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Journal of Electronic Science and Technology 2021年第1期19卷 1-5页

作者： zi-wei Wang Chi-Chang Chang Quan Zou The Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu 610054 the School of Medical Informatics Chung Shan Medical UniversityTaichuang 40201 Medical University Hospital Taichung 40201

The outbreak of coronavirus disease 2019(COVID-2019)has drawn public attention all over the *** a newly emerging area,single cell sequencing also exerts its power in the battle over the *** this review,the up-to-date knowledge of COVID-19 and its receptor is summarized,followed by a collection of the mining of single cell transcriptome profiling data for the information in aspects of the vulnerable cell types in humans and the potential mechanisms of the disease.

关键词： Coronavirus disease 2019(COVID-19) bioinformatics data mining single cell sequencing

Hydrogen peroxide sulfenylates and inhibits the photorespiratory enzyme PGLP1 to modulate plant thermotolerance

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Plant Communications 2024年第6期5卷 139-153页

作者： Zheng-wei Fu Feng Ding Bing-Lei Zhang Wen-Cheng Liu zi-Hong Huang Shi-Hang fan Yu-Rui Feng Ying-Tang Lu wei Hua Key Laboratory of Biology and Genetic Improvement of Oil Crops Ministry of Agriculture and Rural AffairsOil Crops Research Institute of the Chinese Academy of Agricultural SciencesWuhan 430062China State Key Laboratory of Hybrid Rice College of Life SciencesWuhan UniversityWuhan 430072China School of Landscape and Ecological Engineering Hebei University of EngineeringHandan 056038China State Key Laboratory of Crop Stress Adaptation and Improvement School of Life SciencesHenan UniversityKaifeng 475004China Hubei Hongshan Laboratory Wuhan 430070China

Climate change is resulting in more frequent and rapidly changing temperatures at both extremes that severely affect the growth and production of plants,particularly *** stress caused by high temperatures is one of the most damaging factors for ***,the role of hydrogen peroxide(H_(2)O_(2))in modulating plant thermotolerance is largely unknown,and the regulation of photorespiration essential for C3 species remains to be fully ***,we report that heat stress promotes H2O2 accumulation in chloroplasts and that H2O2 stimulates sulfenylation of the chloroplast-localized photorespiratory enzyme 2-phosphoglycolate phosphatase 1(PGLP1)at cysteine 86,inhibiting its activity and promoting the accumulation of the toxic metabolite *** also demonstrate that PGLP1 has a positive function in plant thermotolerance,as PGLP1 antisense lines have greater heat sensitivity and PGLP1-overexpressing plants have higher heat-stress tolerance than the wild ***,our results demonstrate that heat-induced H2O2 in chloroplasts sulfenylates and inhibits PGLP1 to modulate plant ***,targeting CATALASE2 to chloroplasts can largely prevent the heatinduced overaccumulation of H2O2 and the sulfenylation of PGLP1,thus conferring thermotolerance without a plant growth *** findings reveal that heat-induced H2O2 in chloroplasts is important for heat-caused plant damage.

关键词： heat stress photorespiration hydrogen peroxide PGLP1 2-phosphoglycolate

Screening of Amaranth Cultivars(Amaranthus mangostanus L.) for Cadmium Hyperaccumulation

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Agricultural Sciences in China 2009年第3期8卷 342-351页

作者： fan Hong-li ZHOU wei Key Laboratory of Crop Nutrition and Fertilization Ministry of Agriculture~Institute of Agricultural Resources and Regional PlanningChinese Academy of Agricultural Sciences Beijing 100081 P.R. China

The potential harm of soil cadmium pollution to ecological environment and human health has been increasingly widely concerned. Phytoremediation, as a kind of new and effective technology, has become an important method for cleaning up cadmium in contaminated sites. The amaranth （Amaranthus mangostanus L.） is widely distributed and has abundant varieties in China, its rapid growth and large biomass can be served as candidate for cadmium hyperaccumulators for phytoremediation. To obtain cadmium hyper-accumulator, Cd uptake in 23 amaranth cultivars from different ecological region was investigated under hydroponic culture condition. Meanwhile, pot experiment was established to probe phytoremediation potentiality of Cd contaminated soil by amaranth. Three treatment （Cd 5, 10, and 25 mg kg^-1） were imposed to red soil, yellow brown soil, and vegetable soil. The results showed that under hydroponic culture with Cd 3 mg L^-1, the cadmium concentration in the shoots of the cultivar Tianxingmi reached 260 mg kg^-1, and its total cadmium uptake was the highest among various cultivars. In the treatment Cd 25 mg kg^-1, the cadmium concentration in the shoots of the cultivar Tianxingmi reached 212 mg kg^-1, while bioaccumulation factor and shoot purification rate reached 8.50 and 3.8%, respectively. Further, the total biomass and shoot biomass were not decreased significantly under Cd exposure. These results suggested that cultivar Tianxingmi is a typical Cd hyperaccumulator, and can be expected to be used in phytoremediation of Cd contaminated soil.

关键词： cadmium hyperaccumulation amaranth phytoremediation

Chiral Isothiourea-Catalyzed Acylative Dynamic Kinetic Resolution of 3-Hydroxyphthalides for Enantioselective Synthesis of Phthalidyl Esters

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Chinese Journal of Chemistry 2024年第19期42卷 2341-2345页

作者： Zeyang Hao wei Lin zi-Qi Yuan wei Zhang Xin Li State Key Laboratory of Elemento-Organic Chemistry Collge of ChemistryNankai UniversityTianjin 300071China Haihe laboratory of Sustainable Chemical Transformations Tianjin 300192China West China School of Public Health and West China Fourth Hospital Sichuan UniversityChengduSichuan 610041China

Comprehensive Summary Phthalides serve as core structures pervasive in a wide array of natural products and drug molecules,which display a diverse array of biological *** report herein a highly efficient dynamic kinetic resolution of 3-hydroxyphthalides by chiral isothioureas(ITUs)catalyzed asymmetric acylation,facilitating the effective synthesis of a variety of chiral phthalidyl esters with good yields and ***,this reaction features mild reaction conditions,expansive substrate scope as well as good functional group *** addition,the practicality of this method is underscored by the large-scale synthesis,reduced catalyst loading experiment and the synthesis of the chiral phthalidyl ester prodrug.

关键词： Asymmetric catalysis Phthalidyl ester Dynamic kinetic resolution Chiral isothiourea Acylation Methodology and reactions Syntheticmethods

Actin Dynamics Regulates Voltage-Dependent Calcium-Permeable Channels of the Vicia faba Guard Cell Plasma Membrane

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Journal of Integrative Plant Biology 2009年第10期51卷 912-921页

作者： wei Zhang Liu-Min fan National Laboratory of Plant Physiology and Biochemistry College of Biological Sciences China Agricultural University Beijing 100094 China School of Life Sciences Shandong University Jinan 250100 China peking-Yale Joint Center for Plant Molecular Genetics and Agro-Biotechnology National Laboratory of Protein Engineering and Plant Genetic Engineering College of Life Sciences Peking University Beijing 100871 China

Free cytosolic Ca^2＋（[Ca^2＋]cyt） is an ubiquitous second messenger in plant cell signaling, and [Ca^2＋]cyt elevation is associated with Ca^2＋-permeable channels in the plasma membrane and endomembranes regulated by a wide range of stimuli. However, knowledge regarding Ca^2＋ channels and their regulation remains limited in planta. A type of voltage- dependent Ca^2＋-permeable channel was identified and characterized for the Vicia faba L. guard cell plasma membrane by using patch-clamp techniques. These channels are permeable to both Ba^2＋ and Ca^2＋, and their activities can be inhibited by micromolar Gd^3＋. The unitary conductance and the reversal potential of the channels depend on the Ca^2＋ or Ba^2＋ gradients across the plasma membrane. The inward whole-cell Ca^2＋（Ba^2＋） current, as well as the unitary current amplitude and NPo of the single Ca^2＋ channel, increase along with the membrane hyperpolarization. Pharmacological experiments suggest that actin dynamics may serve as an upstream regulator of this type of calcium channel of the guard cell plasma membrane. Cytochalasin D, an actin polymerization blocker, activated the NPo of these channels at the single channel level and increased the current amplitude at the whole-cell level. But these channel activations and current increments could be restrained by pretreatment with an F-actin stabilizer, phalloidin. The potential physiological significance of this regulatory mechanism is also discussed.

关键词： actin dynamics calcium-permeable channels guard cell patch clamp plasma membrane Vicia faba.

In the THALES Trial, Past, Present, and Future Meet

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Neuroscience Bulletin 2021年第4期37卷 588-591页

作者： zi-Xiao Li Xue-wei Xie Ying Xian Vascular Neurology Department of NeurologyBeijing Tiantan HospitalCapital Medical UniversityBeijing100070China China National Clinical Research Center for Neurological Diseases Beijing100070China Chinese Institute for Brain Research Beijing100070China Department of Neurology Duke University Medical CenterDurhamNC27701USA

Patients with minor ischemic stroke or a high-risk transient ischemic attack (TIA) face a high risk of recurrent stroke or other vascular events. The risk is particularly high in the first few weeks after the index event. Dual antiplatelet therapy (DAPT),comprising clopidogrel and aspirin, is an effective strategy for reducing recurrence.

关键词： DAPT Patients aspirin

Cognitive dysfunction in schizophrenia patients caused by downregulation of γ-aminobutyric acid receptor subunits

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World Journal of Psychiatry 2024年第6期14卷 784-793页

作者： Xi Chen Ya-Nan Zhou Xiao-zi Lu Ren-Jiao Li Yi-fan Xiong Xia Sheng wei-wei Zhu Department of Child and Adolescent Psychiatric Brain Hospital of Hunan ProvinceThe Second People’s Hospital of Hunan ProvinceChangsha 410007Hunan ProvinceChina Department of Psychiatry Qingdao Mental Health CenterQingdao 266034Shandong ProvinceChina Department of Psychiatry Brain Hospital of Hunan ProvinceThe Second People’s Hospital of Hunan ProvinceChangsha 410007Hunan ProvinceChina Department of Sleep Disorders and Neurosis Brain Hospital of Hunan ProvinceThe Second People’s Hospital of Hunan ProvinceChangsha 410007Hunan ProvinceChina

BACKGROUND The expression pattern of gamma aminobutyric acid(GABA)receptor subunits are commonly altered in patients with schizophrenia,which may lead to nerve excitation/inhibition problems,affecting cognition,emotion,and *** To explore GABA receptor expression and its relationship with schizophrenia and to provide insights into more effective *** This case-control study enrolled 126 patients with schizophrenia treated at our hospital and 126 healthy volunteers who underwent physical examinations at our hospital during the same *** expression levels of the GABA receptor subunits were detected using 1H-magnetic resonance *** recognized cognitive battery tool,the MATRICS Consensus Cognitive Battery,was used to evaluate the scores for various dimensions of cognitive *** correlation between GABA receptor subunit downregulation and schizophrenia was also *** Significant differences in GABA receptor subunit levels were found between the case and control groups(P0.05).CONCLUSION Downregulation of the GABA receptor subunits is positively correlated with *** other words,when GABA receptor subunits are downregulated in patients,cognitive impairment becomes more severe.

关键词： Cognitive function Schizophrenia Downregulation Gamma-aminobutyric acid receptor subunits Correlation

Transformation of hydroxylated and methoxylated 2,2′,4,4′,5-brominated diphenyl ether(BDE-99) in plants

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Journal of Environmental Sciences 2016年第11期28卷 197-202页

作者： Lili Pan Jianteng Sun Xiaodan Wu zi wei Lizhong Zhu Department of Environmental Science Zhejiang University Hangzhou 310058 China. Zhejiang Provincial Key Laboratory of Organic Pollution Process and Control Hangzhou 310058 China Analysis and Measurement Center Zhejiang University Hangzhou 310058 China

The occurrence and fate of hydroxylated polybrominated diphenyl ethers（OH-PBDEs） and methoxylated polybrominated diphenyl ethers（Me O-PBDEs） have received significant attention. However, there is limited information on the metabolism relationship between OH-pentaB DEs and MeO-pentaB DEs that were frequently detected with relatively high concentrations in the environment. In this study, the biotransformation between OH-BDE-99 and MeO-BDE-99 was investigated in rice, wheat, and soybean plants. All the three plants can metabolize OH-BDE-99 to corresponding homologous methoxylated metabolites, while the transformation from MeO-BDE-99 to OH-BDE-99 could only be found in soybean. The conversion of parent compounds was the highest in soybean, followed by wheat and rice. Transformation products were found mainly in the roots, with few metabolites being translocated to the shoots and solution after exposure. The results of this study provide valuable information for a better understanding of the accumulation and transformation of OH-PBDEs and MeO-PBDEs in different plants.

关键词： OH-PBDEs MeO-PBDEs Biotransformation Plant

Increased BnaMFT-transcript level is associated with secondary dormancy in oilseed rape (Brassica napus L.)

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Journal of Integrative Agriculture 2020年第6期19卷 1565-1576页

作者： LIU Lei fan Wen-qi LIU Fu-xia YI Xin TANG Tang ZHOU Ying TANG zi-wei CHEN Guimin ZHAO Xiang-xiang Jiangsu Key Laboratory for Eco-agriculture Biotechnology Around Hongze Lake/Jiangsu Collaborative Innovation Center of Regional Modern Agriculture and Environment Protection/College of Life Science Huaiyin Normal UniversityHuai'an 223300P.R.China School of Food Science and Engineering Yangzhou UniversityYangzhou 225127P.R.China

Brassica napus cultivars have little or no primary dormancy;however,they are prone to sec on dary dorma ncy in ducti *** dormant seeds can produce volunteer plants,which can result in genetic contamination,reduced quality and biosafety ***,informati on regarding the molecular mecha nism un derlyi ng sec on dary dormancy is *** MOTHER OF FT AND TFL1(MFT)gene,which is evolutionarily conserved in the plant kingdom,acts in a complex gene network in the seed dormancy or germination *** this study,we identified four *** genes that share high homology with AtMFT,named as *** of c/s-acting elements showed that BnaMFT promoters contain multiple seed-specific regulatory elements,and various stress-and hormone-responsive *** experiments validated that BnaMFTs were specifically expressed during seed maturation and in the dry seed,with peaks at 35-42 days after *** were not sufficient for primary dormancy;however,they were significantly enhanced by secondary dormancy induction with PEG6000 ***,BnaMFTtranscripts were elevated by treatment with abscisic acid(ABA),which is known to be accumulated duri ng sec on dary dorma *** results collectively suggest that increased BnaMFT tra nscription levels are associated with sec on dary dorma ncy inducti on in an ABA-depe ndent mariner in ***.

关键词： Brassica napus DELAY OF GERMINATION 1(DOG7) MFT primary dormancy secondary dormancy