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Prognostic and pathological impact of tumor budding in gastric cancer: A systematic review and meta-analysis

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World Journal of Gastrointestinal Oncology 2019年第10期11卷 898-908页

作者： Yi-Xian guo zi-Zhen Zhang Gang Zhao En-hao Zhao Department of Gastrointestinal Surgery Renji Hospital Shanghai Jiao Tong University School of Medicine

BACKGROUND Tumor budding,is a promising prognostic hallmark in many cancers,and can help us better assess the degree of malignancy in gastric cancer(GC)and in colorectal *** the past few years,several articles on the relationship between tumor budding and GC have been published,but different results have been *** the relationship between tumor budding and GC remains controversial,we integrated the data from 7 eligible studies to conduct a systematic review and *** To systematically evaluate the prognostic and pathological impact of tumor budding in *** Literature searches were conducted in the PubMed,Cochrane Library,EMBASE and Web of Science databases,and 7 cohort studies involving 2178 patients met our criteria and included in the *** patients were divided into those with high-grade tumor budding and those with low-grade tumor budding,and the cut-off values for tumor budding varied across the included *** hazard ratios(HRs)with 95%confidence intervals(CIs)were calculated to estimate the impact of tumor budding on overall survival(OS)in GC *** odds ratios(ORs)with 95%CIs were used to determine the correlation between tumor budding and pathological parameters(tumor stage,tumor differentiation,lymphovascular invasion,lymph node metastasis)of *** Seven studies involving 2178 patients were included in the *** combined ORs suggested that high-grade tumor budding was significantly associated with tumor stage(OR=6.63,95%CI:4.01-10.98,P<0.01),tumor differentiation(OR=3.74,95%CI:2.68-5.22,P<0.01),lymphovascular invasion(OR=7.85,95%CI:5.04-12.21,P<0.01),and lymph node metastasis(OR=5.75,95%CI:3.20-10.32,P<0.01).Moreover,high-grade tumor budding predicted a poor 5-year OS(HR=1.79,95%CI:1.53-2.05,P<0.01)in patients with GC and an adverse 5-year OS(HR=1.93,95%CI:1.45-2.42,P<0.01)in patients with intestinal-type *** High-grade tumor budding suggested a poor prognosis in patients with GC o

关键词： Tumor budding Gastric cancer Intestinal-type gastric cancer Epithelialmesenchymal transition

Molecular mechanisms of Biyu decoction as treatment for psoriasis:A network pharmacology and molecular docking study

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World Journal of Clinical Cases 2022年第21期10卷 7224-7241页

作者： zi Wang hao-Min Zhang Yuan-Rui guo Ling-Ling Li Department of Dermatology Dongzhimen HospitalBeijing University of Chinese MedicineBeijing 100700China

BACKGROUND The therapeutic effects of a combination of Chinese medicines called Biyu decoction have been clinically verified,although its molecular targets in psoriasis remain *** To explore the molecular mechanisms of Biyu decoction for psoriasis *** In this network pharmacology and molecular docking study,the Traditional Chinese Medicine Systems Pharmacology database was searched for Biyu decoction active ***,Online Mendelian Inheritance in Man,PharmGkb,Therapeutic Target Database,and DrugBank databases were searched for psoriasis-related *** genes targeted by the decoction’s active ingredient and disease genes were intersected to obtain predictive targets of the drug during psoriasis *** 3.8.0 was used to construct a drug component/target disease *** The functional protein association networks database and Cytoscape were used to construct a protein-protein interaction network and streamline the core *** Gene Ontology and Kyoto Encyclopedia of Genes and Genomes were used for pathway enrichment *** docking technology was used to verify the drug component/target disease *** We screened 117 major active ingredients,including quercetin,kaempferol,naringenin,and acetyl-shikonin,and identified 213 gene targets,such as MAPK3,JUN,FOS,MYC,MAPK8,STAT3,and *** a molecular docking analysis,the main active ingredients demonstrated good binding to the core *** Gene Ontology analysis showed that these ingredients were significantly associated with biological activities,such as transcription factor DNA binding,RNA polymerase II-specific DNA binding of transcription factors,and cytokine receptor binding;responses to lipopolysaccharides,molecules of bacterial origin,and oxidative stress;and were mainly distributed in membrane rafts,microdomains,and *** Kyoto Encyclopedia of Genes and Genomes analysis showed that decoction ingredients act on Th17 cell dif

关键词： Medicine Chinese traditional Molecular docking simulation Protein interaction maps Psoriasis Gene ontology Network pharmacology

Entity perception of Two-Step-Matching framework for public opinions

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Journal of Safety Science and Resilience 2020年第1期1卷 36-43页

作者： Ren-De Li hao-Tian Ma zi-Yi Wang Qiang guo Jian-guo Liu Library and Research Center of Computer Systems Science University of Shanghai for Science and TechnologyShanghai 200093PR China School of Accountancy and Shanghai Key Laboratory of Financial Information Technology Shanghai University of Finance and EconomicsShanghai 200433PR China School of Humanities Shanghai University of Finance and EconomicsShanghai 200433PR China Institute of Sina WRD Big Data Shanghai 201204PR China

Entity perception of ambiguous user comments is a critical problem of target identification for huge amount of public *** this paper,a Two-Step-Matching method is proposed to identify the precise target entity from multiple entities ***,potential entities are extracted by BiLSTM-CRF model and characteristic words by TF-IDF model from public ***,the first matching is implemented between potential entities and an official business directory by Jaro-Winkler distance ***,in order to find the pre-cise one,an industry-characteristic dictionary is developed into the second matching *** precise entity is identified according to the count of characteristic words matching to industry-characteristic *** addition,associated rate(global indicator)and accuracy rate(sample indicator)are defined for evaluation of matching *** results for three data sets of public opinions about major public health events show that the highest associated rate and accuracy rate arrive at 0.93 and 0.95,averagely enhanced by 32%and 30%above the case of using the first matching process *** framework provides the method to find the true target entity of really wanted expression from public opinions.

关键词： Entity perception BiLSTM-CRF model Jaro-Winkler distance algorithm User comments Public opinions

Volatilization behaviour and volatilization kinetics of CaF2-Na2O-CaOSiO2-Al2O3-MgO-B2O3 synthetic mould flux

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Journal of Iron and Steel Research International 2019年第4期26卷 412-421页

作者： Ya-ru Cui hao-yue Fan zi-liang guo guo-hua Wang Xiao-ming Li Jun-xue Zhao Ze Yang School of Metallurgical Engineering Xi'an University of Architecture and TechnologyXi'an 710055ShaanxiChina Inner Mongolia Xinchuang Resources Recycling Co. Ltd.Ordos 014300Inner MongoliaChina

To reduce the volatilization of the volatile-containing slags and obtain accurate measurement results of slag performance,the volatility degree and deviation mechanism must be ***-isothermal thermogravimetric analysis at different heating rates was used to establish the volatilization kinetic model,and it reveals the volatilization mechanism of CaF2-Na2O-CaO-SiO2-Al2O3-MgO-B2O3 synthetic sodium-containing fluoride mould *** results demonstrated that the evaporation of NaF and SiF4 was the decisive factor that led to the change in composition and deviation of properties of the tested *** most probable kinetic mechanism function for the evaporation of volatile component from sodiumcontaining fluoride mould flux could be expressed by g(α)=[—ln(1-α)]^2/3,with an apparent activation energy of 164.866 kJ mol^-1 and pre-exponential factor of 2.13×10^-4 s^-1,where α is the conversion rate at any time step in the volatilization *** reaction mechanism was random nucleation followed by growth,which was the limiting factor for the volatilization of synthetic sodium-containing fluoride mould *** method of increasing heating rate and adding protection gas in the measurement system will help to obtain more accurate results of slag performance.

关键词： Fluoride Slag performance Volatilization kinetics Thermogravimetric analysis Mechanism function

Electro-lubrication in Janus transition metal dichalcogenide bilayers

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Friction 2022年第11期10卷 1851-1858页

作者： hao LI Yufeng guo Wanlin guo State Key Laboratory of Mechanics and Control of Mechanical Structures MOE Key Laboratory for Intelligent Nano Materials and DevicesCollege of Aerospace EngineeringNanjing University of Aeronautics and AstronauticsNanjing 210016China

Lubrication induced by a vertical electric field or bias voltage is typically not applicable to twodimensional(2D)van der Waals(vdW)*** performing extensive first-principles calculations,we reveal that the interlayer friction and shear resistance of Janus transition metal dichalcogenide(TMD)MoXY(X/Y=S,Se,or Te,and X≠Y)bilayers under a constant normal force mode can be reduced by applying vertical electric *** maximum interlayer sliding energy barriers between AA and AB stacking of bilayers MoSTe,MoSeTe,and MoSSe decrease as the positive electric field increases because of the more significant counteracting effect from the electric field energy and the more significant enhancement in interlayer charge transfer in AA ***,the presence of negative electric fields decreases the interlayer friction of bilayer MoSTe,because the electronegativity difference between Te and S atoms reduces the interfacial atom charge differences between AA and AB *** results reveal an electro-lubrication mechanism for the heterogeneous interfaces of 2D Janus TMDs.

关键词： Janus transition metal dichalcogenide(TMD) electro-lubrication electric field tuning first-principles calculations

Controllable combustion behaviors of the laser-controlled solid propellant

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Defence Technology（防务技术） 2022年第1期18卷 38-48页

作者： Bu-ren Duan hao-nan Zhang Li-zhi Wu Zuo-hao Hua zi-jing Bao Ning guo Ying-hua Ye Rui-qi Shen School of Chemical Engineering Narging University of Science and Technology Narjing 210094China Instifute of Space Propulsion Nanjing University of Science and Technology Nanjing 210094China Micro-Nano Energetic Devices Key Laboratory Ministry of Industry and Informnation TedhinologyNanjing210094China Shanghai Space Propulsion Technology Research Instirute Shanghai201109China

Microsatellites have been widely applied in the fields of communication,remote sensing,navigation and science exploration due to its characteristics of low cost,flexible launch mode and short development ***,conventional solid-propellant have difficulties in starting and interrupting combustion because combustion is autonomously sustained after ignition Herein,we proposed a new type of solid-propellant named laser-controlled solid propellant,which is sensitive to laser irradiation and can be started or interrupted by switching on/off the continuous wave *** demonstrate the feasibility and investigate the controllable combustion behaviors under different laser on/off conditions,the combus tion parameters including burning rate,ignition delay time and platform pressure were tested using pressure sensor,high-speed camera and thermographic *** results showed that the increase of laser-on or laser-off duration both will lead to the decrease of propellant combustion performance during re-ignition and re-combustion *** is mainly attributed to the laser attenuation caused by the accumulation of combustion residue and the change of chamber ambient *** the multiple ignition tests revealed that the increased chamber ambient temperature after combustion can make up for the energy loss of laser attenuation and expansion of chamber ***,the laser-controlled combustion performance of solid propellant displayed a decrease trend with the addi-tion of ignition ***,the results still exchibited good laser-controlled agility of laser-controlled solid propellant and manifested its inspiring potential in many aspects of space missions.

关键词： Laser-con trolled solid propellant Laser ablation Multiple ignition Controllable combustion Combustion be haviors

Thermodynamic and experimental study of high-temperature roasting of blast furnace gas ash for recovery of metallic zinc and iron

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Journal of Iron and Steel Research International 2024年第1期31卷 108-120页

作者： zi-han Wang Jing guo Han-jie guo Bin Li School of Metallurgical Engineering University of Science and Technology BeijingBeijing100083China School of Metallurgical Engineering Xi’an University of Architecture and TechnologyXi’an710055ShaanxiChina

A high-temperature reduction roasting method was used to achieve metallic iron and zinc recovery from blast furnace gas ash(BFA).The reduction processes for Zn-containing and Fe-containing oxides were analyzed in detail by using ther-modynamic equilibrium calculation and the principle of minimum free *** results showed that the main reaction in the system is the reduction of ZnFe_(2)_(4)and iron *** the full temperature range,iron oxides were more easily reduced than zinc *** of the amount of CO contained in the system,the reduction of ZnO to Zn was difficult to proceed below the boiling point(906℃)of *** the reduction temperature is below 906℃,the reduction process of zinc ferrate was ZnFe_(2)_(4)→ZnO;when the reduction temperature is above 906℃,its reduction process becomed ZnFe_(2)_(4)→ZnO→Zn(g).The metallization and dezincification rates of the BFA gradually increased with increasing reaction *** the C/O ratio increased,the metallization and dezincification rates first increased and then *** effect of reduction time on BFA reduction was similar to that of reaction temperature.

关键词： Blast furnace gas ash Thermodynamics zinc removal Iron reduction High-temperature reduction roasting Integrated utilization

Experimental Investigation on the Vibration Attenuation of Tensegrity Prisms Integrated with Particle Dampers

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Acta Mechanica Solida Sinica 2022年第4期35卷 672-681页

作者： Si-Qi An hao-Ran Zou Wen-hao Li zi-Chen Deng School of Mechanics Civil Engineering and ArchitectureNorthwestern Polytechnical UniversityXi’an710072China

Tensegrities made of tensile strings and compressed struts possess large strength-to-mass ratio values but tend to experience non-negligible vibration in dynamic environments because of poor structural ***,we introduce particle dampers into a tensegrity prism to attenuate vibration,with the goal of establishing a lightweight and efficient approach of vibration *** integrate the particle dampers and the tensegrity,a novel strut structure formed by assembling a solid strut and a hollow strut is devised,in which granular materials are inserted to develop a particle *** vibration attenuation performance of the tensegrity prism is investigated through exciter *** to the experimental parametric study,the influences of system parameters including excitation magnitude,the filling height of particles,particle size and the configuration of tensegrity prism on the vibration attenuation performance is *** addition,the experimental results regarding the dependence of the vibration attenuation on the system parameters are interpreted by the mechanism of collisions and frictions between particles and between particles and *** maximal vibration attenuation ratio of 76%can be achieved in the ***,this research can provide insights into the design of lightweight tensegrity structures where vibration suppression is important,particularly in some dynamic environments.

关键词： Tensegrity structures Particle dampers Vibration suppression Assembling struts

Intelligent Chinese Medicine:A New Direction Approach for Integrative Medicine in Diagnosis and Treatment of Cardiovascular Diseases

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Chinese Journal of Integrative Medicine 2023年第7期29卷 634-643页

作者： WANG zi-yan guo Zhi-hua The First Clinical College of Chinese Medicine Hunan University of Chinese MedicineChangsha410208China School of Traditional Chinese Medicine Hunan University of Chinese MedicineChangsha410208China Hunan Key Laboratory of Colleges and Universities of Intelligent Traditional Chinese Medicine Diagnosis and Preventive Treatment of Chronic Diseases of Hunan Universities of Chinese Medicine Changsha410208China

High mortality rates from cardiovascular diseases(CVDs)persist *** people are at a higher risk of developing these *** the current high treatment cost for CVDs,there is a need to prevent CVDs and or develop treatment *** and Chinese medicines have been used to treat ***,several factors,such as inaccurate diagnoses,non-standard prescriptions,and poor adherence behavior,lower the benefits of the treatments by Chinese medicine(CM).Artificial intelligence(AI)is increasingly used in clinical diagnosis and treatment,especially in assessing efficacy of CM in clinical decision support systems,health management,new drug research and development,and drug efficacy *** this study,we explored the role of AI in CM in the diagnosis and treatment of CVDs,and discussed application of AI in assessing the effect of CM on CVDs.

关键词： Chinese medicine Western medicine artificial intelligence cardiovascular diseases ischemic heart disease heart failure