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Experimental investigation of closed-loop active control to modulate coherent structures by mu-level method

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Chinese Physics B 2024年第7期33卷 408-417页

作者：白建侠范子椰姜楠李秋营郑小波 Department of Mathematics Tianjin Renai CollegeTianjin 301636China Institute of Mechanics Department of MechanicsSchool of Mechanical EngineeringTianjin UniversityTianjin 300354China College of Energy and Power Engineering Lanzhou University of TechnologyLanzhou 730050China Tianjin Key Laboratory of Modern Engineering Mechanics Tianjin 300354China

The experimental research on zero-net-mass-flux jet closed-loop active control was conducted in the wind *** mu-level method successfully detected burst events of the coherent structures. The streamwise velocity signals in the turbulent boundary layer were measured by HWA. The drag reduction rate of 16.7% is obtained comparable to that of the open-loop control and saves 75% of the input energy at the asynchronous 100 V/160 Hz control case, which reflects the advantages of the closed-loop control. The experimental findings indicate that the intensity increases in the near-wall *** perturbation of the PZT vibrators on the skewness factor is concentrated in the region y+suppressed. The disturbance has the characteristics of stable periodicity,positive and negative symmetry, low intermittency, and high pulsation strength. The conditional phase waveform shows that the fluctuation amplitude increases, indicating amplitude modulation effects on coherent structures.

关键词： turbulent boundary layer(TBL) burst event coherent structures mu-level method

Genomic surveillance for SARS-CoV-2 Variants: Dominance of XBB Replacement — China, January–June 2023

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China CDC weekly 2024年第15期6卷 324-331页

作者： Yenan Feng Qiudong su Lili Li xiaozhou He Peihua Niu xiaojuan Guo xiang Zhao Jing Tang Zhiyuan Jia Ji Wang Changcheng Wu Baicheng xia Zhixiao Chen Yuchao Wu Jing Yang Songqi Chen Cao Chen Shiwen Wang xiaoping Dong National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingChina NHC Key Laboratory of Medical Virology and Viral Diseases National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingChina

Introduction:In the first half of 2023,a global shift was observed towards the predominance of XBB *** faced a significant epidemic between late 2022 and early 2023 due to Omicron subvariants BA.5.2 and *** study aims to depict the evolving variant distribution among provincial-level administrative divisions(PLADs)in China and explore the factors driving the predominance of XBB ***:Sequences from local and imported coronavirus disease 2019(COVID-19)cases recorded between January 1 and June 30,2023,were *** study analyzed the changing distribution of viral variants and assessed how the prior dominance of specific variants,XBB subvariants,and imported cases influenced the prevalence of the XBB replacement ***:A total of 56,486 sequences were obtained from local cases,and 8,669 sequences were from imported *** in April,there was a shift in the prevalence of XBB from imported to local cases,with varying dominance among *** PLADs previously high in BF.7,the rise of XBB was delayed.A positive correlation was found between XBB proportions in imported cases from January to March and local cases in *** distribution pattern of XBB subvariants differed between local and imported cases within the same *** significant differences were noted in the replacement rates of XBB ***:The timing of XBB dominance differed among various PLADs in China in the first half of 2023,correlating closely with the prevalence of XBB variants among imported cases.

关键词： dominance imported distribution

Ultrasomics in liver cancer: Developing a radiomics model for differentiating intrahepatic cholangiocarcinoma from hepatocellular carcinoma using contrast-enhanced ultrasound

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World Journal of Radiology 2024年第7期16卷 247-255页

作者： Li-Ya su Ming Xu Yan-Lin Chen Man-xia Lin xiao-Yan Xie Department of Medical Ultrasound The First Affiliated HospitalInstitute of Diagnostic and Interventional UltrasoundSun Yat-Sen UniversityGuangzhou 510000Guangdong ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)and intrahepatic cholangiocarcinoma(ICC)represent the predominant histological types of primary liver cancer,comprising over 99%of *** their differing biological behaviors,prognoses,and treatment strategies,accurately differentiating between HCC and ICC is crucial for effective clinical ***,an emerging image processing technology,can automatically extract various quantitative image features that may elude the human *** on the application of ultrasound(US)-based radiomics methods in distinguishing HCC from ICC are *** In our retrospective study,we included a total of 280 patients who were diagnosed with ICC(n=140)and HCC(n=140)between 1999 and *** patients were divided into training(n=224)and testing(n=56)groups for *** images and relevant clinical characteristics were *** utilized the XGBoost method to extract and select radiomics features and further employed a random forest algorithm to establish ultrasomics *** compared the diagnostic performances of these ultrasomics models with that of *** Four distinct ultrasomics models were constructed,with the number of selected features varying between models:13 features for the US model;15 for the contrast-enhanced ultrasound(CEUS)model;13 for the combined US+CEUS model;and 21 for the US+CEUS+clinical data *** US+CEUS+clinical data model yielded the highest area under the receiver operating characteristic curve(AUC)among all models,achieving an AUC of 0.973 in the validation cohort and 0.971 in the test *** performance exceeded even the most experienced radiologist(AUC=0.964).The AUC for the US+CEUS model(training cohort AUC=0.964,test cohort AUC=0.955)was significantly higher than that of the US model alone(training cohort AUC=0.822,test cohort AUC=0.816).This finding underscored the significant benefit of incorporating CEUS information in accurately distin-guishing ICC from HC

关键词： Cholangiocarcinoma Hepatocellular carcinoma Contrast-enhanced ultrasound Radiomics Primary liver tumor

连续周年轮作休耕对土壤团聚体稳定性及有机碳的影响

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环境科学 2024年第3期45卷 1644-1654页

作者：鲁泽让李永梅杨春怀夏梓泰程伟威王自林赵吉霞范茂攀云南农业大学资源与环境学院昆明650201

为探究连续周年轮作休耕对红壤团聚体稳定性及有机碳含量的影响,以坡耕地红壤为研究对象,采用湿筛法和重铬酸钾-浓硫酸外加热法分别测定水稳性团聚体和有机碳含量,分析了2020~2022年玉米-苕子-玉米轮作(M-V-M)、玉米-豌豆-玉米轮作(M-P... 详细信息

为探究连续周年轮作休耕对红壤团聚体稳定性及有机碳含量的影响,以坡耕地红壤为研究对象,采用湿筛法和重铬酸钾-浓硫酸外加热法分别测定水稳性团聚体和有机碳含量,分析了2020~2022年玉米-苕子-玉米轮作(M-V-M)、玉米-豌豆-玉米轮作(M-P-M)、玉米-冬闲-玉米(M-F-M)和周年休耕(F-F-F)这4个处理下土壤团聚体稳定性及有机碳含量变化特征以及两者间的相互关系.结果表明,在2021年和2022年中,F-F-F、M-V-M和M-P-M处理的>2 mm团聚体含量较M-F-M分别显著提高了67.01%~100.92%、29.71%~33.67%和29.68%~38.07%;2021年和2022年中F-F-F、M-V-M的团聚体稳定性参数显著高于M-F-M(P2 mm团聚体含量、GMD(几何平均直径)和MWD(平均重量直径)及F-F-F处理的R_(0.25)(>0.25mm团聚体含量)、MWD和>2 mm团聚体含量随着轮作休耕年限的延长而增加,而F-F-F处理下1~2 mm和<0.25 mm团聚体含量随着休耕年限的增加而降低.绿肥轮作和休耕处理均能够提高SOC含量,且F-F-F和M-V-M处理的SOC含量随年限的延长而增加.相关性分析表明,所有处理下SOC含量与R_(0.25)呈极显著正相关,与GMD呈显著正相关;F-F-F处理下的R_(0.25)和GMD及M-V-M处理下的GMD和MWD均与SOC含量显著正相关.结果表明,连续周年轮作休耕有利于提高土壤大团聚体含量、团聚体稳定性和SOC含量,可为我国南方坡耕地红壤区推行合理的连续周年轮作休耕模式和水土流失防治提供理论依据.

关键词：绿肥轮作休耕团聚体稳定性土壤有机碳

Endoscopic ultrasound features of rectal melanoma:A case report and review of literature

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World Journal of Clinical Cases 2024年第16期12卷 2862-2868页

作者： Zhang-E Xiong Xin-xiang Wei Li Wang Chen xia zi-Yin Li Chan Long Bo Peng Ting Wang Department of Gastroenterology Wuhan Third HospitalWuhan 430060Hubei ProvinceChina Department of Pharmacy Wuhan University of Science and TechnologyWuhan 430065Hubei ProvinceChina Department of Pathology Wuhan Third HospitalWuhan 430060Hubei ProvinceChina

BACKGROUND Rectal mucosal melanoma is a rare and highly aggressive *** symptoms include anal pain,an anal mass,or *** such,the disease is usually detected on rectal examination of patients with other suspected anorectal ***,due to its rarity and nonspecific symptoms,melanoma of the rectal mucosa is easily *** suMMARY This report describes the case of a 58-year-old female patient who presented with a history of blood in her stool for the prior one or two months,without any identifiable *** colonoscopy,a bulge of approximately 2.2 cm×2.0 cm was ***,the patient underwent endoscopic ultrasound(EUS)to characterize the depth of invasion of the *** suggested a hypoechoic mucosal mass with involvement of the submucosal layer and heterogeneity of the internal *** surgical intervention,the excised tissue samples were examined and confirmed to be rectal malignant *** patient recovered well with no evidence of recurrence during *** This case shows that colonoscopy with EUS and pathological examination can accurately diagnose rare cases of rectal mucosal melanoma.

关键词： Endoscopic ultrasound Rectal mucosal melanoma Colonoscopy Treatment Case report

Comparative efficacy and safety of Chinese patent medicines of iron deficiency anemia during pregnancy:A network meta-analysis

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World Journal of Clinical Cases 2024年第18期12卷 3515-3528页

作者： Jia-Chen Zou xian-Ling Jia Hai-xia Wang Ying-Jie su Jing-Yu Zhu School of Chinese Medicine Weifang Medical UniversityWeifang 261053Shandong ProvinceChina Traditional Chinese Medicine Department Affiliated Hospital of Weifang Medical UniversityWeifang 261031Shandong ProvinceChina

BACKGROUND Iron deficiency anemia(IDA)is a prevalent nutritional disorder during *** studies indicate that incorporating Chinese patent medicines(CPMs)with oral iron(OI)in treating IDA in pregnancy can reduce adverse effects and improve clinical ***,the comparative efficacy of different CPMs remains *** To assess the safety and effectiveness of different CPMs for treating IDA during pregnancy using network *** We conducted a search for randomized controlled trials(RCTs)that combined CPM and OI for IDA treatment in pregnancy,spanning from 2013 to the *** analysis was performed using Rev Man 5.3 and Stata 14.0 on literature that satisfied the quality *** The analysis included 45 RCTs,encompassing 4422 pregnant patients with *** CPMs were examined,including Shengxuebao Mixture,Shengxuening Tablets(SXN),Yiqi Weixue CPMs(YQWX),Jianpi Shengxue CPMs(JPSX),Yiqi Buxue Tablets,and Compound Hongyi Buxue Oral Liquid(FFHY).Findings indicated that FFHY+OI significantly improved the clinical effective ***+OI was most effective in boosting red blood cells counts and hemoglobin ***+OI showed superior results in improving serum ferritin,and SXN+OI was most effective in increasing serum iron ***+OI was optimal in reducing adverse pregnancy outcomes,while YQBX+OI effectively minimized adverse events.A cluster analysis suggested that SXN+OI could be the potentially optimal therapeutic regimen for IDA in *** This study demonstrates that the combination of OI with CPMs offers better outcomes than OI *** on clinical efficacy and other measured outcomes,SXN+OI emerges as the most effective treatment modality for improving the health of pregnant patients with IDA.

关键词： Chinese patent medicine Network meta-analysis Shengxuebao Mixture Shengxuening Tablets Yiqi Weixue Chinese patent medicines Jianpi Shengxue Chinese patent medicines Yiqi Buxue Tablets Compound Hongyi Buxue Oral Liquid

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以数实融合推动现代化产业体系建设

改革 2024年第5期 12-23页

作者：夏杰长苏敏中国社会科学院财经战略研究院中国社会科学院大学商学院清华大学社会科学学院经济研究所

现代化产业体系是现代化经济体系的重要组成部分,是中国式现代化建设的重要支撑。数实融合是实现产业转型升级和高质量发展的重要途径,具有智能化、网络化、平台化、服务化等特征,是现代产业革命的核心驱动力。中国数字经济和实体经济... 详细信息

现代化产业体系是现代化经济体系的重要组成部分,是中国式现代化建设的重要支撑。数实融合是实现产业转型升级和高质量发展的重要途径,具有智能化、网络化、平台化、服务化等特征,是现代产业革命的核心驱动力。中国数字经济和实体经济融合发展已经取得显著成效,但仍面临着融合深度不足、融合发展不均衡、融合存在局部梗阻、融合面临安全风险和垄断风险等严峻挑战。以数实融合推动现代化产业体系建设,需要全力夯实人工智能底座技术,实现产业发展自主化、产业协同体系化、产业基础高级化,形成现代化产业体系发展合力。

关键词：数实融合现代化产业体系高质量发展

Dynamic immune recovery process after liver transplantation revealed by single-cell multi-omics analysis

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The Innovation 2024年第3期5卷 55-68页

作者： Rui Wang xiao Peng Yixin Yuan Baojie Shi Yuan Liu Hengxiao Ni Wenzhi Guo Qiwei Yang Pingguo Liu Jie Wang Zhaojie su Shengnan Yu Dehua Liu Jinyan Zhang Junjie xia Xueni Liu Hao Li Zhengfeng Yang Zhihai Peng Organ Transplantation Clinical Medical Center of xiamen University Department of General SurgeryXiang’an Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamen 361102China Organ Transplantation Institute of xiamen University Xiamen Human Organ Transplantation Quality Control CenterXiamen Key Laboratory of Regeneration MedicineFujian Provincial Key Laboratory of Organ and Tissue RegenerationSchool of MedicineXiamen UniversityXiamen 361102China Department of General surgery Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China State Key Laboratory of Cellular Stress Biology School of Life SciencesFaculty of Medicine and Life SciencesXiamen UniversityXiamen 361102China Department of Hepatobiliary and Pancreatic surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450000China Department of Hepatobiliary&Pancreatic surgery The National Key Clinical SpecialtyZhongshan Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamen 361102China Precision Research Center for Refractory Diseases Institute for Clinical ResearchShanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 201620China

Elucidating the temporal process of immune remodeling under immunosuppressive treatment after liver transplantation(LT)is critical for precise clinical management ***,we performed a single-cell multi-omics analysis of peripheral blood mononuclear cells(PBMCs)collected from LT patients(with and without acute cellular rejection[ACR])at 13 time *** was performed in two independent cohorts with additional LT patients and healthy *** study revealed a four-phase recovery process after LT and delineated changes in immune cell composition,expression programs,and interactions along this *** intensity of the immune response differs between the ACR and non-ACR ***,the newly identified inflamed NK cells,CD14+RNASE2+monocytes,and FOS-expressing monocytes emerged as predictive indicators of *** study illuminates the longitudinal evolution of the immune cell landscape under tacrolimus-based immunosuppressive treatment during LT recovery,providing a four-phase framework that aids the clinical management of LT patients.

关键词： process analysis precise

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外泌体及其在中枢神经系统中的功能

生物化学与生物物理进展 2024年第2期51卷 378-393页

作者：王子源白宇轩曹罡戴金霞华中农业大学生命科学技术学院武汉430070 华中农业大学农业微生物学国家重点实验室武汉430070 华中农业大学动物医学院武汉430070

外泌体是一类由细胞分泌至胞外的囊泡,生物发生主要涉及细胞质膜的两次内陷、多囊泡体的形成以及外泌体的释放。外泌体具有丰富多样的内含物,包括一些标志性膜蛋白、可溶蛋白、各类RNA分子和DNA片段等。细胞可以通过分泌和接受外泌体来... 详细信息

外泌体是一类由细胞分泌至胞外的囊泡,生物发生主要涉及细胞质膜的两次内陷、多囊泡体的形成以及外泌体的释放。外泌体具有丰富多样的内含物,包括一些标志性膜蛋白、可溶蛋白、各类RNA分子和DNA片段等。细胞可以通过分泌和接受外泌体来实现细胞间的信号交流,外泌体通过膜上携带的配体分子与其他细胞质膜表面的受体相互作用,从而激活细胞的信号转导或与受体细胞质膜发生融合释放内容物进入胞质来发挥调节功能。在中枢神经系统中,神经元及各类神经胶质细胞分泌的神经外泌体可以介导布线式的突触信号传递,但主要还是以容积传递的方式发挥类似神经调质的功能。本文详细阐述了外泌体的生物发生过程及部分重要的功能性成分,就神经外泌体在发生、内容物分选和受控释放三个方面的特性与突触囊泡进行比较,总结了神经外泌体在中枢神经系统中发挥的生理功能及其在神经退行性疾病和抑郁症发生、发展中作用的研究进展,并对外泌体在神经系统疾病早期诊断及靶向治疗方面的应用前景进行了展望。

关键词：外泌体神经元神经胶质细胞容积传递中枢神经系统疾病诊断靶向递送