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Chinese Journal of Aeronautics 2024年第8期37卷 106-123页

作者： Yifan WANG Zhengping ZOU Pengcheng DU Lichao yao Huoxing liu Yusen XU Research Institute of Aero-Engine Beihang UniversityBeijing 102206China National Key Laboratory of Science and Technology on Aero-Engine and Aero-Thermodynamics Beihang UniversityBeijing 102206China

An advanced precooled airbreathing engine with a closed Brayton cycle is a promising solution for high-speed propulsion,of which the Synergetic Air Breathing Rocket Engine(SABRE)is a representative *** performance of the latest SABRE-4 cycle was analyzed in this ***,a relatively complete engine performance model that considers the characteristics of turbomachinery and heat exchangers was ***,Sobol’global sensitivity analysis of key performance parameters was carried out to identify the most influential design *** specific impulses under different target specific thrusts were obtained by particle swarm optimization,of which the thermodynamic parameters corresponding to a specific thrust of 1.12 kN·s·kg^(-1)and a specific impulse of 3163 s were chosen as the design *** different control laws were analyzed in contrast,and the charge control method had the strongest ability of thrust regulation as well as maintaining a favorable specific impulse ***,working characteristics under the charge control and over a typical flight envelope were calculated,in which the average value of the maximum specific impulse was as high as 5315 *** study would help to deepen the understanding of SABRE-4 thermodynamic characteristics and other precooled airbreathing engine cycles with similar layouts.

关键词： Hypersonic Precooled airbreathing engine Thermodynamic cycle Control law Working characteristics

Current optimization-based control of dual three-phase PMSM for low-frequency temperature swing reduction

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Defence Technology（防务技术） 2024年第4期34卷 238-246页

作者： Linlin Lu Xueqing Wang Luhan Jin Qiong liu Yun Zhang yao Mao Key Laboratory of Optical Engineering Chinese Academy of SciencesChengdu 610209China Institute of Optics and Electronics Chinese Academy of SciencesChengdu 610209China University of Chinese Academy of Sciences Beijing 100049China College of Electrical Engineering Sichuan UniversityChengdu 610065China

In this paper,a control scheme based on current optimization is proposed for dual three-phase permanent-magnet synchronous motor(DTP-PMSM)drive to reduce the low-frequency temperature *** reduction of temperature swing can be equivalent to reducing maximum instantaneous phase copper loss in this ***,a two-level optimization aiming at minimizing maximum instantaneous phase copper loss at each electrical angle is ***,the optimization is transformed to a singlelevel optimization by introducing the auxiliary variable for easy *** that singleobjective optimization trades a great total copper loss for a small reduction of maximum phase copper loss,the optimization considering both instantaneous total copper loss and maximum phase copper loss is proposed,which has the same performance of temperature swing reduction but with lower total *** this way,the proposed control scheme can reduce maximum junction temperature by 11%.Both simulation and experimental results are presented to prove the effectiveness and superiority of the proposed control scheme for low-frequency temperature swing reduction.

关键词： Dual three-phase PMSM Low-frequency temperature swing Copper loss Current optimization Connected neutral points

Estimating Critical Clearing Time of Grid Faults Using DA of State-Reduction Model of Power Systems

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CSEE Journal of Power and Energy Systems 2024年第2期10卷 807-820页

作者： Yang liu Zhongyang Chen Huanjin yao Lin Yi Q.H.Wu School of Electric Power Engineering South China University of TechnologyGuangzhou 510640China China Southern Power Grid Research Institute Guangzhou 510663China

This paper proposes a critical clearing time (CCT) estimation method by the domain of attraction (DA) of a state-reduction model of power systems using sum of squares (SOS) programming. By exploiting the property of the Jacobian matrix and the structure of the boundary of the DA, it is found the DA of the state-reduction model and that of the full model of a power system are topological isomorphism. There are one-to-one correspondence relationships between the number of equilibrium points, the type of equilibrium points, and solutions of the two system models. Based on these findings, an expanding interior algorithm is proposed with SOS programming to estimate the DA of the state-reduction model. State trajectories of the full model can be transformed to those of the state-reduction model by orthogonal or equiradius projection. In this way, CCT of a grid fault is estimated with the DA of the state-reduction model. The calculational burden of SOS programming in the DA estimation using the state-reduction model is rather small compared with using the full model. Simulation results show the proposed expanding interior algorithm is able to provide a tight estimation of DA of power systems with higher accuracy and lower time costs.

关键词： Critical clearing time domain of attraction expanding interior algorithm state-reduction model SOS programming

Microplastic exposure disturbs sleep structure,reduces lifespan,and decreases ovary size in Drosophila melanogaster

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Zoological Research 2024年第4期45卷 805-820页

作者： Wei Yan zi-Jie Li zi-Yi Lin Shu-Qin Ji William Ka Fai Tse Zhi-Qiang Meng Chang liu Lei Li Shenzhen-Hong Kong Institute of Brain Science Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518000China CAS Key Laboratory of Brain Connectome and Manipulation the Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518000China Laboratory of Developmental Disorders and Toxicology Center for Promotion of International Education and ResearchFaculty of AgricultureKyushu UniversityFukuokaFukuoka 819-0395Japan Shenzhen Key Laboratory of Drug Addiction the Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518000China Guangdong Provincial Key Laboratory of Brain Connectome and Behavior Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518000China

The organ-specific toxicity resulting from microplastic(MP)exposure has been extensively explored,particularly concerning the gut,liver,testis,and ***,under natural conditions,these effects are not restricted to specific organs or *** whether MP exposure presents a systemic threat to an entire organism,impacting factors such as lifespan,sleep,and fecundity,is *** this study,we investigated the effects of dietary exposure to two different doses of MPs(1–5μm)using the terrestrial model organism Drosophila *** indicated that the particles caused gut damage and remained within the digestive *** MP exposure significantly shortened the lifespan of adult *** short-term exposure disrupted sleep patterns,increasing the length of daytime sleep ***,one week of MP exposure reduced ovary size,with a trend towards decreased egg-laying in mated *** MPs did not penetrate the brain or ovaries,transcriptome analysis revealed altered gene expression in these *** the ovary,Gene Ontology(GO)analysis indicated genotoxic effects impacting inflammation,circadian regulation,and metabolic processes,with significant impacts on extracellular structure-related *** the brain,GO analysis identified changes in pathways associated with proteolysis and carbohydrate ***,this study provides compelling evidence of the systemic negative effects of MP exposure,highlighting the urgent need to address and mitigate environmental MP pollution.

关键词： Microplastics Sleep Lifespan Reproduction Risk assessment Drosophila melanogaster

Amide naphthotubes:Biomimetic macrocycles for selective molecular recognition

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Chinese Chemical Letters 2024年第4期35卷 124-131页

作者： Cheng-Da Zhao Huan yao Shi-yao Li Fangfang Du Li-Li Wang liu-Pan Yang School of Pharmaceutical Science Postdoctoral Research Station of Basic MedicineHengyang Medical SchoolUniversity of South ChinaHengyang 421001China

Selective molecular recognition in water is routine for bioreceptors,but remains challenging for synthetic *** is principally because noncovalent interactions are usually less efficient in aqueous *** mimicking the cavity feature of bioreceptors,*** Jiang proposed and clarified the concept of“endo-functionalized cavity”.Through situating polar binding sites into a deep hydrophobic cavity,we designed and synthesized several macrocyclic hosts,among which amide naphthotubes are the most *** hosts can selectively recognize various polar molecules including organic micropollutants,drug molecules,and chiral molecules in water by employing the hydrophobic effect and shielded hydrogen *** addition,these biomimetic hosts have been applied in spectroscopic analysis,adsorptive separation and *** this review,we provide an overview of recent advances on amide naphthotubes with special emphasis on the efforts of Jiang's *** are convinced that these biomimetic macrocycles will make further contributions to supramolecular chemistry and beyond.

关键词： Molecular recognition Supramolecular chemistry Amide naphthotube Endo-functionalized cavity Biomimetic macrocycle

Asymptotic Inference in the Random Coefficient Autoregressive Model with Time-functional Variance Noises

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Acta Mathematicae Applicatae Sinica 2024年第2期40卷 320-346页

作者： En-wen ZHU zi-wei DENG Han-jun ZHANG Jun CAO Xiao-hui liu Department of Mathematics and Statistics Changsha University of Science and TechnologyChangsha 410114China School of Mathematics and Computational Science Xiangtan UniversityXiangtan 411105China School of Statistics and Data Science and Key Laboratory of Data Science in Finance and EconomicsJiangxi University of Finance and EconomicsNanchang 330013China

This paper considers the random coefficient autoregressive model with time-functional variance noises,hereafter the RCA-TFV *** first establish the consistency and asymptotic normality of the conditional least squares estimator for the constant *** semiparametric least squares estimator for the variance of the random coefficient and the nonparametric estimator for the variance function are constructed,and their asymptotic results are reported.A simulation study is presented along with an analysis of real data to assess the performance of our method in finite samples.

关键词： random coefficient autoregressive model time-functional variance conditional least squares semiparametric least squares

Urea-induced interfacial engineering enabling highly reversible aqueous zinc-ion battery

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Rare Metals 2024年第4期43卷 1599-1609页

作者： Bin-Rui Xu Quan-An Li Yong liu Guang-Bin Wang zi-He Zhang Feng-Zhang Ren School of Material Science and Engineering Henan University of Science and TechnologyLuoyang471023China School of Information Engineering Henan University of Science and TechnologyLuoyang471023China Longmen Laboratory Luoyang471023China Provincial and Ministerial Co-Construction of Collaborative Innovation Center for Non-Ferrous Metal New Materials and Advanced Processing Technology Luoyang471023China

Aqueous zinc-ion batteries(AziBs)have been regarded as prospective rechargeable energy storage devices because of the high theoretical capacity and low redox potential of Zn ***,the uncontrollable formation of dendrites and the water-induced side reactions at the Zn/electrolyte interface,and the poor reversibility under a high current density(>2 mA·cm^(-2))and large area capacity(>2 mAh·cm^(-2))still limit the practical applications of ***,a strategy that can overcome these difficulties is urgently ***,we introduce an environmentally friendly and low-cost additive,namely urea,to the electrolyte of AziBs to induce uniform Zn deposition and suppress the side *** of the adsorption behavior,electrochemical characterization,and observations of the morphology revealed the interfacial modification induced by urea on the Zn/electrolyte interface,demonstrating its huge potential in ***,the long-term cycling stability(over2100 h)of a Zn/Zn symmetric cell under a high current density of 5 mA·cm^(-2)and a capacity of 5 mAh·cm^(-2)was achieved with a 1 mol·L^(-1)ZnSO_(4)electrolyte with the urea ***,the assembled Zn/NH_4V_4O_(10)full cell with urea exhibited excellent cycling performance and an outstanding average Coulombic efficiency of 99.98%.These results indicate that this is a low-cost and effective additive strategy for realizing highly reversible AziBs.

关键词： Zn anode Urea additive Interface engineering Dendrite growth Side reaction

AZGP1P2/UBA1/RBM15 Cascade Mediates the Fate Determinations of Prostate Cancer Stem Cells and Promotes Therapeutic Effect of Docetaxel in Castration-Resistant Prostate Cancer via TPM1 m6A Modification

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Research 2024年第3期6卷 151-167页

作者： Hong Wang Jj liu Xiaojun Zhu Bin Yang Zuping He Xudong yao Department of Urology Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghaiChina Urologic Cancer Institute School of MedicineTongji UniversityShanghaiChina. Department of Urology Surgery The Affiliated Hospital of Inner Mongolia Medical UniversityHohhotChina. The Key Laboratory of Model Animals and Stem Cell Biology in Hunan Province School of MedicineHunan Normal UniversityThe Engineering Research Center of Reproduction and Translational Medicine of Hunan ProvinceChangshaChina Shanghai Key Laboratory of Reproductive Medicine Shanghai Jiao Tong University School of MedicineShanghaiChina.

Prostate cancer(PCa)is a common malignant tumor with high morbidity and mortality *** prostate cancer stem cell(PCSC)model provides novel insights into the pathogenesis of PCa and its therapeutic ***,the roles and molecular mechanisms of specific genes in mediating fate decisions of PCSCs and carcinogenesis of PCa remain to be *** this study,we have explored the expression,function,and mechanism of AZGP1P2,a pseudogene of AZGP1,in regulating the stemness and apoptosis of PCSCs and treatment resistance of docetaxel in castration-resistant prostate cancer(CRPC).We revealed that AZGP1P2 was downregulated in CRPC cell lines and PCSCs,while it was positively associated with progression-free *** of the AZGP1P2 enhanced the sensitivity of docetaxel treatment in CRPCs via inhibiting their *** pull-down associated with mass spectrometry analysis,co-immunoprecipitation assay,and RNA immunoprecipitation assay demonstrated that AZGP1P2 could bind to UBA1 and RBM15 as a“writer”of methyltransferase to form a ***1,an E1 ubiquitin-activating enzyme,contributed to RBM15 protein degradation via ubiquitination *** RNA immunoprecipitation assay displayed that RBM15 controlled the mRNA decay of TPM1 in m6A ***,a xenograft mouse model and patient-derived organoids showed that the therapeutic effect of docetaxel in CRPC was increased by AZGP1P2 in ***,these results imply that AZGP1P2 mediates the stemness and apoptosis of PCSCs and promotes docetaxel therapeutic effect by suppressing tumor growth and metastasis via UBA1/RBM15-mediated TPM1 mRNA decay in CRPC.

关键词： Prostate TPM1 m6A

Three‑Dimensional Nano‑displacement Measurement by Four‑Beam Laser Interferometry

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Nanomanufacturing and Metrology 2024年第2期7卷 42-49页

作者： Xu Zhang zi Wang Mengnan liu Zhengxun Song Zuobin Wang Litong Dong International Research Centre for Nano Handling and Manufacturing of China Changchun University of Science and TechnologyChangchun 130022China Centre for Opto/Bio‑Nano Measurement and Manufacturing Zhongshan Institute of Changchun University of Science and TechnologyZhongshan 528437China Ministry of Education Key Laboratory for Cross‑Scale Micro and Nano Manufacturing Changchun University of Science and TechnologyChangchun 130022China JR3CN&IRAC University of BedfordshireLuton LU13JUUK

A 3D nano-displacement measurement method,where the difference in phase between the beams in a four-beam laser interference is changed,is *** results demonstrate that the variation of phase difference causes the deviation of the interference pattern in the laser interference *** on this theory,we design and build a four-beam laser interference *** corner cube prism in the optical path is shifted,and the phase of the beam is changed by applying different voltages to a piezoelectric *** phase difference is obtained by analyzing the lattice pattern with subpixel precision,and then the displacement is determined by correlation *** experimental measurement results are consistent with the theoretical analysis,thereby verifying the feasibility of this measurement method.

关键词： Four-beam laser interferometry Phase difference 3D displacement Correlation operation

Traditional Chinese Medicine Erhuang Suppository for Treatment of Persistent High-risk Human Papillomavirus Infection and Its Impact on Transcriptome of Uterine Cervix

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Current Medical Science 2024年第4期44卷 841-853页

作者： zi-zhuo WANG Hui-li WANG Wei XIONG Juan DU Rong liu Department of Obstetrics and Gynecology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Department of Pharmacology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Objective High-risk human papillomavirus(HR-HPV)infection is the chief cause of cervical intraepithelial neoplasia(CIN)and cervical *** Erhuang suppository(EHS)is a traditional Chinese medicine(TCM)prepared from realgar(As2S2),Coptidis rhizoma,alumen,and borneolum syntheticum and has been used for antiviral and antitumor ***,whether EHS can efficiently alleviate HR-HPV infection remains *** study was conducted to evaluate the efficacy of EHS for the treatment of persistent HR-HPV infection in the uterine *** In this study,we evaluated the therapeutic efficacy of EHS in a randomized controlled clinical trial with a 3-month ***,70 patients with persistent HR-HPV infection were randomly assigned to receive intravaginal administration of EHS or *** DNA,ThinPrep cytologic test(TCT),colposcopy,and safety evaluation were carried out after *** analysis was performed to compare transcriptome profiles before and after EHS treatment.A K14-HPV16 mouse model was generated to confirm the efficiency of *** After 3 months,74.3%(26/35)of the patients in the treatment group were HPV negative,compared to 6.9%(2/29)in the placebo ***-throughput microarrays revealed distinct transcriptome profiles after *** differentially expressed genes were significantly enriched in complement activation,immune response,and apoptotic *** K14-HPV16 mouse model also validated the remarkable efficacy of *** This study demonstrated that EHS is effective against HR-HPV infection and cervical ***,no obvious systemic toxicity was observed in patients during the *** superior efficacy and safety of EHS demonstrated its considerable value as a potential cost-effective drug for the treatment of HPV infection and HPV-related cervical diseases.

关键词： Traditional Chinese Medicine Erhuang suppository human papillomavirus cervical diseases transcriptomics