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黑茸补肾颗粒对白消安诱导的精子发生障碍小鼠模型治疗作用的研究

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中华男科学杂志 2022年第11期28卷 1031-1037页

作者：杨子朝王小龙张迪马帅郑连文长春中医药大学中医学院吉林长春130041 吉林省妇幼保健院中医科吉林长春130041 吉林大学第二医院生殖医学中心吉林长春130041

目的:探索黑茸补肾颗粒对白消安诱导的小鼠精子发生障碍的治疗作用,并揭示其调控睾丸生精功能的机制。方法:将48只雄性小鼠随机分为6组,分别为空白对照(BC)组、阴性对照组(NC)、HKTG-1组、HKTG-2组、HKTG-3组、HKTG-4组。除BC组外,其余... 详细信息

目的:探索黑茸补肾颗粒对白消安诱导的小鼠精子发生障碍的治疗作用,并揭示其调控睾丸生精功能的机制。方法:将48只雄性小鼠随机分为6组,分别为空白对照(BC)组、阴性对照组(NC)、HKTG-1组、HKTG-2组、HKTG-3组、HKTG-4组。除BC组外,其余组通过腹腔注射40 mg/kg体重的白消安建立精子发生障碍小鼠模型,BC组、NC组给予生理盐水灌胃,HKTG-1组给予黑茸补肾颗粒药剂1中添加鹿茸400 mg/kg体重、HKTG-2组给予黑茸补肾颗粒药剂1中添加鹿茸800 mg/kg体重、HKTG-3组给予黑茸补肾颗粒药剂2中添加黑蚁400 mg/kg体重、HKTG-4组给予黑茸补肾颗粒药剂2中添加黑蚁800 mg/kg体重,药剂研磨后以生理盐水为溶剂灌胃给小鼠,1次/d,连续给药5周,记录各组小鼠每日平均体重,造模结束后记录各组小鼠睾丸重量,HE染色检测小鼠睾丸组织显微结构,实时荧光定量PCR检测标记基因表达水平。结果:与BC组相比,NC组和黑茸补肾颗粒治疗组小鼠的体重及日增重无显著差异;与NC组相比,HKTG-1组睾丸重量显著增加(P<0.05);睾丸组织HE染色结果显示,与NC组相比,HKTG-1和HKTG-2组的生精小管中有大量生殖细胞,包括管腔中已变形的精子细胞,HKTG-3和HKTG-4组的生精小管中也出现了一定数量的生殖细胞(精原精母细胞),但管腔中几乎没有变形的精子细胞。睾丸组织的实时荧光定量PCR结果显示,与NC组相比,HKTG-1组的总生殖细胞标记基因(Ddx4)、精原细胞标记基因(Dazl)、精母细胞标记基因(Sycp3)相对表达量显著上调,精子细胞标记基因(Tnp1)则显著上调(P<0.05)。HKTG-1组的支持细胞数量显著降低(P<0.05),支持细胞标记基因(Sox9)下调,这与其生殖细胞数量多相对应。HKTG-3、HKTG-4组的Ddx4、Dazl、Sycp3和Tnp1基因相对表达量无显著变化,支持细胞数量也没有显著变化。与NC组相比,HKTG-1组显著改善小鼠睾丸组织的精子发生,表现为上调减数分裂相关基因(Meioc、Stra8、Spo11)的表达。结论:黑茸补肾颗粒可能是通过促进减数分裂的发生,改善小鼠睾丸组织内生精细胞的功能,进而增加精子的生成。

关键词：黑茸补肾颗粒非梗阻性无精子症白消安小鼠

Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

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Neural Regeneration Research 2025年第1期20卷 6-20页

作者： Xiu-Yun zhao De-En Xu Ming-Lei Wu Ji-Chuan Liu zi-Ling Shi Quan-Hong Ma Department of Neurology and Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular *** reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and *** this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular *** also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative *** summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve *** review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.

关键词： autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response

Defect Engineering:Can it Mitigate Strong Coulomb Effect of Mg^(2+)in Cathode Materials for Rechargeable Magnesium Batteries?

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Nano-Micro Letters 2025年第1期17卷 135-159页

作者： Zhengqing Fan Ruimin Li Xin Zhang Wanyu zhao Zhenghui Pan Xiaowei yang School of Chemistry and Chemical Engineering Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China School of Chemistry and Chemical Engineering Taiyuan University of TechnologyTaiyuan 030024People’s Republic of China School of Materials Science and Engineering Tongji UniversityShanghai 201804People’s Republic of China

Rechargeable magnesium batteries(RMBs)have been considered a promising“post lithium-ion battery”system to meet the rapidly increasing demand of the emerging electric vehicle and grid energy storage ***,the sluggish diffusion kinetics of bivalent Mg^(2+)in the host material,related to the strong Coulomb effect between Mg^(2+)and host anion lattices,hinders their further development toward practical *** engineering,regarded as an effective strategy to break through the slow migration puzzle,has been validated in various cathode materials for *** this review,we first thoroughly understand the intrinsic mechanism of Mg^(2+)diffusion in cathode materials,from which the key factors affecting ion diffusion are further ***,the positive effects of purposely introduced defects,including vacancy and doping,and the corresponding strategies for introducing various defects are *** applications of defect engineering in cathode materials for RMBs with advanced electrochemical properties are also ***,the existing challenges and future perspectives of defect engineering in cathode materials for the overall high-performance RMBs are described.

关键词： Rechargeable magnesium battery Sluggish diffusion kinetic Defect engineering Cathode materials Ion migration

Protein nanoparticles as potent delivery vehicles for polycytosine RNA-binding protein one

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World Journal of Diabetes 2025年第1期16卷 222-225页

作者： zi-Yu zhao Pei-Li Luo Xia Guo Zheng-Wei Huang State Key Laboratory of Bioactive Molecules and Druggability Assessment Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative DrugsCollege of PharmacyJinan UniversityGuangzhou 511436Guangdong ProvinceChina

Ma et al recently reported in the World Journal of Diabetes that ferroptosis occurs in osteoblasts under high glucose conditions,reflecting diabetes *** condition could be protected by the upregulation of the gene encoding polycytosine RNA-binding protein 1(PCBP1).Additionally,Ma et al used a lentivirus infection system to express *** the authors’method of administration can be improved in terms of stability and cost,we propose delivering PCBP1 to treat type 2 diabetic osteoporosis by encapsulating it in protein ***,PCBP1 is small and ***,intravenous injection can help deliver PCBP1 across the mucosa while avoiding acid and enzyme-catalyzed ***,incorporating PCBP1 into nanoparticles prevents its interaction with water or oxygen and protects PCBP1’s structure and ***,the safety of the protein materials and the industrialization techniques for large-scale production of protein nanoparticles must be comprehensively investigated before clinical application.

关键词： Polycytosine RNA-binding protein 1 Protein nanoparticle Osteoblast Ferroptosis Diabetes

“Zero‑Strain” NiNb_(2)O_(6) Fibers for All‑Climate Lithium Storage

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Nano-Micro Letters 2025年第1期17卷 348-360页

作者： Yan zhao Qiang Yuan Liting yang Guisheng Liang Yifeng Cheng Limin Wu Chunfu Lin Renchao Che College of Physics Donghua UniversityShanghai 201620People’s Republic of China School of Materials Science and Engineering Institute of Materials for Energy and EnvironmentQingdao UniversityQingdao 266071People’s Republic of China Laboratory of Advanced Materials Shanghai Key Laboratory of Molecular Catalysis and Innovative MaterialsAcademy for Engineering&TechnologyFudan UniversityShanghai 200438People’s Republic of China Zhejiang Laboratory Hangzhou 311100People’s Republic of China Inner Mongolia University Hohhot 010021People’s Republic of China

Niobates are promising all-climate Li^(+)-storage anode material due to their fast charge transport,large specific capacities,and resistance to electrolyte ***,their moderate unit-cellvolume expansion(generally 5%–10%)during Li^(+)storage causes unsatisfactory long-term ***,“zero-strain”NiNb_(2)O_(6) fibers are explored as a new anode material with comprehensively good electrochemical *** Li^(+)storage,the expansion of electrochemical inactive NiO_(6) octahedra almost fully offsets the shrinkage of active NbO_(6) octahedra through reversible O *** superior volume-accommodation capability of the NiO_(6) layers guarantees the“zero-strain”behavior of NiNb_(2)O_(6) in a broad temperature range(0.53%//0.51%//0.74%at 25//−10//60℃),leading to the excellent cyclability of the NiNb_(2)O_(6) fibers(92.8%//99.2%//91.1%capacity retention after 1000//2000//1000 cycles at 10C and 25//−10//60℃).This NiNb_(2)O_(6) material further exhibits a large reversible capacity(300//184//318 mAh g−1 at 0.1C and 25//−10//60℃)and outstanding rate performance(10 to 0.5C capacity percentage of 64.3%//50.0%//65.4%at 25//−10//60℃).Therefore,the NiNb_(2)O_(6) fibers are especially suitable for large-capacity,fast-charging,long-life,and all-climate lithium-ion batteries.

关键词： NiNb_(2)O_(6)porous fiber “Zero-strain”mechanism Electrochemical property Harsh-temperature operation Operando characterization

Constructing Donor–Acceptor‑Linked COFs Electrolytes to Regulate Electron Density and Accelerate the Li^(+)Migration in Quasi‑Solid‑State Battery

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Nano-Micro Letters 2025年第1期17卷 456-471页

作者： Genfu zhao Hang Ma Conghui Zhang Yongxin yang Shuyuan Yu Haiye Zhu Yongjiang Sun Hong Guo School of Materials and Energy International Joint Research Center for Advanced Energy Materials of Yunnan ProvinceYunnan UniversityKunming 650091People’s Republic of China Yunnan Yuntianhua Co. LtdR&D CenterKunming 650228People’s Republic of China Southwest United Graduate School Kunming 650091People’s Republic of China

Regulation the electronic density of solid-state electrolyte by donor–acceptor(D–A)system can achieve highly-selective Li^(+)transportation and conduction in solid-state Li metal *** study reports a high-performance solid-state electrolyte thorough D–A-linked covalent organic frameworks(COFs)based on intramolecular charge transfer *** other reported COFbased solid-state electrolyte,the developed concept with D–A-linked COFs not only achieves electronic modulation to promote highly-selective Li^(+)migration and inhibit Li dendrite,but also offers a crucial opportunity to understand the role of electronic density in solid-state Li metal *** introduced strong electronegativity F-based ligand in COF electrolyte results in highlyselective Li^(+)(transference number 0.83),high ionic conductivity(6.7×10^(-4)S cm^(−1)),excellent cyclic ability(1000 h)in Li metal symmetric cell and high-capacity retention in Li/LiFePO_(4)cell(90.8%for 300 cycles at 5C)than substituted C-and N-based *** is ascribed to outstanding D–A interaction between donor porphyrin and acceptor F atoms,which effectively expedites electron transferring from porphyrin to F-based ligand and enhances Li^(+)***,we anticipate that this work creates insight into the strategy for accelerating Li^(+)conduction in high-performance solid-state Li metal batteries through D–A system.

关键词： Electronic modulation engineering Donor-acceptor-linked covalent organic frameworks Quasi-solid-state Li metal battery

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塔顶排架结构对进水塔动力响应的影响

水电能源科学 2024年第7期42卷 160-164页

作者：杨子照张继勋任旭华陈旻铭河海大学水利水电学院江苏南京210098

进水塔顶部启闭机室通常为排架结构,地震时往往先发生损坏导致水电站无法正常运行。为探索塔顶排架结构对进水塔动力响应的影响,针对某抽水蓄能电站下水库的进水口结构动力响应开展研究。基于双自由度无阻尼简化体系进行理论探索,并采... 详细信息

进水塔顶部启闭机室通常为排架结构,地震时往往先发生损坏导致水电站无法正常运行。为探索塔顶排架结构对进水塔动力响应的影响,针对某抽水蓄能电站下水库的进水口结构动力响应开展研究。基于双自由度无阻尼简化体系进行理论探索,并采用三维非线性有限元数值模拟方法计算进水塔有、无塔顶排架两种工况的自振特性、位移、加速度、应力、损伤体积比和能量耗散等指标来对比研究。任意时刻的地震反应用时程分析法求解,并引入黏弹性人工边界模拟地基辐射阻尼作用。结果表明,地震时进水塔—排架系统可能会产生鞭梢效应进而减小进水塔的动力响应。塔顶排架使进水塔的自振频率提高约2.10%~3.80%,使塔体关键点最大相对位移的最大值及最大加速度的最大值减小,减幅分别大于23.94%、22.30%。有排架时进水塔的拉应力降低而压应力增大,损伤体积比、塑性耗散能、损伤耗散能最大可减小23.93%以上。塔顶排架结构可以减小进水塔地震动力响应,对进水塔的抗震性能具有积极影响。

关键词：进水塔排架结构动力响应黏弹性人工边界混凝土塑性损伤

Correlations of the expression of Cx43,SCFFBXW7,p-cyclin E1(Ser73),p-cyclin E1(Thr77)and p-cyclin E1(Thr395)in colon cancer tissues

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 207-213页

作者： Rong-Gang Luan Ming-Da Liu zi-Feng Deng Cong-Lan Lu Mei-Ling Yu Ming-Yu Zhang Rong Liu Ran An You-Liang Yao Dong-Bei Guo Yong-Xing Zhang Lei zhao Department of Gastrointestinal Surgery Air Force Hospital of Eastern TheaterAnhui Medical UniversityNanjing 230032Jiangsu ProvinceChina State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics School of Public HealthXiamen UniversityXiamen 361102Fujian ProvinceChina Trauma Surgery Air Force Hospital of Eastern TheaterAnhui Medical UniversityNanjing 230032Jiangsu ProvinceChina Department of Orthopaedics Air Force Hospital of Eastern TheaterAnhui Medical UniversityNanjing 230032Jiangsu ProvinceChina

BACKGROUND Previous cellular studies have demonstrated that elevated expression of Cx43 promotes the degradation of cyclin E1 and inhibits cell proliferation through ***,reduced expression results in a loss of this capacity to facilitate cyclin E *** ubiquitination and degradation of cyclin E1 may be associated with phosphorylation at specific sites on the protein,with Cx43 potentially enhancing this process by facilitating the phosphorylation of these critical *** To investigate the correlation between expression of Cx43,SKP1/Cullin1/F-box(SCF)FBXW7,p-cyclin E1(ser73,thr77,thr395)and clinicopathological indexes in colon *** Expression levels of Cx43,SCFFBXW7,p-cyclin E1(ser73,thr77,thr395)in 38 clinical colon cancer samples were detected by immunohistochemistry and were analyzed by statistical methods to discuss their *** Positive rate of Cx43,SCFFBXW7,p-cyclin E1(Ser73),p-cyclin E1(Thr77)and p-cyclin E1(Thr395)in detected samples were 76.32%,76.32%,65.79%,5.26%and 55.26%*** expressions of these proteins were not related to the tissue type,degree of tissue differentiation or lymph node ***43 and SCFFBXW7(r=0.749),p-cyclin E1(Ser73)(r=0.667)and p-cyclin E1(Thr395)(r=0.457),SCFFBXW7 and p-cyclin E1(Ser73)(r=0.703)and p-cyclin E1(Thr395)(0.415)were correlated in colon cancer(P<0.05),and expressions of the above proteins were positively correlated in colon *** Cx43 may facilitate the phosphorylation of cyclin E1 at the Ser73 and Thr195 sites through its interaction with SCFFBXW7,thereby influencing the ubiquitination and degradation of cyclin E1.

关键词： Colon cancer Cx43 SCFFBXW7 Phosphorylation of cyclin E1 Sites of cyclin E1 Correlation analysis

Study on the prediction and inverse prediction of detonation properties based on deep learning

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Defence Technology（防务技术） 2023年第6期24卷 18-30页

作者： zi-hang yang Ji-li Rong zi-tong zhao Department of Mechanics School of Aerospace EngineeringBeijing Institute of TechnologyBeijing100081China

The accurate and efficient prediction of explosive detonation properties has important engineering significance for weapon *** methods for predicting detonation performance include empirical formulas,equations of state,and quantum chemical calculation *** recent years,with the development of computer performance and deep learning methods,researchers have begun to apply deep learning methods to the prediction of explosive detonation *** deep learning method has the advantage of simple and rapid prediction of explosive detonation ***,some problems remain in the study of detonation properties based on deep *** example,there are few studies on the prediction of mixed explosives,on the prediction of the parameters of the equation of state of explosives,and on the application of explosive properties to predict the formulation of *** on an artificial neural network model and a one-dimensional convolutional neural network model,three improved deep learning models were established in this work with the aim of solving these *** training data for these models,called the detonation parameters prediction model,JWL equation of state(EOS)prediction model,and inverse prediction model,was obtained through the KHT thermochemical *** training,the model was tested for overfitting using the validation-set *** the model-accuracy test,the prediction accuracy of the model for real explosive formulations was tested by comparing the predicted value with the reference *** results show that the model errors were within 10%and 3%for the prediction of detonation pressure and detonation velocity,*** accuracy refers to the prediction of tested explosive formulations which consist of TNT,RDX and *** the prediction of the equation of state for explosives,the correlation coefficient between the prediction and the reference curves was above *** the prediction of the inverse predi

关键词： Deep learning Detonation properties KHT thermochemical Code JWL equation of states Artificial neural network One-dimensional convolutional neural network