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Efficiency and safety of Tripterygium Wilfordii Hook F for IgA nephropathy: an update systematic review and meta-analysis

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Pharmacology Discovery 2024年第2期4卷 24-31页

作者： zi-Yi He Hui-Chuan tian Yan Zhao Rui-Yu Mou Hong-Wei Yuan Department of Cardiology The Second Affiliated Hospital of Tianjin University of Chinese MedicineTianjin 300150China Department of Oncology The First Affiliated Hospital of Tianjin University of Chinese MedicineTianjin 300110China Department of Oncology National Clinical Research Center of Chinese Acupuncture and MoxibustionTianjin 301617China Department of Chinese Medicine Macao University of Science and TechnologyMacao 999078China

Background:Immunoglobulin A Nephropathy(IgAN)currently stands as the most prevalent primary chronic glomerular disease *** latest guidelines recommend the application of renin-angiotensin system inhibitors(RASi)in conjunction with corticosteroids for the treatment of IgAN patients exhibiting persistent proteinuria of≥1 g/***,numerous randomized controlled trials(RCTs)have revealed a heightened risk of adverse events associated with corticosteroid ***-glycoside of Tripterygium wilfordii Hook.f.(GTW),a traditional Chinese medicine(TCM),has been employed in the treatment of Chronic Kidney Disease(CKD)for an extensive *** years have witnessed an increasing number of RCTs providing evidence supporting the effectiveness of GTW therapy in *** this,there remains a paucity of systematic reviews on the application of GTW therapy for ***,this study undertakes a systematic review to assess the clinical efficacy and safety of GTW therapy,aiming to elucidate the role of GTW therapy in the treatment of ***:To collect relative information of randomized controlled trials(RCTs)of GTW in the treatment of IgAN,we searched for theses and dissertations publicized before April 10,2023,in PubMed,Embase,the Cochrane Library,China National Knowledge Infrastructure(CNKI),Wanfang Data knowledge service platform(Wanfang Data),Chinese Scientific Journal Database(VIP),and Clinical *** language limitation is English and ***,two reviewers performed literature screening,data extraction,and quality evaluation,and the meta-analysis was carried out with RevMan 5.4 and StataSE 15.0 ***:21 RCTs involving 1,405 Chinese patients were *** to ACEI/ARB alone or in combination,GTW with RASi or alone reduced 24 h-Upro,ALB,Scr,GFR,BUN,CD4+,VEGF,ET-1,and improved clinical ***,no associations were found for TC,Ccr,and adverse events due to limited ***:This study hi

关键词： Tripterygium IgA nephropathy systematic review meta-analysis

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车联网V2I场景下基于GNN的SC-FDMA智能信道估计

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电子学报 2024年第3期52卷 772-782页

作者：廖勇尹子松田肖懿重庆大学微电子与通信工程学院重庆400044

随着车联网的迅猛发展,车对路基础设施(Vehicle to Infrastructure,V2I)通信对车联网的可靠性和时延提出了更高的要求,而信道估计是接收机高可靠低时延通信的重要保障.为解决传统信道插值算法不能有效拟合V2I信道快时变特性、自适应多... 详细信息

随着车联网的迅猛发展,车对路基础设施(Vehicle to Infrastructure,V2I)通信对车联网的可靠性和时延提出了更高的要求,而信道估计是接收机高可靠低时延通信的重要保障.为解决传统信道插值算法不能有效拟合V2I信道快时变特性、自适应多普勒频移能力弱和传统神经网络可解释性不强的问题,本文提出基于图神经网络(Graph Neural Network,GNN)的单载波频分多址(Single Carrier-Frequency Division Multiple Access,SC-FDMA)智能信道估计算法.该算法将信道频率响应中的数据点作为图的节点、符号间时域相关性作为边,将图化后的数据送入GraphSAGE信道插值器(GraphSAGE Channel Interpolator,GCI)中,通过边更新、聚合操作、节点更新三大模块进行网络训练,同时采用多普勒频移矢量作为节点特征控制网络拟合不同多普勒条件的信道,使得网络具备可解释性.最后,系统仿真验证了在不同速度环境下算法的有效性和鲁棒性,较线性插值、样条插值以及全连接网络,本文所提GCI在低、中和高速移动环境下具有最优的误码率(Bit Error Rate,BER)和归一化均方误差(Normalized Mean Square Error,NMSE)性能,特别地,在200 km/h高速移动条件下GCI的优势更为明显.

关键词：车联网 V2I 双选衰落信道高速移动多普勒频移 GNN 信道估计信道频率响应

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Comparative analysis of two digestive tract reconstruction methods in total laparoscopic radical total gastrectomy

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World Journal of Gastrointestinal Surgery 2024年第4期16卷 1109-1120页

作者： tian-Xiang Dong Dong Wang Qun Zhao Zhi-Dong Zhang Xue-Feng Zhao Bi-Bo Tan Yu Liu Qing-Wei Liu Pei-Gang Yang Ping-An Ding Tao Zheng Yong Li zi-Jing Liu Third Department of Surgery of the Fourth Hospital of Hebei Medical University Hebei Key Laboratory of Precision Diagnosis and Comprehensive Treatment of Gastric CancerShijiazhuang 050011Hebei ProvinceChina

BACKGROUND The incidence of gastric cancer has significantly increased in recent *** resection is the main treatment,but the method of digestive tract reconstruction after gastric cancer surgery remains *** the current study,we sought to explore a reasonable method of digestive tract reconstruction and improve the quality of life and nutritional status of patients after *** this end,we statistically analyzed the clinical results of patients with gastric cancer who underwent jejunal interposition double-tract reconstruction(DTR)and esophageal jejunum Roux-en-Y reconstruction(RY).AIM To explore the application effect of DTR in total laparoscopic radical total gastrectomy(TLTG)and evaluate its safety and *** We collected the relevant data of 77 patients who underwent TLTG at the Fourth Hospital of Hebei Medical University from October 2021 to January *** them,35 cases were treated with DTR,and the remaining 42 cases were treated with traditional *** 1:1 propensity score matching,the cases were grouped into 31 cases per group,with evenly distributed *** clinical characteristics and short-and long-term clinical outcomes of the two groups were statistically *** The two groups showed no significant differences in basic data,intraoperative blood loss,number of lymph node dissections,first defecation time after operation,postoperative hospital stay,postoperative complications,and laboratory examination results on the 1st,3rd,and 5th days after *** operation time of the DTR group was longer than that of the RY group[(307.58±65.14)min vs(272.45±62.09)min,P=0.016],but the first intake of liquid food in the DTR group was shorter than that in the RY group[(4.45±1.18)d vs(6.0±5.18)d,P=0.028].The incidence of reflux heartburn(Visick grade)and postoperative gallbladder disease in the DTR group was lower than that in the RY group(P=0.033 and P=0.038).Although there was no significant difference in bod

关键词： Gastric cancer Jejunal interposition double-tract reconstruction Roux-en-Y reconstruction Laparoscope

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Three-Channel Interference Interpretation of Fano Profile

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Chinese Physics Letters 2024年第5期41卷 30-34页

作者：李波李天钧马子茹王希源黄新朝朱林繁 Department of Modern Physics University of Science and Technology of ChinaHefei 230026China European XFEL Holzkoppel 422869 SchenefeldGermany

Fano resonance is a ubiquitous phenomenon, and it is commonly interpreted as a two-channel interference of the discrete and continuous channels. The present work investigates the Fano profile from a perspective of the temporal evolution of the wave function. By exciting the atom with a δ pulse and calculating the evolution of the wave function, the Fano formula is deduced. The results clearly show that the Fano resonance is of a three-channel interference, which is different from the traditional understanding. The three channels are revealed as the groundcontinuum, ground-discrete-continuum, and a previously unmentioned third channel, i.e., ground-continuumdiscrete-continuum. The present three-channel interpretation can be easily generalized to other physical systems,contributing to a deeper understanding of the Fano profile.

关键词： function profile continuum

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Transcriptomic Landscape Analysis Reveals a Persistent DNA Damage Response in Metabolic Dysfunction-associated Steatohepatitis Post-dietary Intervention

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Journal of Clinical and Translational Hepatology 2024年第9期12卷 765-779页

作者： zi-Yuan Zou tian-Yi Ren Jia-Qi Li Ting-Ying Jiao Meng-Yu Wang Lei-Jie Huang Shuang-Zhe Lin Yuan-Yang Wang Xiao-Zhen Guo Ye-Yu Song Rui-Xu Yang Cen Xie Jian-Gao Fan Center for Fatty Liver Department of GastroenterologyXinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghaiChina University of Chinese Academy of Sciences BeijingChina Human Phenome Institute School of Life SciencesFudan UniversityShanghaiChina Department of Gastroenterology Ningbo No.2 HospitalNingboZhejiangChina Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition ShanghaiChina

Background and Aims:Metabolic dysfunction-associated steatotic liver disease(MASLD)and its more advanced form,metabolic dysfunction-associated steatohepatitis,have emerged as the most prevalent liver diseases ***,lifestyle modification is the foremost guidelinerecommended management strategy for ***,it remains unclear which detrimental signals persist in MASLD even after disease ***,we aimed to examine the persistent changes in liver transcriptomic profiles following this ***:Male C57BL/6J mice were divided into three groups:Western diet(WD)feeding,chow diet(CD)feeding,or diet reversal from WD to *** 16 weeks of feeding,RNA sequencing was performed on the mice’s livers to identify persistent alterations characteristic of ***,RNA sequencing databases containing high-fat diet-fed P53-knockout mice and human MASLD samples were ***:WD-induced MASLD triggered persistent activation of the DNA damage response(DDR)and its primary transcription factor,P53,long after the resolution of the hepatic phenotype through dietary *** levels of P53 might promote apoptosis,thereby exacerbating metabolic dysfunction-associated steatohepatitis,as they strongly correlated with hepatocyte ballooning,an indicator of apoptosis ***,P53 knockout in mice led to downregulated expression of apoptosis signaling in the ***,P53 may regulate apoptosis by transcriptionally activating the expression of apoptosis-enhancing nuclease(AEN).Consistently,P53,AEN,and the apoptosis process all exhibited persistently elevated expression and showed a strong inter-correlation in the liver following dietary ***:The liver demonstrated upregulation of DDR signaling and the P53-AEN-apoptosis axis both during and after exposure to *** findings provide new insights into the mechanisms of MASLD relapse,highlighting DDR signaling as a promising target to prevent MASLD recu

关键词： Apoptosis DNA Damage Metabolic dysfunction-associated steatotic liver disease RNA-Seq Tumor suppressor protein P53 Western Diets

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有限多孔介质诱导活性哑铃的聚集行为

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物理学报 2024年第16期73卷 36-44页

作者：金燕石子璇金奕扬田文得张天辉陈康苏州大学物理科学与技术学院软凝聚态物理及交叉研究中心苏州215006

自然界的许多活性物质都处在复杂的环境中,例如动物群体穿过丛林、微生物在土壤中迁移、细菌被设计用于感知肿瘤的多孔环境等.活性物质在复杂环境中的行为是一个值得探究的课题,在生物物理、医疗工程、工业领域具有可观的应用意义.本文... 详细信息

自然界的许多活性物质都处在复杂的环境中,例如动物群体穿过丛林、微生物在土壤中迁移、细菌被设计用于感知肿瘤的多孔环境等.活性物质在复杂环境中的行为是一个值得探究的课题,在生物物理、医疗工程、工业领域具有可观的应用意义.本文用活性哑铃代表细菌等具有形状各向异性的活性物质,采用郎之万动力学模拟,研究它们渗透有限多孔介质的行为.研究发现在低温和适当的活性力下,活性哑铃能在介质内外聚集并形成4种稳定的聚集结构.4种聚集结构分别是中空巨聚集、介质内中空聚集、密实巨聚集、介质内密实聚集.定向运动的持久性决定了活性哑铃的聚集程度.4种聚集结构的密度、极性序参量、热力学温度在介质内外的分布有明显的区别.本研究结果有助于进一步理解活性物质在复杂环境中的生命活动,为微流器件的设计、药物的输运等医学操作提供新的思路.

关键词：活性物质多孔介质郎之万动力学模拟

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Establishment of a Multiplex Detection Method for Common Bacteria in Blood Based on Human Mannan-Binding Lectin Protein-Conjugated Magnetic Bead Enrichment Combined with Recombinase-Aided PCR Technology

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Biomedical and Environmental Sciences 2024年第4期37卷 387-398页

作者： ZHAO zi Jin CHEN Xiao Ping HUA Shao Wei LI Feng Yu ZHAO Meng XING Chen Hao WANG Jie tian Feng Yu ZHANG Rui Qing LYU Xiao Na HAN Zhi Qiang WANG Yu Xin LI Hong Yi SHEN Xin Xin MA Xue Jun TIE Yan Qing Graduate School Hebei North UniversityZhangjiakou 075000HebeiChina Department of Clinical Laboratory Hebei General HospitalShijiazhuang 050051HebeiChina National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases NHC Key Laboratory of Medical Virology and Viral DiseasesNational Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China National Institute for Communicable Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijing 102206China Department of Clinical Laboratory Pathology Diagnostic Center Shiyan General HospitalShiyan 442000HubeiChina Graduate School Hebei Medical University Shijiazhuang 050031HebeiChina

Objective Recombinase-aided polymerase chain reaction(RAP)is a sensitive,single-tube,two-stage nucleic acid amplification *** study aimed to develop an assay that can be used for the early diagnosis of three types of bacteremia caused by Staphylococcus aureus(SA),Pseudomonas aeruginosa(PA),and Acinetobacter baumannii(AB)in the bloodstream based on recombinant human mannanbinding lectin protein(M1 protein)-conjugated magnetic bead(M1 bead)enrichment of pathogens combined with *** Recombinant plasmids were used to evaluate the assay *** blood influenza bacteria were used for the specific *** and clinical plasma samples were enriched with M1 beads and then subjected to multiple recombinase-aided PCR(M-RAP)and quantitative PCR(qPCR)*** analysis was used to evaluate the consistency between the two *** The M-RAP method had sensitivity rates of 1,10,and 1 copies/μL for the detection of SA,PA,and AB plasmids,respectively,without cross-reaction to other bacterial *** M-RAP assay obtained results forzing M1 bead enrichment has been developed and can be potentially used for the early detection of bacteremia.

关键词： Staphylococcus aureus Pseudomonas aeruginosa Acinetobacter baumannii Human Mannan-binding lectin protein Bloodstream infection Recombinase-aided PCR assay Multiple detection

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中外数学教科书“用圆弧表示角”本质的比较研究

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数学教育学报 2024年第4期33卷 91-97页

作者：巩子坤田荣飞杭州师范大学经亨颐教育学院浙江杭州310036 浙江省杭州市十三中教育集团浙江杭州310012

中小学数学教科书中用圆弧表示角的方式尚未统一,无法凸显角的本质,主要原因在于“用圆弧表示角”的本质尚不明确.“用圆弧表示角”的本质为:用圆弧长度(圆弧所对半径相等)表示角的大小;带有方向(箭头)的圆弧,既可表示角的方向,也可表... 详细信息

中小学数学教科书中用圆弧表示角的方式尚未统一,无法凸显角的本质,主要原因在于“用圆弧表示角”的本质尚不明确.“用圆弧表示角”的本质为:用圆弧长度(圆弧所对半径相等)表示角的大小;带有方向(箭头)的圆弧,既可表示角的方向,也可表示角的优劣.对中国近百年(15个版本)教科书的比较发现:“用圆弧表示角”的编排逐渐统一,但角的静态定义不利于体现“用圆弧表示角”的本质;对“圆弧所对半径相等”的认识仍不清晰.国外教科书的情况也大致相同.提出建议:早早引入角的动态定义,统一圆弧所对半径,凸显角的本质.

关键词：用圆弧表示角角的本质教科书比较

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Stratigraphic framework and sedimentary evolution during the Cryogenian-Ediacaran transition in northeastern Sichuan Basin,South China

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Petroleum Science 2024年第2期21卷 823-835页

作者： Yi Zhang Hong-Wei Kuang Yong-Qing Liu Qiang Shi Dong-Ge Wang Ke-Ning Qi Yu-Chong Wang Da-Wei Qiao Xiao-Shuai Chen Li-Zhi Wu Meng tian Long Chen Yi Wei Liao-Yuan Song Jian Li zi-Gang Wu Yun-Qian Liu Xuan-Chun Liu An-Qing Chen Zhi-Wei Liao Institute of Geology Chinese Academy of Geological SciencesBeijing100037China State Key Laboratory of Coal Mine Disaster Dynamics and Control School of Resources and Safety EngineeringChongqing UniversityChongqing400044China No.205 Geological Team Chongqing Bureau of Geology and Minerals ExplorationChongqing401121China Chongqing Institute of Geological Survey Chongqing401122China Key Laboratory of Deep-time Geography and Environment Reconstruction and Applications of Ministry of Natural Resources Chengdu University of TechnologyChengdu610059SichuanChina

The northeastern Sichuan area in the northern Yangtze margin has unique Ediacaran geological records,especially the Doushantuo Formation(DST),and become a hot research area in recent ***,the Cryogenian-Ediacaran(C-E)boundary has not been precisely identified,which restricts the in-depth study of geological information during this crucial transitional period and is unfavorable for a systematic and complete understanding of the Yangtze Block and even the global paleogeographic *** study conducted stratigraphy,sedimentology,and chronostratigraphy to establish the stratigraphic framework and sedimentary evolution of the C-E transition strata in northeastern *** results showed that the Ediacaran sediments,without the cap dolomite,unconformably overlaid the Cryogenian sediments in the studied *** Member II of the DST,characterized by 50-160 m of red-green sandstone(approximately equivalent to the original Chengkou“Guanyinya Formation”),directly overlaid the Cryogenian sediments and displayed a 623±2.3 Ma maximum depositional age from the detrital zircon U-Pb *** stratigraphic correlations indicate that the C-E transition strata in northeastern Sichuan had a consistent lithological association and sedimentary sequence characteristics but differed from the Three ***,the upper Nantuo massive glacial diamictites transition to the icebergs rafted lonestone-bearing mudstones at the top,then change upward to DST barrier coast *** proposed DST of the northeastern Sichuan Basin was divided into three lithostratigraphic members without the regional Member I cap dolomite:(i)Member II purple-red,gray-green sandstone strata,(ii)MemberⅢblack mudstone strata,and(iii)Member IV P-Mn bearing *** the C-E transition,the study area experienced(i)the global deglaciation stage in the terminal Marinoan glaciation and(ii)the filling-leveling up stage with clastic rocks in the early ***,the early Ediacaran

关键词： Marinoan glaciation Doushantuo formation Cap dolomite Deglacial and coastal deposits Detrital zircon U-Pb dating

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三明市区景观格局时空演变及生态网络构建研究

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生态与农村环境学报 2024年第3期40卷 335-344页

作者：曾真艾婧文王梓凌何天友郑郁善福建农林大学风景园林与艺术学院福建福州350002

生态网络的构建充分利用了山地型城市所具备的良好生态环境,减弱了快速城市化带来的负面影响,提升了区域生态系统服务能力和生物多样性。以三明市区为研究区域,对比分析了2000、2010和2020年3个时期的景观格局、生态源地和生态阻力面的... 详细信息

生态网络的构建充分利用了山地型城市所具备的良好生态环境,减弱了快速城市化带来的负面影响,提升了区域生态系统服务能力和生物多样性。以三明市区为研究区域,对比分析了2000、2010和2020年3个时期的景观格局、生态源地和生态阻力面的变化,运用形态学空间格局分析(morphological spatial pattern analysis,MSPA)方法、电路理论和重力模型等判定重要生态源地,构建生态廊道,并提出相应的优化策略。结果表明:(1)2000—2020年三明市区核心区面积占研究区域总面积的比例均超过50%,但呈现逐年下降趋势。(2)三明市区有11个重要生态源地,构建了24条生态廊道。(3)运用重力模型将廊道分为3类,其中1级廊道2条,2级廊道5条,3级廊道17条。(4)识别出22个踏脚石、47个生态夹点、54个障碍点和114个断裂点。(5)提出修复生态断裂点、建设踏脚石、保护生态夹点、去除生态障碍点的优化策略来提升生态网络稳定性,增强区域景观连通性。研究结果可为山地城市的生态网络构建提供参考。

关键词：三明市区景观格局形态学空间格局分析电路理论重力模型生态网络

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