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Electrosynthesis of α-phenyllevulinic acid from benzalacetone and carbon dioxide

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Journal of Chemistry and Chemical Engineering 2007年第1期1卷 40-44页

作者： LIN Mei-yu WANG Huan LIU ying-zi zhang Kai LU Jia-xing Shanghai Key Laboratory of Green Chemistry and Chemical Process Departmentof Chemistry East ChinaNormal University Shanghai 200062 China

Electrocarboxylation ofbenzalacetone was studied in the presence of an atmospheric pressure of CO2 The only carboxylic product obtained was α-phenyl levulinic acid in a one-compartment electrochemical cell equipped with a Mg sacrificial anode at the controlled potential conditions. Influences of the solvents, the electrolytes, the cathode materials, the electrolysis potentials, the concentrations of substrate and the temperatures were studied to improve the yield. The maximal yield is 69% in MeCN-0.1 mol/L TEABF4 on Stainless steel-Mg under a controlled potential of-1.6 V ***/AgI until 2 F/mol of charge had passed through the cell at 0 ℃.

关键词： CO2 benzalacetone α-phenyllevulinic acid electrosynthesis

Effects of Al and Ni doping on oxidation and corrosion resistance of electrophoretic deposited YSZ coatings

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Transactions of Nonferrous Metals Society of China 2017年第7期27卷 1551-1557页

作者： Li-li WANG Wei WANG Ye-li FAN Xiao-xiao QI Ji-hua LIU zi-ying zhang School of Materials Engineering Shanghai University of Engineering Science Shanghai 201620 China

Yttria-stablized zirconia(YSZ)/(Ni,Al)coatings were deposited on Inconel600alloy substrate by the electrophoreticdeposition combined with vacuum sintering *** effects of isothermal oxidation at1100°C on the composition of thecoatings and the crack healing were investigated,and the corrosion resistance of the coatings in3.5%NaCl(mass fraction)solutionwas also *** results showed that the cracks on the coating gradually healed up with the increase of the isothermal *** isothermal oxidation process,the coating composed of Ni3Al was transformed toα-***α-Al2O3particulates can seal the defects such as pores and cracks,and meanwhile prevent the oxygen diffusion into the *** curves and EIS results indicated that the coatings oxidized for40h had a more positive corrosion potential,higherbreakdown potential,higher impedance module at low frequency and much lower corrosion current density compared with YSZcoated and uncoated Inconel600alloys.

关键词： electrophoretic deposition corrosion composite coating superalloy

Application of multiplex ligation-dependent probe amplification in the genetic testing of oculocutaneous albinism

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Chinese Medical Journal 2019年第16期132卷 2011-2012页

作者： ying-zi zhang Da-Yong Bai Zhan Qi Su-Zhou Zhao Xiu-Min Yang Wei Li Ai-Hua Wei Department of Dermatology Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China Shunyi Women and Children's Hospital of Beijing Children's Hospital Beijing 101300China Department of Ophthalmology Beijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijing 100045China Laboratory for Genetics of Birth Defects Beijing Pediatric Research InstituteBeijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijing 100045China Fulgent Technologies Incorporated Shanghai 201404China

To the Editor: Oculocutaneous albinism (OCA) is an autosomal recessive disorder caused by a group of mutations related to the regulation of melanin synthesis and melanosome biogenesis. The prevalence of OCA worldwide is approximately 1 in 17,000.[1] Other than symptomatic treatment, there is no effective treatment for albinism. Due to the variability in clinical phenotypes, it is difficult to classify sub-types simply by clinical features;therefore, molecular and genetic analyses are the most reliable methods for confirming diagnosis, carrier screening, and pre-natal diagnosis.

关键词： oculocutaneous albinism genetic

基于主体主观偏好的协同产品开发项目动态任务选择及仿真

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管理工程学报 2017年第1期31卷 185-191页

作者：李英姿张硕张晓冬胡杨北京科技大学东凌经济管理学院北京100083

针对协同产品开发项目的动态性、不确定性和复杂性的特点,首先对该过程中的任务类型及其特征进行了详细的说明,并提出了协同产品开发过程中的动态任务选择问题;其次,提出了基于设计主体主观偏好的动态任务选择方法,该方法考虑了设计主... 详细信息

针对协同产品开发项目的动态性、不确定性和复杂性的特点,首先对该过程中的任务类型及其特征进行了详细的说明,并提出了协同产品开发过程中的动态任务选择问题;其次,提出了基于设计主体主观偏好的动态任务选择方法,该方法考虑了设计主体的偏好:性格偏好与工作量偏好,以及任务的客观属性:重要度、紧急度和匹配度,从而在保证关键任务优先执行的同时,充分体现协同产品开发过程中设计主体的自主性、主动性和协作性;最后,对比仿真实验的结果表明,本文提出的方法能够有效地缩短产品开发周期,并能够清晰描述设计主体在过程中的动态任务选择行为过程。

关键词：设计主体主观偏好协同产品开发动态任务选择

NOX4 exacerbates Parkinson's disease pathology by promoting neuronal ferroptosis and neuroinflammation

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Neural Regeneration Research 2025年第7期20卷 2038-2052页

作者： Zhihao Lin Changzhou ying Xiaoli Si Naijia Xue Yi Liu Ran Zheng ying Chen Jiali Pu Baorong zhang Department of Neurology The Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina

Parkinson's disease is primarily caused by the loss of dopaminergic neurons in the substantia nigra ***,a novel form of regulated cell death characterized by iron accumulation and lipid peroxidation,plays a vital role in the death of dopaminergic ***,the molecular mechanisms underlying ferroptosis in dopaminergic neurons have not yet been completely *** oxidase 4 is related to oxidative stress,however,whether it regulates dopaminergic neuronal ferroptosis remains *** aim of this study was to determine whether NADPH oxidase 4 is involved in dopaminergic neuronal ferroptosis,and if so,by what *** found that the transcriptional regulator activating transcription factor 3 increased NADPH oxidase 4 expression in dopaminergic neurons and astrocytes in an 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-induced Parkinson's disease *** oxidase 4 inhibition improved the behavioral impairments observed in the Parkinson's disease model animals and reduced the death of dopaminergic ***,NADPH oxidase 4 inhibition reduced lipid peroxidation and iron accumulation in the substantia nigra of the Parkinson's disease model ***,we found that NADPH oxidase 4 interacted with activated protein kinase Cαto prevent ferroptosis of dopaminergic ***,by lowering the astrocytic lipocalin-2 expression,NADPH oxidase 4 inhibition reduced 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-induced *** findings demonstrate that NADPH oxidase 4 promotes ferroptosis of dopaminergic neurons and neuroinflammation,which contribute to dopaminergic neuron death,suggesting that NADPH oxidase 4 is a possible therapeutic target for Parkinson's disease.

关键词： dopaminergic neuron ferroptosis NADPH oxidase 4(NOX4) neuroinflammation Parkinson's disease

Broadband and perfect terahertz absorber based on multilayer metamaterial with cross-ring patterned structures

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Optoelectronics Letters 2025年第1期21卷 1-6页

作者： WEN Jin LIU Zhanzhi WU Zhengwei PAN Yu zhang ying School of Science Xi'an Shiyou University Shaanxi Key Laboratory of Measurement and Control Technology for Oil and Gas Wells

Broadband and perfect terahertz absorber based on multilayer metamaterial using cross-ring patterned structures is proposed and investigated. The structure of the absorber is double absorption layers consisting of a chromium cross ring and eight isosceles right triangles. The unique structure of the double absorbing layers excites the electric dipole multimode resonance, giving rise to high absorption performance. Meanwhile, the influence of construal parameters on absorber behavior is also discussed. The numerical results show that the absorption achieves over 90% ranging from 2.45 THz to 6.25 THz and 99% absorption in the range of 3.7—5.3 THz. The realization of broadband and perfect absorber is described using the impedance matching principle. It is obviously found that the absorber is insensitive to the high angle of incidence for both transverse electric(TE) and transverse magnetic(TM) polarizations. Compared with the former reports, this absorber has remarkable improved absorption efficiency and smaller period. The terahertz absorber may be found applications in the fields of energy capture and thermal detection.

关键词： Metamaterials

Visualizing charge transfer and nuclear quantum effects in the hydrogen bond network of water

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Science China Chemistry 2025年

作者： ying Gao Haotian Wang Bin zhang Department of Chemistry School of Science Tianjin University

Water, one of the most common and important solvents on earth, is widely used in biology, physics, chemistry, and other fields [1]. The hydrogen bond interactions between water molecules form a highly dynamic and syne...

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Storage time affects the level and diagnostic efficacy of plasma biomarkers for neurodegenerative diseases

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Neural Regeneration Research 2025年第8期20卷 2373-2381页

作者： Lifang Zhao Mingkai zhang Qimeng Li Xuemin Wang Jie Lu ying Han Yanning Cai Department of Clinical Biobank Xuanwu HospitalCapital Medical UniversityBeijingChina Beijing Geriatric Medical Research Center BeijingChina Department of Neurology Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Radiology and Nuclear Medicine Xuanwu HospitalCapital Medical UniversityBeijingChina Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics BeijingChina Key Laboratory of Neurodegenerative diseases Ministry of EducationBeijingChina School of Biomedical Engineering Hainan UniversityHaikouHainan ProvinceChina Center of Alzheimer’s Disease Beijing Institute for Brain DisordersBeijingChina National Clinical Research Center for Geriatric Diseases BeijingChina Institute of Biomedical Engineering Shenzhen Bay LaboratoryGaoke Innovation CenterShenzhenGuangdong ProvinceChina Department of Neurobiology Xuanwu HospitalCapital Medical UniversityBeijingChina

Several promising plasma biomarker proteins,such as amyloid-β(Aβ),tau,neurofilament light chain,and glial fibrillary acidic protein,are widely used for the diagnosis of neurodegenerative ***,little is known about the long-term stability of these biomarker proteins in plasma samples stored at-80°*** aimed to explore how storage time would affect the diagnostic accuracy of these biomarkers using a large *** samples from 229 cognitively unimpaired individuals,encompassing healthy controls and those experiencing subjective cognitive decline,as well as 99 patients with cognitive impairment,comprising those with mild cognitive impairment and dementia,were acquired from the Sino Longitudinal Study on Cognitive Decline *** samples were stored at-80°C for up to 6 years before being used in this *** results showed that plasma levels of Aβ42,Aβ40,neurofilament light chain,and glial fibrillary acidic protein were not significantly correlated with sample storage ***,the level of total tau showed a negative correlation with sample storage ***,in individuals without cognitive impairment,plasma levels of total protein and tau phosphorylated protein threonine 181(p-tau181)also showed a negative correlation with sample storage *** was not observed in individuals with cognitive ***,we speculate that the diagnostic accuracy of plasma p-tau181 and the p-tau181 to total tau ratio may be influenced by sample storage ***,caution is advised when using these plasma biomarkers for the identification of neurodegenerative diseases,such as Alzheimer's ***,in cohort studies,it is important to consider the impact of storage time on the overall results.

关键词： Alzheimer’s disease amyloid-β diagnostic ability glial fibrillary acidic protein neurodegeneration neurofilament light chain plasma biomarkers single molecule array storage time tau

Flexible molecules dedicate to release strain of inverted inorganic perovskite solar cell

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Journal of Energy Chemistry 2025年第1期100卷 87-93页

作者： Hongrui Sun Sanlong Wang Pengyang Wang Yali Liu Shanshan Qi Biao Shi ying Zhao Xiaodan zhang Institute of Photoelectronic Thin Film Devices and Technology Renewable Energy Conversion and Storage Center State Key Laboratory of Photovoltaic Materials and CellsNankai University Key Laboratory of Photoelectronic Thin Film Devices and Technology of Tianjin Haihe Laboratory of Sustainable Chemical Transformations Engineering Research Center of Thin Film Photoelectronic Technology of Ministry of Education Collaborative Innovation Center of Chemical Science and Engineering (Tianjin)

The tensile strain in inorganic perovskite films induced by thermal annealing is one of the primary factors contributing to the inefficiency and instability of inorganic perovskite solar cells （IPSCs）,which reduces the defect formation ***,a flexible molecule 5-maleimidovaleric acid （5-MVA） was introduced as a strain buffer to release the residual strain of *** anhydride and carboxyl groups in 5-MVA interact strongly with the uncoordinated Pb2+through Lewis acid-base reaction,thus tightly“pull”the perovskite *** in-between soft carbon chain increased the structural flexibility of CsPbI2.85Br0.15perovskite materials,which effectively relieved the intrinsic internal strain of CsPbI2.85Br0.15,resisted the corrosion of external strain,and also reduced the formation of defects such as VIand *** addition,the introduction of 5-MVA improved crystal quality,passivated residual defects,and narrowed energy level ***,power conversion efficiency （PCE） of NiOxbased inverted IPSCs increased from 19.25% to 20.82% with the open-circuit voltage enhanced from 1.164 V to 1.230 *** release of strain also improved the stability of CsPbI2.85Br0.15perovskite films and devices.

关键词： Perovskite solar cells