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LOW DOSE PIRFENIDONE SUPPRESSES TRANSFORMING GROWTH FACTOR BETA-1 AND TISSUE INHIBITOR OF METALLOPROTEINASE-1, AND PROTECTS RATS FROM LUNG FIBROSIS INDUCED BY BLEOMYCIN

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Chinese Medical Sciences Journal 2006年第3期21卷 145-151页

作者： Xin-lun Tian Wei Yao zi-jian guo Li gu Yuan-jue Zhu Department of Respiratory Medicine Peking Union Medical College Hospital Chinese Academy of Medical Sciences ＆Peking Union Medical College Beijing 100730

Objective To investigate the optimal dosage of pirfenidone for the treatment of pulmonary fibrosis induced by bleomycin in Wistar rats, and the alteration of expressions of transforming growth factor beta-1 （ TGF-β1 ）, tissue inhibitor of metalloproteinase-1 （ TIMP-1 ）, and matrix metalloproteinase-13 （ MMP-13 ） in lung tissue. Methods Male Wistar rats were endotracheally instilled with bleomycin or normal saline. Pirfenidone （25-800 mg · kg^-l · d^-1 ）, dexamethasone （3 mg/kg）, or 1% carboxymethylcellulose sodium were given daily by feed 2 days before instillation of bleomycin. Groups T7 and T14 were fed pirfenidone 50 mg · kg^-1 · d^-1 at 7 days or 14 daYs after bleomycin instillation. Lungs were harvested at 28 days after bleomycin instillation. Patholological changes in luffg tissues were evaluated with HE staining. Lung collagen was stained by sirius red and measured by content of hydroxypro- line. Expression of proteins of TGF-β1 TIMP-1, and MMP-13 were detected by Western blotting. Results At doses of 25, 50, and 100 mg· kg^- 1 · d ^- 1, pirfenidone had significant anti-fibrotic effects for bleomy- cin-induced rat pulmonary fibrosis, and these effects were most significantly attenuated at the dosage of 50 mg · kg^-1 ·d^ -1（ HE： P 〈 0. 01, P 〈 0.01, and P = 0.064; sirius red： P 〈0.05, P 〈 0.01, and P 〈 0.05 ; hydroxyproline： P = 0.595, P 〈 0.01, and P = 0.976）. Pirfenidone at a dosage of 50 mg · kg^- l · d^-1 inhibited protein expression of TGF-131 and TIMP-1 in lung tissue in the early phase （0.79 and 0.75 times of control group）, but had no effect on ex- nr^eelnn nf MMP-13. Conclusion Low dose pirfenidone, especially at dosage of 50 mg · kg^-1 · d^-1, has significant anti-fibrotic effects on bleomycin-induced rat pulmonary fibrosis. Pirfenidone partially inhibits the enhancement of the expression of TGF-131 and TIMP-β1 in lung tissue.

关键词： pulmonary fibrosis bleomycin pirfenidone transforming growth factor beta-1 tissue inhibitor of metalloproteinase-1

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Temperature-dependent tensile properties of ultrafine-grained C-doped CoCrFeMnNi high-entropy alloy

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Rare Metals 2022年第8期41卷 2877-2885页

作者： Yan-Zhong Tian Si-Yuan Peng Shang-Feng Chen zi-jian gu Yang Yang Xiu-Ling Shang guan-Yu Deng Li-Hong Su Shi-Jie Sun Key Laboratory for Anisotropy and Texture of Materials(Ministry of Education) School of Materials Science and EngineeringNortheastern UniversityShenyang110819China Innovation Center of GD Midea Air-Conditioning Equipment Co. LtdFoshan528311China School of Mechanical MaterialsMechatronic and Biomedical EngineeringUniversity of WollongongWollongongNSW2500Australia Institute of Metal Research Chinese Academy of SciencesShenyang110016China

Metallic materials can be strengthened by various kinds of plastic deformation ***,the deformed materials suffer poor ductility and thermal stability due to the high-density *** this work,we prepared fully recrystallized ultrafine-grained(UFG)1%CCoCrFeMnNi high-entropy alloy(C-HEA)through cold rolling and annealing ***-static tensile tests were performed at temperatures between 77 and 823 *** micros true tures of the samples after tensile tests were characterized,and deformation mechanisms were *** is a transition of deformation mechanisms from twinning and dislocation slip to dislocation slip and grain boundary sliding with temperature *** UFG C-HEA exhibits balanced strength and ductility from the cryogenic temperature to high temperatures,indicating highly adaptive microstructure and mechanical *** strength and uniform elongation of the UFG C-HEA decrease monotonously with temperature increasing,but the elongation to failure exhibits the lowest value at the medium *** grain boundary sliding is supposed to assist the unconventionally high elongation at 823 K.

关键词： High-entropy alloy Temperature Ductility Strength Ultrafine grain

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Plastic surgery after solid organ transplantations

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Chinese Medical Journal 2009年第10期122卷 1184-1187页

作者： QI Fa-zhi ZHANG Yong YANG Zhen FENG zi-hao gu jian-ying Department of Plastic and Reconstructive Surgery Zhongshan Hospital Fudan University Shanghai 200032 China

Background More patients receive organ transplantation surgeries due to the advancement in immunosuppressive agents and surgical techniques. Some of those patients may need to undergo plastic or reconstructive surgery. Long-term use of immunosuppressive agents raises some serious problems. Therefore, this study aimed to introduce our experience about the safety and effectiveness of plastic surgeries after solid organ allograft transplantation. Methods A retrospective review of 17 transplant recipients who underwent different reconstructive or cosmetic operations was carried out. The subjects included 1 heart transplant, 1 liver transplant and 15 kidney transplant recipients. Results All patients tolerated the plastic surgery procedures well. Flaps and skin grafts were the main constructive methods. There were no postoperative infections and wound dehiscence. Transferred flaps survived completely. Skin grafts took well. Three of the cosmetic surgery patients were satisfied with the results. Conclusions Immunosuppressed organ transplant recipients can successfully undergo major reconstructive and cosmetic surgery when given special attention.

关键词： allograft organ transplantation plastic surgery

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Clinicopathological differences between patients with schistosomal appendicitis and non schistosomal appendicitis:A retrospectively study of past ten years

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World Journal of Clinical Cases 2025年第2期13卷 24-32页

作者： Xiao-Yi Wang Yao Hao zi-jian Wang Xiu-Liang Xu jiang-Hua Yang Department of Infectious Diseases The First Affiliated of Wannan Medical CollegeWuhu 241001Anhui ProvinceChina

BACKGROUND Chronic schistosomiasis causes multiple organ and multiple system diseases,especially the digestive *** eggs are mainly deposited in the stomach,liver and colorectal,but a few eggs are deposited in the appendix and cause *** present,there are few studies on schistosomal *** To explore the differences in epidemiological,clinical and pathological characteristics between schistosomal appendicitis and non-schistosomal appendicitis over the past decade in order to assess the impact of schistosomiasis on *** The differences of general data,clinical data and laboratory examination data of patients with appendicitis from October 2013 to October 2023 were retrospectively *** patients were divided into two groups for *** were 136 patients in schistosomal appendicitis group and 5418 patients in non-schistosomal appendicitis *** Schistosomal appendicitis accounted for 2.45%of all patients with appendicitis,and the annual proportion in the past decade was 2.2%,2.9%,1.8%,1.9%,3.4%,3.1%,1.9%,1.6%,3%,2.6%,*** prevalence of schistosomal appendicitis was middle-aged and elderly males,with an average age of 61.73±15.335 *** main population of non-schistosomal appendicitis was middle-aged men,with an average age of 35.8±24.013 years(P<0.001).The distribution of pathological types of appendicitis was different between the two groups(P<0.001).The incidence of acute suppurative appendicitis in non-schistosomal appendicitis was higher than that in schistosomal appendicitis[odds ratio(OR)=0.504;95%confidence interval(CI):0.349-0.728;P<0.001].The proportion of acute attack of chronic appendicitis in schistosomal appendicitis was higher than that in non-schistosomal appendicitis(OR=2.614;95%CI:1.815-3.763;P<0.001).The proportion of schistosomal appendicitis patients complicated with colorectal cancer was higher than that of nonschistosomal appendicitis patients(OR=5.087;95%CI:1.427-

关键词： Schistosomal appendicitis Schistosomiasis Appendix Colorectal cancer Clinicopathological characteristics

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Anisotropic characteristics of granular materials under simple shear

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Journal of Central South University 2013年第8期20卷 2275-2284页

作者： QIAN jian-gu YOU zi-pei HUANG Mao-song Key Laboratory of Geotechnical and Underground Engineering of Ministry of Education (Tongji University) Shanghai 200092 China Department of Geotechnical Engineering Tongji University Shanghai 200092 China

The discrete element method was used to investigate the microscopic characteristics of granular materials under simple shear loading conditions. A series of simple tests on photo-elastic materials were used as a benchmark. With respect to the original experimental observations, average micro-variables such as the shear stress, shear strain and the volumetric dilatancy were extracted to illustrate the performance of the DEM simulation. The change of anisotropic density distributions of contact normals and contact forces was demonstrated during the course of simple shear. On the basis of microscopic characteristics, an analytical approach was further used to explore the macroscopic behaviors involving anisotropic shear strength and anisotropic stress-dilatancy. This results show that under simple shear loading, anisotropic shear strength arises primarily due to the difference between principal directions of the stress and the fabric. In addition, non-coaxiality, referring to the difference between principal directions of the strain rate and the stress, generates less stress-dilatancy. In particular, the anisotropic hardening and anisotropic stress-dilatancy will reduce to the isotropic hardening and the classical Taylor’s stress-dilatancy under proportional loading.

关键词： simple shear discrete element method anisotropy non-coaxiality

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基于机器学习筛选猪活体肌内脂肪含量间接选育和构建预测模型的关键性状

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南京农业大学学报 2025年第1期48卷 161-170页

作者：吴建杨文孟孜查成万吴望军南京农业大学动物科技学院江苏南京210095

[目的]本研究旨在探究猪断奶重、屠宰前活体重、背膘厚等性状因素对猪肌内脂肪(intramuscular fat,IMF)含量的影响,确定影响猪IMF含量的关键性状因素。[方法]以805头皮特兰×[杜洛克×(长白×大白)]四元商品猪群为试验对象,记录性别,测... 详细信息

[目的]本研究旨在探究猪断奶重、屠宰前活体重、背膘厚等性状因素对猪肌内脂肪(intramuscular fat,IMF)含量的影响,确定影响猪IMF含量的关键性状因素。[方法]以805头皮特兰×[杜洛克×(长白×大白)]四元商品猪群为试验对象,记录性别,测定初生重、断奶重、屠宰前活体重和IMF含量等14个性状,然后通过相关性分析从14个性状中初步筛选出影响IMF含量的性状因素,再通过随机森林模型评估各性状因素对IMF含量影响的重要性,进一步通过LASSO回归和逐步回归筛选出影响IMF含量的关键性状因素;在此基础上,利用广义线性模型(generalized linear model,GLM)分析关键性状因素不同水平对IMF含量的影响。[结果]相关性分析结果显示,猪IMF含量与断奶重(r=0.13, P0.05)。胸腰椎结合处背膘厚大于26 mm组的平均IMF含量(2.73%)显著高于其他背膘厚组(P0.05)。[结论]本研究通过机器学习确定了性别、断奶重、屠宰前活体重和胸腰椎结合处背膘厚4个与IMF含量显著相关的活体可测定性状,并发现平均IMF含量随着屠宰前活体重和胸腰椎结合处背膘厚的增加呈明显的上升趋势。

关键词：猪肌内脂肪间接选择模型构建机器学习活体可测定性状

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Three-dimensional numerical simulation and earth pressure analysis on double-row piles with consideration of spatial effects

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2011年第10期12卷 758-770页

作者： zi-han WANG jian ZHOU Department of Geotechnical Engineering Tongji University Shanghai 200092 China

As a new kind of technology in retaining structures, the characteristics of double-row piles are significantly affected by spatial effects. In this paper, double-row piles as a retaining structure are simulated numerically in three-dimension by finite element software PLAXIS 3D FOUNDATION. The behavior differences of piles in different positions around the foundation pit are analyzed. By changing the parameters, including the length-width ratio, the excavation depth, the distance between rows and the diameter of piles, the variations of the lateral deformation, the bending moment and the earth pressure around the piles are determined. The reasonable values of parameters and some suggestions with consideration of earth pressure are proposed for the design of double-row piles as a retaining structure. The results show that the lateral deformation and bending moment are the largest in the middle of long side of the foundation pit, which is identified as the most unfavorable position. It is indicated that the earth pressure between rows above pit bottom is close to active earth pressure, while the earth pressure between rows under pit bottom is close to static earth pressure. It is suggested that 1/2-2/3 of pile length, 0.6-1.2 m, 3d-6d, and 2d-2.5d be chosen as embedded depth of piles, diameter of piles, distance between rows, and distance between piles, respectively, where d is the pile diameter.

关键词： Double-row piles Retaining structure Spatial effect Finite element Earth pressure

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New multi-camera calibration algorithm based on 1D objects

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第6期9卷 799-806页

作者： zi-jian ZHAO Yun-cai LIU Institute of linage Processing and Pattern Recognition Shanghai Jiao Tong University Shanghai 200240 China

A new calibration algorithm for multi-camera systems using 1D calibration objects is proposed. The algorithm inte- grates the rank-4 factorization with Zhang (2004)'s method. The intrinsic parameters as well as the extrinsic parameters are re- covered by capturing with cameras the 1D object's rotations around a fixed point. The algorithm is based on factorization of the scaled measurement matrix, the projective depth of which is estimated in an analytical equation instead of a recursive form. For more than three points on a 1D object, the approach of our algorithm is to extend the scaled measurement matrix. The obtained parameters are finally refined through the maximum likelihood inference. Simulations and experiments with real images verify that the proposed technique achieves a good trade-off between the intrinsic and extrinsic camera parameters.

关键词： Multi-camera calibration Homography Factorization Scaled measurement matrix Projective depth

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Poly(ethylene carbonate)-based electrolytes with high concentration Li salt for all-solid-state lithium batteries

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Rare Metals 2018年第6期37卷 488-496页

作者： zi-jian He Li-Zhen Fan Beijing Advanced Innovation Center for Materials Genome Engineering Institute of Advanced Materials and Technology University of Science and Technology Beijing

High-performance solid polymer electrolyte （SPE） has long been desired for the next-generation high energy density and safe rechargeable lithium batteries. A SPE composed of 80 wt% lithium bis（trifluo-romethanesulfonyl）imide （LiTFSI）, 20% poly（ethylene carbonate）（PEC） and a polyamide （PA） fiber membrane backbone was prepared by solution-casting method. This solid electrolyte exhibits quite high ionic conductivity and lithium ion transference number （t＋）, and excellent mechanical strength. The as-prepared solid electrolyte shows good wettability to porous electrodes during cycles, which is beneficial to form ionically conductive phase throughout porous electrodes. All-solid-state LiFePO4lLi cells assembled with the as-prepared solid electrolyte deliver a high initial discharge specific capacity of 125.7 mAh·g^-1 and good cycling stability at 55 ℃ （93.4% retention at 1C after 200 cycles）, and superior cycle performance. Outstanding electrochemical performance can be mainly ascribed to the improved ionic conductivity in the entire porous electrodes due to the good wettability of SPE.

关键词： Solid polymer electrolyte All-solid-state lithium batteries Poly(ethylene carbonate) Wettability Porous electrodes

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喷印金属微滴撞击粗糙表面的分子动力学模拟

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原子与分子物理学报 2025年第4期42卷 73-80页

作者：苏仁健陈小勇游自浩桂林电子科技大学机电工程学院桂林541004 广西制造系统与先进制造技术重点实验室桂林541004

研究金属微滴撞击固体表面的行为对预测微滴形态和实现高精度的喷印制造具有重要的意义.然而,由于微纳尺度下金属微滴撞击实验的难以开展,目前涉及金属微滴撞击粗糙表面的形态变化和热毛细效应机理尚不清楚.本文采用分子动力学模拟研究... 详细信息

研究金属微滴撞击固体表面的行为对预测微滴形态和实现高精度的喷印制造具有重要的意义.然而,由于微纳尺度下金属微滴撞击实验的难以开展,目前涉及金属微滴撞击粗糙表面的形态变化和热毛细效应机理尚不清楚.本文采用分子动力学模拟研究了镓铟微滴撞击粗糙表面的动态行为,定量分析了撞击速度、粗糙结构和不同温度对微滴撞击行为的影响.结果表明:随着撞击速度的提高,微滴先后呈现沉积、弹跳和破碎飞溅三种模式,且微滴的最大铺展因子与韦伯数呈幂函数关系.此外,通过修饰基底粗糙结构发现,结构间距或高度的变化对微滴的弹跳行为存在不同的影响机制,可以有效促使或抑制微滴的弹跳行为.最后,分析得出随着温度的提高,微滴的铺展直径会变大,产生的黏性耗散也会增大.研究结果对金属微滴撞击行为的有效预测提供了理论基础.

关键词：金属微滴撞击粗糙基底分子动力学

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