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Myricetin protects against lipopolysaccharide-induced disseminated intravascular coagulation by anti-inflammatory and anticoagulation effect

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Asian Pacific Journal of Tropical Medicine 2018年第3期11卷 255-259页

作者： Jing-Yi Tan Xue-qin Chen Bi-Jun Kang zi-xi qin Jia-Hong Chen Ren-Dong Hu Liang-Cai Wu Pharmacology Department of Basic Medical Sciences School of Medicine Jinan University The 6th Affiliated Hospital.Sun Yat-sen University

Objective: To explore the therapeutic effect and mechanism of myricctin on disseminated intravascular coagulation(DIC). Methods: The DIC model was established by injection of60 mg/kg LPS in KM mice, and the treatment groups were injected myricetin with different concentrations(25 or 50 mg/kg) 30 min before the model was established. Both coagulation indicators and organ function were tested, including PT, APTT, fibrinogen. AST, ALT. BUN and tissue section. In vitro, the inflammatory model of RAW 264.7 macrophage cells were established by 10 μg/mL LPS. The treatment group was treated with 50 μmol/mL myricetin for 30 min before LPS, and the expression of TNF-a and p-NF-KB was detected, further to explore the therapeutic mechanism. Results: LPS-induced DIC led to a reduction of fibrinogen and a rise of PT, APTT,AST, ALT, BUN levels, but the treatment of myricctin significantly inhibited these abnormalities. Histopathology analysis also revealed that myricetin remarkably protected the liver and renal damage. In vitro, the expression of TNF-α and p-NF-κB induced by LPS was repressed by myricetin. Conclusions: This study provides new insights into the protective effects of myricetin in LPS-induced DIC by anticoagulant and anti-inflammatory via suppressing the activation of p-NF-κB which decreased TNF-α level.

关键词： Myricetin Lipopolysaccharide Disseminated intravascular coagulation Anti-inflammatory Macrophages

Effects of Ti-and Nb-based transition element from single to multiple compound oxides and carbon-based composite additives on Mg-MgH2 hydrogen storage material

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Tungsten 2025年第1期7卷 32-49页

作者： Li-Rong xiao Chen Chen Shuo Wang zi-Yin Dai Hideo Kimura Cui Ni Chuan-xin Hou Xue-qin Sun Si-Jie Guo Wei Du xiu-Bo xie School of Environmental and Material Engineering Yantai University Bosch HUAYU Steering Systems (Yantai) Co. Ltd.Ytp/MFE University of Tennessee Knoxville Shandong Key Laboratory of Eco-Environmental Science for the Yellow River Delta Shandong University of Aeronautics

MgH2is considered as a promising hydrogen storage material for its high hydrogen storage capacity,low cost and abundant resource ***,the low kinetics and high enthalpy formation of MgH2limit its wide *** the perspective of adding catalysts to enhance the hydrogen storage properties of Mg-MgH2,this article elaborated the main catalysts based on Ti and Nb transition elements,including single oxide catalysts,binary oxides catalysts（combined with Ni,Na,Sr,V,etc.）,multiple catalysts bound to carbon,and composite catalysts with Ti and Nb elements combined with MXene ***,the main pathways of various catalysts to reduce the reaction activity and broaden the hydrogen desorption channel were also *** Ti-based catalysts can enhance the reactive sites of the matrix by forming multivalent states,while Nb-based catalysts broaden the hydrogen reaction channels by forming tiny *** improving the size structure and enhancing the grain size stability,combined with carbon materials should be the future considerations.

关键词： Catalysts Mg-based hydrogen storage alloys Solid hydrogen storage Transition metal elements

毛竹PheTCP19b基因可变剪接体对芽发育的影响

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农业生物技术学报 2025年第1期33卷 43-54页

作者：郝琴申孜闫小玲周敏舒郭小勤浙江农林大学竹子研究院/省部共建亚热带森林培育国家重点实验室

可变剪接(alternative splicing, AS)是一种转录后的修饰过程，在生物体各种生理过程中发挥重要作用。TCP是一种植物特有的转录因子，参与植物多种生长发育调控过程。为深入探究毛竹(Phyllostachys edulis) TCP19b基因可变剪接体的表达... 详细信息

可变剪接(alternative splicing, AS)是一种转录后的修饰过程，在生物体各种生理过程中发挥重要作用。TCP是一种植物特有的转录因子，参与植物多种生长发育调控过程。为深入探究毛竹(Phyllostachys edulis) TCP19b基因可变剪接体的表达特性及生物学功能，本研究采用RT-PCR技术克隆了毛竹TCP19b基因全长CDS，采用qRT-PCR技术和GUS组织染色分析了可变剪接体的表达量及表达部位，通过亚细胞定位及遗传转化分析了可变剪接体编码蛋白的定位及生物学功能。结果显示，毛竹PheTCP19b基因发生了可变剪接，产生了2种可变剪接体PheTCP19bα和PheTCP19bβ，分别编码346和382个氨基酸，2种可变剪接体都包含保守的bHLH结构域。PheTCP19b与水稻(Oryza sativa) OsTCP19亲缘关系最近。2个可变剪接体的组织特异性表达模式存在一定差异，PheTCP19bα的组织特异性强，而PheTCP19bβ表现出组成型表达特性，油菜素内酯(brassinolide, BR)可诱导2个可变剪接体的表达。2个可变剪接体蛋白均富集在细胞核。PheTCP19bα和PheTCP19bβ均可以将拟南芥(Arabidopsis thaliana) brc1突变体多分枝表型回补到野生型表型。本研究为进一步探讨PheTCP19b基因不同剪接体在芽发育过程中的分子机制提供了基础资料。

关键词：毛竹 TCP转录因子可变剪接(AS) 芽发育油菜素内酯(BR)

NANOG: A promising target for digestive malignant tumors

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World Journal of Gastroenterology 2014年第36期20卷 13071-13078页

作者： Ai-xi Sun Chang-Jiang Liu zi-qin Sun Zhi Wei Department of Gastroenterology The General Hospital of Jinan Military Command

NANOG has been extensively researched since its discovery by Chambers et al. NANOG is a homeodomain transcription factor and an essential regulator of embryonic stem cell(ESC) self-renewal, which inhibits differentiation. Cancer stem cells(CSCs) are a small subset of cells that are thought to drive uncontrolled tumor growth; CSCs retain the tumor capabilities of self-renewal and propagation. The existence of CSCs was recently shown by direct experimental evidence. NANOG is expressed in CSCs and ESCs, although it remains unclear whether ESCs and CSCs share similar mechanisms in the regulation of physical and biological processes. Several studies suggest that the expression level of NANOG is high in cancer tissues and low or absent in normal tissues. High levels of NANOG expression are associated with advanced stages of cancer and a poor prognosis, indicating that it plays a vital role in tumor transformation, tumorigenesis, and tumor metastasis. NANOG is part of a complex regulatory network that controls cell fate determination, proliferation, and apoptosis. NANOG cooperates with other regulators, such as microflora, transcription factors, and kinases, in cancer cells. NANOG might have a promising future in anti-cancer and other therapeutic treatments, which could improve human health.

关键词： NANOG Cancer stem cells Gastrointestinal tumor Anti-cancer

Screening-Assisted Dynamic Multiple Testing with False Discovery Rate Control

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Journal of Systems Science & Complexity 2023年第2期36卷 716-754页

作者： MUSHTAQ Iram ZHOU qin zi Xuemin School of Statistics and Data Science LPMC and KLMDASRNankai UniversityTianjin 300071China School of Mathematics and Statistics Jiangsu Normal UniversityXuzhou 221116China School of Science Tianjin University of Technology and EducationTianjin 300350China

In the era of big data,high-dimensional data always arrive in streams,making timely and accurate decision *** has become particularly important to rapidly and sequentially identify individuals whose behavior deviates from the *** at identifying as many irregular behavioral patterns as possible,the authors develop a large-scale dynamic testing system in the framework of false discovery rate(FDR)*** fully exploiting the sequential feature of datastreams,the authors propose a screening-assisted procedure that filters streams and then only tests streams that pass the filter at each time point.A data-driven optimal screening threshold is derived,giving the new method an edge over existing *** some mild conditions on the dependence structure of datastreams,the FDR is shown to be strongly controlled and the suggested approach for determining screening thresholds is asymptotically *** studies show that the proposed method is both accurate and powerful,and a real-data example is used for illustrative purpose.

关键词： Change-point false discovery rate high-dimensional datastreams large-scale inference sequential analysis weak dependence structure

Multiple Change Points Detection in High-Dimensional Multivariate Regression

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Journal of Systems Science & Complexity 2022年第6期35卷 2278-2301页

作者： MA xiaoyan ZHOU qin zi Xuemin School of Statistics and Data Science LPMC and KLMDASRNankai UniversityTianjin 300071China School of Mathematics and Statistics Jiangsu Normal UniversityXuzhou 221116China School of Science Tianjin University of Technology and EducationTianjin 300222China

This paper considers the problem of detecting structural changes in a high-dimensional regression setting. The structural parameters are subject to abrupt changes of unknown magnitudes at unknown locations. The authors propose a new procedure that minimizes a penalized least-squares loss function via a dynamic programming algorithm for estimating the locations of change points. To alleviate the computational burden, the authors adopt a prescreening procedure by eliminating a large number of irrelevant points before implementing estimation procedure. The number of change points is determined via Schwarz’s information criterion. Under mild assumptions, the authors establish the consistency of the proposed estimators, and further provide error bounds for estimated parameters which achieve almost-optimal rate. Simulation studies show that the proposed method performs reasonably well in terms of estimation accuracy, and a real data example is used for illustration.

关键词： Consistency dynamic programming low-rank structure multi-task learning nuclear norm

Efficiency of Profinite Rigidity of Triangle Groups

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Acta Mathematica Sinica,English Series 2022年第10期38卷 1939-1948页

作者： Ji Ming MA zi xi WANG School of Mathematical Sciences Fudan UniversityShanghai 200433P.R.China

It is already known that finitely-generated Fuchsian groups are profinitely rigid among all lattices of connected Lie groups by the result of Bridson,Conder and *** the triangle groups are distinguished among themselves by their finite *** focus on the question about quantifying the size of a quotient which separates two triangle groups and give an explicit upper bound.

关键词： Triangle groups profinite completion finite quotients

FAT10 level in human gastric cancer and its relation with mutant p53 level,lymph node metastasis and TNM staging

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World Journal of Gastroenterology 2009年第18期15卷 2228-2233页

作者： Feng Ji xi Jin Chun-Hua Jiao qin-Wei Xu zi-Wei Wang Yue-Liang Chen Department of Digestive Diseases First Affiliated Hospital of Zhejiang University Medical SchoolHangzhou 310003 Zhejiang Province China

AIM:To investigate the role of FAT10 and mutant p53 in the pathogenesis,severity and prognosis of gastric ***:FAT10,mutant p53 mRNA and protein levels were measured by reverse transcription(RT)-PCR and immunohistochemistry in gastric cancer tissue(n = 62),tumoradjacent tissue(n = 62) and normal gastric tissue(n = 62).Relation of FAT10 and mutant p53 expression with clinicopathological features and clinical outcomes of gastric cancer patients were ***:The FAT10,mutant p53 mRNA and protein levels were signif icantly higher in gastric cancer than in its adjacent and normal *** FAT10 and mutant p53 levels in gastric cancer tissue were significantly correlated with lymph node metastasis and tumor,nodes,metastasis(TNM) ***,the high FAT10 level was associated with the overall survival rate of *** Cox-proportional hazards model analysis showed that mRNA and protein levels of FAT10 and mutant p53,lymph node metastasis,distant metastasis and TNM stage were the independent prognostic factors for gastric ***:FAT10 may be involved in gastric carcinogenesis,and is a potential marker for the prognosis of gastric cancer ***10 and mutant p53 may play a common role in the carcinogenesis of gastric cancer.

关键词： Gastric cancer FAT10 Mutant p53 Prognosis

Flood management of Dongting Lake after operation of Three Gorges Dam

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Water Science and Engineering 2017年第4期10卷 303-310页

作者： xi-jun Lai zi-ming Wang Key Laboratory of Watershed Geographic Sciences Nanjing Institute of Geography&LimnologyChinese Academy of Sciences(CAS)Nanjing 210008China Zhejiang Institute of Hydraulics and Estuary Hangzhou 310020Chin

Full operation of the Three Gorges Dam(TGD) reduces flood risk of the middle and lower parts of the Yangtze River Basin. However,Dongting Lake, which is located in the Yangtze River Basin, is still at high risk for potentially severe flooding in the future. The effects of the TGD on flood processes were investigated using a hydrodynamic model. The 1998 and 2010 flood events before and after the operation of the TGD, respectively, were analyzed. The numerical results show that the operation of the TGD changes flood processes, including the timing and magnitude of flood peaks in Dongting Lake. The TGD can effectively reduce the flood level in Dongting Lake, which is mainly caused by the flood water from the upper reach of the Yangtze River. This is not the case, however, for floods mainly induced by flood water from four main rivers in the catchment. In view of this, a comprehensive strategy for flood management in Dongting Lake is required. Non-engineering measures, such as warning systems and combined operation of the TGD and other reservoirs in the catchment, as well as traditional engineering measures, should be further improved. Meanwhile, a sustainable philosophy for flood control, including natural flood management and lake restoration, is recommended to reduce the flood risk.

关键词： Three Gorges Dam Flood control Water level Hydrodynamic model Dongting Lake