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Study on the prediction and inverse prediction of detonation properties based on deep learning

Defence Technology（防务技术） 2023年第6期24卷 18-30页

作者： zi-hang Yang Ji-li Rong zi-tong zhao Department of Mechanics School of Aerospace EngineeringBeijing Institute of TechnologyBeijing100081China

The accurate and efficient prediction of explosive detonation properties has important engineering significance for weapon *** methods for predicting detonation performance include empirical formulas,equations of state,and quantum chemical calculation *** recent years,with the development of computer performance and deep learning methods,researchers have begun to apply deep learning methods to the prediction of explosive detonation *** deep learning method has the advantage of simple and rapid prediction of explosive detonation ***,some problems remain in the study of detonation properties based on deep *** example,there are few studies on the prediction of mixed explosives,on the prediction of the parameters of the equation of state of explosives,and on the application of explosive properties to predict the formulation of *** on an artificial neural network model and a one-dimensional convolutional neural network model,three improved deep learning models were established in this work with the aim of solving these *** training data for these models,called the detonation parameters prediction model,JWL equation of state(EOS)prediction model,and inverse prediction model,was obtained through the KHT thermochemical *** training,the model was tested for overfitting using the validation-set *** the model-accuracy test,the prediction accuracy of the model for real explosive formulations was tested by comparing the predicted value with the reference *** results show that the model errors were within 10%and 3%for the prediction of detonation pressure and detonation velocity,*** accuracy refers to the prediction of tested explosive formulations which consist of TNT,RDX and *** the prediction of the equation of state for explosives,the correlation coefficient between the prediction and the reference curves was above *** the prediction of the inverse predi

关键词： Deep learning Detonation properties KHT thermochemical Code JWL equation of states Artificial neural network One-dimensional convolutional neural network

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Identification of key genes and pathways in gastric signet ring cell carcinoma based on transcriptome analysis

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World Journal of Clinical Cases 2020年第4期8卷 658-669页

作者： zi-tong zhao Yang Li Hong-Yu Yuan Fu-Hai Ma Yong-Mei Song Yan-Tao Tian State Key Laboratory of Molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Pancreatic and Gastric Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

BACKGROUND Gastric signet ring cell carcinoma(GSRCC)is one of the most malignant *** has the features of high invasiveness,rapid progression,and resistance to ***,systematic analyses of mRNAs have not yet been performed for *** To identify key mRNAs and signaling pathways in *** A transcriptome analysis of two GSRCC and two non-GSRCC samples was performed in this *** expressed mRNAs and pathways were identified based on the KEGG and PANTHER pathway *** interactive relationships among the differential genes were mapped with the STRING *** real-time polymerase chain reaction was used to validate the key gene expression in *** About 1162 differential genes(using a 2-fold cutoff,P<0.05)were identified in GSRCC compared with *** enriched KEGG and PANTHER pathways for the differential genes included immune response pathways,metabolic pathways,and metastasis-associated *** genes(MAGEA2,MAGEA2B,MAGEA3,MAGEA4,MAGEA6,MUC13,GUCA2A,FFAR4,REG1A,and REG1B)were identified as hub genes in the protein-protein interaction *** expression levels of five genes(MAGEA2,MAGEA3,MAGEA4,MAGEA6,and REG1B)showed potential clinical *** We have identified the potential key genes and pathways in GSRCC,and these hub genes and pathways could be diagnostic markers and therapeutic targets for GSRCC.

关键词： Signet ring cell Transcriptome sequencing Gastric carcinoma Bioinformatical analysis Pathway Gene

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SCC-UEFAS, an urban-ecological-feature based assessment system for sponge city construction

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Environmental Science and Ecotechnology 2022年第4期12卷 8-17页

作者： zi-tong zhao Hou-Ming Cheng Sheng Wang Hai-Yan Liu zi-Ming Song Jun-Hui Zhou Ji-Wei Pang Shun-Wen Bai Shan-Shan Yang Jie Ding Nan-Qi Ren State Key Laboratory of Urban Water Resource and Environment Harbin Institute of TechnologyHarbin150000China Central&Southern China Municipal Engineering Design and Research Institute Co. LtdWuhan430010China China Energy Conservation and Environmental Protection Group Beijing100089China

An effective sponge city construction evaluation system plays a crucial role in evaluating sponge city construction *** construction of a sponge city evaluation system still faces challenges related to incomplete index selection and unscientific weight *** studies have focused on the comprehensive assessment of sponge city construction in the early *** study constructed a scientific assessment indicator system and a quantitative indicator weight at all levels by literature review and statistical analysis methods from an objective *** demonstrate how to utilize our evaluation methods,three construction schemes randomly generated by MATLAB were evaluated under evaluation states of constant weight and variable weight,*** 3 had the highest score of 0.638 under the constant weight assessment,but it cannot practically be the final construction scheme due to the imbalance between *** to the constant weight assessment,a variable weight assessment can effectively balance the states of the evaluation index with changes in the decision *** the three schemes,Scheme 2 is the best choice with a value of 0.0355 under variable weight evaluation due to punishment and incentives in the variable weight *** concept of“punishing”a disadvantageous indicator and“motivating”an advantageous indicator increases the relative advantages of the indices,ultimately affecting the assessment results of schemes and leading to a more balanced *** study provides reasonable analysis and decision-making mechanisms to support decision-making and guide the scientific selection of a construction scheme.

关键词： Sponge city evaluation system Principal component analysis Factor analysis Variable weight theory

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高考试题难度预估研究

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数学教育学报 2018年第5期27卷 13-16页

作者：任子朝佟威赵轩陈昂教育部考试中心北京100084

高考由于其高利害性和敏感性,不能通过考前试测预先掌握试题难度,只能在命题过程中依靠命题人员主观预估确定试题的难度.在命题人员对每个试题进行难度预估后,可以采用各种统计方法对预估值进行数据处理,例如求预估难度与实测难度的相... 详细信息

高考由于其高利害性和敏感性,不能通过考前试测预先掌握试题难度,只能在命题过程中依靠命题人员主观预估确定试题的难度.在命题人员对每个试题进行难度预估后,可以采用各种统计方法对预估值进行数据处理,例如求预估难度与实测难度的相关系数,计算每人预估的平均差异,计算预估值的标准差等.根据数据处理的结果,确定对预估值与实测值的拟合程度和每个命题人员的预估精度,从而在以后的年份科学地利用预估数据预测高考试题的实测难度.

关键词：高考预估难度实测难度统计分析

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Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

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Neural Regeneration Research 2025年第1期20卷 6-20页

作者： Xiu-Yun zhao De-En Xu Ming-Lei Wu Ji-Chuan Liu zi-Ling Shi Quan-Hong Ma Department of Neurology and Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular *** reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and *** this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular *** also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative *** summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve *** review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.

关键词： autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response

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Clinicopathological parameters predicting recurrence of pT1N0 esophageal squamous cell carcinoma

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World Journal of Gastroenterology 2018年第45期24卷 5154-5166页

作者： Li-Yan Xue Xiu-Min Qin Yong Liu Jun Liang Hua Lin Xue-Min Xue Shuang-Mei Zou Mo-Yan Zhang Bai-Hua Zhang Zhou-Guang Hui zi-tong zhao Li-Qun Ren Yue-Ming Zhang Xiu-Yun Liu Yan-Ling Yuan Jian-Ming Ying Shu-Geng Gao Yong-Mei Song Gui-Qi Wang Sanford M Dawsey Ning Lu Department of Pathology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Center for Cancer Precision Medicine Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Department of Endoscopy National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Department of Radiation Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Department of Medical Record National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Department of Thoracic Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College The 2nd Department of Thoracic Surgery Hunan Cancer Hospital The Affiliated Cancer Hospital of Xiangya School of Medicine CSU State Key Laboratory of Molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Department of Pathology Chengde Medical College Metabolic Epidemiology Branch Division of Cancer Epidemiology and Genetics National Cancer Institute

AIM To identify the clinicopathological characteristics of pT1 N0 esophageal squamous cell carcinoma(ESCC) that are associated with tumor recurrence. METHODS We reviewed 216 pT1 N0 thoracic ESCC cases who underwent esophagectomy and thoracoabdominal two-field lymphadenectomy without preoperative chemoradiotherapy. After excluding those cases with clinical follow-up recorded fewer than 3 mo and those who died within 3 mo of surgery, we included 199 cases in the current analysis. Overall survival and recurrencefree survival were assessed by the Kaplan-Meier method, and clinicopathological characteristics associated with any recurrence or distant recurrence were evaluated using univariate and multivariate Cox proportional hazards models. Early recurrence(≤ 24 mo) and correlated parameters were assessed using univariate and multivariate logistic regression *** Forty-seven(24%) patients had a recurrence at 3 to 178(median, 33) mo. The 5-year recurrence-free survival rate was 80.7%. None of 13 asymptomatic cases had a recurrence. Preoperative clinical symptoms, upper thoracic location, ulcerative or intraluminal mass macroscopic tumor type, tumor invasion depth level, basaloid histology, angiolymphatic invasion, tumor thickness, submucosal invasion thickness, diameter of the largest single tongue of invasion, and complete negative aberrant p53 expression were significantly related to tumor recurrence and/or recurrence-free survival. Upper thoracic tumor location, angiolymphatic invasion, and submucosal invasion thickness were independent predictors of tumor recurrence(Hazard ratios = 3.26, 3.42, and 2.06, P < 0.001, P < 0.001, and P = 0.002, respectively), and a nomogram for predicting recurrence-free survival with these three predictors was constructed. Upper thoracic tumor location and angiolymphatic invasion were independent predictors of distant recurrence. Upper thoracic tumor location, angiolymphatic invasion, submucosal invasion thickness, and diameter o

关键词： Esophageal squamous cell carcinoma Tumor recurrence Lymph node negative esophageal cancer Recurrence-free survival Clinicopathological parameters

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Hydrogen sulfide reduces oxidative stress in Huntington's disease via Nrf2

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Neural Regeneration Research 2025年第6期20卷 1776-1788页

作者： zige Jiang Dexiang Liu Tingting Li Chengcheng Gai Danqing Xin Yijing zhao Yan Song Yahong Cheng tong Li Zhen Wang Department of Physiology School of Basic Medical SciencesCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina Department of Medical Psychology and Ethics School of Basic Medicine SciencesCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina Department of Neurosurgery Surgery Qingdao Municipal HospitalQingdaoShandong ProvinceChina

The pathophysiology of Huntington's disease involves high levels of the neurotoxin quinolinic acid. Quinolinic acid accumulation results in oxidative stress, which leads to neurotoxicity. However, the molecular and cellular mechanisms by which quinolinic acid contributes to Huntington's disease pathology remain unknown. In this study, we established in vitro and in vivo models of Huntington's disease by administering quinolinic acid to the PC12 neuronal cell line and the striatum of mice, respectively. We observed a decrease in the levels of hydrogen sulfide in both PC12 cells and mouse serum, which was accompanied by down-regulation of cystathionine β-synthase, an enzyme responsible for hydrogen sulfide production. However, treatment with NaHS(a hydrogen sulfide donor) increased hydrogen sulfide levels in the neurons and in mouse serum, as well as cystathionine β-synthase expression in the neurons and the mouse striatum, while also improving oxidative imbalance and mitochondrial dysfunction in PC12 cells and the mouse striatum. These beneficial effects correlated with upregulation of nuclear factor erythroid 2-related factor 2 expression. Finally, treatment with the nuclear factor erythroid 2-related factor 2inhibitor ML385 reversed the beneficial impact of exogenous hydrogen sulfide on quinolinic acid-induced oxidative stress. Taken together, our findings show that hydrogen sulfide reduces oxidative stress in Huntington's disease by activating nuclear factor erythroid 2-related factor 2,suggesting that hydrogen sulfide is a novel neuroprotective drug candidate for treating patients with Huntington's disease.

关键词： apoptosis cystathionine-β-synthase nuclear factor erythroid 2-related factor 2 Huntington's disease hydrogen sulfide mitochondrion neuroplasticity oxidative stress quinolinic acid reactive oxygen species

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Impact of Startup Strategy and Buffer Tank Volume on the Compressor Inlet State for a 3-MW sCO2 Brayton Cycle

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Journal of Thermal Science 2025年第1期34卷 159-175页

作者： zhao Decai WANG Bo Key Laboratory of Advanced Energy and Power Institute of Engineering Thermophysics(IET)Chinese Academy of Sciences (CAS) University of Chinese Academy of Sciences

The supercritical carbon dioxide（sCO2） Brayton cycle system has become an emerging and highly promising method of thermal power conversion due to its efficiency advantage,system compactness,and excellent adaptability of the heat *** the low carbon sCO2Brayton cycle testbed with cycle output power approaching 3 MW,a relatively detailed dynamic simulation model of the entire system is constructed to explore the dynamic response characteristics of the system with different startup strategies and different buffer tank volumes during the startup *** simulation results indicate that the smaller the volume of the buffer tank,the more rapid and obvious the parameter fluctuation in the buffer tank during the *** the allowable relative deviation limit of density is 5%,then the ratio of the buffer tank volume to the volume of the entire closed loop should not be lower than 36.80%.The strategy of simultaneous temperature and speed increase during turbine bypass start can effectively reduce the fluctuation of compressor inlet parameters and reach the steady-state more *** paper provides the recommended matching table for the opening of the turbine bypass valve（TBV） and the main regulating valve（MGV） to reduce the parameter fluctuation during the bypass *** effectiveness of the proposed turbine bypass and bypass switching startup strategy is verified by simulation,which may be used as a reference for test bench's future debugging and operation.

关键词： buffer tank dynamic characteristic dynamic model sCO2 Brayton cycle startup strategy

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Reverse modulation of defect density of Ce-MOF-808 by solventassisted ligand exchange for dicyclopentadiene hydrogenation

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Science China Chemistry 2025年

作者： Danfeng zhao Fajie Hu Rushuo Li Xinmeng Xu zhaokun Wang Zuoshuai Xi Jun tong Xiubing Huang Ge Wang Advanced Innovation Center for Materials Genome Engineering Beijing Key Laboratory of Function Materials for Molecule & Structure Construction School of Materials Science and Engineering University of Science and Technology Beijing

Defect engineering is a pivotal strategy for tailoring the electronic structure and physicochemical properties of catalysts, yet the straightforward manipulation of defect density in porous materials presents a current challenge. In this work, we achieved precise control over the coordination unsaturated site（CUS） content and pore architecture of Ce-MOF-808 by employing 2-fluorobenzoic acid（2-FBA） as a modifier. Leveraging the p Kadisparities among three ligands（1,3,5-tricarboxylic benzoic acid,formic acid, and 2-FBA）, we preserved the spn topology of Ce-MOF within an aqueous system, while realizing partial substitution of the auxiliary ligands and saturation of the CUS. The amount of 2-FBA was negatively correlated with the number of ligand defects, and the consequent decrease in Ce3+content and the increase in the number of ligand linkages also induced crystal structure transformation. The modulation of the defect structure was correlated with the catalytic performance of dicyclopentadiene（DCPD） hydrogenation reaction, in which Ce-MMF0.15, constructed by the modulation of 0.15 mol amount of 2-fluorobenzoic acid, exhibited an optimal ligand defect density and micro-mesoporous structure, enabling almost complete conversion of DCPD at 100 ℃ and 2 MPa. This article also elucidates the correlation between the regulation of defect density and the accessibility of frustrated Lewis pair（FLP） active sites, guiding the application of novel porous intrinsic FLP materials in hydrogenation catalysis.

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Liquid refractive index measurement method based on orthogonal polarization laser self-mixing interference

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Optoelectronics Letters 2025年

作者： zhao Yan WANG Haipeng DU Shengzhi tong Jigang KANG Jun School of Electrical Engineering and Automation， Tianjin University of Technology Tianjin Key Laboratory for Control Theory and Applications in Complicated Systems Department of Electrical Engineering， Tshwane University of Technology

In this paper， a novel method combining orthogonal polarization laser self-mixing interference is proposed. The method utilizes a rotating cuvette to measure the refractive index of liquids at different concentrations. The cuvette is filled with the liquid to be measured and rotated by a certain angle. The change in the number of interference fringes， caused by comparing an empty cuvette with a liquid-filled cuvette， is used to calculate the refractive index of the liquid. A four-fold logic subdivision algorithm is then used to improve measurement resolution. The experimental results show that for pure water and different NaCl and glucose solutions concentrations， the average relative errors are 0.47%， 0.59%， and 2.17%， respectively， with the maximum relative error within ±2.54%. The standard deviation of all solutions is less than 3.4%.

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