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Calculus bovis inhibits M2 tumor-associated macrophage polarization via Wnt/β-catenin pathway modulation to suppress liver cancer

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World Journal of Gastroenterology 2024年第29期30卷 3511-3533页

作者： Zhen Huang Fan-Ying Meng Lin-Zhu Lu Qian-Qian Guo Chang-Jun Lv Nian-Hua Tan Zhe Deng Jun-Yi Chen zi-Shu Zhang Bo Zou Hong-Ping Long Qing zhou Sha Tian Si Mei Xue-Fei Tian College of Integrated Chinese and Western Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Hunan Key Laboratory of Translational Research in Formulas and Zheng of Traditional Chinese Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Key Laboratory of Traditional Chinese Medicine for Mechanism of Tumor Prevention and Treatment Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina The First Clinical College of Traditional Chinese Medicine Hunan University of Traditional Chinese MedicineChangsha 410007Hunan ProvinceChina Department of Hepatology Hunan University of Chinese MedicineChangsha 410007Hunan ProvinceChina The First Hospital of Hunan University of Chinese Medicine Hunan University of Chinese MedicineChangsha 410007Hunan ProvinceChina Faculty of Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina

BACKGROUND Calculus bovis(CB),used in traditional Chinese medicine,exhibits anti-tumor effects in various cancer *** also constitutes an integral component of a compound formulation known as Pien Tze Huang,which is indicated for the treatment of liver ***,its impact on the liver cancer tumor microenvironment,particularly on tumor-associated macrophages(TAMs),is not well *** To elucidate the anti-liver cancer effect of CB by inhibiting M2-TAM polarization via Wnt/β-catenin pathway *** This study identified the active components of CB using UPLC-Q-TOF-MS,evaluated its anti-neoplastic effects in a nude mouse model,and elucidated the underlying mechanisms via network pharmacology,transcriptomics,and molecular *** vitro assays were used to investigate the effects of CB-containing serum on HepG2 cells and M2-TAMs,and Wnt pathway modulation was validated by real-time reverse transcriptase-polymerase chain reaction and Western blot *** This study identified 22 active components in CB,11 of which were detected in the *** investigations have demonstrated the ability of CB to effectively inhibit liver tumor *** integrated approach employing network pharmacology,transcriptomics,and molecular docking implicated the Wnt signaling pathway as a target of the antineoplastic activity of CB by suppressing M2-TAM *** vitro and in vivo experiments further confirmed that CB significantly hinders M2-TAM polarization and suppresses Wnt/β-catenin pathway *** inhibitory effect of CB on M2-TAMs was reversed when treated with the Wnt agonist SKL2001,confirming its pathway *** This study demonstrated that CB mediates inhibition of M2-TAM polarization through the Wnt/β-catenin pathway,contributing to the suppression of liver cancer growth.

关键词： Calculus bovis M2 tumor-associated macrophage polarization Liver cancer Wnt/β-catenin pathway Tumor microenvironment

Optical bound states in the continuum in periodic structures:mechanisms,effects,and applications

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Photonics Insights 2024年第1期3卷 1-26页

作者： Jiajun Wang Peishen Li Xingqi Zhao Zhiyuan Qian Xinhao Wang Feifan Wang Xinyi zhou Dezhuan Han Chao Peng Lei Shi Jian zi State Key Laboratory of Surface Physics Key Laboratory of Micro-and Nano-Photonic Structures(Ministry of Education)and Department of PhysicsFudan UniversityShanghaiChina State Key Laboratory of Advanced Optical Communication Systems and Networks School of ElectronicsPeking UniversityBeijingChina College of Physics Chongqing UniversityChongqingChina Institute for Nanoelectronic devices and Quantum computing Fudan UniversityShanghaiChina Collaborative Innovation Center of Advanced Microstructures Nanjing UniversityNanjingChina Shanghai Research Center for Quantum Sciences ShanghaiChina

Optical bound states in the continuum(BICs)have recently stimulated a research boom,accompanied by demonstrations of abundant exotic phenomena and *** ultrahigh quality(Q)factors,optical BICs have powerful abilities to trap light in optical structures from the continuum of propagation waves in free *** the high Q factors enabled by the confined properties,many hidden topological characteristics were discovered in optical *** in periodic structures with well-defined wave vectors,optical BICs were discovered to carry topological charges in momentum space,underlying many unique physical *** high Q factors and topological vortex configurations in momentum space enabled by BICs bring new degrees of freedom to modulate *** have enabled many novel discoveries in light-matter interactions and spin-orbit interactions of light,and BIC applications in lasing and sensing have also been well explored with many *** this paper,we review recent developments of optical BICs in periodic structures,including the physical mechanisms of BICs,explored effects enabled by BICs,and applications of *** the outlook part,we provide a perspective on future developments for BICs.

关键词： bound state in the continuum light trapping topological charge polarization vortex momentum space light field manipulation photonic crystal slab nanophotonics

环境规制、绿色技术创新与可持续发展——被调节的中介效应分析

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经济问题 2024年第8期 95-102页

作者：单春霞周文洁耿紫珍西安外国语大学商学院陕西西安710128 西安交通大学经济与金融学院陕西西安710061

基于创新理论、可持续发展理论,探讨环境规制、绿色技术创新对可持续发展的影响路径。对中国30个省区市2000—2020年的面板数据样本的研究发现:环境规制正向影响可持续发展,环境规制显著促进绿色技术创新,绿色技术创新对可持续发展有正... 详细信息

基于创新理论、可持续发展理论,探讨环境规制、绿色技术创新对可持续发展的影响路径。对中国30个省区市2000—2020年的面板数据样本的研究发现:环境规制正向影响可持续发展,环境规制显著促进绿色技术创新,绿色技术创新对可持续发展有正向推动作用。环境规制通过绿色技术创新对可持续发展发挥部分正向中介效应,政府补贴正向调节绿色技术创新在环境规制与可持续发展之间第二阶段的中介效应。此外研究还发现企业规模、政府干预在各自的最优区间内,能够最大程度提高环境规制对可持续发展的正向影响。

关键词：环境规制绿色技术创新可持续发展政府补贴

18α甘草次酸对葡聚糖硫酸钠诱导小鼠急性溃疡性结肠炎的保护作用及机制研究

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中国医师杂志 2024年第2期26卷 234-239页

作者：张娟周萍穆先敏南京医科大学第二附属医院临床试验中心南京210011 南京医科大学第二附属医院老年医学科南京210011 南京医科大学第二附属医院生物治疗科南京210011

目的探究18α甘草次酸(18α-GA)对葡聚糖硫酸钠(DSS)诱导小鼠急性溃疡性结肠炎(UC)的保护作用,为18α-GA的临床应用提供理论依据和实验基础。方法将40只雄性C57BL/6J小鼠随机分为5组:DSS模型组,阳性药对照组,18α-GA高、中、低剂量组,每... 详细信息

目的探究18α甘草次酸(18α-GA)对葡聚糖硫酸钠(DSS)诱导小鼠急性溃疡性结肠炎(UC)的保护作用,为18α-GA的临床应用提供理论依据和实验基础。方法将40只雄性C57BL/6J小鼠随机分为5组:DSS模型组,阳性药对照组,18α-GA高、中、低剂量组,每组8只,5组小鼠均采用3%DSS溶液连续喂养7 d建立急性UC动物模型,同时各组分别每天腹腔注射100 mg/kg生理盐水、100 mg/kg柳氮磺吡啶、40 mg/kg 18α-GA、20 mg/kg 18α-GA、10 mg/kg 18α-GA。每天测量并记录小鼠的体重,评估小鼠疾病活动指数(DAI)。第8天处死小鼠,取小鼠结肠测量其长度;切片观察结肠黏膜并进行病理学评分;蛋白免疫印迹法(Western blot)检测结肠组织中NOD样受体热蛋白结构域相关蛋白3(NLRP3)炎症小体通路相关蛋白表达;酶联免疫吸附试验(ELISA)测定结肠组织中IL-1β含量。结果与DSS模型组比较,18α-GA高、中剂量组第7天时的体重减轻幅度明显更小(均P<0.05);结肠长度更长(均P<0.05),结肠黏膜病理学评分明显更低(均P<0.05);结肠组织中GSDMD、cleaved-caspase1及IL-1β的表达显著更低(均P<0.05);18α-GA高剂量组DAI评分更低(P<0.05);结肠组织中NLRP3表达更低(P<0.05)。结论18α-GA可通过抑制NLRP3炎症小体通路的激活,改善DSS诱导的小鼠急性溃疡性结肠炎。

关键词：结肠炎,溃疡性 18α-甘草次酸 NLRP3蛋白白细胞介素1β 炎性肠疾病

双子叶植物下胚轴和顶端弯钩发育及其对出苗的调控机制

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生物技术通报 2024年第4期40卷 23-32页

作者：花子晴周静远董合忠山东师范大学生命科学学院济南250014 山东省农业科学院经济作物研究所济南250100 中国农业大学农学院北京100094

出苗是植物生产的首要环节,影响甚至决定最终产量和品质。双子叶植物出苗受下胚轴生长与顶端弯钩发育的影响。下胚轴生长与顶端弯钩发育是一连续的动态过程,是种子出苗的重要保障。其中,下胚轴稳健生长是幼苗顶土出苗的动力来源,顶端弯... 详细信息

出苗是植物生产的首要环节,影响甚至决定最终产量和品质。双子叶植物出苗受下胚轴生长与顶端弯钩发育的影响。下胚轴生长与顶端弯钩发育是一连续的动态过程,是种子出苗的重要保障。其中,下胚轴稳健生长是幼苗顶土出苗的动力来源,顶端弯钩则在幼苗顶土过程中保护幼嫩的子叶和顶端分生组织不受伤害。本文以下胚轴和顶端弯钩发育为重点,综述了双子叶植物通过细胞骨架的排列方式调控下胚轴伸长与增粗的分子机制,以及顶端弯钩形成、维持与展开阶段的细胞差异生长机制;阐述了光照、温度等主要环境因子和植物内源激素对下胚轴及顶端弯钩发育的协同调控效应与机理,以及播种方式和留苗数量等农艺措施通过优化环境因子调控下胚轴与顶端弯钩生长发育,提高出苗率和成苗率的效果。最后,提出了进一步研究揭示下胚轴与顶端弯钩发育的分子机制,以及弯钩和下胚轴发育对逆境的适应机制,实现在更高水平上对双子叶植物出苗成苗有效调控的意见。本文为深入认识双子叶植物出苗机制,创新植物播种保苗技术提供重要参考。

关键词：下胚轴顶端弯钩双子叶植物调控机制出苗

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multidisciplinary and multiscale nanoscience research roadmap based on large scientific facilities

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Science China Chemistry 2024年第8期67卷 2497-2523页

作者： Yuan Zeng Shuhan Zhang Yuecong Guo Yalin Cong Xu Ding Peihua Li Yunxiang Lin Wenzhi Ren Hui Su Weigang Sun Liuxin Xu Guikai Zhang Shihua Chen Yu Chen Weiren Cheng Shengqi Chu Yong Guan Jinru Han Jie Lin Hengjie Liu Zheyi Liu Pan Luo Fanchun Meng Sicong Qiao Zongyin Song Ying Wang Zhao Wu Chenyu Yang Meng Yang Shirui Yang zi Yin Zhibin Yin Pengjun Zhang Hongyu Zhang Pingping Zheng Jia zhou Wanlin zhou Pengfei An He Cheng Chunhai Fan Xingjiu Huang Yong Lei Lina Li mu Li Qinghua Liu Shuming Peng Li Song Zhihu Sun Yangchao Tian Fangjun Wang Lihua Wang Liming Wang Shiqiang Wei Aiguo Wu Chunlei Xiao Xueming Yang Panchao Yin Jing Zhang Mingxin Zhang Yaling Wang Chunying Chen CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety New Cornerstone Science LaboratoryNational Center for Nanoscience and TechnologyBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China National Synchrotron Radiation Laboratory University of Science and Technology of ChinaHefei 230029China Institute of Solid State Physics Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031China Institutes of Physical Science and Information Technology Anhui UniversityHefei 230601China Ningbo Key Laboratory of Biomedical Imaging Probe Materials and Technology Zhejiang International Cooperation Base of Biomedical Materials Technology and ApplicationCAS Key Laboratory of Magnetic Materials and DevicesNingbo Cixi Institute of Biomedical EngineeringZhejiang Engineering Research Center for Biomedical MaterialsNingbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo 315201China Advanced Energy Science and Technology Guangdong Laboratory Huizhou 516000China College of Chemistry and Chemical Engineering Hunan Normal UniversityChangsha 410081China State Key Laboratory of Luminescent Materials and Devices South China Advanced Institute for Soft Matter Science and TechnologySouth China University of TechnologyGuangzhou 510640China Beijing Synchrotron Radiation Facility Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China CAS Key Laboratory of Separation Sciences for Analytical Chemistry Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China State Key Laboratory of Molecular Reaction Dynamics Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China Institute of Advanced Science Facilities Shenzhen 518107China State Key Laboratory of Coal Conversion Institute of Coal ChemistryChinese Academy of SciencesTaiyuan 030001China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Acade

With the advancement of modern science and technology, large scientific facilities are increasingly oriented toward demand and application, and can be used for basic research as well as serving multiple disciplines. Developing large scientific facilities and related analytical technologies enhances understanding of large scientific facilities and popularizes their application in research across multiple disciplines. The combination of light or neutron sources from large scientific facilities and advanced analytical technologies can be achieved for materials structure information, dynamics study of chemical reactions, high dissociation of biomolecules, 3D visualization of energy materials or biological samples, etc. We first introduce the progress of domestic large scientific facilities of synchrotron radiation(SR) and free electron lasers(FELs) with different wavelengths and neutron *** further discuss the comparison between Chinese and typical foreign facilities in X-ray radiation from X-ray tubes, synchrotrons, X-ray FELs, and neutron sources based on physical parameters of light and neutron sources. In addition, we focus on the technological progress and perspectives combined with advanced X-ray radiation and neutron sources of large scientific facilities in China, especially in the nanoscience fields of energy catalysis and biological science. We hope that this roadmap will provide references on technology and methods to experimental users, as well as prospects for future development of technologies based on large research infrastructure facilities. Comprehensive studies and guidelines for basic research to practical application in various disciplines can be made with the assistance of large scientific facilities.

关键词： large scientific facilities synchrotron radiation FEL light sources neutron sources spectroscopic analysis methods X-ray imaging techniques structural information chemical dynamics

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A semi-analytical method to compute acoustic nonlinearity parameter of Cu,Ag and Au

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Rare Metals 2023年第3期42卷 1050-1055页

作者： zi-mu Chen Zheng Zhang School of Materials Science and Engineering Beihang UniversityBeijing 100191China

In this paper,a semi-analytical method was proposed to evaluate the acoustic nonlinearity parameter for single crystals of Cu,Ag and *** acoustic nonlinearity parameter can be derived analytically by general expressions in terms of the interatomic potentials with the distances between each pair of atoms in these transition *** evaluate the acoustic nonlinearity parameter,one needs to conduct one step molecular static simulation and obtain the equilibrium positions of all the ***,based on this method,numerical experiments with molecular dynamic code LAMMPS were given to compute the acoustic nonlinearity parameter of Cu,Ag and *** illustrate the validity of these expressions,comparison was made between calculation results and data in the *** agreement is *** of the analytical nature of this method,it provides a fundamental understanding of the nonlinear elastic behavior of these transition metals.

关键词： Nondestructive testing Semi-analytical Acoustic nonlinearity parameter Molecular static simulation

SIHC:一种高效的时态图上k-core查询算法

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计算机学报 2024年第5期47卷 1045-1064页

作者：周军锋王春花杜明陈子阳东华大学计算机科学与技术学院上海201620 上海立信会计金融学院信息管理学院上海201620

许多实体之间的关系可以建模为时态图,其中每条边都与表示其发生的时间相关联,k-core是捕获密集子图的基本模型,在近些年得到了广泛研究.给定时间区间I=[s,e]和k值,时态图G上的k-core子图查询从区间I对应的快照图GI中返回相应的k-core子... 详细信息

许多实体之间的关系可以建模为时态图,其中每条边都与表示其发生的时间相关联,k-core是捕获密集子图的基本模型,在近些年得到了广泛研究.给定时间区间I=[s,e]和k值,时态图G上的k-core子图查询从区间I对应的快照图GI中返回相应的k-core子图.针对时态图中的k-core子图查询问题,现有方法是基于PHC索引(Pruned Historical Core-Index)的算法.对任意可能的k值,PHC索引维护了所有可能出现在某个时间区间的k-core子图中的顶点集Sk,且为集合中每个顶点存储了一组时间区间,用于判定该点是否属于给定时间区间的k-core子图.基于PHC索引查询k-core子图时,需要访问Sk集合中的所有顶点,并判断每个顶点的可满足性.由于Sk集合对应于最大区间快照图的k-core子图里的所有顶点,且实际中用户查询区间对应的快照图往往比最大区间快照图小得多,基于PHC索引的查询算法存在许多无效判断,需要对大量不在结果集中的顶点进行检测,且无效检测次数随着查询区间的缩短而增多,从而导致算法效率较低.针对该问题,本文提出一种新的索引,即最短区间历史核索引SIHC(Shortest Interval Historical Core Index).SIHC索引的基本思想是通过维护最短k核区间到顶点的倒排表,查询处理时,可基于用户给定的时间区间定位到SIHC索引中满足条件的区间,进而直接得到满足条件的k-core子图中的顶点,从而避免了基于PHC索引进行查询时所需的大量无效判断.我们从理论上证明了基于SIHC索引处理时态图上k-core子图查询的正确性,并设计了高效的索引构建算法.最后,基于真实世界的时态图进行了实验,实验结果表明本文提出的算法比现有算法快1~2个数量级.

关键词：图数据管理时态图密集子图 k-core 最短k核区间

巷道蝶形破坏强度准则低敏感性研究及工程应用

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岩土力学 2024年第1期45卷 117-130页

作者：刘洪涛韩子俊刘勤裕陈子晗韩洲张红凯杨永松中国矿业大学(北京)能源与矿业学院北京100083 巷道支护与灾害防治煤炭行业工程研究中心北京100083

巷道围岩的塑性区形态对巷道的破坏形式及破坏程度有重要影响。为探究三向应力场下塑性区形态演化过程,基于弹性力学推导了轴向应力表达式,并依据蝶形塑性区边界方程求解思路,确定了三维强度准则下三向塑性区近似解的求解方法。通过等... 详细信息

巷道围岩的塑性区形态对巷道的破坏形式及破坏程度有重要影响。为探究三向应力场下塑性区形态演化过程,基于弹性力学推导了轴向应力表达式,并依据蝶形塑性区边界方程求解思路,确定了三维强度准则下三向塑性区近似解的求解方法。通过等球应力p、等偏应力q以及不同Lode角θσ来确定围岩应力加载方案,对不同三维强度准则下的围岩塑性区形态演化规律进行深入研究,论证了蝶形破坏的准则低敏感性。基于蝶形破坏理论对羊场湾160206回风巷道的非对称变形破坏机制及控制技术进行深入分析。研究结果表明:(1)在相同p、q及不同θσ的应力加载条件下,5种强度准则下的塑性区形态均呈现圆形、类椭圆及蝶形的演化规律,且每种强度准则在相同θσ的情况下围岩的塑性区形态基本一致。(2)相同应力大小、不同应力方向的加载方案下,围岩的塑性区形态大不相同。圆巷围岩的塑性区形态很大程度上由水平侧压比决定,轴向侧压对围岩的塑性区尺寸影响较大,对塑性区形态影响较小。(3)羊场湾160206回风巷道在叠加采动影响下顶板呈现非对称大变形破坏,基于蝶形塑性区支护思路,应用非对称锚杆索+超前单元支架+钻孔卸压的协同支护技术,取得了良好的支护效果。

关键词：塑性区边界蝶形塑性区强度准则采动影响巷道围岩控制