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Endoscopic features and treatments of gastric cystica profunda

World Journal of Gastroenterology 2024年第7期30卷 673-684页

作者： zi-han geng Yan Zhu Pei-Yao Fu Yi-Fan Qu Wei-Feng Chen Xia Yang Ping-Hong Zhou Quan-Lin Li Endoscopy Center and Endoscopy Research Institute Zhongshan HospitalFudan UniversityShanghai 200032China

BACKGROUND Gastric cystica profunda(GCP)represents a rare condition characterized by cystic dilation of gastric glands within the mucosal and/or submucosal *** is often linked to,or may progress into,early gastric cancer(EGC).AIM To provide a comprehensive evaluation of the endoscopic features of GCP while assessing the efficacy of endoscopic treatment,thereby offering guidance for diagnosis and *** This retrospective study involved 104 patients with GCP who underwent endoscopic *** demographic and clinical data,regular patient followups were conducted to assess local *** Among the 104 patients diagnosed with GCP who underwent endoscopic resection,12.5%had a history of previous gastric *** primary site predominantly affected was the cardia(38.5%,n=40).GCP commonly exhibited intraluminal growth(99%),regular presentation(74.0%),and ulcerative mucosa(61.5%).The leading endoscopic feature was the mucosal lesion type(59.6%,n=62).The average maximum diameter was 20.9±15.3 mm,with mucosal involvement in 60.6%(n=63).Procedures lasted 73.9±57.5 min,achieving complete resection in 91.3%(n=95).Recurrence(4.8%)was managed via either surgical intervention(n=1)or through endoscopic resection(n=4).Final pathology confirmed that 59.6%of GCP cases were associated with *** analysis indicated that elderly males were more susceptible to GCP associated with ***,multivariate analysis identified lesion morphology and endoscopic features as significant risk *** analysis demonstrated no statistically significant difference in recurrence between GCP with and without EGC(P=0.72).CONCLUSION The findings suggested that endoscopic resection might serve as an effective and minimally invasive treatment for GCP with or without EGC.

关键词： Gastric cystica profunda Early gastric cancer Endoscopic features Endoscopic resection Endoscopy

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Human colorectal cancer cells frequently express IgG and display unique Ig repertoire

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World Journal of Gastrointestinal Oncology 2019年第3期11卷 195-207页

作者： zi-han geng Chun-Xiang Ye Yan Huang Hong-Peng Jiang Ying-Jiang Ye Shan Wang Yuan Zhou Zhan-Long Shen Xiao-Yan Qiu Department of Immunology School of Basic Medical SciencesPeking University NHC Key Laboratory of Medical Immunology (Peking University) Key Laboratory of Molecular Immunology Chinese Academy of Medical Sciences Department of Gastrointestinal Surgery Peking University People's Hospital Key Laboratory of Colorectal Cancer Diagnosis and Treatment Research Institute of Computational Medicine School of Artificial Intelligence Hebei University of Technology Department of Biomedical Informatics School of Basic Medical Sciences Center for Noncoding RNA Medicine Peking University

BACKGROUND There is growing evidence proving that many human carcinomas, including colon cancer, can overexpress immunoglobulin(Ig); the non B cancer cell-derived Ig usually displayed unique V(D)J rearrangement pattern that are distinct from B cell-derived Ig. Especially, the cancer-derived Ig plays important roles in cancer initiation, progression, and metastasis. However, it still remains unclear if the colon cancer-derived Ig can display unique V(D)J pattern and sequencing, which can be used as novel target for colon cancer *** To investigate the Ig repertoire features expressed in human colon cancer *** Seven cancerous tissue samples of colon adenocarcinoma and corresponding noncancerous tissue samples were sorted by fluorescence-activated cell sorting using epithelial cell adhesion molecule as a marker for epithelial cells. Ig repertoire sequencing was used to analyze the expression profiles of all 5 classes of Ig heavy chains(IgH) and the Ig repertoire in colon cancer cells and corresponding normal epithelial *** We found that all 5 IgH classes can be expressed in both colon cancer cells and normal epithelial cells. Surprisingly, unlike the normal colonic epithelial cells that expressed 5 Ig classes, our results suggested that cancer cells most prominently express IgG. Next, we found that the usage of Ig in cancer cells caused the expression of some unique Ig repertoires compared to normal cells. Some VH segments, such as VH3-7, have been used in cancer cells, and VH3-74 was frequently present in normal epithelial cells. Moreover, compared to the normal cell-derived Ig, most cancer cell-derived Ig showed unique VHDJH ***, even if the same VHDJH pattern was seen in cancer cells and normal cells, cancer cell-derived IgH always displayed distinct hypermutation hot *** We found that colon cancer cells could frequently express IgG and unique IgH repertoires, which may be involved in carcinogenesis of colon

关键词： Immunoglobulin repertoire Sequencing Colorectal cancer VDJ pattern VJ pattern

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Submucosal tunneling endoscopic biopsy and myotomy for management of unknown esophageal stenosis

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Gastroenterology Report 2022年第1期10卷 635-637页

作者： Xiao-Yue Xu zi-han geng Tian-Yin Chen Quan-Lin Li Ming-Yan Cai Jia-Xin Xu Dan-Feng Zhang Jian-Wei Hu Ping-Hong Zhou Endoscopy Center and Endoscopy Research Institute Zhongshan HospitalFudan UniversityShanghai Collaborative Innovation Center of EndoscopyShanghaiP.R.China

Introduction Esophageal stenosis is usually congenital or secondary to esophageal injury,esophagitis,and esophageal neoplasia[1,2].The mainstay treatment for benign esophageal stenosis is dilatation with either balloons or esophageal bougienage[3,4].A self-expandable metal stent(SEMS)is recommended for malignant and refractory esophageal stenosis[5].The treatment can be distinct according to different *** ultrasonography-guided fine-needle aspiration/biopsy(EUS-FNA/FNB)may be conducive to clarifying the etiology of esophageal ***,the small amount of tissue obtained by EUS-FNA/FNB may provide less pathological *** we report a new technique—submucosal tunneling endoscopic biopsy and myotomy(STEBM)derived from the peroral endoscopic myotomy(POEM)procedure to relieve stenosis and get a sufficient amount of tissue to make a definite diagnosis.

关键词： esophageal stenosis biopsy

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Pudilan Xiaoyan oral liquid regulates tissue inflammation and apoptosis in mice with influenza virus pneumonia

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Traditional Medicine Research 2024年第6期9卷 55-63页

作者： Shan Cao Shuang-Rong Gao Chen Ni zi-han geng Ying-Li Xu Bo Pang Meng-Ping Chen Yu Zhang Shan-Shan Guo Yu-Jing Shi Li-Qi Ni Kun Wang Rong-Hua Zhao Xiao-Lan Cui Yan-Yan Bao Institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing 100700China Jumpcan Pharmaceutical Group Co. Ltd.Taizhou 225400China

Background:The influenza A virus is the primary cause of respiratory infections and poses a global health *** Xiaoyan oral liquid(PDL)exhibits anti-inflammatory and immunomodulatory *** is commonly employed in clinical practice to manage upper respiratory tract ***,there is still much to uncover regarding its potential therapeutic ***:Institute of cancer research mice were infected with influenza A virus via nasal *** general state of the mice,lung index,and lung index inhibition rate were used to evaluate the efficacy of ***-linked immunosorbent assay,western blotting,and immunohistochemistry were used to observe the presence of proteins and cytokines in the lung *** was evaluated using the TUNEL ***:PDL improved the mental state of influenza A virus-infected mice,reduced the lung index,and inhibited viral *** expression of interleukin-1βand tumor necrosis factor-αwere decreased,whereas the expression of interleukin-10 in the lung tissue was increased due to PDL *** addition,PDL treatment modulated Toll-like receptor 4 and MyD88 expressions in the lung *** significantly reduced apoptosis and decreased cleaved caspase-3 and PARP levels,whereas increased B-cell lymphoma-2 expression in the lung ***,the moderate-dose group of PDL exhibited a more pronounced *** findings indicate that PDL exerts a protective effect against pneumonia injury in influenza A virus-infected ***:PDL inhibited the inflammatory response and regulated apoptosis by regulating Toll-like receptor 4 and MyD88 protein expressions,thereby protecting the lung tissue from viral infection-induced lung tissue injury.

关键词： Pudilan Xiaoyan oral liquid influenza A virus immune response apoptosis Toll-like receptors

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Aikang tablets inhibit growth of human lung cancer xenografts in mice

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Tumor Microenvironment Research 2020年第4期2卷 104-116页

作者： Yan-Yan Bao Xin Mao Ying-Jie Gao Lei Bao Yu-Jing Shi Shan-Shan Guo zi-han geng Rong-Mei Yao Xiao-Lan Cui Institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing 100700China School of Pharmaceutical Sciences Southern Medical UniversityGuangzhou 510515China

Background:Chinese medicines have shown some advantages in preventing and controlling ***-associated macrophages and the immune factors of the tumor microenvironment all exist in the tumor microenvironment and play important role in the development and prognosis of ***,targeting tumor-associated macrophages and immune factors to prevent and treat tumors has become a hotspot in the field of antitumor research of the traditional Chinese ***:The inhibition of Chinese patent drug Aikang tablets to the growth of lung cancer was evaluated by calculating the relative tumor volume and relative tumor growth rate using the mouse model of human lung cancer *** effect of Aikang tablets on the tumor microenvironment was studied through the detection of the immune factors in the tumor microenvironment and serum with high-throughput liquid protein chip ***-associated macrophages,M1,M2,and M2/M1 were examined histologically and analyzed ***:In this study,2.8 and 1.4 g/kg/day Aikang tablets could significantly inhibit the growth of human lung adenocarcinoma(P<0.05).Moreover,2.8,1.4,and 0.7 g/kg/day Aikang tablets significantly downregulated the MCP-3,MIP-2,and IL-2 serum content(P<0.05);1.4 and 0.7 g/kg/day Aikang tablets significantly downregulated the MCP-1 serum content(P<0.05),1.4 g/kg/day Aikang tablets significantly downregulated the MIP-1αserum content(P<0.05).Simultaneously,2.8 g/kg/day Aikang tablets significantly downregulated the MIP-1βcontent in the tumor microenvironment(P<0.01);1.4 g/kg/day Aikang tablets significantly downregulated regulated upon activation,normal T Cell expressed and presumably secreted content in the tumor microenvironment(P<0.01);and 0.7 g/kg/day Aikang tablets significantly downregulated the MCP-1 and MCP-3 contents in tumor microenvironment(P<0.01).The results also showed that 2.8 and 1.4 g/kg/day Aikang tablets significantly increased the number of the M1 subtypes(P<0.

关键词： Chinese medicines Lung cancer Tumor-associated macrophage Tumor microenvironment

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Experimental study on pharmacodynamics of pudilan xiaoyan oral liquid for preventing and treating respiratory virus infection

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Infectious Diseases Research 2022年第1期3卷 21-27页

作者： Li-Run Zhou Lei Bao Yan-Yan Bao Rong-Hua Zhao Jing Sun Shan-Shan Guo zi-han geng Xiao-Lan Cui Yu-Jing Shi Institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing 100700China

Background:Pudilan Xiaoyan Oral Liquid(PDL),a famous traditional Chinese formula for treating acute and chronic *** evaluate the broad-spectrum antiviral effect of Pudilan Xiaoyan Oral Liquid,and provide a basis for clinical ***:Its inhibitory effect on different respiratory viruses was observed by cytopathic *** potential mechanism of the anti-influenza effect was determined by neuraminidase *** order to observe the therapeutic effect of PDL on viral pneumonia caused by different respiratory *** viral pneumonia model was established by nasal infection with different respiratory viruses,and then PDL was given Therapeutic and prophylactically to evaluate its pharmacodynamic activity in ***:The results of in vitro experiments showed that PDL had different inhibitory effects on cytopathic effects caused by different respiratory *** it has obvious inhibitory effect on the neuraminidase activity of influenza A virus,which indicates that it exerts anti-influenza virus effect by inhibiting neuraminidase activity of influenza *** results in vivo showed that PDL exhibited an inhibitory effect on pulmonary index(PI)and effectively reduced the degree of lesions in the *** lethal rate of mice was significantly decreased while survival time of mice was dramatically increased by PDL treatment in comparison to infection control,***:Our study demonstrates that PDL had a significant protection and treatment effect for respiratory virus infection in vitro and in vivo.

关键词： Pudilan respiratory virus pharmacodynamic evaluation in vivo and in vitro models viral pneumonia

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Crystallization Modulation and Holistic Passivation Enables Efficient Two‑Terminal Perovskite/CuIn(Ga)Se_(2)Tandem Solar Cells

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Nano-Micro Letters 2025年第1期17卷 205-215页

作者： Cong geng Kuanxiang Zhang Changhua Wang Chung Hsien Wu Jiwen Jiang Fei Long Liyuan han Qifeng han Yi‑Bing Cheng Yong Peng State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070People’s Republic of China Triumph Photovoltaic Materials Co. Ltd.No.1001 Yannan AvenueHigh‑Tech Development DistrictBengbuAnhui 233000People’s Republic of China College of Materials Science and Engineering Guilin University of TechnologyGuilin 541004People’s Republic of China State Key Laboratory of Metal Matrix Composites Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

Two-terminal(2-T)perovskite(PVK)/CuIn(Ga)Se_(2)(CIGS)tandem solar cells(TSCs)have been considered as an ideal tandem cell because of their best bandgap matching regarding to Shockley–Queisser(S–Q)***,the nature of the irregular rough morphology of commercial CIGS prevents people from improving tandem device *** this paper,D-homoserine lactone hydrochloride is proven to improve coverage of PVK materials on irregular rough CIGS surfaces and also passivate bulk defects by modulating the growth of PVK *** addition,the minority carriers near the PVK/C60 interface and the incompletely passivated trap states caused interface recombination.A surface reconstruction with 2-thiopheneethylammonium iodide and N,N-dimethylformamide assisted passivates the defect sites located at the surface and grain ***,LiF is used to create this field effect,repelling hole carriers away from the PVK and C60 interface and thus reducing *** a result,a 2-T PVK/CIGS tandem yielded a power conversion efficiency of 24.6%(0.16 cm^(2)),one of the highest results for 2-T PVK/CIGS TSCs to our *** validation underscores the potential of our methodology in achieving superior performance in PVK/CIGS tandem solar cells.

关键词： PVK/CIGS TSCs Irregular rough surfaces Modulating the growth PVK/C60 interface recombination

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Endoscopic resection for calcifying fibrous tumors of the gastrointestinal tract

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World Journal of Clinical Oncology 2024年第2期15卷 282-289页

作者： zi-han geng Yan Zhu Pei-Yao Fu Yi-Fan Qu Shi-Yao Chen Yun-Shi Zhong Yi-Qun Zhang Wei-Feng Chen Wen-Zheng Qin Jian-Wei Hu Ming-Yan Cai Li-Qing Yao Quan-Lin Li Ping-Hong Zhou Endoscopy Center and Endoscopy Research Institute Zhongshan HospitalFudan UniversityShanghai 200032China Shanghai Collaborative Innovation Center of Endoscopy Shanghai 200032China

BACKGROUND Calcifying fibrous tumors(CFTs)are rare mesenchymal lesions that can occur in various sites throughout the body,including the tubular gastrointestinal(GI)*** To analyze the clinical findings of 36 patients with GI tract CFTs to provide guidance for diagnosis and *** This retrospective study included 36 patients diagnosed with CFTs of the GI *** collected demographic and clinical information and conducted regular follow-ups to assess for local *** The stomach was the most commonly involved site,accounting for 72.2%of the 36 *** mucosal resection(n=1,2.8%),endoscopic submucosal dissection(n=14,38.9%),endoscopic full-thickness resection(n=16,44.4%),and submucosal tunneling endoscopic resection(n=5,13.9%)were used to resect calcifying fibrous ***,34(94.4%)CFTs underwent complete endoscopic resections with a mean procedure time of 39.8±29.8 *** average maximum diameter of the tumors was 10.6±4.3 *** complications,such as bleeding or perforation,occurred during an average hospital stay of 2.9±1.2 *** addition,two patients developed new growth of CFTs near the primary tumor sites,and none of the patients developed distant metastases during the follow-up *** GI tract CFTs are rare and typically benign tumors that can be effectively managed with endoscopic procedures.

关键词： Endoscopic resection Calcifying fibrous tumor Gastrointestinal tract

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A cellulose-based lithium-ion battery separator with regulated ionic transport and high thermal stability for extreme environments

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Nano Research 2025年第1期18卷 315-322页

作者： Kun-Peng Yang Song Xie zi-Meng han Hao-Cheng Liu Chong-han Yin Wen-Bin Sun Zhang-Chi Ling Huai-Bin Yang De-han Li Qing-Fang Guan Shu-Hong Yu Department of Chemistry New Cornerstone Science LaboratoryInstitute of Biomimetic Materials&ChemistryAnhui Engineering Laboratory of Biomimetic MaterialsDivision of Nanomaterials&ChemistryHefei National Research Center for Physical Sciences at the MicroscaleUniversity of Science and Technology of ChinaHefei 230026China Institute of Innovative Materials Department of Materials Science and EngineeringDepartment of ChemistrySouthern University of Science and TechnologyShenzhen 518055China

Separators play a critical role in lithium-ion ***,the restrictions of thermal stability and inferior electrical performance in commercial polyolefin separators significantly limit their applications under harsh ***,we report a cellulose-assisted self-assembly strategy to construct a cellulose-based separator massively and *** an ultrahigh ionic conductivity in electrolytes of 3.7 mS·cm^(-1) and the ability to regulate ion transport,the obtained separator is a promising alternative for high-performance lithium-ion *** addition,integrated with high thermal stability,the cellulose-based separator endows batteries with high safety at high temperatures,greatly expanding the application scenarios of energy storage devices in extreme environments.

关键词： lithium-ion batteries bio-inspired materials battery separators cellulose nanofiber ultrahigh ionic conductivity high safety

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领导倾听内涵及其多层次效应

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心理科学进展 2025年第1期33卷 25-41页

作者：刘庚韩翼卢俊阳江西农业大学经济管理学院南昌330045 中南财经政法大学工商管理学院武汉430073 江西师范大学历史文化与旅游学院南昌330022

面对错综复杂和快速变化的商业环境,组织要想做出快速响应,领导者的有效倾听显得非常重要。通过文献综述发现,现有研究尚未对领导倾听的概念形成统一界定,且理论视角和研究层次较为单一,这不利于我们深入理解领导倾听的内涵及其多层次... 详细信息

面对错综复杂和快速变化的商业环境,组织要想做出快速响应,领导者的有效倾听显得非常重要。通过文献综述发现,现有研究尚未对领导倾听的概念形成统一界定,且理论视角和研究层次较为单一,这不利于我们深入理解领导倾听的内涵及其多层次效应。事实上,作为一种领导行为,领导倾听不仅会对领导者自身产生影响,而且会给团队及其下属带来影响。因此,本研究基于二元互动情境,从沟通信息和支持员工两方面对领导倾听的内涵进行探索性研究,并从领导力效能的评价对象(领导者、团队、员工)出发,结合多层次、多理论、多研究方法的全景研究范式逐步揭示领导倾听对不同对象的不同效应、黑箱机制及边界条件。本研究不仅开拓了倾听研究的新思路和新视角,而且为企业增强领导倾听的积极效能提供了管理启示。

关键词：领导倾听领导力效能领导工作绩效团队追随行为员工建言

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