检索结果-南通市图书馆

Activation of natural killer T cells contributes to Th1 bias in the murine liver after 14 d of ethinylestradiol exposure

引用

World Journal of Gastroenterology 2022年第26期28卷 3150-3163页

作者： Meng-Zhi Zou Wei-Chao Kong Heng Cai Meng-Tao Xing zi-xun yu Xin Chen Lu-Yong Zhang Xin-Zhi Wang New Drug Screening Center China Pharmaceutical UniversityNanjing 210009Jiangsu ProvinceChina Department of Pharmacology China Pharmaceutical UniversityNanjing 210009Jiangsu ProvinceChina Center for Drug Research and Development Guangdong Pharmaceutical UniversityGuangzhou 510006Guangdong ProvinceChina

BACKGROUND As the main component of oral contraceptives(OCs),ethinylestradiol(EE)has been widely applied as a model drug to induce murine intrahepatic *** clinical counterpart of EE-induced cholestasis includes women who are taking OCs,sex hormone replacement therapy,and susceptible pregnant *** intrahepatic cholestasis of pregnancy(ICP)as an example,ICP consumes the medical system due to its high-risk fetal burden and the impotency of ursodeoxycholic acid in reducing adverse perinatal *** To explore the mechanisms and therapeutic strategies of EE-induced cholestasis based on the liver immune *** Male C57BL/6J mice or invariant natural killer T(iNKT)cell deficiency(Jα18-/-mice)were administered with EE(10 mg/kg,subcutaneous)for 14 *** Both Th1 and Th2 cytokines produced by NKT cells increased in the liver skewing toward a Th1 *** expression of the chemokine/chemokine receptor Cxcr6/Cxcl16,toll-like receptors,Ras/Rad,and PI3K/Bad signaling was upregulated after EE *** also influenced bile acid synthase Cyp7a1,Cyp8b1,and tight junctions ZO-1 and Occludin,which might be associated with EEinduced *** cell deficiency(Jα18-/-mice)robustly alleviated cholestatic liver damage and lowered the expression of the abovementioned signaling *** Hepatic NKT cells play a pathogenic role in EE-induced intrahepatic *** research improves the understanding of intrahepatic cholestasis by revealing the hepatic immune microenvironment and also provides a potential clinical treatment by regulating iNKT cells.

关键词： Natural killer T cell Th1/Th2 IFN-γ Estrogen Cholestasis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A novel evasion guidance for hypersonic morphing vehicle via intelligent maneuver strategy

引用

Chinese Journal of Aeronautics 2024年第5期37卷 441-461页

作者： xun LI Xiaogang WANG Hongyu ZHOU yu LI Department of Aerodynamics Harbin Institute of TechnologyHarbin 150001China Beijing Aerospace Technology Institute Beijing 100074China

This paper presents a novel evasion guidance law for hypersonic morphing vehicles,focusing on determining the optimized wing's unfolded angle to promote maneuverability based on an intelligent ***,the pursuit-evasion problem is modeled as a Markov decision *** the agent's action consists of maneuver overload and the unfolded angle of wings,which is different from the conventional evasion guidance designed for fixed-shape *** reward function is formulated to ensure that the miss distances satisfy the prescribed bounds while minimizing energy ***,to maximize the expected cumulative reward,a residual learning method is proposed based on proximal policy optimization,which integrates the optimal evasion for linear cases as the baseline and trains to optimize the performance for nonlinear engagement with multiple ***,offline training guarantees improvement of the constructed evasion guidance law over conventional ***,the guidance law for online implementation includes only analytical *** maps from the confrontation state to the expected angle of attack and the unfolded angle while retaining high computational *** show that the proposed evasion guidance law can utilize the change of unfolded angle to extend the maximum overload *** it surpasses conventional maneuver strategies by ensuring better evasion efficacy and higher energy efficiency.

关键词： Hypersonic vehicles Variable-sweep wings Evasion guidance Reinforcement learning Pursuit-evasion problem

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Regeneration of the heart:f rom molecular mechanisms to clinical therapeutics

引用

Military Medical Research 2024年第1期11卷 80-97页

作者： Qian-yun Guo Jia-Qi Yang xun-xun Feng yu-Jie Zhou Beijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic Disease Beijing Institute of Heart Lung and Blood Vessel DiseaseClinical Center for Coronary Heart DiseaseDepartment of CardiologyBeijing Anzhen HospitalCapital Medical UniversityBeijing 100029China

Heart injury such as myocardial infarction leads to cardiomyocyte loss,fibrotic tissue deposition,and scar *** changes reduce cardiac contractility,resulting in heart failure,which causes a huge public health *** personnel,compared with civilians,is exposed to more stress,a risk factor for heart diseases,making cardiovascular health management and treatment innovation an important topic for military *** far,medical intervention can slow down cardiovascular disease progression,but not yet induce heart *** the past decades,studies have focused on mechanisms underlying the regenerative capability of the heart and applicable approaches to reverse heart *** have emerged from studies in animal models and early clinical *** interventions show the potential to reduce scar formation and enhance cardiomyocyte proliferation that counteracts the pathogenesis of heart *** this review,we discuss the signaling events controlling the regeneration of heart tissue and summarize current therapeutic approaches to promote heart regeneration after injury.

关键词： Heart regeneration Cardiac disease Therapeutics Signaling mechanisms

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

High incidence combination of multiple primary malignant tumors of the digestive system

引用

World Journal of Gastroenterology 2022年第41期28卷 5982-5992页

作者： Xiao-Bo Yang Long-Hao Zhang Jing-Nan Xue yun-Chao Wang Xu Yang Nan Zhang Dan Liu Yan-yu Wang zi-yu xun Yi-Ran Li Hui-Shan Sun Li-Jin Zhao Hai-Tao Zhao Department of Liver Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100006China Digestive Disease Hospital Affiliated to Zunyi Medical University Department of General SurgeryAffiliated Hospital of Zunyi Medical UniversityZunyi 563099Guizhou ProvinceChina

BACKGROUND Clinical reports of multiple primary malignant tumors(MPMTs)in the digestive system are *** China,although the survival rate of patients with MPMTs is increasing,the quality of life is very *** patients have reached the advanced stage when the second primary tumor is found,resulting in no early intervention and *** is due to the misunderstanding of MPMTs by clinicians,who treat such tumors as ***,before a patient has a second primary tumor,doctors should understand some common combinations of digestive system MPMTs to provide clinical guidance to the *** To explore the high incidence combination of digestive system MPMTs under heterochronism and *** A total of 1902 patients with MPMTs at Peking Union Medical College Hospital were analyzed *** were divided into metachronous MPMT and synchronous MPMT groups,and then the high incidence combinations of the first primary cancer and the second primary cancer in metachronous cancer and synchronous cancer were *** and age differences between metachronous and synchronous tumors were tested by the chi square test and t test,respectively.A P value<0.05 was considered as statistically significant,and SPSS version 26.0(SPSS Inc.,Chicago,Illinois,United States)was used for statistical *** Among the 1902 patients with MPMTs confirmed by pathology,1811(95.2%)cases were secondary primary cancers,89(4.7%)cases were tertiary primary cancers,and 2(0.1%)cases were quaternary primary ***(88.2%)of the secondary primary cancers were identified as metachronous multiple primary cancers six months after diagnosis of the first primary *** top ten most common MPMTs in the first primary cancer group ranged from high to low as follows:Breast cancer,thyroid cancer,nonuterine cancer,lung cancer,colon cancer,kidney cancer,uterine cancer,bladder cancer,rectal cancer,and gastric *** highest incidence rate of the

关键词： Multiple primary malignant tumors Colon cancer Rectal cancer Metachronous carcinoma High incidence combinations First primary carcinoma

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Clinical outcomes of lenvatinib plus transarterial chemoembolization with or without programmed death receptor-1 inhibitors in unresectable hepatocellular carcinoma

引用

World Journal of Gastroenterology 2023年第10期29卷 1614-1626页

作者： Yan-yu Wang Xu Yang yun-Chao Wang Jun-yu Long Hui-Shan Sun Yi-Ran Li zi-yu xun Nan Zhang Jing-Nan Xue Cong Ning Jun-Wei Zhang Cheng-Pei Zhu Long-Hao Zhang Xiao-Bo Yang Hai-Tao Zhao Department of Liver Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Department of General Surgery Digestive Disease HospitalAffiliated Hospital of Zunyi Medical UniversityZunyi 563003Guizhou ProvinceChina

BACKGROUND Programmed death receptor-1(PD-1)inhibitors have been approved as secondline treatment regimen in hepatocellular carcinoma(HCC),but it is still worth studying whether patients can benefit from PD-1 inhibitors as first-line drugs combined with targeted drugs and locoregional *** To estimate the clinical outcome of transarterial chemoembolization(TACE)and lenvatinib plus PD-1 inhibitors for patients with unresectable HCC(uHCC).METHODS We carried out retrospective research of 65 patients with uHCC who were treated at Peking Union Medical College Hospital from September 2017 to February 2022.45 patients received the PD-1 inhibitors,lenvatinib,TACE(PD-1-Lenv-T)therapy,and 20 received the lenvatinib,TACE(Lenv-T)*** terms of the dose of lenvatinib,8 mg was given orally for patients weighing less than 60 kg and 12 mg for those weighing more than 60 *** the patients in the PD-1 inhibitor combination group,15 received Toripalimab,14 received Toripalimab,14 received Camrelizumab,4 received Pembrolizumab,9 received Sintilimab,and 2 received Nivolumab,1 with *** to the investigators’assessment,TACE was performed every 4-6 wk when the patient had good hepatic function(Child-Pugh class A or B)until disease progression *** evaluated the efficacy by the modified Response Evaluation Criteria in Solid Tumors(mRECIST criteria).We accessd the safety by the National Cancer Institute Common Terminology Criteria for Adverse Events,v *** key adverse events(AEs)after the initiation of combination therapy were *** Patients with uHCC who received PD-1-Lenv-T therapy(n=45)had a clearly longer overall survival than those who underwent Lenv-T therapy(n=20,26.8 vs 14.0 mo;P=0.027).The median progression-free survival time between the two treatment regimens was also measured{11.7 mo[95%confidence interval(CI):7.7-15.7]in the PD-1-Lenv-T group vs 8.5 mo(95%CI:3.0-13.9)in the Lenv-T group(P=0.028)}.The objective response rates of

关键词： Lenvatinib Programmed death receptor-1 inhibitor Immunotherapy Hepatocellular carcinoma Transarterial chemoembolization Combination therapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Simultaneously enhanced electrochemical performance and air stability of Ni-rich cathode with a modified washing process

引用

Rare Metals 2024年第1期43卷 87-97页

作者： Ben-Rui Hu Ying-Yi yuan yu-Cheng Wang xun-Hui Xiong School of Environment and Energy Guangdong Provincial Key Laboratory of Advanced Energy Storage MaterialsSouth China University of TechnologyGuangzhou 510640China

Water washing has been regarded as one of the most effective strategies to remove surface residual lithium of nickel-rich layered oxides for lithium-ion batteries(LIBs).However,the loss of lattice lithium during the water washing process deteriorates the electrochemical performances and air ***,washing the LiNi_(0.90)Co_(0.05)Al_(0.02)O_(2)(NCA) with ammonium dihydrogen phosphate(NH_(4)H_(2)PO_(4)) solution has been proposed to simultaneously enhance electrochemical performances and air stability,in which in-situ generated Li_(3)PO_(4) coating layer on surface of NCA can suppress the loss of lattice ***,as a fast ionic conductor,Li_(3)PO_(4) coating layer on NCA can prevent the direct contact with electrolyte/*** a result,the NH_(4)H_(2)PO_(4) solution washed NCA cathode can deliver a high capacity of131.9 mAh·g^(-1) at 10.0C rate as well as impressive cycle stability with a capacity retention of 83.1% after 100 cycles at 1.0C,much higher than those of water washed NCA(WS-NCA) *** exposed in air for 7 days,the NH_(4)H_(2)PO_(4) solution washed NCA electrode can more effectively maintain the structural integrity as well as the electrochemical performances than water-washed *** work provides a simple and effective approach to enhance the cycle stability and air stability of Nickel-rich cathode materials.

关键词： Layered Ni-rich cathode Residual lithium Li_(3)PO_(4)coating Rate performance Air stability

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Updates of developments in interventional therapy for elderly patients with cardiovascular diseases

引用

Journal of Geriatric Cardiology 2024年第1期21卷 1-3页

作者： Hua SHEN xun-xun FENG Qian-yun GUO yu-Jie ZHOU Beijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic Disease Beijing Institute of Heart Lung and Blood Vessel DiseaseClinical Center for Coronary Heart DiseaseDepartment of CardiologyBeijing Anzhen HospitalCapital Medical UniversityBeijingChina

Cardiovascular diseases(CVD)are the leading cause of death in the world and one of the most common diseases in the elderly,with high prevalence and poor prognosis,which seriously affect the health of the elder *** report showed that global deaths from CVD increased from 12.4 million in 1990 to 19.8 million in 2022,reflecting the global population growth and aging,as well as the impact of metabolic,environmental,and behavioral risks.[1]With the progress of aging population,the burden of CVD in the elderly in China has increased year by year,and factors including multiple complications,organ function decline,and high complication rate have made the interventional treatment of CVD in the elderly one of the difficulties and focuses in the field of cardiology in China.

关键词： diseases patients prognosis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Constructing high coordination number of Ir-O-Ru bonds in IrRuO_(x)nanomeshes for highly stable acidic oxygen evolution reaction

引用

Nano Research 2024年第6期17卷 5073-5079页

作者： Ge yu Ruilong Li Yida Zhang Xingen Lin Gongming Wang xun Hong Center of Advanced Nanocatalysis(CAN) Department of Applied ChemistryUniversity of Science and Technology of ChinaHefei 230026China National Synchrotron Radiation Laboratory(NSRL) University of Science and Technology of ChinaHefei 230029China

IrRu bimetallic oxides are recognized as the promising acidic oxygen evolution reaction(OER)catalysts,but breaking the trade-off between their activity and stability is an unresolved ***,addressing the issues of mass transport obstruction of IrRu bimetallic oxides under high current remains a challenge for the development of proton exchange membrane water electrolysis(PEM-WE).Herein,we prepared an IrRuO_(x)nanomeshes(IrRuO_(x)NMs)with high coordination number(CN)of Ir-O-Ru bonds in a mixed molten salt with high solubility of the Ir/Ru precursor.X-ray absorption spectroscopy analysis revealed that the IrRuO_(x)NMs possess high coordination number of Ir-O-Ru bonds(CNIr-O-Ru=5.6)with a distance of 3.18Å.Moreover,the nanomesh structures of IrRuO_(x)NMs provided hierarchical channels to accelerate the transport of oxygen and water,thus further improving the electrochemical ***,the IrRuO_(x)NMs as OER catalysts can simultaneously achieve high activity and stability with low overpotential of 196 mV to reach 10 mA·cm^(−2)and slightly increase by 70 mV over 650 h *** electrochemical mass spectrometry tests suggest that the preferred OER mechanism for IrRuO_(x)NMs is the adsorbent evolution mechanism,which is beneficial for the robust structural stability.

关键词： oxygen evolution reaction IrRuO_(x) Ir-O-Ru bonds two-dimensional(2D)nanomesh proton exchange membrane device mass transport

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Transfer RNA-derived fragment tRF-23-Q99P9P9NDD promotes progression of gastric cancer by targeting ACADSB

引用

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第5期25卷 438-450页

作者： yu ZHANG Xinliang GU Yang LI xun LI yuejiao HUANG Shaoqing JU Medical School of Nantong University Nantong UniversityNantong 226001China Department of Laboratory Medicine Affiliated Hospital of Nantong UniversityNantong 226001China Research Center of Clinical Medicine Affiliated Hospital of Nantong UniversityNantong 226001China Department of Medical Oncology Affiliated Hospital of Nantong UniversityNantong 226001China

Gastric cancer(GC)is one of the most common gastrointestinal *** a newly discovered type of non-coding RNAs,transfer RNA(tRNA)-derived small RNAs(tsRNAs)play a dual biological role in *** previous studies have demonstrated the potential of tRF-23-Q99P9P9NDD as a diagnostic and prognostic biomarker for *** this work,we confirmed for the first time that tRF-23-Q99P9P9NDD can promote the proliferation,migration,and invasion of GC cells in *** dual luciferase reporter gene assay confirmed that tRF-23-Q99P9P9NDD could bind to the 3'untranslated region(UTR)site of acyl-coenzyme A dehydrogenase short/branched chain(ACADSB).In addition,ACADSB could rescue the effect of tRF-23-Q99P9P9NDD on GC ***,we used Gene Ontology(GO),the Kyoto Encyclopedia of Genes and Genomes(KEGG),and Gene Set Enrichment Analysis(GSEA)to find that downregulated ACADSB in GC may promote lipid accumulation by inhibiting fatty acid catabolism and ***,we verified the correlation between ACADSB and 12 ferroptosis genes at the transcriptional level,as well as the changes in reactive oxygen species(ROS)levels by flow *** summary,this study proposes that tRF-23-Q99P9P9NDD may affect GC lipid metabolism and ferroptosis by targeting ACADSB,thereby promoting GC *** provides a theoretical basis for the diagnostic and prognostic monitoring value of GC and opens upnew possibilities for treatment.

关键词： Transfer RNA(tRNA)-derived small RNA(tsRNA) Gastric cancer(GC) Acyl-coenzyme A dehydrogenase short/branched chain(ACADSB) Molecular mechanism Treatment Ferroptosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Strip flatness prediction of cold rolling based on ensemble methods

引用

Journal of Iron and Steel Research International 2024年第1期31卷 237-251页

作者： Wu-quan Yang Zhi-ting Zhao Liang-yu Zhu xun-yang Gao Li Wang School of Mechanical and Power Engineering Shenyang University of Chemical TechnologyShenyang110142LiaoningChina

Aiming at the problem of insufficient prediction accuracy of strip flatness at the outlet of cold tandem rolling,the prediction performance of strip flatness based on different ensemble methods was studied and a high-precision prediction ensemble model of strip flatness at the outlet was ***,based on linear regression(LR),K nearest neighbors(KNN),support vector regression,regression trees(RT),and backpropagation neural network(BPN),bagging,boosting,and stacking ensemble methods were used for ensemble ***,three existing ensemble models,i.e.,random forest,extreme random tree(ET)and extreme gradient boosting,were used to conduct experiments and compare the *** research shows that bagging,boosting,and stacking three ensemble methods have the most significant improvement in the prediction accuracy of the regression trees model,which is increased by 5.28%,6.51%,and 5.32%,*** the same time,the stacking ensemble method improves both the simple model and the complex model,and the improvement effect on the simple base model is the greatest,which is 4.69%higher than that of the base model *** all of the ensemble models,the stacking ensemble model of level-1(ET,AdaBoost-RT,LR,BPN)paired with level-2(LR)was discovered to be the best model(EALB-LR)and can be further studied for industrial applications.

关键词： Tandem cold rolling Flatness prediction Machine learning Ensemble method

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：