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Metal-Catalyzed Substrate-Directed Enantioselective Functionalization of Unactivated Alkenes

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Chinese Journal of Chemistry 2019年第11期37卷 1174-1180页

作者： zi-xuan wang Xiao-Yan Bai Bi-Jie Li Center of Basic Molecular Science(CBMS) Department of ChemistryTsinghua UniversityBeijing 100084China

Alkenes are versatile compounds that are available on large scales in industry or through chemical *** functionalization of unactivated alkenes in a chemo-,regio-,diastereo-and enantioselective fashion is a highly sought-after goal in organic ***-directed enantioselective functionalization of unactivated alkenes provides an important strategy to achieve this *** a functional group on the alkene substrate as a native coordinating group,a two-point binding mode of the substrate to the metal center enables effective control of regio-;diastereo-and *** this strategy,a variety of enantioselective functionalization methods have been developed *** recent advances in this area are highlighted here.

关键词： synthesis. enantioselective versatile

Psychological intervention reduces postembolization pain during hepatic arterial chemoembolization therapy:A complementary approach to drug analgesia

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World Journal of Gastroenterology 2008年第6期14卷 931-935页

作者： zi-xuan wang Si-Liang Liu Chun-Hui Sun Qian wang Department of Interventional Radiology Qingdao Municipal Hospital Qingdao 266000 Shandong Province China Department of Gastroenterology Affiliated Hospital of Medical College Qingdao University Qingdao 266000 Shandong Province China Department of Gastroenterology Qingdao 3rd People's Hospital Qingdao 266000 Shandong Province China

AIM: To assess whether psychological intervention reduces postembolization pain during hepatic arterial chemoembolization therapy. METHODS: Two hundred and sixty-two patients, who required hepatic arterial chemoembolization for hepatic malignancy and postembolization pain, were randomized into control group (n = 46, receiving medication) and intervention group (n = 216, receiving psychological intervention and medication in turn). The symptom checklist-90 (SCL-90) was used to scale the psychological symptoms of the patients before operation. Pain was scored with a 0 to 10 numeric rating scale (NRS-10) before and after analgesia as well as after psychological intervention (only in intervention group). RESULTS: All psychological symptomatic scores measured with SCL-90 in the intervention group were higher than the normal range in Chinese (P < 0.05). The somatization, phobia and anxiety symptomatic scores were associated with pain numerical rating score before analgesia (r = 0.141, 0.157 and 0.192, respectively, P < 0.05). Patients in both groups experienced pain relief after medication, psychotherapy or psychotherapy combined with medication during the procedure (P < 0.01). Only some patients in the intervention group reported partial or entire pain relief (29.17% and 2.31%) after psychological intervention. The pain score after analgesia in the intervention group was significantly lower than that in the control group (P < 0.01).CONCLUSION: Severe psychological distress occurs in patients with hepatic malignancy. Psychological intervention reduces pain scores significantly during hepatic arterial chemoembolization therapy and is thus, highly recommended as a complementary approach to drug analgesia.

关键词： Liver neoplasms Radiology Psychological intervention Non-pharmacologica Pain

Stimulating factors for regulation of osteogenic and chondrogenic differentiation of mesenchymal stem cells

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World Journal of Stem Cells 2023年第5期15卷 369-384页

作者： Jia-Qi Zhou Hao-Yang Wan zi-xuan wang Nan Jiang Division of Orthopaedics and Traumatology Department of OrthopaedicsNanfang HospitalSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina

Mesenchymal stem cells(MSCs),distributed in many tissues in the human body,are multipotent cells capable of differentiating in specific *** is usually considered that the differentiation process of MSCs depends on specialized external stimulating factors,including cell signaling pathways,cytokines,and other physical *** findings have revealed other underrated roles in the differentiation process of MSCs,such as material morphology and *** relevant achievements have substantially advanced the applicability of MSCs,some of these regulatory mechanisms still need to be better ***,limitations such as long-term survival in vivo hinder the clinical application of MSCs *** review article summarizes current knowledge regarding the differentiation patterns of MSCs under specific stimulating factors.

关键词： Mesenchymal stem cells Differentiation Osteogenic Chondrogenic Literature review

Are allometric model parameters of aboveground biomass for trees phylogenetically constrained?

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Plant Diversity 2023年第2期45卷 229-233页

作者： Xing-Zhao Huang Fang-Bing Li zi-xuan wang Yi Jin Hong Qian School of Forestry&Landscape of Architecture Anhui Agricultural UniversityHefei 230036China State Key Laboratory of Vegetation and Environmental Change Institute of BotanyChinese Academy of SciencesBeijing 100093China Key Laboratory of National Forestry and Grassland Administration on Biodiversity Conservation in Karst Mountainous Areas of Southwestern China Guizhou Normal UniversityGuiyang 550025China Research and Collections Center Illinois State Museum1011 East Ash StreetSpringfieldIL 62703USA

Knowledge of which biological and functional traits have,or lack,phylogenetic signal in a particular group of organisms is important to understanding the formation and functioning of biological *** biomass models reflecting tree growth characteristics are commonly used to predict forest ***,few studies have examined whether model parameters are constrained by ***,we use a comprehensive database(including 276 tree species) compiled from 894 allometric biomass models published in 302 articles to examine whether parameters a and b of the model W=aD~b(where W stands for aboveground biomass,D is diameter at breast height) exhibit phylogenetic signal for all tree species as a whole and for different groups of tree *** either model parameter,we relate difference in model parameter between different tree species to phylogenetic distance and to environmental distance between pairwise *** study shows that neither model parameter exhibits phylogenetic signals(Pagel's λ and Blomberg's K both approach zero).This is the case regardless of whether all tree species in our data set were analyzed as a whole or tree species in different taxonomic groups(gymnosperm and angiosperm),leaf duration groups(evergreen and deciduous),or ecological groups(tropical,temperate and boreal) were analyzed *** study also shows that difference in each parameter of the allometric biomass model is not significantly related to phylogenetic and environmental distances between tree species in different sites.

关键词： Allometric biomass model Pagel'sλ Blomberg's K Phylogenetic constraint

Premorbid Steatohepatitis Increases the Seriousness of Dextran Sulfate Sodium-induced Ulcerative Colitis in Mice

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Journal of Clinical and Translational Hepatology 2022年第5期10卷 847-859页

作者： Meng-Yu wang zi-xuan wang Lei-Jie Huang Rui-Xu Yang zi-Yuan Zou Wen-Song Ge Tian-Yi Ren Jian-Gao Fan Department of Gastroenterology Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina Shanghai Key Lab of Pediatric Gastroenterology and Nutrition ShanghaiChina

Background and Aims:The concurrence of nonalcoholic steatohepatitis(NASH)and ulcerative colitis(UC)is increasingly seen in clinical practice,but the underlying mechanisms remain *** study aimed to develop a mouse model of the phenomenon by combining high-fat high-cholesterol diet(HFHCD)-induced NASH and dextran sulfate sodium(DSS)-induced UC,that would support mechanistic ***:Male C57BL/6 mice were randomly assigned to two groups receiving either a chow diet or HFHCD for 12 weeks of NASH *** mice were divided into four subgroups for UC modeling:(1)A control group given a chow diet with normal drinking water;(2)A colitis group given chow diet with 2%DSS in drinking water;(3)A steatohepatitis group given HFHCD with normal drinking water;and(4)A steatohepatitis+colitis group given HFHCD with 2%DSS in drinking ***:NASH plus UC had high mortality(58.3%).Neither NASH nor UC alone were *** DSS-induced colitis did not exacerbate histological liver injury in HFHCD-fed mice,premorbid NASH significantly increased UC-related gut injury compared with UC *** was characterized by a significantly shorter colon,more colonic congestion,and a higher histopathological score(p<0.05).Inflammatory(tumor necrosis factor-alpha,interleukin 1 beta,C-C motif chemokine ligand 2,and nuclear factor kappa B)and apoptotic(Bcl2,Bad,Bim,and Bax)signaling pathways were significantly altered in distal colon tissues collected from mice with steatohepatitis+colitis compared with the other experimental ***:Premorbid steatohepatitis significantly aggravated DSS-induced colitis and brought about a lethal *** links between NASH and UC pathogeneses can be investigated using this model.

关键词： Inflammatory bowel disease Ulcerative colitis Nonalcoholic fatty liver disease Mouse model Mortality

Necroptosis contributes to non-alcoholic fatty liver disease pathoetiology with promising diagnostic and therapeutic functions

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World Journal of Gastroenterology 2024年第14期30卷 1968-1981页

作者： Hong-Ju Sun Bo Jiao Yan wang Yue-Hua Zhang Ge Chen zi-xuan wang Hong Zhao Qing Xie Xiao-Hua Song Department of General Medicine Qingdao Central HospitalUniversity of Health and Rehabilitation Sciences(Qingdao Central Medical Group)Qingdao 266042Shandong ProvinceChina Department of Gastroenterology Qingdao Central HospitalUniversity of Health and Rehabilitation Sciences(Qingdao Central Medical Group)Qingdao 266042Shandong ProvinceChina Department of Medical Administration Qingdao Central HospitalUniversity of Health and Rehabilitation Sciences(Qingdao Central Medical Group)Qingdao 266042Shandong ProvinceChina Qingdao Medical College Qingdao UniversityQingdao 266042Shandong ProvinceChina Department of Infectious Diseases Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China

Nonalcoholic fatty liver disease(NAFLD)is the most prevalent type of chronic liver ***,the disease is underappreciated as a remarkable chronic disorder as there are rare managing *** studies have focused on determining NAFLD-caused hepatocyte death to elucidate the disease pathoe-tiology and suggest functional therapeutic and diagnostic ***,ferroptosis,and necroptosis are the main subtypes of non-apoptotic regulated cell deaths(RCDs),each of which represents particular *** the complexity of the findings,the present study aimed to review these types of RCDs and their contribution to NAFLD progression,and subsequently discuss in detail the role of necroptosis in the pathoetiology,diagnosis,and treatment of the *** study revealed that necroptosis is involved in the occurrence of NAFLD and its progression towards steatohepatitis and cancer,hence it has potential in diagnostic and therapeutic ***,further studies are necessary.

关键词： Nonalcoholic fatty liver disease Apoptosis Necroptosis Cell death Diagnosis Treatment

The crucial role of fish mucus in regulating progeny inflammation and microbial homeostasis

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Water Biology and Security

Water Biology and Security 2024年第2期3卷 31-45页

作者： zi-xuan wang Hao-Yue Xu Qiu-Lu He Yong-Yao Yu Zhen Xu Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture Institute of HydrobiologyChinese Academy of SciencesWuhan 430072China College of Advanced Agricultural Sciences University of Chinese Academy of SciencesBeijing100049China College of Animal Science and Technology Yangtze UniversityJingzhou434024China Department of Aquatic Animal Medicine College of FisheriesHuazhong Agricultural UniversityWuhan430070China

Maternal immunity plays a vital role in protecting offspring from pathogen invasion,and it is present in nearly all *** the most ancient vertebrates,teleost fish continuously secrete a substantial amount of mucus due to their unique living environment,and often exhibit schooling *** studies have highlighted the presence of numerous immune components in the mucus of fish,that plays a crucial role in resisting *** hypothesize that this represents a distinctive maternal immune response mechanism in *** this study,we established a dextran sulfate sodium(DSS)-induced injury model by immersing zebrafish larvae in 0.5%*** elicited robust inflammatory responses and showed DSS-induced alterations in microbial abundance via 16S rRNA *** changes included the disruption of normal gut structure;an increase in goblet cells;increased expression of inflammatory cytokines;and infiltration of neutrophils and macrophages into the gut,as well as an increase in pathogenic bacteria and a decline in probiotic ***,we conducted a mucus protection test by adding adult zebrafish mucus in fish tank water containing 0.5%DSS to test our *** suspected,the mucus from adult zebrafish exhibited a protective role in defending zebrafish larvae against DSSinduced enteritis by alleviating excessive inflammatory responses and increasing probiotic *** conclusion,our results confirm a significant role of adult fish mucus in the immune response of teleost fish to DSSinduced ***,our findings show that the mucus of adult zebrafish may represent a novel form of maternal immunization,playing roles analogous to mammalian milk in immune regulatory functions.

关键词： Mucus Maternal immunity Inflammatory response Dextran sulfate sodium(DSS) Zebrafish

Label-Free Quantitative Proteomics Analysis of the Sorafenib Resistance in HepG2 Cells

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Journal of Analysis and Testing 2022年第3期6卷 308-317页

作者： zi-xuan wang Hong-Wei Chu Kai-Guang Yang Bao-Feng Zhao Zhen Liang Li-Hua Zhang Yu-Kui Zhang CAS Key Laboratory of Separation Science for Analytical Chemistry National Chromatographic R.&A.CenterDalian Institute of Chemical PhysicsChinese Academy of ScienceDalian 116023China University of Chinese Academy of Sciences Beijing 100039China Zhang Dayu School of Chemistry Dalian University of TechnologyDalian 116024China

Drug resistance of sorafenib seriously affects the treatment effect of late-stage hepatocellular carcinoma(HCC)***,the precise mechanism of resistance to sorafenib remains ***,to obtain a deep understand of sorafenib resistance mechanisms and find potential therapeutic targets are very important for improving the clinical prognosis of HCC *** this study,a label-free quantitative proteomics method was performed to investigate the proteins differentially expressed between HepG2 and the sorafenib-acquired resistance HepG2(HepG2-R)*** total,84 differential expressed proteins were identified between the two cell *** analysis results demonstrated the dysregulated metabolic processes have a significant impact on the drug resistance of HepG2-R *** them,the expression of Microsomal glutathione S-transferase 1(MGST1)in two cell lines was further confirmed by western blot ***,colony formation assay and trypan blue dye assay results revealed that MGST1 is closely connected with the sorafenib resistance of HepG2-R cells,and the knockdown of MGST1 increased the sensitivity of sorafenib resistance HepG2-R cells to sorafenib *** conclusion,these results lay a foundation for deciphering the mechanism for HCC sorafenib resistance and present a possibility of MGST1 serving as a therapeutic target for the treatment of sorafenib resistance HCC.

关键词： Drug resistance Hepatocellular carcinoma Quantitative proteomics Sorafenib

肝动脉化疗栓塞中心理干预与药物治疗疼痛216例

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世界华人消化杂志 2008年第9期16卷 1017-1020页

作者：王子轩孙春辉王倩青岛市市立医院介入放射科山东省青岛市266000 青岛市第三人民医院消化内科山东省青岛市266000 青岛大学医学院附属医院山东省青岛市266000

目的:探讨心理干预和药物治疗在肝动脉栓塞过程中的止痛疗效.方法:接受动脉化疗栓塞治疗的肝癌患者262例,分为药物治疗组(n=46)和联合治疗组(n= 216,心理干预、药物序贯治疗).术前采用症状自评量表(SCL-90)进行心理测验.两组患者的一般... 详细信息

目的:探讨心理干预和药物治疗在肝动脉栓塞过程中的止痛疗效.方法:接受动脉化疗栓塞治疗的肝癌患者262例,分为药物治疗组(n=46)和联合治疗组(n= 216,心理干预、药物序贯治疗).术前采用症状自评量表(SCL-90)进行心理测验.两组患者的一般资料、心理状况及镇痛治疗前疼痛评分无统计学差异.术中采用数字疼痛量表(NRS-10)依次测定镇痛治疗前、心理干预后(仅联合治疗组)和镇痛治疗后的右上腹疼痛程度.结果:经药物治疗、心理干预和联合治疗后患者的疼痛均有明显缓解(t′=4.47,5.79,20.24,P<0.01).三种方案的镇痛疗效(治疗前疼痛评分-治疗后疼痛评分)存在显著的统计学差异(F=21.98,P<0.01).其中药物治疗和联合治疗效果优于单纯心理干预(2.71±4.05,3.40±3.82 vs 1.24±2.76,P<0.01).联合治疗效果最佳,但疗效评分与药物治疗无显著的统计学差异.结论:药物联合心理干预可有效缓解肝动脉化疗栓塞术中疼痛.

关键词：肝肿瘤放射学介入性疼痛