvement of Horticultural Crops of the Ministry of Agriculture Sino-Dutch Joint Laboratory of Horticultural GenomicsInstitute of Vegetables and FlowersChinese Academy of Agricultural SciencesBeijing 100081China Key Laboratory of Qualityand Safety Control for Subtropical Fruitand Vegetable Ministry of Agriculture and Rural AffairsCollege of Horticulture ScienceZhejiang A&F UniversityHangzhouZhejiang 311300China Huasheng Agriculture Limited Liability Company QingzhouShangdong 262500China

Tomato is a model system for studying fleshy fruit *** fertilization,cell division and expansion in the pericarp are crucial for fruit development and determine the final fruit ***3 was found to be expressed in the tomato ovary wall/pericarp of zero to two days post-anthesis fruits as a KNOX I class member,but its function in fruit development was ***,we found that mutations of TKN3 by CRISPR/Cas9 caused fruit developmental defects,and fruit weight was dramatically reduced in the tkn3cr *** observation of fruit pericarps revealed that mutation of TKN3 repressed cell expansion after fertilization,leading to flattened cells in the mesocarp and thereby thinner pericarps in red ***,tkn3cr mutants also displayed pleiotropic phenotypes including enlarged leaves and floral organs,indicating conserved functions in meristem maintenance and leaf *** two-hybrid and BiFC assays further showed that TKN3 could interact with Solyc10g086640(a homolog of Arabidopsis PNY),which has a similar expression pattern as ***-wide identification of genes regulated by TKN3 indicated that the auxin and gibberellin(GA)pathways might mediate the function of *** works revealed that TKN3 controls cell expansion in pericarps,and provides new insights into the roles of KNOX proteins in fruit development.

关键词： Solanum lycopersicum TKN3 Tomato fruits Cell expansion BELLs Transcription factor

Upper mantle discontinuity structure beneath the Hindu Kush:Insights into dynamics of the Indian slab

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Science China Earth Sciences 2025年第3期68卷 720-729页

作者： Qinghui cui yuanze ZHOU yuan GAO Lijun LIU Key Laboratory of Earthquake Prediction Institute of Earthquake ForecastingChina Earthquake Administration College of Earth and Planetary Sciences University of Chinese Academy of Sciences Institute of Geology and Geophysics Chinese Academy of Sciences Department of Geology University of Illinois at Urbana-Champaign

Upper mantle discontinuities play an important role in slab dynamics and mantle responses in the subduction *** increasing numbers of seismological observations in the Hindu Kush, fine structures of mantle discontinuities still remain less explored, highlighting less understood interactions of the Indian slab and discontinuities. Here we collected a large dataset of several dense seismic networks/arrays, extracted near-source SdP waves in P-wave codas using the N-th root slant stackings, and then systematically imaged upper mantle discontinuities around the Indian slab beneath Hindu Kush. In comparison with the IASP91 model, we confirmed an abrupt topographic transition of the 410-km discontinuity(410) from uplifts of up to 41 km to depressions of less than 20 km near the slab edge and a slightly depressed 660-km discontinuity(660) with depths of 660 to 668 km below the slab front, as well as a fluctuating 300-km discontinuity(300) with depths of 264 to 337 km. We suggest that the 410 is elevated by the Indian slab due to the interior coldness, and deepened near the slab edge by the hot upwelling slab-entrained mantle that escapes below the slab bottom. Based on a depressed 410 inside the Indian slab and a 660with slight depressions below the slab, we infer that the subducted Indian slab currently stretches into the upper MTZ. Moreover,we interpret the fluctuant 300 as the coesite to stishovite phase transition in the subduction-zone mantle enriched in the *** considered alongside other studies, our results can provide more insights into the dynamics of the Indian slab and mantle responses.

关键词： Hindu Kush subduction zone Upper mantle discontinuities Indian slab Hot slab-entrained mantle N-th root slant stacking

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Effect of initial microstructure on microstructure evolution and mechanical properties of 0.12C martensitic steels during quenching and tempering

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Journal of Iron and Steel Research International 2025年第1期32卷 260-269页

作者： Ya-ru Wang zi-yong Hou He Yang Jun Zhao Zhi-yuan Chang Fan-mao Meng Ling Zhang Gui-lin Wu Xiao-xu Huang State Key Laboratory of Vanadium and Titanium Resource Comprehensive Utilization Panzhihua 617000SichuanChina State Key Laboratory of Advanced Special Steel Shanghai Key Laboratory of Advanced FerrometallurgySchool of Materials Science and EngineeringShanghai UniversityShanghai 200444China International Joint Laboratory for Light Alloys(Ministry of Education) College of Materials Science and EngineeringChongqing UniversityChongqing 400044China Institute of Steel Technology for Automobile and Household Appliance Pangang Group Co.Ltd.Panzhihua 617000SichuanChina ATB Motor(Shanghai)Co. Ltd.Keen International CenterShanghai 200041China Beijing Advanced Innovation Center for Materials Genome Engineering University of Science and Technology BeijingBeijing 100083China

The microstructure evolution and mechanical properties of a Fe-0.12C-0.2Si-1.6Mn-0.3Cr-0.0025B(wt.%)steel with different initial microstructures,i.e.,hot rolled(HR)and cold rolled-annealed(CRA),were studied through optical microscopy,scanning electron microscopy,electron channeling contrast imaging,microhardness and room temperature uniaxial tensile *** water quenching from 930℃ to room temperature,a fully martensitic microstructure was obtained in both as-quenched HR and CRA specimens,which shows a microhardness of 480±5 HV,and no significant difference in microstructure and microhardness was *** test results show that the product of tensile strength and total elongation(UTS×TE)of the as-quenched HR specimen,i.e.,24.1 GPa%,is higher than that of the as-quenched CRA specimen,i.e.,18.9 GPa%.While,after being tempered at 300℃,the martensitic microstructures and mechanical properties of the two as-quenched specimens change significantly due to the synergy role of the matrix phase softening and the precipitation *** the maximum UTS×TE,it is 18.9 GPa%obtained in the as-quenched CRA one,while that is 24.4 GPa%obtained in the HR specimen after tempered at 300℃ for 5 min.

关键词： Initial microstructure Lath martensite Quenching Tempering Mechanical property

Poorly controlled type Ⅱ diabetes mellitus significantly enhances postoperative chemoresistance in patients with stage Ⅲ colon cancer

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World Journal of Gastroenterology 2025年第3期31卷 29-41页

作者： Ruo-Yu Guan Jia-Wei Wu zi-Yun yuan Zhi-yuan Liu zi-Zhu Liu Zhi-Cong Xiao Jing-Hui Li Cheng-Zhi Huang Jun-Jiang Wang Xue-Qing Yao Guangdong Cardiovascular Institute Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesSouthern Medical UniversityGuangzhou 510080Guangdong ProvinceChina Department of Gastrointestinal Surgery Department of General SurgeryGuangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou 510080Guangdong ProvinceChina Department of General Surgery Guangdong Provincial People’s Hospital Ganzhou Hospital(Ganzhou Municipal Hospital)Ganzhou 341000Jiangxi ProvinceChina Shantou University Medical College Shantou 515041Guangdong ProvinceChina School of Medicine South China University of TechnologyGuangzhou 510006Guangdong ProvinceChina Gannan Medical University Ganzhou 341000Jiangxi ProvinceChina

BACKGROUND Type Ⅱ diabetes mellitus(T2DM)has been associated with increased risk of colon cancer(CC)and worse prognosis in patients with *** effects of T2DM on postoperative chemoresistance rate(CRR)and long-term disease-free survival(DFS)and overall survival(OS)in patients with stage Ⅲ CC who receive curative resection remain *** To investigate whether T2DM or glycemic control is associated with worse postoperative survival outcomes in stage Ⅲ *** This retrospective cohort study included 278 patients aged 40-75 years who underwent surgery for stage Ⅲ CC from 2018 to *** on preoperative T2DM history,the patients were categorized into non-DM(n=160)and DM groups(n=118).The latter was further divided into well-controlled(n=73)and poorly controlled(n=45)groups depending on the status of glycemic ***,OS,and CRR were compared between the groups and Cox regression analysis was used to identify risk *** Patients in the DM and non-DM groups demonstrated similar DFS,OS,and CRR(DFS:72.03%vs 78.75%,P=0.178;OS:81.36%vs 83.12%,P=0.638;CRR:14.41%vs 7.5%,P=0.063).Poorly controlled DM was associated with a significantly worse prognosis and higher CRR than well-controlled DM(DFS:62.22%vs 78.07%,P=0.021;OS:71.11%vs 87.67%,P=0.011;CRR:24.40%vs 8.22%,P=0.015).High preoperative fasting plasma glucose[DFS:Hazard ratio(HR)=2.684,P<0.001;OS:HR=2.105,P=0.019;CRR:HR=2.214,P=0.005]and glycosylated hemoglobin levels(DFS:HR=2.344,P=0.006;OS:HR=2.119,P=0.021;CRR:HR=2.449,P=0.009)indicated significantly poor prognosis and high CRR,while T2DM history did not(DFS:HR=1.178,P=0.327;OS:HR=0.933,P=0.739;CRR:HR=0.997,P=0.581).CONCLUSION Increased preoperative fasting plasma glucose and glycosylated hemoglobin levels,but not T2DM history,were identified as risk factors associated with poor postoperative outcomes and high CRR in patients with stage Ⅲ CC.

关键词： Colon cancer Chemoresistance Diabetes mellitus Prognosis TypeⅡdiabetes mellitus

Comparative proteomic analysis of plasma exosomes reveals the functional contribution of N-acetyl-alpha-glucosaminidase to Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2998-3012页

作者： yuan Zhao Yidan Zhang Xin Liu Jian Zhang Ya Gao Shuyue Li cui Chang Xiang Liu Guofeng Yang Department of Geriatrics Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Department of Neurosurgery The Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina

Parkinson’s disease is the second most common progressive neurodegenerative disorder,and few reliable biomarkers are available to track disease *** proteins,DNA,mRNA,and lipids carried by exosomes reflect intracellular changes,and thus can serve as biomarkers for a variety of *** this study,we investigated alterations in the protein content of plasma exosomes derived from patients with Parkinson’s disease and the potential therapeutic roles of these proteins in Parkinson’s *** a tandem mass tag-based quantitative proteomics approach,we characterized the proteomes of plasma exosomes derived from individual patients,identified exosomal protein signatures specific to patients with Parkinson’s disease,and identified N-acetyl-alpha-glucosaminidase as a differentially expressed protein.N-acetyl-alpha-glucosaminidase expression levels in exosomes from the plasma of patients and healthy controls were validated by enzyme-linked immunosorbent assay and western *** results demonstrated that the exosomal N-acetyl-alpha-glucosaminidase concentration was not only lower in Parkinson’s disease,but also decreased with increasing Hoehn-Yahr stage,suggesting that N-acetyl-alpha-glucosaminidase could be used to rapidly evaluate Parkinson’s disease ***,western blot and immunohistochemistry analysis showed that N-acetyl-alpha-glucosaminidase levels were markedly reduced both in cells treated with 1-methyl-4-phenylpyridinium and cells overexpressingα-synuclein compared with control ***,N-acetyl-alpha-glucosaminidase overexpression significantly increased cell viability and inhibitedα-synuclein expression in 1-methyl-4-phenylpyridinium-treated *** together,our findings demonstrate for the first time that exosomal N-acetyl-alpha-glucosaminidase may serve as a biomarker for Parkinson’s disease diagnosis,and that N-acetyl-alpha-glucosaminidase may reduceα-synuclein expression and 1-methyl-4-phenylpyridinium-induced n

关键词： biomarker diagnosis exosomes N-acetyl-alpha-glucosaminidase Parkinson’s disease proteomic α-synuclein

Valence electron matching law for MXene-based single-atom catalysts

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Journal of Energy Chemistry 2025年第2期101卷 641-650页

作者： Pei Song Yuhang Zhou zishan Luo Hang Zhang Xi Sun Sen Lu Zepeng Jia Hong cui Weizhi Tian Rong Feng Lingxia Jin Hongkuan yuan School of Mechanical Engineering Shaanxi University of Technology Shaanxi Key Laboratory of Industrial Automation Shaanxi University of Technology Shaanxi Key Laboratory of Catalysis College of Chemical & Environment Science Shaanxi University of Technology School of Physical Science and Technology Southwest University

Single-atom catalysts（SACs） have attracted considerable interest in the fields of energy and environmental science due to their adjustable catalytic *** this study,we investigated the matching of valence electron numbers between single atoms and adsorbed intermediates（O,N,C,and H） in MXene-anchored SACs（M-Ti2C/M-Ti2CO2）.The density functional theory results demonstrated that the sum of the valence electron number（VM） of the interface-doped metal and the valence electron number（VA） of the adsorbed intermediates in M-Ti2C followed the 10-valence electron matching ***,based on the 10-valence electron matching law,we deduced that the sum of the valence electron number（k） and VMfor the molecular adsorption intermediate interactions in M-Ti2CO2adhered to the 11-valence electron matching *** repulsion between the interface electrons in M-Ti2CO2and H2O weakened the adsorption of intermediates,Furthermore,we applied the 11-valence electron matching law to guide the design of catalysts for nitrogen reduction reaction,specifically for N2→ NNH conversion,in the *** sure independence screening and sparsifying operator algorithm was used to fit a simple three-dimensional descriptor of the adsorbate（R2up to 0.970） for catalyst *** study introduced a valence electron matching principle between doped metals（single atoms） and adsorbed intermediates（atomic and molecular） for MXene-based catalysts,providing new insights into the design of high-performance SACs.

关键词： Density functional theory Nitrogen reduction reaction Sure independence screening and sparsifying operator Valence electron matching law