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SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF 3,6-DISUBSTITUTED S-TRIAZOLO[3,4-b]-1,3,4-THIADIAZOLES

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Chinese Chemical Letters 1991年第4期2卷 277-278页

作者： zi Yi zhang xin CHEN Department of Chemistry,Lanzhou University,Lanzhou 730000

A series of 3,6-disubstituted s-triazolo[3,4-b]-1,3,4-thiadiazoles have been synthesized,whose structures were determined by elemental and spectral analyses;all the new compounds showed significant antibacterial activ... 详细信息

关键词： DMF 甲酰胺 SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF 3,6-DISUBSTITUTED S-TRIAZOLO[3,4-b THIADIAZOLES

Reduction of self-heating effect in SOI MOSFET by forming a new buried layer structure

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Nuclear Science and Techniques 2003年第2期14卷 119-122页

作者： ZHU Ming, LIN Qing, LIU Xiang-Hua, LIN zi-xin, zhang Zheng-Xuan, LIN Cheng-Lu(State Key Laboratory of Functional Materials for Informatics, Shanghal Institute of Microsystem and Information Technology,the Chinese Academy of Sciences, Shanghai 200050) Shanghai Institute of Microsystem and Information Technology the Chinese Academy of Sciences State Key Laboratory of Functional Materials for Informatics 上海 200050

An inherent self-heating effect of the silicon-on-insulator (SOI) devices limits their application at high current levels. In this paper a novel solution to reduce the self-heating effect is proposed, based on N+ and O+ co-implantation into silicon wafer to form a new buried layer structure. This new structure was simulated using Medici program, and the temperature distribution and output characteristics were compared with those of the conventional SOI counterparts. As expected, a reduction of self-heating effect in the novel SOI device was observed.

关键词：自动加热效应埋存层状结构绝缘硅片 SOI 二氧化硅

Failure characteristics and its influencing factors of talus-derived rock mass during open-pit mining

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Transactions of Nonferrous Metals Society of China 2013年第2期23卷 462-471页

作者：王贵和杨宇友张辉张子新中国地质大学(北京)工程技术学院北京100083 上海建科工程咨询有限公司上海200032 同济大学工木工程学院上海200092

The failure characteristic of talus-derived rock mass continues to challenge quantitative hazard assessments in open-pit mining. Physical model test was used to assess the failure modes and mechanisms on talus-derived rock mass. The different types of failure modes of the talus-derived rock mass were introduced and a possible failure mechanism relation between the failure zone and the structure of the talus-derived rock mass was also shown. The physical model test results indicate that the rainfall has significant influence on the stability and failure modes of talus-derived rock mass during open-pit mining. The development of the seepage area caused by rainfall initiates the localized failure in that particular area, and the initiation of localized instability is mainly induced by stress changes concentrated in the seepage area.

关键词： talus-derived rock mass model test failure mode rainfall open-pit mining

Selenium regulates proliferation and differentiation of ATDC5 chondrogenic cells

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Selenium regulates proliferation and differentiation of ATDC...

Effective Nikuradse Roughness on the Mobile Plan Bed

2012全国发育生物学大会

作者： Ji-dong Yan,zi-xin Min,Rui zhang,Fu-jun zhang,She-min Lu. Department of Genetics and Molecular Biology,Xi’an Jiaotong University School of Medicine,Xi’an,Shaanxi 710061, China

Selenium(Se) is an essential micronutrient and low Se intake in Se-deficient areas plays roles in an endemic osteochondropathy,which characterized by chondronecrosis in growth plate and articular ***,the biological activities of Se on cartilage are largely *** found that Se stimulated proliferation of ATDC5 chondrogenic cell through acceleration of cell cycle progression accompanied with cyclin D1 ***,Se increased intracellular ATP content and decreased intracellular superoxide anion concentration,while suppression of intracellular ATP synthesis by glycolysis inhibitor or mitochondrial uncoupler both abrogated Se-mediated cyclin D1 *** also observed that Se enhanced mineralization of ATDC5 chondrogenic cell under differentiation condition through induction of alkaline phosphates(ALP).In addition,we examined effects of Se status on gene expression levels of selenoproteins because Se exerts its biological functions predominantly through selenoproteins(Sel).We demonstrated that all 24 selenoprotein gene in mouse genome were detectable in ATDC5 mouse chondrogenic cell except deiodinase 1(DIO1),DIO2,and selenoprotein V(Sel V).Furthermore,gene expression levels of three selenoproteins,glutathione peroxidase 1(GPx1),Sel H,and Sel W were dramatically upregulated,and eight selenoproteins,thioredoxin reductases 1(TrxR1),Sel I,Sel M,Sel N,Sel P,Sel R, Sel S,and Sel T were moderately upregulated by Se ***,gene expression levels of three seleproteins, TrxR2,Selenophosphate synthetase 2(SPS2),and Sel O were downregulated after Se *** contrast,mRNA levels of the others selenoproteins were not affected by Se supplementation. Conclusion:Our observations provides evidence for a role of Se on chondrocyte proliferation and differentiation,and further supports the relationship between Se status and cartilage functions that may lead to better utilization of Se for cartilage homeostasis.

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China Ocean Engineering 2018年第6期32卷 730-736页

作者： CHEN xin LI Yong zhang zi-chao Beijing Engineering Research Center of Safety and Energy Saving Technology for Water Supply Network System China Agricultural University Tianjin Centre China Geological Survey School of Electric Power North China University of Water Resources and Electric Power

Nikuradse roughness(ks) is very important in the sediment transport prediction because it is related to the evaluations of the velocity distribution, shear stress and erosion depth. Dimensionless Nikuradse roughness(ks/D,where D is the sediment diameter) is usually given 1–2.5 on the immobile plan bed or at low shear stress. But it behaves differently on the mobile plan bed at high shear stress with much sediment picked up to movement when the Shields parameter(Θ) is larger than 0.8–1.0. The effective Nikuradse roughness on the mobile plan bed was derived indirectly from the erosion depth correlated to the mobile plan bed thickness considering the mass conservation in the present study. The proposed erosion depth confirmed the relation to the Shields parameters with an extra factor consisting of suspended sediment and its damping to turbulence. The decrement of the erosion depth caused by the increment of the sediment diameter at large shear stress was obtained, which was usually absent in classical empirical formulas based on the bedload theory. Good agreement with experiments was achieved by the present prediction of the Nikuradse roughness, erosion depth and sediment transport rate. Discussion was mainly focused on the prediction improvement caused by considering the impact of suspended sediment and its damping to turbulence.

关键词： mobile plan bed Nikuradse roughness oscillatory sheet flow sediment transport

ON POTENT ELEMENTS AND PSEUDO CLEAN RINGS

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数学杂志 2025年第1期45卷 39-47页

作者： DING Yan GAO Han-peng LIU xin-yi YAN zi-yi zhang Ting School of Mathematical Sciences Anhui UniversityHefei 230601China

In this paper,potent index of an element and pseudo clean rings are *** properties and examples of pseudo clean rings are *** also show that Zm is pseudo clean for every 2≤m∈Z and pseudo clean rings are ***,we prove... 详细信息

关键词： clean rings strongly J-clean rings pseudo clean rings potent elements

A Lightweight Dynamic Enforcement of Privacy Protection for Android

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Journal of Computer Science & Technology 2019年第4期34卷 901-923页

作者： zi-Peng zhang Ming Fu xin-Yu Feng School of Computer Science and Technology University of Science and Technology of ChinaHefei 230026China OS Kernel Laboratory Huawei Technologies Co.Ltd.Shanghai 200135China State Key Laboratory for Novel Software Technology Nanjing UniversityNanjing 210023China

Inter-process communication(IPC)provides a message passing mechanism for information exchange between *** has been long believed that IPCs can be abused by malware writers to launch collusive information leak using two or more *** work on privacy protection focuses on the simple information leak caused by the individual applications and lacks effective approaches to preventing the collusive information leak caused by IPCs between multiple *** this paper,we propose a hybrid approach to prevent the collusive information leak based on information flow *** approach combines static information flow analysis and dynamic runtime checking *** leak caused by individual processes is prevented through static information flow control,and dynamic checking is done at runtime to prevent the collusive information *** a combination may effectively reduce the runtime overhead of pure dynamic checking,and reduce false-alarms in pure static *** develop this approach based on an abstract and simplified programming model,and formalize a novel definition of the leak-freedom property as our target security property.A simulation-based proof technique is used to prove that our approach is able to guarantee *** proofs are mechanized in Coq.

关键词： privacy protection dynamic runtime checking static information flow control Android verification

[Evaluation of the toxicity of perfluorooctanoic acid toward human colorectal cancer cells using multi-dimensional approaches]

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Se pu = Chinese journal of chromatography 2025年第1期43卷 96-103页

作者： Rui-Jia zhang Ying-Shi Lin Lan-Yin Tu zi-Tong Chen Wei-Wei zhang Tian-Gang Luan Bao-Wei Chen School of Life and Health Sciences Hainan University Haikou 570228 China. School of Life Sciences Sun Yat-sen University Guangzhou 510275 China. School of Artificial Intelligence Sun Yat-sen University Zhuhai 519082 China. Guangzhou Center for Disease Control and Prevention Guangzhou 510440 China. School of Marine Sciences Sun Yat-sen University Zhuhai 519082 China.

While human exposure to perfluorooctanoic acid (PFOA) can lead to ulcerative colitis, the molecular mechanisms responsible for PFOA-induced intestinal toxicity are unclear. Herein, we examined the toxicity of PFOA toward human colorectal cancer cells (HCT116) from three dimensions: the cytotoxic phenotype, cell respiration, and transcription levels of metabolism-related genes. Formazan was used to assess how PFOA exposure affects HCT116-cell relative viability, after which the mitochondrial respiratory activities of these cells were determined by analyzing extracellular flux. The quantitative real-time polymerase chain reaction (qPCR) method was used to detect metabolism-related gene expression levels. The cytotoxicity assay revealed that the HCT116 showed significantly inhibited relative activities compared to those of the control when exposed to 300 μmol/L PFOA for 48 h (<0.01), with most cells retained at the G0/G1 stage. In contrast, the mitochondrial respiratory activities of the HCT116 were promoted by concentrations of PFOA as low as 50 μmol/L. Two genes related to cellular metabolism (dipeptidase 1 () and sphingosine kinase 1 ()) were found to be related to the PFOA-promoted formation of ulcerative colitis using our self-developed Metabolic Gene and Pathway Query software and Comparative Toxicogenomics Database (CTD). The qPCR studies revealed that and expression levels were enhanced by 8-10 times in HCT116 exposed to 300 μmol/L PFOA relative to the control, whereas this trend was not observed for HCT116 exposed to 50 μmol/L PFOA. Collectively, these results suggest that the respiratory activity of cellular mitochondria may serve as an index for determining the interference effects associated with PFOA and that metabolic pathways mediated by and may be involved in the development of PFOA-induced ulcerative colitis. Future studies should investigate the relationships between changes in metabolism-related genes ( and ) and the mitochondrial respiratory act

关键词： Metabolic Gene and Pathway Query software human colorectal enterotoxicity metabolic disorder perfluorooctanoic acid (PFOA)

Surface effects on cylindrical indentation of a soft layer on a rigid substrate

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Acta Mechanica Sinica 2020年第2期36卷 422-429页

作者： Min Li Huan-xin zhang zi-Long Zhao Xi-Qiao Feng Institute of Biomechanics and Medical Engineering AMLDepartment of Engineering MechanicsTsinghua UniversityBeijing 100084China

In this paper,theoretical and numerical methods are combined to investigate the two-dimensional,cylindrical indentation of an elastic soft layer bonded on a rigid *** incorporating the Gurtin-Murdoch’s theory of surface elasticity into the Kerr model,we account for surface effects on the indentation behavior of a soft *** governing differential relation between the surface pressure and displacement of the film-substrate system is *** an incompressible thin layer,the explicit solutions are derived,which are simple and *** element simulations are performed using an explicit restart algorithm to study the indentation properties of the layer-substrate system and to examine the validity and accuracy of the theoretical *** work holds promise for applications in mechanical characterization of soft materials,such as biological tissues and cells.

关键词： Soft materials Indentation Surface effect Contact Kerr model