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Dielectric anisotropy in liquid crystal mixtures with nematic and smectic phases

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Chinese Physics B 2024年第8期33卷 519-524页

作者：汤星舟叶家耀王子烨姜皓译尚小虎杨朝雁李炳祥 Nanjing University of Posts and Telecommunications College of Electronic and Optical Engineering&College of Flexible Electronics(Future Technology)Nanjing 210023China National Laboratory of Solid State Microstructures College of Engineering and Applied SciencesNanjing UniversityNanjing 210023China

The modulation of dielectric anisotropy(△ε)is pivotal for elucidating molecular interactions and directing the alignment of liquid *** this study,we combine liquid crystals with opposing dielectric anisotropies to explore the impact of varying concentrations on their *** report the sign-reversal of△εin both the nematic and smectic A phases of these mixed liquid crystals,alongside a dual-frequency behaviour across a broad temperature *** research further quantifies the influence of mixture ratios under various temperatures and electric field *** exploration may pave the way for the discovery of new physical phenomena.

关键词： mixed liquid crystal dielectric anisotropy tunable nematic smectic

A Method of Generating Semi-Experimental Biomedical Datasets

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Journal of Beijing Institute of Technology 2024年第3期33卷 219-226页

作者： Jing wang Naike Du zi He Xiuzhu ye School of Information and Electronics Beijing Institute of TechnologyBeijing 100081China

This paper proposed a method to generate semi-experimental biomedical datasets based on full-wave simulation *** system noise such as antenna port couplings is fully considered in the proposed datasets,which is more realistic than synthetical *** this paper,datasets containing different shapes are constructed based on the relative permittivities of human ***,a back-propagation scheme is used to obtain the rough reconstructions,which will be fed into a U-net convolutional neural network(CNN)to recover the high-resolution *** results show that the network trained on the datasets generated by the proposed method can obtain satisfying reconstruction results and is promising to be applied in real-time biomedical imaging.

关键词： electromagnetic imaging dataset biomedical imaging

Dynamic manipulation of multimodal emission in Er^(3+)-activated non-core-shell structure for optical thermometry and information security

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Rare Metals 2024年第4期43卷 1702-1712页

作者： Xuan Liu zi-Xia Lin Yin-Biao Shi Xiao-Yan wang Ming-ye Ding Xiao-Fei Yang College of Science Nanjing Forestry UniversityNanjing210037China Testing Center Yangzhou UniversityYangzhou225009China

Regulating luminescent dynamics of lanthanide-based luminescent materials via external stimuli is of great significance in the fields of optical thermometry and high-level ***,it is still a huge challenge to realize multimodal emissions with tunable color outputs from a single activator in simple structures via smart dynamic control of photon transition ***,we present a mechanistic strategy to achieve multimodal luminescence of Er^(3+)activators with color-switchable outputs in a non-core-shell *** the control of excitation dynamics(λ_(ex)=980,808,1532,377 nm),the population among the intermediate en ergy levels of Er^(3+)and the interaction between Er^(3+)and Yb^(3+)could be precisely modulated through energy transfer and migration processes,leading to the generation of colortunable multimodal luminescence upon diverse excitation modes(non-steady-state,single-/dual-wavelength steady,thermal activation).Inspired by its special luminescent performance,the as-obtained material exhibits great potential in noncontact thermometry,multimodal anticounterfeiting,and high-capacity information encryption by performing a series of proof-of-concept *** findings might provide a conceptual model to modulate the luminescent dynamics in a simple-structured system for the generation of color-adjustable multimodal emissions,which is convenient for the development of advanced luminescent materials toward versatile cuttingedge applications.

关键词： Lanthanide ions Multimodal emission Upconversion Downshifting Anti-counterfeiting Luminescent thermometry

Ki-67 Change in Anthracyline-containing Neoadjuvant Chemotherapy Response in Breast Cancer

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Current Medical Science 2024年第1期44卷 156-167页

作者： zi-guo YANG Le-hao REN Feng wang Pi-lin wang Wen-yan wang Shu-ye LIN Department of General Surgery Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China Department of Critical Care Medicine Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Cancer Research Center Beijing Chest HospitalCapital Medical University/Beijing Tuberculosis and Thoracic Tumor Research InstituteBeijing 101149China

Objective Anthracycline-containing regimens are irreplaceable in neoadjuvant chemotherapy(NAC)for breast cancer(BC)at ***,30% of early breast cancer(EBC)patients are resistant to anthracycline-containing chemotherapy,leading to poor prognosis and higher ***-67 is associated with the prognosis and response to therapy,and it changes after *** A total of 105 BC patients who received anthracycline-containing NAC were ***,the optimal model of Ki-67 was selected,and its predictive efficacy was ***(IHC)was used to determine the estrogen receptor(ER),progesterone receptor(PR),and human epidermal growth factor receptor 2(HER-2)status and Ki-67 *** in situ hybridization(FISH)was used to verify the HER-2 when the IHC score was 2+.Results The post-NAC Ki67 level after treatment with anthracycline drugs was lower than pre-NAC Ki-67(19.6%±23.3%vs.45.6%±23.1%,P<0.001).Furthermore,patients with the Ki-67 decrease had a border line higher pathological complete response(pCR)rate(17.2%vs.0.0%,P=0.068),and a higher overall response rate(ORR)(73.6%vs.27.8%,P<0.001),when compared to patients without the Ki-67 *** ΔKi-67 and ΔKi-67%were valuable markers for the prediction of both the pCR rate and *** area under the curve(AUC)for ΔKi-67 on pCR and ORR was 0.809(0.698-0.921)and 0.755(0.655-0.855),respectively,while the AUC for ΔKi-67% on pCR and ORR was 0.857(0.742-0.972)and 0.720(0.618-0.822),*** logistic regression model 1 revealed thatΔKi-67 was an independent predictor for both pCR[odds ratio(OR)=61.030,95% confidence interval(CI)=4.709-790.965;P=0.002]and ORR(OR=10.001,95%CI:3.044-32.858;P<0.001).Multivariate logistic regression model 2 revealed thatΔKi-67%was also an independent predictor for both pCR(OR=408.922,95%CI=8.908-18771.224;P=0.002)and ORR(OR=5.419,95%CI=1.842-15.943;P=0.002).Conclusions The present study results suggest thatΔKi67 andΔKi67%are candidate predictor

关键词： breast cancer change in Ki-67 neoadjuvant chemotherapy anthracycline,response

A generalization of Banach's lemma and its applications to perturbations of bounded linear operators

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Applied Mathematics(A Journal of Chinese Universities) 2024年第2期39卷 363-369页

作者： wang zi DING Jiu wang Yu-wen School of Mathematics Sciences Harbin Normal UniversityHarbin 150025China School of Mathematics and Natural Sciences The University of Southern MississippiHattiesburg MS 39406-5043USA Academic Committee Harbin Institute of PetroleumHarbin 150027China

Let X be a Banach space and let P:X→X be a bounded linear *** an algebraic inequality on the spectrum of P,we give a new sufficient condition that guarantees the existence of(I-P)^(-1) as a bounded linear operator on X,and a bound on its spectral radius is also *** generalizes the classic Banach *** apply the result to the perturbation analysis of general bounded linear operators on X with commutative perturbations.

关键词： Banach lemma spectral radius generalized inverse perturbation analysis

Semi-supervised remote sensing image scene classification with prototype-based consistency

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Chinese Journal of Aeronautics 2024年第2期37卷 459-470页

作者： Yang LI Zhang LI zi wang Kun wang Qifeng YU College of Aerospace Science and Engineering National University of Defense TechnologyChangsha 410073China

Deep learning significantly improves the accuracy of remote sensing image scene classification,benefiting from the large-scale ***,annotating the remote sensing images is time-consuming and even tough for *** neural networks trained using a few labeled samples usually generalize less to new unseen *** this paper,we propose a semi-supervised approach for remote sensing image scene classification based on the prototype-based consistency,by exploring massive unlabeled *** this end,we,first,propose a feature enhancement module to extract discriminative *** is achieved by focusing the model on the foreground ***,the prototype-based classifier is introduced to the framework,which is used to acquire consistent feature *** conduct a series of experiments on NWPU-RESISC45 and Aerial Image Dataset(AID).Our method improves the State-Of-The-Art(SOTA)method on NWPU-RESISC45 from 92.03%to 93.08%and on AID from 94.25%to 95.24%in terms of accuracy.

关键词： Semi-supervised learning Remote sensing Scene classification Prototype network Deep learning

Pairs of thiol-substituted 1,2,4-triazole-based isomeric covalent inhibitors with tunable reactivity and selectivity

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Chinese Chemical Letters 2024年第7期35卷 329-335页

作者： Shiqi Xu zi ye Shuang Shang Fengge wang Huan Zhang Lianguo Chen Hao Lin Chen Chen Fang Hua Chong-Jing Zhang State Key Laboratory of Bioactive Substance and Function of Natural Medicines Beijing Key Laboratory of Active Substance Discovery and Druggability EvaluationInstitute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China State Key Laboratory of Bioactive Substance and Function of Natural Medicines Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study(BZ0150)Institute of Materia MedicaPeking Union Medical College and Chinese Academy of Medical SciencesBeijing 100050China The First Affiliated Hospital of Wenzhou Medical University Wenzhou 325000China

Covalent bioactive compounds are successfully used in clinic and attracted intense research efforts in the fundamental study as well as drug *** advantageous effects of covalent compounds compared with non-covalent ones are highly dependent on electrophilic ***,electrophilic warheads with tunable reactivity and selectivity are highly demanded in fields of medicinal chemistry and chemical ***,we report a novel electrophilic warhead,chloromethyl group activated by thiol-substituted 1,2,***,a pair of regioisomers could be simultaneously occurred in the step of alkylation during the synthesis of this unique *** is a rare example that the alkylation could simultaneously generate these two separable regioisomers of 1,2,4-triazole at the nitrogen or sulfur *** covalent-working mechanism of this new warhead is confirmed by various chemoproteomics experiments including target identification and binding site ***,the reactivity and selectivity of this new electrophilic warhead could be efficiently tuned by virtue of stereo ***,one pair of regioisomers(19S and 19X)induced distinct modes of cell *** 19S could induce apoptosis of colon cancer cells while 19X could induce both apoptosis and ***,this study provides pairs of novel electrophilic warheads that could be useful not only in supporting the design of covalent compounds for drug discovery but also in providing chemical probes for the fundamental biological study.

关键词： Electrophilic warhead Covalent inhibitor 1,2,4-Triazole Chemical proteomics GSTO1

Rapid prediction of damaged ship roll motion responses in beam waves based on stacking algorithm

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Journal of Hydrodynamics 2024年第2期36卷 394-405页

作者： Xin-ran Liu Ting-qiu Li zi-ping wang School of Naval Architecture Ocean and Energy Power EngineeringWuhan University of TechnologyWuhan430063China

Accurate modeling for highly non-linear coupling of a damaged ship with liquid sloshing in waves is still of considerable interest within the computational fluid dynamics(CFD)and AI *** paper describes a data-driven Stacking algorithm for fast prediction of roll motion response amplitudes in beam waves by constructing a hydrodynamics model of a damaged ship based on the dynamic overlapping grid CFD *** general idea is to optimize various parameters varying with four types of classical base models like multi-layer perception,support vector regression,random forest,and hist gradient boosting *** offers several attractive properties in terms of accuracy and efficiency by choosing the standard DTMB 5415 model with double damaged compartments for *** is clearly demonstrated that the predicted response amplitude operator(RAO)in the regular beam waves agrees well with the experimental data available,which verifies the accuracy of the established damaged ship hydrodynamics *** high-quality CFD samples,therefore,implementation of the designed Stacking algorithm with its optimal combination can predict the damaged ship roll motion amplitudes effectively and accurately(e.g.,the coefficient of determination 0.9926,the average absolute error 0.0955 and CPU 3s),by comparison of four types of typical base models and their various ***,the established Stacking algorithm provides one potential that can break through problems involving the time-consuming and low efficiency for large-scale lengthy CFD simulations.

关键词： Ship motion damaged ship computational fluid dynamics(CFD) machine learning stacking algorithm

Finite Element Simulation Analysis of a Novel 3D-FRSPA for Crawling Locomotion

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Computer Modeling in Engineering & Sciences 2024年第5期139卷 1401-1425页

作者： Bingzhu wang Xiangrui ye College of Mechanics and Materials Hohai UniversityNanjing211100China Department of Fundamental Ma’anshan UniversityMa’anshan243100China

A novel three-dimensional-fiber reinforced soft pneumatic actuator(3D-FRSPA)inspired by crab claw and human hand structure that can bend and deform independently in each segment is *** has an omni-directional bending configuration,and the fibers twined symmetrically on both sides to improve the bending performance of *** this paper,the static and kinematic analysis of 3D-FRSPA are carried out in *** effects of fiber,pneumatic chamber and segment length,and circular air chamber radius of 3D-FRSPA on the mechanical performance of the actuator are discussed,*** soft mobile robot composed of 3D-FRSPA has the ability to ***,the crawling processes of the soft mobile robot on different road conditions are studied,respectively,and the motion mechanism of the mobile actuator is *** numerical results show that the soft mobile robots have a good comprehensive performance,which verifies the correctness of the *** work shows that the proposed structures have great potential in complex road conditions,unknown space detection and other operations.

关键词： 3D-FRSPA bionic structure theoretical modeling crawling application obstacle avoidance analysis numerical investigation