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Self organizing optimization and phase transition in reinforcement learning minority game system

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Frontiers of physics 2024年第4期19卷 297-309页

作者： Si-Ping Zhang Jia-Qi Dong Hui-Yu Zhang Yi-Xuan Lü Jue Wang zi-gang huang Key Laboratory of Biomedical Information Engineering of Ministry of Education Key Laboratory of Neuro-informatics&Rehabilitation Engineering of Ministry of Civil Affairsand Institute of Health and Rehabilitation ScienceSchool of Life Science and TechnologyXi’an Jiaotong UniversityXi’an 710049China Lanzhou Center for Theoretical Physics and Key Laboratory of Theoretical Physics of Gansu Province Lanzhou UniversityLanzhou 730000China

Whether the complex game system composed of a large number of artificial intelligence(AI)agents empowered with reinforcement learning can produce extremely favorable collective behaviors just through the way of agent self-exploration is a matter of practical *** this paper,we address this question by combining the typical theoretical model of resource allocation system,the minority game model,with reinforcement *** individual participating in the game is set to have a certain degree of intelligence based on reinforcement learning *** particular,we demonstrate that as AI agents gradually becomes familiar with the unknown environment and tries to provide optimal actions to maximize payoff,the whole system continues to approach the optimal state under certain parameter combinations,herding is effectively suppressed by an oscillating collective behavior which is a self-organizing pattern without any external *** interesting phenomenon is that a first-order phase transition is revealed based on some numerical results in our multi-agents system with reinforcement *** order to further understand the dynamic behavior of agent learning,we define and analyze the conversion path of belief mode,and find that the self-organizing condensation of belief modes appeared for the given trial and error rates in the AI ***,we provide a detection method for period-two oscillation collective pattern emergence based on the Kullback–Leibler divergence and give the parameter position where the period-two appears.

关键词： oscillatory evolution collective behaviors phase transition reinforcement learning minority game

Tuning the porosity of {Co12IICo8III（μ3-OH）24（X）}11+ supramolecular frameworks by reaction time for D2/H2 separation

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Science China Chemistry 2025年

作者： Zhuozhou Xie Zhu Zhuo zi-Ang Nan Qing Li Xiufang Li zi-Xiu Lu Linzhe Lü Jin Liu Luyao Liu Wenjing Wang Wei Wang Daqiang Yuan You-Gui huang State Key Laboratory of Structure Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences University of Chinese Academy of Sciences Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials Xiamen Institute of Rare Earth Materials Haixi InstitutesChinese Academy of Sciences State Key Laboratory of Physical Chemistry of Solid Surfaces Department of Chemistry College of Chemistry and Chemical EngineeringXiamen University

Systematicly tuning the porosities of porous materials is crucial for targeted gas mixture separation,yet it remains a longstanding *** a common strategy,altering the phenylene ring count in the organic building units has been exploited to adjust pore apertures in metal organic frameworks （MOFs） and covalent organic frameworks （COFs）,resulting in only a stepwise pore size variation of approximately 2.8?.Unlike MOFs and COFs,the porosities for supramolecular assembly frameworks are highly dependent on the packings of the molecular building units in the *** above strategy cannot be applied to supramolecular assembly frameworks and other strategies are required to adjust pore apertures in supramolecular frameworks,especially to achieve porous materials with the optimal pore size for D2/H2separation （～3?）.Here,we successfully modulate the porosity of supramolecular frameworks of[CoII1+12CoIII8L12（μ3-OH）24（X）]1clusters （L=mono-deprotonated 1-iminoisoindole-3-amine,X=ClO?4or Cl?） by controlling the duration of self-assembly *** simply adjusting the reaction time,we obtain three[CoII12CoIII8L12（μ3-OH）24（X）]11+supramolecular frameworks:[CoII12CoIII8（μ3-OH）24（ClO4）L12)]·（Cl）4·（HCO2）7（1）,[CoII12CoIII8L12（μ3-OH）24（Cl）]·（ClOI4）4·（Cl）6·（HCO2）·（H2O）10（2）,and[CoI12CoIII8L12（μ3-OH）24（Cl）]·（Cl）11·（H2O）12（3）.The different stacking patterns of the[CoII12CoIII8L12（μ3-OH）24（X）]11+clusters in these frameworks lead to significantly varied stabilities and *** 1 exhibits permanent porosity with interconnected channels and maintains stability under harsh *** contrast,compound 2 is nearly nonporous,and compound 3 becomes unstable upon *** pores of compound 1 show higher affinity to D2than H2,and the pore aperture diameter of compound 1 （～3.06?） meets the optimal porosity for D2/***,compound 1 demonstrates moderate D2/H2separation at 77 K (retention time:～7 min/g for D2/H2/Ne （10/10/80 vol%） in a flow of 5 mL

关键词：

Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan huang Yi-De Zhang Jie Chen Hai-Di Fan Wan Wang Bin Wang Ju-Yun Ma Peng-Peng Li Hai-Wei Pu Xin-Yian Guo Jian-gang Shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

数字化转型赋能企业绿色技术创新的影响研究——基于中国上市公司的经验数据

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工业技术经济 2025年第1期44卷 96-105页

作者：李刚黄苗苗安徽财经大学经济学院蚌埠233030

在“双碳”目标背景下,企业通过数字化转型推动绿色技术创新,这不仅关乎其自身生存发展,也是促进中国经济可持续发展的微观基础。本文基于2009~2023年沪深A股上市公司数据,实证检验数字化转型对企业绿色技术创新的影响。研究发现:(1)数... 详细信息

在“双碳”目标背景下,企业通过数字化转型推动绿色技术创新,这不仅关乎其自身生存发展,也是促进中国经济可持续发展的微观基础。本文基于2009~2023年沪深A股上市公司数据,实证检验数字化转型对企业绿色技术创新的影响。研究发现:(1)数字化转型有助于提升企业绿色技术创新水平,且估计结果十分稳健;(2)数字化转型通过增强内部能力、提高外部市场关注和增加政府补贴促进企业绿色技术创新;(3)异质性分析表明,在国有企业和环境规制强度高的区域,数字化转型对企业绿色技术创新的推动作用更为显著。本文为理解数字化转型赋能企业绿色技术创新提供经验证据,并为我国推动数字化转型以促进经济可持续发展提供理论和实践参考。

关键词：数字化转型绿色技术创新内部能力外部市场关注政府补贴高维固定效应双碳经济可持续发展

Peficitinib suppresses diffuse-type tenosynovial giant cell tumor by targeting TYK2 and JAK/STAT signaling

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Science China Life Sciences 2025年

作者： Shan Lu Chenxi Cao Wenjia Zhang Jiayi Li Jingli Yang zisheng huang Zhijun Wu Baitao Liu Hongjie huang Haijun Wang Yongjian Wang Dingge Liu Zhihua Zhang Kaiping Liu gang Yang Xi Gong Hui Dai Yingjia Li Erdan Dong Xin Zhang Yan Zhang Haihe Laboratory of Cell Ecosystem Institute of Cardiovascular Diseases The First Affiliated Hospital of Dalian Medical University Institute of Cardiovascular Sciences School of Basic Medical Sciences Peking University Health Science Center Department of Cardiology and Institute of Vascular Medicine Peking University Third HospitalState Key Laboratory of Vascular Homeostasis and Remodeling Peking University Department of Sports Medicine Peking University Third Hospital Institute of Sports Medicine of Peking University Beijing Key Laboratory of Sports Injuries Engineering Research Center of Sports Trauma Treatment Technology and Devices Ministry of Education State Key Laboratory of Membrane Biology Institute of Molecular Medicine College of Future Technology Peking University Peking University Health Science Centre Peking University Department of Immunology School of Basic Medical Sciences NHC Key Laboratory of Medical Immunology Peking University Research Center for Cardiopulmonary Rehabilitation University of Health and Rehabilitation Sciences Qingdao Hospital (Qingdao Municipal Hospital) School of Health and Life Sciences University of Health and Rehabilitation Sciences Research Unit of Medical Science Research Management/Basic and Clinical Research of Metabolic Cardiovascular Diseases Chinese Academy of Medical Sciences

Diffuse-type tenosynovial giant cell tumor(dTGCT) is a destructive but rare benign proliferative synovial neoplasm. Although surgery is currently the main treatment modality for dTGCT, the recurrence risk is up to 50%. Therefore, there is a great need for effective drugs against dTGCT with minor side effects. The Janus kinase(JAK)/signal transducer and activator of transcription(STAT) signaling plays a central role in rheumatoid arthritis(RA), a disease with similar characteristics as dTGCT, but its function in dTGCT remains *** fibroblast-like synoviocytes(FLS) and macrophages were isolated from 10 synovial tissue samples from dTGCT patients for the screening and validation of the five clinically approved JAK inhibitors to treat RA against dTGCT. Cell viability, cell death, inflammation and the activity of the JAK family members of cultured dTGCT FLS(both 2-D and 3-D) and macrophages were investigated for the efficacy of the JAK inhibitors. Here, we found that similar to RA, JAK/STAT signaling was markedly activated in the dTGCT synovium. Of the 5 JAK inhibitors, peficitinib was shown to have the most potency in addressing some of the pathological responses of dTGCT FLS and *** potency of peficitinib was much higher than pexidartinib, which is the only FDA-approved drug for dTGCT. Mechanistically, peficitinib inhibited tyrosine kinase 2(TYK2), a JAK family member necessary for the pathological progression of dTGCT FLS and macrophages. In summary, we not only revealed JAK/STAT(especially TYK2) signaling as the major mechanism underlying dTGCT, but also identified peficitinib as a promising drug against dTGCT.

关键词：

[Evaluation of the toxicity of perfluorooctanoic acid toward human colorectal cancer cells using multi-dimensional approaches]

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Se pu = Chinese journal of chromatography 2025年第1期43卷 96-103页

作者： Rui-Jia Zhang Ying-Shi Lin Lan-Yin Tu zi-Tong Chen Wei-Wei Zhang Tian-gang Luan Bao-Wei Chen School of Life and Health Sciences Hainan University Haikou 570228 China. School of Life Sciences Sun Yat-sen University Guangzhou 510275 China. School of Artificial Intelligence Sun Yat-sen University Zhuhai 519082 China. Guangzhou Center for Disease Control and Prevention Guangzhou 510440 China. School of Marine Sciences Sun Yat-sen University Zhuhai 519082 China.

While human exposure to perfluorooctanoic acid (PFOA) can lead to ulcerative colitis, the molecular mechanisms responsible for PFOA-induced intestinal toxicity are unclear. Herein, we examined the toxicity of PFOA toward human colorectal cancer cells (HCT116) from three dimensions: the cytotoxic phenotype, cell respiration, and transcription levels of metabolism-related genes. Formazan was used to assess how PFOA exposure affects HCT116-cell relative viability, after which the mitochondrial respiratory activities of these cells were determined by analyzing extracellular flux. The quantitative real-time polymerase chain reaction (qPCR) method was used to detect metabolism-related gene expression levels. The cytotoxicity assay revealed that the HCT116 showed significantly inhibited relative activities compared to those of the control when exposed to 300 μmol/L PFOA for 48 h (<0.01), with most cells retained at the G0/G1 stage. In contrast, the mitochondrial respiratory activities of the HCT116 were promoted by concentrations of PFOA as low as 50 μmol/L. Two genes related to cellular metabolism (dipeptidase 1 () and sphingosine kinase 1 ()) were found to be related to the PFOA-promoted formation of ulcerative colitis using our self-developed Metabolic Gene and Pathway Query software and Comparative Toxicogenomics Database (CTD). The qPCR studies revealed that and expression levels were enhanced by 8-10 times in HCT116 exposed to 300 μmol/L PFOA relative to the control, whereas this trend was not observed for HCT116 exposed to 50 μmol/L PFOA. Collectively, these results suggest that the respiratory activity of cellular mitochondria may serve as an index for determining the interference effects associated with PFOA and that metabolic pathways mediated by and may be involved in the development of PFOA-induced ulcerative colitis. Future studies should investigate the relationships between changes in metabolism-related genes ( and ) and the mitochondrial respiratory act

关键词： Metabolic Gene and Pathway Query software human colorectal enterotoxicity metabolic disorder perfluorooctanoic acid (PFOA)

基于功能化COFs材料的样品前处理技术在新兴污染物中的研究进展

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分析测试学报 2025年第1期44卷 12-24页

作者：潘自宇刘智敏许志刚昆明理工大学理学院云南昆明650500

新兴污染物因具有环境持久性、生物累积性、生物毒性以及在环境中痕量存在等特点而备受全球众多国家关注。因此,对环境、食品以及生物样品中的新兴污染物进行高灵敏检测至关重要。传统样品前处理技术存在耗时长、吸附剂用量大,以及对不... 详细信息

新兴污染物因具有环境持久性、生物累积性、生物毒性以及在环境中痕量存在等特点而备受全球众多国家关注。因此,对环境、食品以及生物样品中的新兴污染物进行高灵敏检测至关重要。传统样品前处理技术存在耗时长、吸附剂用量大,以及对不稳定污染物的分析准确性差等缺点,因此,亟需开发设计具有高选择性、高传质效率的新型材料作为前处理技术的吸附剂,以实现新兴污染物的高选择、高灵敏检测。共价有机骨架材料(COFs),特别是功能化的COFs材料,因具有比表面积大、结构可设计、稳定且构筑基元丰富等诸多优点而被广泛用于新兴污染物的富集。该文主要综述了近年来功能化COFs材料的合成策略及其作为样品前处理吸附剂在环境、食品和生物样品中新兴污染物中的分析应用,并对该类材料的未来发展趋势进行了展望。

关键词：新兴污染物功能化COFs材料样品前处理技术

Novel design of a personnel safety system for Hefei Light Source-Ⅱ

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Nuclear Science and Techniques 2019年第6期30卷 114-121页

作者： zi-Yu huang Ke Xuan Chuan Li Ji-gang Wang Gong-Fa Liu National Synchrotron Radiation Laboratory University of Science and Technology of China

The Hefei Light Source-Ⅱ(HLS-Ⅱ) is a vacuum ultraviolet synchrotron light source. The personnel safety system (PSS), which is a personnel access control system, is a crucial part of the HLS-Ⅱ, as it protects the staff and users at HLS-Ⅱfrom radiation damages. The prior version of HLS-Ⅱ PSS was based on an access control system called SiPass. This lacked the personnel management function. Meanwhile, as the prior PSS is a turn-key system, it was not effective for sharing information. To overcome these drawbacks, the novel design of PSS for HLS-Ⅱ is proposed based on the Siemens redundant programmable logic controller under the Experimental Physics and Industrial Control System. The proposed PSS consists of a safety interlock system, access control system, and a radiation monitoring system. The safety interlock system is used to define the interlock logic. The access control system is designed to restrict the access of staff and users at HLS-Ⅱ, and to provide a personnel management function. The radiation monitoring system is used to monitor the radiation dose rate in both the light source and the surrounding areas. This paper details the architecture and the specific design of the novel PSS. The off-line test results demonstrate that the proposed system has achieved the design objectives.

关键词： Personnel safety system Personnel management Redundant programmable logic controller PROFINET Experimental Physics and Industrial Control System

Carbon shell coated hollow NiCoSe_(x)composite as high-performance anode for lithium storage

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Rare Metals 2021年第11期40卷 3185-3194页

作者： zi-Zhong Chen Jia-gang Hou Ji Zhou Peng huang Hai-Qing Wang Cai-Xia Xu Institute for Advanced Interdisciplinary Research(iAIR) University of JinanJinan 250022China Shandong Collaborative Innovation Center of Technology and Equipements for Biological Diagnosis and Therapy Jinan 250022China Qilu University of Technology(Shandong Academy of Sciences) Jinan 250353China

Hollow NiCoSe_(x)(H-NiCoSe_(x)) nanospheres encapsulated with carbon shell were prepared via one-step easy solvothermal method followed by the carbon coating process.H-NiCoSe_(x)@C has large interior void with the uniform dimension around 350 nm and the thickness of carbon shell around 20-30 *** with the large interior void as well as robust protective carbon shell,H-NiCoSe_(x)@C can retain the reversible capacity of 805.6 mAh·g^(-1) after 100 cycles at 200 mA·g^(-1).In particular,H-NiCoSe_(x)@C delivers large reversible capacity of 1532.2 mAh·g^(-1) upon cycling for 1000 loops at 1000 mA·g^(-1)with the capacity retention as high as 128.2% upon long period of *** at the high rate of 3000 mA·g^(-1),its specific capacity still retains up to 659.3 mAh·g^(-1).The superior lithium storage performances for H-NiCoSe_(x)@C profit from its robust hollow core-shell structure as well as enhanced electrical conductivity and ion transport.

关键词： Selenide Hollow sphere Carbon shell Lithium-ion batteries Anode