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Influence of the continuing COVID-19 epidemic on sleep quality and psychological status of healthcare workers in private institutions

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World Journal of Psychiatry 2024年第10期14卷 1495-1505页

作者： Man-In Ho Zhe-Hao wu Yu-Ying Chen Weng-Io Leong Jue Wang Hua Zhou zi-tuo wu Ying-Qi Mao Jia-An Du Yi Zheng Yi Yu Paulo Do Lago Comandante Li-Li Yu Qi-Biao wu Faculty of Chinese Medicine Medical Sciences DivisionMacao University of Science and TechnologyMacao 999078China Department of Child Rehabilitation Children Health CareJieyang Women Infant Health Care HospitalJieyang 522000Guangdong ProvinceChina Macao Association for Analytical Psychology Macao 999078China The State Key Laboratory of Quality Research in Chinese Medicine Macao University of Science and TechnologyMacao 999078China State Key Laboratory of Dampness Syndrome of Chinese Medicine The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510006Guangdong ProvinceChina Guangdong Provincial Hospital of Chinese Medicine Guangdong Provincial Academy of Chinese Medical SciencesGuangzhou 511400Guangdong ProvinceChina Chinese Medicine Guangdong Laboratory(Hengqin Laboratory) Guangdong-Macao In-Depth Cooperation Zone in HengqinHengqin 519000Guangdong ProvinceChina University Hospital Macao University of Science and TechnologyMacao 999078China Department of Rehabilitation The First Affiliated Hospital of Zhejiang Chinese Medical University(Zhejiang Provincial Hospital of Chinese Medicine)Hangzhou 310006Zhejiang ProvinceChina Department of Clinical Nutrition The Second Affiliated Hospital of Zhejiang Chinese Medical UniversityXinhua Hospital of Zhejiang ProvinceHangzhou 310000Zhejiang ProvinceChina Associação dos Investigadores Praticantes e Promotores da Medicina Chinesa de MacaoMacao 999078China Zhuhai MUST Science and Technology Research Institute Macao University of Science and TechnologyZhuhai 519099Guangdong ProvinceChina Guangdong-Hong Kong-Macao Joint Laboratory for Contaminants Exposure and Health Guangdong University of TechnologyGuangzhou 510000Guangdong ProvinceChina

BACKGROUND On January 22,2020,Macao reported its first case of coronavirus disease 2019(COVID-19)*** August 2021,the situation had escalated into a crisis of community *** response,the government launched a recruitment campaign seeking assistance and services of healthcare workers(HCWs)from the private sector throughout *** participants faced concerns about their own health and that of their families,as well as the responsibility of maintaining public health and *** study aims to determine whether the ongoing epidemic has caused them physical and psychological *** To examine the influence of COVID-19 on the sleep quality and psychological status of HCWs in private institutions in Macao during the *** Data were collected from December 2020 to January *** consecutive surveys were *** Pittsburgh Sleep Quality Index(PSQI)scale,Self-Rating Anxiety Scale(SAS),and Self-Rating Depression Scale(SDS)were employed as investigation *** In the first-stage survey,32%of HCWs experienced a sleep disorder,compared to 28.45%in the second-stage survey.A total of 31.25%of HCWs in the first-stage survey and 28.03%in the second had varying degrees of anxiety.A total of 50.00%of HCWs in the first-stage survey and 50.63%in the second experienced varying degrees of *** difference in PSQI scores,SAS scores,or SDS scores were observed between the two surveys,indicating that the COVID-19 epidemic influenced the sleep quality and psychological status of *** negative influence persisted over both periods but did not increase remarkably for more than a ***,a positive correlation was observed between the PSQI,SAS,and SDS scores(r=0.428-0.775,P<0.01),indicating that when one of these states deteriorated,the other two tended to deteriorate as *** The sleep quality,anxiety,and depression of HCWs in private institution in Macao were affected by the COVID-19 *** these fac

关键词： COVID-19 Healthcare workers Sleep quality Anxiety Depression Psychological status

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Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

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Neural Regeneration Research 2025年第1期20卷 6-20页

作者： Xiu-Yun Zhao De-En Xu Ming-Lei wu Ji-Chuan Liu zi-Ling Shi Quan-Hong Ma Department of Neurology and Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular *** reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and *** this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular *** also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative *** summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve *** review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.

关键词： autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response

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Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

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Science China Chemistry 2025年第1期68卷 288-296页

作者： Shuai Liu Wen-Qiang Xu Ying-Tong Di Man-Cheng Tang Ding-Kang Chen Ming-Ming Cao Yao-Wen Chang Hong-Yu Tang Chun-Mao Yuan Jun-Bo Yang Zhi-Li Zuo Han Guo zi-Fei Xu Ying Zeng Yun-Dong wu Xiao-Jiang Hao Key Laboratory of Phytochemistry and Natural Medicines (Chinese Academy of Sciences) Kunming Institute of Botany Chinese Academy of Sciences University of Chinese Academy of Sciences Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical Oncogenomics Peking University Shenzhen Graduate School Shenzhen Bay Laboratory State Key Laboratory of Microbial Metabolism School of Life Sciences & Biotechnology Shanghai Jiao Tong University State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University Molecular Biology Experimental Center Germplasm Bank of Wild Species in Southwest China Kunming Institute of Botany Chinese Academy of Sciences Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of Botany Chinese Academy of Sciences Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical Sciences

In the intricate process of natural product biosynthesis, a metabolon can enhance metabolic flux by associating sequential enzymes. A fungal metabolon, comprising of flavin-dependent monooxygenase Spe F and P450 monooxygenase Spe G, is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide B. Using notoamide E as a substance, Spe F/Spe G metabolon can control the stereoselectivity of its 2,3-epoxidation, followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-m A with dienyl iminium unit. Subsequently,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol rearrangement. This provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

关键词： metabolon Diels-Alder reaction semipinacol rearrangement biosynthesis notoamides spiro polycyclic alkaloids

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基于机器学习筛选猪活体肌内脂肪含量间接选育和构建预测模型的关键性状

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南京农业大学学报 2025年第1期48卷 161-170页

作者：吴建杨文孟孜查成万吴望军南京农业大学动物科技学院江苏南京210095

[目的]本研究旨在探究猪断奶重、屠宰前活体重、背膘厚等性状因素对猪肌内脂肪(intramuscular fat,IMF)含量的影响,确定影响猪IMF含量的关键性状因素。[方法]以805头皮特兰×[杜洛克×(长白×大白)]四元商品猪群为试验对象,记录性别,测... 详细信息

[目的]本研究旨在探究猪断奶重、屠宰前活体重、背膘厚等性状因素对猪肌内脂肪(intramuscular fat,IMF)含量的影响,确定影响猪IMF含量的关键性状因素。[方法]以805头皮特兰×[杜洛克×(长白×大白)]四元商品猪群为试验对象,记录性别,测定初生重、断奶重、屠宰前活体重和IMF含量等14个性状,然后通过相关性分析从14个性状中初步筛选出影响IMF含量的性状因素,再通过随机森林模型评估各性状因素对IMF含量影响的重要性,进一步通过LASSO回归和逐步回归筛选出影响IMF含量的关键性状因素;在此基础上,利用广义线性模型(generalized linear model,GLM)分析关键性状因素不同水平对IMF含量的影响。[结果]相关性分析结果显示,猪IMF含量与断奶重(r=0.13, P0.05)。胸腰椎结合处背膘厚大于26 mm组的平均IMF含量(2.73%)显著高于其他背膘厚组(P0.05)。[结论]本研究通过机器学习确定了性别、断奶重、屠宰前活体重和胸腰椎结合处背膘厚4个与IMF含量显著相关的活体可测定性状,并发现平均IMF含量随着屠宰前活体重和胸腰椎结合处背膘厚的增加呈明显的上升趋势。

关键词：猪肌内脂肪间接选择模型构建机器学习活体可测定性状

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Effect of Al_(2)O_(3) content on the viscosity and structure of CaO-SiO_(2)-Cr_(2)O_(3)-Al_(2)O_(3) slags

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International Journal of Minerals,Metallurgy and Materials 2022年第8期29卷 1522-1531页

作者： Fang Yuan Zheng Zhao Yanling Zhang tuo wu State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China

The effect of Al_(2)O_(3) content on the viscosity and structure of CaO-SiO_(2)-Cr_(2)O_(3)Al_(2)O_(3) slags was investigated to facilitate recycling of Cr in steelmaking *** slags exhibit good Newtonian behavior at high *** viscosity of acidic slag first increases from 0.825 to 1.141 Pa·s as the Al_(2)O_(3) content increases from 0 to 10wt%and then decreases to 1.071 Pa·s as the Al_(2)O_(3) content increases further to 15wt%.The viscosity of basic slag first increases from 0.084 to 0.158 Pa·s as the Al_(2)O_(3) content increases from 0 to 15wt%and then decreases to 0.135 Pa·s as the Al_(2)O_(3) content increases further to 20wt%.Furthermore,Cr_(2)O_(3)containing slag requires less Al_(2)O_(3) to reach the maximum viscosity than Cr_(2)O_(3)free slag;the Al_(2)O_(3) contents at which the behavior changes are 10wt%and 15wt%for acidic and basic slags,*** ac-tivation energy of the slags is consistent with the viscosity *** spectra demonstrate that[AlO_(4)]tetrahedra appear initially and were replaced by[AlO_(6)]octahedra with further addition of Al_(2)O_(3).The dissolved organic phosphorus content of the slag first increases and then de-creases with increasing Al_(2)O_(3) content,which is consistent with the viscosity and Raman results.

关键词： viscosity structure Cr-containing slag Raman spectra

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Kinetics of hot metal desulfurization using CaO-SiO2-Al2O3-Na2O-TiO2 slag

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Journal of Iron and Steel Research International 2019年第10期26卷 1041-1051页

作者： Kang-hui Zhang Yan-ling Zhang tuo wu State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China

Kinetics of hot metal desulfurization were studied using CaO-SiO2-Al2O3-Na2O-TiO2 slag in the range of 1400-1500℃on a laboratory *** results of kinetic experiments indicate that the desulfurization rate increases as the temperature,Al2O3 content,Na2O content,and TiO2 content increase and basicity increases from 1.01 to 1.75,but decreases when basicity increases from 1.75 to *** melting effect of slag is promoted as the temperature,Na2O content,and TiO2 content increase and Al2O3 content increases from 12.13 to 17.17 mass%,but worsened as basicity increases and Al2O3 content increases from 17.17 to 22.27 mass%.A kinetic model of hot metal desulfurization has been developed to calculate the mass transfer coefficient and the mass transfer resistance of sulfur in *** mass transfer coefficient of sulfur increases as the temperature,Al2O3 content,Na2O content,and TiO2 content increase and basicity *** mass transfer coefficients of sulfur were in the range of(5.02-23.78)×10^-7 m s^-*** activation energy was estimated to be 464.06 kJ mo1^-1 at the temperature from 1400 to 1450℃and 176.35 kJ mol-1 at the temperature from 1450 to 1500℃.The sulfur distribution at the slag-metal interface was observed using a mineral liberation *** result shows that the mass transfer of sulfur in slag is the controlling step at high temperature during the desulfurization process.

关键词： Hot metal desulfurization Kinetics Model Liquid area Kinetic parameter

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Influence of Cr_(2)_(3)content on viscosity and rheological behavior of Cr_(2)O_(3)-containing slags

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Journal of Iron and Steel Research International 2022年第4期29卷 601-611页

作者： Fang Yuan Zheng Zhao Yan-ling Zhang tuo wu State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China

The rheological behavior of Cr_(2)_(3)-containing slags was investigated using a rotating cylinder viscometer and the solid fraction and phases of Cr_(2)_(3)in molten slags were also calculated and observed at different ***,the viscosities of CaO–SiO2–Cr_(2)_(3)(–10%Al2O3)slags were measured from 1703 to 1953 K and the influence of Cr_(2)_(3)content on the viscosity and rheological behavior of molten slags was *** calculation revealed that the solid fraction of the molten slags varied with the Cr_(2)_(3)content and maximum temperature,and the fluid properties transitioned from Newtonian to non-Newtonian behavior when the solid fraction reached 5%.Moreover,the increase in Cr_(2)_(3)content led to an increase in the viscosity as the slags displayed Newtonian flow characteristics and a decrease in the viscosity when slags exhibited non-Newtonian flow *** viscosity results of Cr_(2)_(3)-containing slag from 1703 to 1953 K and from 1703 to 1813 K were also discussed with the morphologies.

关键词： Viscosity Rheology behavior Cr_(2)_(3)-containing slag Morphology

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大喂入量履带式联合收获机载荷测试系统构建与分析

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农机化研究 2025年第4期47卷 65-69,76页

作者：李顾鹏李耀明夏圣博杜拓吴颖江苏大学农业工程学院江苏镇江212013

为了给大喂入量联合收获机传动系统的设计和动力分配提供科学合理的依据,需要得到主要工作部件在不同工况下的工作载荷。为此,以沃得公司的巨龙360型履带式联合收获机为样机(发动机额定功率128.5 kW、喂入量≥10 kg/s),并根据样机的结... 详细信息

为了给大喂入量联合收获机传动系统的设计和动力分配提供科学合理的依据,需要得到主要工作部件在不同工况下的工作载荷。为此,以沃得公司的巨龙360型履带式联合收获机为样机(发动机额定功率128.5 kW、喂入量≥10 kg/s),并根据样机的结构特点设计了履带式联合收获机载荷测试系统。同时,在田间试验时测得了主要工作部件的载荷信号,旨在为大喂入量履带式联合收获机的传动系统设计及动力分配提供数据支持。

关键词：联合收获机载荷测试大喂入量覆带式

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SOLUTION OF THE ENSO DELAYED OSCILLATOR WITH HOMOTOPY ANALYSIS METHOD

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Journal of Hydrodynamics 2009年第1期21卷 131-135页

作者： wu zi-ku School of Science Qingdao Agriculture University Qingdao 266109 China

An ENSO delayed oscillator is considered. The E1 Nino atmospheric physics oscillation is an abnormal phenomenon involved in the tropical Pacific ocean-atmosphere interactions. The conceptual oscillator model should consider the variations of both the eastern and western Pacific anomaly patterns. Using the homotopy analysis method, the approximate expansions of the solution of corresponding problem are constructed. The method is based on a continuous variation from an initial trial to the exact solution. A Maclaurin series expansion provides a successive approximation of the solution through repeated application of a differential operator with the initial trial as the first term. This approach does not require the use of perturbation parameters and the solution series converges rapidly with the number of terms. Comparing the approximate analytical solution by homotopy analysis method with the exact solution, we can find that the homotopy analysis method is valid for solving the strong nonlinear ENSO delayed oscillator model.

关键词： ENSO delayed oscillator homotopy analysis method strong nonlinear

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Scaling Behaviors of Polymers on Lipid Membranes:Coupling of Polymer Chain Dynamics and Surface Thermal Fluctuations

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Chinese Journal of Polymer Science 2023年第3期41卷 459-464,I0010页

作者： zi-Ren Chen wu Zhou Lei Shen School of Chemistry Chemical Engineering and Life ScienceWuhan University of TechnologyWuhan 430070China

Despite extensive researches on the motion of polymer chains on lipid membranes,the effect of membrane fluctuations on polymer chain dynamics remains poorly *** we report single molecule tracking experiments that allow for comparable measurements of polymer chain diffusion dynamics on nanotubular and planar phospholipid *** observe a super-diffusion behavior and no apparent chain-length-dependent mobility of polymer chains on nanotubular membranes,while a Brownian motion and apparent chain-lengthdependent mobility of polymer chains on planar *** suggest the super-diffusion nature of polymer chains may be due to the thermal-fluctuations of lipid nanotubes,which can be described from a statistical thermodynamic phenomenon coupling of polymer chain dynamics and surface thermal *** suggest that the existence of surface environment fluctuations should influence the dynamics of the adsorbed polymer *** study provides previously uncharacterized insights into polymer diffusion dynamics on thermal-fluctuating flexible surfaces,which is essential to understanding the effect of environment fluctuations on polymer chain behaviors.

关键词： Polymer diffusion Lipid membrane Scaling behavior

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