检索结果-南通市图书馆

Zuo Gui Wan Promotes Osteogenesis via PI3K/AKT Signaling Pathway:Network Pharmacology Analysis and Experimental Validation

在线全文

学校读者我要写书评

暂无评论

Current Medical Science 2023年第5期43卷 1051-1060页

作者： Shuo YANG Bin ZHANG Yu-guo WANG zi-wei liu Bo QIAO Juan XU Li-sheng ZHAO Department of Stomatology The First Medical CenterChinese PLA General HospitalBeijing 100853China Department of Traditional Chinese Medicine Chinese PLA General HospitalBeijing 100853China

Objective Osteogenesis is vitally important for bone defect repair,and Zuo Gui Wan(ZGW)is a classic prescription in traditional Chinese medicine(TCM)for strengthening ***,the specific mechanism by which ZGW regulates osteogenesis is still *** current study is based on a network pharmacology analysis to explore the potential mechanism of ZGW in promoting *** A network pharmacology analysis followed by experimental validation was applied to explore the potential mechanisms of ZGW in promoting the osteogenesis of bone marrow mesenchymal stem cells(BMSCs).Results In total,487 no-repeat targets corresponding to the bioactive components of ZGW were screened,and 175 target genes in the intersection of ZGW and osteogenesis were *** 28 core target genes were then obtained from a PPI network analysis.A GO functional enrichment analysis showed that the relevant biological processes mainly involve the cellular response to chemical stress,metal ions,and ***,KEGG pathway enrichment analysis revealed that multiple signaling pathways,including the phosphatidylinositol-3-kinase/protein kinase B(PI3K/AKT)signaling pathway,were associated with ZGW-promoted *** experimental validation showed that ZGW could increase alkaline phosphatase(ALP)activity as well as the mRNA and protein levels of ALP,osteocalcin(OCN),and runt related transcription factor 2(Runx 2).What’s more,Western blot analysis results showed that ZGW significantly increased the protein levels of p-PI3K and p-AKT,and the increases of these protein levels significantly receded after the addition of the PI3K inhibitor ***,the upregulated osteogenic-related indicators were also suppressed by the addition of *** ZGW promotes the osteogenesis of BMSCs via PI3K/AKT signaling pathway.

关键词： Zuo Gui Wan network pharmacology bone marrow mesenchymal stem cells osteogenesis PI3K/AKT signaling pathway

High Performance Microwave Absorption Material Based on Metal-Backboned Polymer

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2024年第12期42卷 1881-1887,I0006页

作者： Jia-Ning Xu Kai-Wen Zeng Yi-Feng Zhang Yi-Bei Yang zi-wei liu Yue liu Jia-Jia Wang Kai-Lin Zhang Yan-Ru-Zhen Wu Hao Sun Hui-Sheng Peng State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular ScienceInstitute of Fiber Materials and Devicesand Laboratory of AdvancedMaterialsFudanUniversityShanghai200438China Frontiers Science Center for Transformative Molecules Schoolof Chemistry and Chemical Engineeringand Zhangjiang Institute for Advanced StudyShanghai JiaoTongUniversityShanghai200240China

Metal-backboned polymers with anisotropy microstructures are promising for conductive,optoelectronic,and magnetic functional ***,the structure-property relationships governing the interplay between the chemical structure and electromagnetic property of the metal-backboned polymer have been rarely *** we report a carbon/nickel hybrid from metal-backboned polymer to serve as electromagnetic wave-absorbing materials,which exhibit high microwave absorption capacity and tunable absorption *** presence of nickel backbones promote the generation of heterogeneous interfaces with carbon during calcination,thereby enhancing the wave-absorbing capacity of the carbon/nickel *** C/Ni hybrids show a minimal reflection loss of-49.1 dB at 13.04 GHz,and its frequency of the absorption band can be adjusted by controlling the thickness of the absorption layer.

关键词： Nickel Metal-backboned polymer Carbon Hybrid material

Laser-direct-writing of 3D self-supported NiS2/MoS2 heterostructures as an efficient electrocatalyst for hydrogen evolution reaction in alkaline and neutral electrolytes

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Catalysis 2019年第8期40卷 1147-1152页

作者： Peng-Fei Cheng Ting Feng zi-wei liu De-Yao Wu Jing Yang Institute of New-Energy Materials Key Laboratory of Advanced Ceramics and Machining Technology of Ministry of EducationSchool of Materials Science and EngineeringTianjin UniversityTianjin 300072China

Searching for low-cost widely applicable electrocatalysts for hydrogen production is very important. Here, 3D self-supported NiS2/MoS2 heterostructures were synthesized via a one-step millisecond- laser-direct-writing method;these structures exhibited excellent hydrogen evolution reaction activities over a wide pH range. The current density of 10 mA cm^-2 could be reached at low overpotentials of 98 and 159 mV in alkaline and neutral electrolytes, respectively. Such an outstanding electrocatalytic performance should be attributed to the integration of the 3D self-supported nanostructures, the high conductivity of the framework, and particularly, the incalculable heterointerfaces formed between NiS2 and MoS2. This work provides a new strategy to study interfacial engineering and the mechanism of interface enhancement.

关键词： Heterostructure Hydrogen evolution reaction Laser-direct-writing

MASS SPECTROMETRY SYNTIIESIS OF PHENYL COBALT TETRAPHENYI. PORPHYRIN

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 1991年第10期2卷 797-800页

作者： Xiang GAO zi Yang liu wei Ping JIA Shu Ying liu Changchun Institute of Applied Chemistry Chinese Academy Of Sciences, Changchun, 130022

It has been found that phenyl cobalt tetraphenylporphyrin (C_6H_5Cotpp) was formed when cobalt tetraphenylporphyrin (Cotpp) and benzene were introduced into the ion source of mass spectrometer, the mass spectra of Cot... 详细信息

关键词： Co MASS SPECTROMETRY SYNTIIESIS OF PHENYL COBALT TETRAPHENYI PORPHYRIN 555 Bell

Genetic variation of the 8-kDa glycoprotein family from Echinococcus granulosus, Taenia multiceps and Taenia hydatigena

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2011年第18期124卷 2849-2856页

作者： JIA Wan-zhong YAN Hong-bin LOU Zhong-zi NI Xing-wei liu Hong-xia LI Hong-min GUO Ai-jiang FU Bao-quan State Key Laboratory of Veterinary Etiological Biology KeyLaboratory of Veterinary Parasitology of Gansu Province KeyLaboratory of Veterinary Public Health of Ministry of AgricultureLanzhou Veterinary Research Institute Chinese Academy ofAgricultural Sciences Lanzhou Gansu 730046 China

Background Echinococcosis, coenurosis and cysticercosis are debilitating diseases which prevail in China. Immunological diagnosis of metacestodosis is important in disease control. The 8-kDa glycoproteins from taeniid cestodes have successfully been used for diagnosis of human cysticercosis in immunological assays. The aim of the present study was to investigate genetic variations and phylogenetic relationships of the 8-kDa proteins for evaluating the possibility of utilizing these proteins as diagnostic antigens for other metacestode infections. Methods The genes and complementary DNAs （cDNAs） encoding the 8-kDa proteins from Echinococcus （E.） granulosus, Taenia （T.） multiceps and T. hydatigena were amplified using PCR method. Their amplicons were cloned into the vector pMD18 and the positive clones were sequenced. Sequence data were analyzed with the SeqMan program, and sequence homology searches were performed using the BLAST program. Alignments were conducted using the ClustalX program, and the phylogenetic analyses were performed with the Protein Sequences Program and the Puzzle Program using the Neighbor-joining method. Results Fifteen, 18 and 22 different genomic DNA sequences were identified as members of the 8-kDa protein gene family from E. granulosus, T. multiceps and T. hydatigena, respectively. Eight, four and six different cDNA clones respectively from E. granulosus, T. multiceps and T. hydatigena were characterized. Analysis of these sequences revealed 54 unique 8-kDa protein sequences. Phylogenetic trees demonstrated that the taeniid 8-kDa proteins are clustered into eight clades at least： Ts18, Ts14, TsRS1, TsRS2, T8kDa-1, T8kDa-2, T8kDa-3 and T8kDa-4. Conclusion We found that the gene family encoding for the taeniid 8-kDa antigens is comprised of many members with high diversity, which will provide molecular evidence for cross-reaction or specific reaction among metacestode infections and may contribute to the development of promising immunological

关键词： Echinococcus granulosus Taenia multiceps Taenia hydatigena 8-kDa glycoprotein genetic variation

Three-dimensional fracture of UO2 ceramic pellets by phase field modeling

在线全文

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 169-180页

作者： wei Xiong Xuan Ye Hongzhang Cheng Xiaoming liu Institute of Nuclear and New Energy Technology Collaborative Innovation Center of Advanced Nuclear Energy Technology Key Laboratory of Advanced Reactor Engineering and Safety of Ministry of Education Tsinghua University State Key Laboratory of Nonlinear Mechanics Institute of Mechanics Chinese Academy of Sciences School of Engineering Science University of Chinese Academy of Sciences

Fracture is the primary failure type for the UO2ceramic pellets,which are operated under irradiation and thermal processes,and physically confined by the *** this work,by combining closely coupled physical processes of heat conduction,heat transfer,and mechanical deformation with the cohesive phase field framework,we proposed a high-precision modeling of quasistatic cracking of three-dimensional （3D） UO2ceramic fuel pellets under high temperature and *** simulation results agree well with the experimental results,indicating that the proposed method has the potential to capture 3D crack modes in the interested time ***,we studied the relation of the 3D fracture patterns of fuel pellets with the peak power *** was found that the power level plays a critical role in determining the competition between radial and circumferential cracks,as well as transverse penetrating cracks.

关键词： phase field method nuclear fuel pellet coupled thermo-mechanical model thermal fracture

Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第1期20卷 6-20页

作者： Xiu-Yun Zhao De-En Xu Ming-Lei Wu Ji-Chuan liu zi-Ling Shi Quan-Hong Ma Department of Neurology and Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular *** reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and *** this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular *** also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative *** summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve *** review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.

关键词： autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response

PI3K/AKT signaling and neuroprotection in ischemic stroke:molecular mechanisms and therapeutic perspectives

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第10期20卷 2758-2775页

作者： Tianlong liu Xiaolin Li Xiaowei Zhou wei Chen Aidong Wen Minna liu Yi Ding Department of Pharmacy Xijing HospitalFourth Military Medical UniversityXi’anShaanxi ProvinceChina Department of Pharmacy The 940 Hospital of Joint Logistics Support Forces of Chinese PLALanzhouGansu ProvinceChina Department of Pharmacy The 944 Hospital of Joint Logistics Support Forces of Chinese PLAJiuquanGansu ProvinceChina Department of Nephrology The 940 Hospital of Joint Logistics Support Forces of Chinese PLALanzhouGansu ProvinceChina

It has been reported that the PI3K/AKT signaling pathway plays a key role in the pathogenesis of ischemic *** a result,the development of drugs targeting the PI3K/AKT signaling pathway has attracted increasing attention from *** article reviews the pathological mechanisms and advancements in research related to the signaling pathways in ischemic stroke,with a focus on the PI3K/AKT signaling *** key findings include the following:(1)The complex pathological mechanisms of ischemic stroke can be categorized into five major types:excitatory amino acid toxicity,Ca^(2+)overload,inflammatory response,oxidative stress,and apoptosis.(2)The PI3K/AKT-mediated signaling pathway is closely associated with the occurrence and progression of ischemic stroke,which primarily involves the NF-κB,NRF2,BCL-2,mTOR,and endothelial NOS signaling pathways.(3)Natural products,including flavonoids,quinones,alkaloids,phenylpropanoids,phenols,terpenoids,and iridoids,show great potential as candidate substances for the development of innovative anti-stroke medications.(4)Recently,novel therapeutic techniques,such as electroacupuncture and mesenchymal stem cell therapy,have demonstrated the potential to improve stroke outcomes by activating the PI3K/AKT signaling pathway,providing new possibilities for the treatment and rehabilitation of patients with ischemic *** investigations should focus on the direct regulatory mechanisms of drugs targeting the PI3K/AKT signaling pathway and their clinical translation to develop innovative treatment strategies for ischemic stroke.

关键词： apoptosis autophagy inflammation ischemic stroke neuroprotection oxidative stress pathogenesis phosphatidylinositol 3-kinase protein kinase B therapeutics

Neuroprotective potential for mitigating ischemia-reperfusion-induced damage

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第8期20卷 2199-2217页

作者： zi Ye Runqing liu Hangxing Wang Aizhen Zuo Cen Jin Nan Wang Huiqi Sun Luqian Feng Hua Yang The Clinical Medical College Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Division of Infectious Diseases Department of Internal MedicinePeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina School of Medical Imaging Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Division of Gastroenterology First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina The Second Clinical Medical College Lanzhou UniversityLanzhouGansu ProvinceChina Department of Neurosurgery Affiliated Hospital of Guizhou Medical UniversityGuiyangGuizhou ProvinceChina

Reperfusion following cerebral ischemia causes both structural and functional damage to brain tissue and could aggravate a patient's condition;this phenomenon is known as cerebral ischemia-reperfusion *** studies have elucidated the neuroprotective role of the sirtuin protein family(Sirtuins)in modulating cerebral ischemia-reperfusion ***,the potential of utilizing it as a novel intervention target to influence the prognosis of cerebral ischemia-reperfusion injury requires additional *** this review,the origin and research progress of Sirtuins are summarized,suggesting the involvement of Sirtuins in diverse mechanisms that affect cerebral ischemia-reperfusion injury,including inflammation,oxidative stress,blood-brain barrier damage,apoptosis,pyroptosis,and *** therapeutic avenues related to Sirtuins that may improve the prognosis of cerebral ischemia-reperfusion injury were also investigated by modulating Sirtuins expression and affecting representative pathways,such as nuclear factor-kappa B signaling,oxidative stress mediated by adenosine monophosphate-activated protein kinase,and the forkhead box *** review also summarizes the potential of endogenous substances,such as RNA and hormones,drugs,dietary supplements,and emerging therapies that regulate Sirtuins *** review also reveals that regulating Sirtuins mitigates cerebral ischemia-reperfusion injury when combined with other risk *** Sirtuins show promise as a potential target for the treatment of cerebral ischemiareperfusion injury,most recent studies are based on rodent models with circadian rhythms that are distinct from those of humans,potentially influencing the efficacy of Sirtuinstargeting drug ***,this review provides new insights into the role of Sirtuins in the pathology and treatment of cerebral ischemia-reperfusion injury.

关键词： apoptosis autophagy blood-brain barrier dietary supplements drug hormones inflammation neuroprotection oxidative stress prognosis pyroptosis reperfusion injury risk factors RNA therapeutics