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Asian Journal of Andrology 2024年第2期26卷 195-204页

作者： Zhao Yang Jia-Qi Chen Tian-Jie Liu Yu-Le Chen Zhen-Kun Ma Yi-Zeng Fan zi-xi wang Shan Xu Ke wang xin-Yang wang Lei Li Hong-Jun xie Department of Urology The First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710061China

Tumor-derived exosomes have been shown to play a key role in organ-specific metastasis,and the androgen receptor regulates prostate cancer(PCa)*** is unclear whether the androgen receptor regulates the recruitment of prostate cancer cells to the bone microenvironment,even bone metastases,through ***,we found that exosomes isolated from PCa cells after knocking down androgen receptor(AR)or enzalutamide treatment can facilitate the migration of prostate cancer cells to *** addition,AR silencing or treatment with the AR antagonist enzalutamide may increase the expression of circular RNA-deoxyhypusine synthase(circ-DHPS)in PCa cells,which can be transported to osteoblasts by ***-DHPS acts as a competitive endogenous RNA(ceRNA)against endogenous miR-214-3p to promote C-C chemokine ligand 5(CCL5)levels in *** the level of CCL5 in osteoblasts could recruit more PCa cells into the bone ***,blocking the circ-DHPS/miR-214-3p/CCL5 signal may decrease exosome-mediated migration of prostate cancer cells to osteoblasts.

关键词： androgen receptor circRNA exosome prostate cancer

Efficiency of Profinite Rigidity of Triangle Groups

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Acta Mathematica Sinica,English Series 2022年第10期38卷 1939-1948页

作者： Ji Ming MA zi xi wang School of Mathematical Sciences Fudan UniversityShanghai 200433P.R.China

It is already known that finitely-generated Fuchsian groups are profinitely rigid among all lattices of connected Lie groups by the result of Bridson,Conder and *** the triangle groups are distinguished among themselves by their finite *** focus on the question about quantifying the size of a quotient which separates two triangle groups and give an explicit upper bound.

关键词： Triangle groups profinite completion finite quotients

Multi-Omics Analysis Provides Insight into the Possible Molecular Mechanism of Hay Fever Based on Gut Microbiota

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Engineering 2022年第8期8卷 115-125页

作者： Pei Han Li-Sha Li zi-xi wang Lin xi Hang Yu Lin Cong Zheng-Wei Zhang Jie Fu Ran Peng Li-Bin Pan Shu-Rong Ma Xue-Yan wang Hong-Tian wang xiang-Dong wang Yan wang Jin-Lyu Sun Jian-Dong Jiang State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China Department of Allergy National Clinical Research Center for Dematologic and Immunologic DiseasesBeijing Key Laboratory of Precision Medicine for Diagnosis and Treatment on Allergic DiseasesPeking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Department of Allergy&Department of Otorhinolaryngology Head and Neck Surgery&Key Laboratory of Otolaryngology Head and Neck Surgery Ministry of EducationBeijing Tongren HospitalCapital Medical UniversityBeijing 100005China Department of Allergy Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China Beijing Key Laboratory of Nasal Diseases Beijing Institute of OtolaryngologyBeijing Tongren HospitalCapital Medical UniversityBeijing 100005China

Due to the worldwide epidemic of allergic disease and a cure nowhere in sight,there is a crucial need to explore its pathophysiological *** allergic disease has been associated with gut dysbiosis,we searched for a possible mechanism from the perspective of the molecular interface between host and microbiota with concurrent metabolomics and microbiome composition ***-Dawley rats were injected with Artemisia pollen extract to stimulate a hyper reaction to *** hyper reaction decreased the circulation of valine,isoleucine,aspartate,glutamate,glutamine,indole-propionate(IPA),and myo-inositol,and reduced short-chain fatty acids(SCFAs)in *** beneficial genera belonging to Ruminococcaceae,Lachnospiraceae,and Clostridiales declined in the model group,whereas Helicobacter and Akkermansia were only expressed in the model ***,the expression of intestinal claudin-3 and liver fatty acid binding protein was downregulated in the model group and associated with metabolic changes and *** results suggest that alterations in amino acids as well as their derivatives(especially valine,and IPA which is the reductive product of tryptophan),SCFAs,and the gut microbiome(specifically Akkermansia and Helicobacter)may disrupt the intestinal barrier function by inhibiting the expression of claudin proteins and affecting the mucus layer,which further results in hay fever.

关键词： Metabolome Gut microbiota Hay fever Allergic diseases Intestinal barrier dysfunction

Carbon uptake by cement in China:Estimation and contribution to carbon neutrality goals

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Science China Earth Sciences 2024年第6期67卷 2056-2067页

作者： Mingjing MA zi HUANG Jiaoyue wang Le NIU Wenfeng ZHANG xiaowei XU Fengming xi Zhu LIU Institute of Applied Ecology Chinese Academy of SciencesShenyang 110016China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China Department of Earth System Science Tsinghua UniversityBeijing 100084China Department of Engineering Science University of OxfordOxfordOX13UK

Cement is a widely used construction material *** manufacturing contributes to anthropogenic CO_(2)emissions ***,its alkaline compounds can absorb CO_(2)from the surrounding environment and engage in a carbonation reaction,thereby functioning as a carbon *** a major cement producer and consumer,China has an important responsibility to rigorously investigate and accurately account for cement carbon *** study presents a comprehensive analytical model of cement carbon uptake from China,revealing a substantial increase in carbon uptake from 1930 to 2021,peaking at 426.77 Mt CO_(2)(95% Confidence Interval:317.67-874.33 Mt CO_(2))in *** uptake accounts for 8.10% to 45.40% of China’s annual land sink and 2.51% to 4.54% of the global land *** cumulative carbon uptake by cement is approximately 7.06 Gt CO_(2)(95%CI:5.22–9.44 Gt CO_(2))during this period,offsetting 50.7% of the total emissions(13.91 Gt CO_(2),95%CI:12.44–17.00 Gt CO_(2))from the cement ***,cement mortar contributed to most absorption(65.64%).From a life cycle perspective,the service stage of cement materials is the period where the largest CO_(2)sink is formed,accounting for 90.03% of the ***,the potential for carbon sequestration in cement materials and their waste is ***,the model improves the accuracy of cement carbon accounting,supporting both China and global carbon neutrality ***,it is crucial for China to achieve its carbon neutrality goals sooner by prioritizing the environmental benefits of cement materials and wastes,and accelerating the development and commercialization of CO_(2)sequestration technologies for cement and its by-products.

关键词： Cement Carbon uptake Life cycle assessment Carbon emission reduction Carbon neutrality

Bioengineered skin organoids:from development to applications

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Military Medical Research 2024年第3期11卷 449-466页

作者： zi-Xuan Hong Shun-Tian Zhu Hao Li Jing-Zhi Luo Yu Yang Yang An xi wang Kai wang Department of Physiology and Pathophysiology School of Basic Medical SciencesState Key Laboratory of Vascular Homeostasis and RemodelingPeking UniversityBeijing 100191China Department of Hepatopancreatobiliary Surgery the Third Affiliated Hospital of Soochow UniversityChangzhou 213000JiangsuChina Department of Plastic Surgery Peking University Third HospitalBeijing 100191China Clinical Stem Cell Research Center Peking University Third HospitalBeijing 100191China State Key Laboratory of Cardiovascular Disease Fuwai HospitalBeijing 100037China Beijing Key Laboratory of Metabolic Disorder Related Cardiovascular Disease Capital Medical UniversityBeijing 100050China

Signifcant advancements have been made in recent years in the development of highly sophisticated skin *** as three-dimensional(3D)models that mimic human skin,these organoids have evolved into complex structures and are increasingly recognized as efective alternatives to traditional culture models and human skin due to their ability to overcome the limitations of two-dimensional(2D)systems and ethical *** inherent plasticity of skin organoids allows for their construction into physiological and pathological models,enabling the study of skin development and dynamic *** review provides an overview of the pivotal work in the progression from 3D layered epidermis to cyst-like skin organoids with ***,it highlights the latest advancements in organoid construction facilitated by state-of-the-art engineering techniques,such as 3D printing and microfuidic *** review also summarizes and discusses the diverse applications of skin organoids in developmental biology,disease modelling,regenerative medicine,and personalized medicine,while considering their prospects and limitations.

关键词： Skin organoid Organoid generation Skin appendage Tissue engineering Disease modelling Regenerative medicine

Genetic mechanism of body size variation in groupers:Insights from phylotranscriptomics

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Zoological Research 2024年第2期45卷 314-328页

作者： Wei-Wei Zhang Zhuo-Ying Weng xi wang Yang Yang Duo Li Le wang xiao-Chun Liu zi-Ning Meng State Key Laboratory of Biocontrol Institute of Aquatic Economic Animals and Guangdong Province Key Laboratory of Aquatic Economic AnimalsSchool of Life SciencesSun Yat-sen UniversityGuangzhouGuangdong 510275China Southern Laboratory of Ocean Science and Engineering(Zhuhai) ZhuhaiGuangdong 519000China Area of Ecology and Biodiversity School of Biological SciencesUniversity of Hong KongHong Kong SAR 999077China Molecular Population Genetics Group Temasek Life Sciences LaboratorySingapore City 117604Singapore

Animal body size variation is of particular interest in evolutionary biology,but the genetic basis remains largely *** studies have shown the presence of two parallel evolutionary genetic clusters within the fish genus Epinephelus with evident divergence in body size,providing an excellent opportunity to investigate the genetic basis of body size variation in ***,we performed phylotranscriptomic analysis and reconstructed the phylogeny of 13 epinephelids originating from the South China *** genetic clades with an estimated divergence time of approximately 15.4 million years ago were correlated with large and small body size,respectively.A total of 180 rapidly evolving genes and two positively selected genes were identified between the two *** enrichment analyses of these candidate genes revealed distinct enrichment categories between the two *** pathways and genes may play important roles in body size variation in groupers through complex regulatory *** on our results,we speculate that the ancestors of the two divergent groups of groupers may have adapted to different environments through habitat selection,leading to genetic variations in metabolic patterns,organ development,and lifespan,resulting in body size divergence between the two locally adapted *** findings provide important insights into the genetic mechanisms underlying body size variation in groupers and species differentiation.

关键词： Phylotranscriptomics Grouper Body size Rapidly evolving genes(REGs) Positively selected genes(PSGs)

Preparation of yttrium oxide coating with enhanced thermal shock resistance on refractories used for titanium alloy melting and casting

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Journal of Iron and Steel Research International 2024年第6期31卷 1411-1422页

作者： Ao Chen Yan Ma Zhou-fu wang Hao Liu xi-tang wang Sen-na Chen Chen-xin Zhang zi-yi Tang Wei-dong Fu Wei Cheng The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina xiangyang Juli High Technology Material Co. Ltd.Xiangyang 441705HubeiChina xiangyang Public Inspection and Testing Center Xiangyang 441000HubeiChina

In order to enhance the service life of refractories for melting and casting of titanium alloy,preparation of yttrium oxide coatings on the refractories surface is an effective *** improvement of thermal shock stability of the coating is beneficial to its spalling resistance during the high-temperature service,and the available slurry with good performance is the *** effects of the varieties and contents of dispersant(sodium tripolyphosphate,sodium hexametaphosphate,sodium pyrophosphate,citric acid and polycarboxylate ammonium salt)and binder(aluminum dihydrogen phosphate,zirconium acetate and yttria sol)on the stability,rheological and thixotropic properties of yttrium oxide waterbased slurry were investigated,and the effects of slurry composition design on the thermal shock resistance of the coating were *** results showed that the introduction of polycarboxylate ammonium salt as dispersant significantly improved the stability of the slurry,and the varieties of the binders had significant effects on the dispersibility of the *** aluminum dihydrogen phosphate and polycarboxylate ammonium salt were used as binder and dispersant,respectively,the slurry had better stability,suitable rheological and thixotropic *** using aluminum dihydrogen phosphate as binder,the coating had good thermal shock resistance and no obvious cracks were observed for the coating after thermal shock,which was attributed to the yttrium aluminate binding phase generated in the *** effective method was provided for preparing yttrium oxide coatings with enhanced thermal shock resistance applied in the process of titanium alloy melting and casting.

关键词： Yttrium oxide-Slurry Stability Rheological property Thixotropic property-Coating Thermal shock resistance

Boosting Hydrogen Storage Performance of MgH_(2) by Oxygen Vacancy-Rich H-V_(2)O_(5) Nanosheet as an Excited H-Pump

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Nano-Micro Letters 2024年第8期16卷 398-416页

作者： Li Ren Yinghui Li zi Li xi Lin Chong Lu Wenjiang Ding Jianxin Zou National Engineering Research Center of Light Alloys Net Forming&State Key Laboratory of Metal Matrix Composites Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China Shanghai Engineering Research Center of Mg Materials and Applications&School of Materials Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China Center of Hydrogen Science Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China Instrumental Analysis Center of SJTU Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

MgH_(2) is a promising high-capacity solid-state hydrogen storage material,while its application is greatly hindered by the high desorption temperature and sluggish ***,intertwined 2D oxygen vacancy-rich V_(2)O_(5) nanosheets(H-V_(2)O_(5))are specifically designed and used as catalysts to improve the hydrogen storage properties of MgH_(2).The as-prepared MgH_(2)-H-V_(2)O_(5) composites exhibit low desorption temperatures(Tonset=185℃)with a hydrogen capacity of 6.54 wt%,fast kinetics(Ea=84.55±1.37 kJ mol^(-1) H_(2) for desorption),and long cycling ***,hydrogen absorption can be achieved at a temperature as low as 30℃ with a capacity of 2.38 wt%within 60 ***,the composites maintain a capacity retention rate of~99%after 100 cycles at 275℃.Experimental studies and theoretical calculations demonstrate that the in-situ formed VH_(2)/V catalysts,unique 2D structure of H-V_(2)O_(5) nanosheets,and abundant oxygen vacancies positively contribute to the improved hydrogen sorption ***,the existence of oxygen vacancies plays a double role,which could not only directly accelerate the hydrogen ab/de-sorption rate of MgH_(2),but also indirectly affect the activity of the catalytic phase VH_(2)/V,thereby further boosting the hydrogen storage performance of MgH_(2).This work highlights an oxygen vacancy excited“hydrogen pump”effect of VH_(2)/V on the hydrogen sorption of Mg/MgH_(2).The strategy developed here may pave a new way toward the development of oxygen vacancy-rich transition metal oxides catalyzed hydride systems.

关键词： Hydrogen storage MgH_(2) V_(2)O_(5)nanosheets Oxygen vacancies VH_(2)

Chiral Phenol-2NO Ligand Cooperation with Achiral Organic Base in the Zn(II)-Catalyzed Asymmetric Alkylation Reaction of Indoles

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Chinese Journal of Chemistry 2024年第13期42卷 1474-1480页

作者： Ke-Lan Xu Yu-Heng wang xi-Rui wang Pan Hu Bo-Wen Pan Wen-Jing Zhang zi-Yue Chen Ying Zhou xiong-Li Liu National&Local Joint Engineering Research Center for the Exploitation of Homology Resources of Southwest Medicine and Food Guizhou UniversityGuiyangGuizhou 550025China College of Pharmaceutical Sciences Guizhou University of Traditional Chinese MedicineGuiyangGuizhou 550025China Green Catalysis Center and College of ChemistryZhengzhou UniversityZhengzhouHenan 450001China

The privileged C_(2)-symmetric rigid phenol-type ligand is more attractive but challenging in asymmetric ***,we designed and synthesized a class of rigid-featured chiral tridentate Phenol-2NO ligands,that incorporate the advantages of both the phenol skeleton and pyrroloimidazolone-based N-oxide moiety,from readily available L-prolinamides in operationally simple two steps and up to 44%overall *** importantly,using an achiral quinoline derivative as an additive,the newly developed Phenol-2NO ligand could serve as the anioic ligand upon deprotonative activation to coordinate to Zn(II)to form a highly enantioselective catalyst for the asymmetric Michael-type Friedel-Crafts alkylation reaction of indoles with 2,*** yields(up to 90%)and high enantioselectivities(up to 99%ee)are obtained for a wide range of substrates under mild *** and DFT calculations revealed the reaction mechanism and the origins of the *** also represented the first activation of phenol-type ligand/metal complex by an achiral organic base as the additive in asymmetric catalysis.

关键词： Phenol-2NO C_(2)-Symmetric Rigid-featured Tridentate ligand Asymmetric catalysis Alkylation Synthesis design Heterocycles

Thermodynamic and experimental study of high-temperature roasting of blast furnace gas ash for recovery of metallic zinc and iron

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Journal of Iron and Steel Research International 2024年第1期31卷 108-120页

作者： zi-han wang Jing Guo Han-jie Guo Bin Li School of Metallurgical Engineering University of Science and Technology BeijingBeijing100083China School of Metallurgical Engineering Xi’an University of Architecture and TechnologyXi’an710055ShaanxiChina

A high-temperature reduction roasting method was used to achieve metallic iron and zinc recovery from blast furnace gas ash(BFA).The reduction processes for Zn-containing and Fe-containing oxides were analyzed in detail by using ther-modynamic equilibrium calculation and the principle of minimum free *** results showed that the main reaction in the system is the reduction of ZnFe_(2)_(4)and iron *** the full temperature range,iron oxides were more easily reduced than zinc *** of the amount of CO contained in the system,the reduction of ZnO to Zn was difficult to proceed below the boiling point(906℃)of *** the reduction temperature is below 906℃,the reduction process of zinc ferrate was ZnFe_(2)_(4)→ZnO;when the reduction temperature is above 906℃,its reduction process becomed ZnFe_(2)_(4)→ZnO→Zn(g).The metallization and dezincification rates of the BFA gradually increased with increasing reaction *** the C/O ratio increased,the metallization and dezincification rates first increased and then *** effect of reduction time on BFA reduction was similar to that of reaction temperature.

关键词： Blast furnace gas ash Thermodynamics zinc removal Iron reduction High-temperature reduction roasting Integrated utilization