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Gut microbiota and diabetic kidney diseases: Pathogenesis and therapeutic perspectives

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World Journal of Diabetes 2022年第4期13卷 308-318页

作者： Jia-Ran Lin zi-ting wang Jiao-Jiao Sun Ying-Ying Yang Xue-Xin Li Xin-Ru wang Yue Shi Yuan-Yuan Zhu Rui-ting wang Mi-Na wang Fei-Yu Xie Peng Wei Ze-Huan Liao Graduate School Beijing University of Chinese MedicineBeijing 100029China Department of Nephrology and Endocrinology Dongzhimen Hospital Affiliated to Beijing University of Chinese MedicineBeijing 100700China Department of Environmental Medicine Karolinska InstitutetStockholm 17165Sweden First Clinical Medical College Beijing University of Chinese MedicineBeijing 100029China Clinical Research Center Shanghai First Maternity and Infant HospitalSchool of MedicineTongji UniversityShanghai 201204China Department of Medical Epidemiology and Biostatistics Karolinska InstitutetSolna 17165Sweden Department of Medical Biochemistry and Biophysics Karolinska InstitutetStockholm 17121Sweden Department of Acupuncture and Moxibustion First Clinical Medical CollegeBeijing University of Chinese MedicineBeijing 100029China Second Clinical Medical College Beijing University of Chinese MedicineBeijing 100029China Dongzhimen Hospital Beijing University of Chinese MedicineBeijing 100029China Department of Acupuncture and Moxibustion Beijing Hospital of Traditional Chinese MedicineCapital Medical UniversityBeijing Key Laboratory of Acupuncture NeuromodulationBeijing 100010China School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing 100029China Department of Oncology Wangjing Hospital of China Academy of Chinese Medical SciencesBeijing 100102China School of Biological Sciences Nanyang Technological UniversitySingapore 637551Singapore Department of Microbiology Tumor and Cell Biology(MTC)Karolinska InstitutetStockholm 17177Sweden

Diabetic kidney disease(DKD)is one of the major chronic complications of diabetes mellitus(DM),as well as a main cause of end-stage renal *** the last few years,substantial research studies have revealed a contributory role of gut microbiota in the process of DM and *** of gut microbiota like lipopolysaccharide,short-chain fatty acids,and trimethylamine N-oxide are key mediators of microbial–host ***,the underlying mechanisms of how gut microbiota influences the onset and progression of DKD are relatively ***,strategies to remodel the composition of gut microbiota or to reduce the metabolites of microbiota have been found recently,representing a new potential remedial target for *** this minireview,we will address the possible contribution of the gut microbiota in the pathogenesis of DKD and its role as a therapeutic target.

关键词： Diabetes Gut microbiota Insulin resistance Diabetic kidney disease Pathogenesis Therapeutic targets

Hierarchically Porous Polypyrrole Foams Contained Ordered Polypyrrole Nanowire Arrays for Multifunctional Electromagnetic Interference Shielding and Dynamic Infrared Stealth

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Nano-Micro Letters 2025年第4期17卷 399-418页

作者： Yu-long Liu ting-yu Zhu Qin wang zi-jie Huang De-xiang Sun Jing-hui Yang Xiao-dong Qi Yong wang School of Chemistry Key Laboratory of Advanced Technologies of Materials(Ministry of Education)Southwest Jiaotong UniversityChengdu 610031People’s Republic of China

As modern communication and detection technologies advance at a swift pace,multifunctional electromagnetic interference(EMI)shielding materials with active/positive infrared stealth,hydrophobicity,and electric-thermal conversion ability have received extensive *** the aforesaid requirements simultaneously remains a huge *** this research,the melamine foam(MF)/polypyrrole(PPy)nanowire arrays(MF@PPy)were fabricated via one-step electrochemical *** hierarchical MF@PPy foam was composed of three-dimensional PPy micro-skeleton and ordered PPy nanowire *** to the upwardly grown PPy nanowire arrays,the MF@PPy foam possessed good hydrophobicity ability with a water contact angle of 142.00°and outstanding stability under various harsh ***,the MF@PPy foam showed excellent thermal insulation property on account of the low thermal conductivity and elongated ligament characteristic of PPy nanowire ***,taking advantage of the high conductivity(128.2 S m^(-1)),the MF@PPy foam exhibited rapid Joule heating under 3 V,resulting in dynamic infrared stealth and thermal camouflage *** importantly,the MF@PPy foam exhibited remarkable EMI shielding effectiveness values of 55.77 dB and 19,928.57 dB cm^(2)g^(-1).Strong EMI shielding was put down to the hierarchically porous PPy structure,which offered outstanding impedance matching,conduction loss,and multiple *** innovative approach provides significant insights to the development of advanced multifunctional EMI shielding foams by constructing PPy nanowire arrays,showing great applications in both military and civilian fields.

关键词： Polypyrrole nanowire arrays Hierarchical foam Hydrophobicity Infrared stealth Electromagnetic interference shielding

Nb-based Josephson parametric amplifier for superconducting qubit measurement

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Chinese Physics B 2019年第11期28卷 109-113页

作者： Fei-Fan Su zi-ting wang Hui-Kai Xu Shou-Kuan Zhao Hai-Sheng Yan Zhao-Hua Yang Ye Tian Shi-Ping Zhao Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of Sciences(CAS)Beijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China CAS Center for Excellence in Topological Quantum Computation University of Chinese Academy of SciencesBeijing 100190China

We report a fabrication process and characterization of the Josephson parametric amplifier(JPA) for the single-shot quantum state measurement of superconducting multiqubit system. The device is prepared using Nb film as its base layer,which is convenient in the sample patterning process like e-beam lithography and film etching. Our results show that the JPA has a bandwidth up to 600 MHz with gain above 15 dB and noise temperature approaching the quantum limit. The qubit state differentiation measurements demonstrate the signal-to-noise ratio around 3 and the readout fidelity above 97%and 91% for the ground and first-excited states, respectively.

关键词： superconducting qubit Josephson parametric amplifier device fabrication quantum nondemolition measurement

Experiments and modeling of microstructural and mechanical behaviors of laser-welded Ni-based superalloy at high temperatures

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Chinese Journal of Aeronautics 2025年第1期38卷 99-114页

作者： ting HOU Yong LI Degang wang Yuelin wang Marko VILOTIC School of Mechanical Engineering and Automation Beihang UniversityBeijing 100191China Department of Structure Shenyang Aircraft Designand Research InstituteShenyang 110000China Engineering Center Shenyang Aircraft CorporationShenyang 110000China Faculty of Technical Science University of Novi SadNovi Sad 21102Serbia

The performance of welded Ni-based superalloys at high temperatures is essential to be evaluated due to their particular service environment for aero-engines and high-speed *** tensile properties and related microstructural evolutions such as the carbide precipitate and grain of a laser-welded Ni-based alloy were experimentally and numerically investigated at different temperatures(20,300,500,800℃).The results show that at room temperature,the strength of the Base Material(BM)was slightly smaller,with a difference of less than 1%,than the Welded Material(WM),which can be attributed to the more uniformly distributed needle-shaped carbide precipitates in the WM than those nonuniformly coarser spherical ones in the *** at 300℃ and 500℃,the strength of WM decreased more obviously compared with that of BM due to the more apparent growth of grain:13.52%loss in yield strength in WM alloys as compared with BM alloys at 300℃,and 16.57% at 500℃.At 800℃,the strength of BM and WM both decreased to a similar level due to Dynamic Recrystallization(DRX).However,a much higher elongation was observed for the BM than WM(less than 50%of BM),which can be attributed to the enhanced dislocation accumulation capability of the large spherical carbides along grain boundaries on the fracture surface in ***,a unified model considering the welding effects on both microstructures(dislocation,carbides,and grain)and mechanical properties evolutions at different temperatures was developed and *** on this model,the key temperature ranges(20–600℃)where apparent weakening of strength and uniform plasticity occurs for welded structures were identified,providing a direct guidance for potential structure and process design.

关键词： Ni-based superalloy Microstructure Mechanical properties Constitutive model High temperature

MXene Hybridized Polymer with Enhanced Electromagnetic Energy Harvest for Sensitized Microwave Actuation and Self‑Powered Motion Sensing

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Nano-Micro Letters 2025年第3期17卷 265-279页

作者： Yu‑Ze wang Yu‑Chang wang ting‑ting Liu Quan‑Liang Zhao Chen‑Sha Li Mao‑Sheng Cao School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081People’s Republic of China School of Materials Science and Engineering Peking UniversityBeijing 100871People’s Republic of China School of Mechanical and Material Engineering North China University of TechnologyBeijing 100144People’s Republic of China Key Laboratory of Functional Inorganic Material Chemistry Ministry of Education of the People’s Republic of ChinaHeilongjiang UniversityHarbin 150080People’s Republic of China

Polymeric microwave actuators combining tissue-like softness with programmablemicrowave-responsive deformation hold great promise for mobile intelligentdevices and bionic soft robots. However, their application is challenged by restricted electromagneticsensitivity and intricate sensing coupling. In this study, a sensitized polymericmicrowave actuator is fabricated by hybridizing a liquid crystal polymer with Ti3C2Tx(MXene). Compared to the initial counterpart, the hybrid polymer exhibits unique spacechargepolarization and interfacial polarization, resulting in significant improvements of230% in the dielectric loss factor and 830% in the apparent efficiency of electromagneticenergy harvest. The sensitized microwave actuation demonstrates as the shortenedresponse time of nearly 10 s, which is merely 13% of that for the initial shape memory polymer. Moreover, the ultra-low content of MXene (upto 0.15 wt%) benefits for maintaining the actuation potential of the hybrid polymer. An innovative self-powered sensing prototype that combinesdriving and piezoelectric polymers is developed, which generates real-time electric potential feedback (open-circuit potential of ~ 3 mV) duringactuation. The polarization-dominant energy conversion mechanism observed in the MXene-polymer hybrid structure furnishes a new approachfor developing efficient electromagnetic dissipative structures and shows potential for advancing polymeric electromagnetic intelligent devices.

关键词： Microwave absorption Electromagnetic response Energy harvest Self-sensing Soft actuator

Riemann-Hilbert Problem and Multiple High-order Poles Solutions of the Focusing mKdV Equation with Nonzero Boundary Conditions

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Acta Mathematicae Applicatae Sinica 2025年第1期41卷 234-251页

作者： zi-yi wang Shou-fu TIAN Jin-jie YANG School of Mathematics China University of Mining and TechnologyXuzhou 221116China

The focusing modified Korteweg-de Vries(mKdV)equation with multiple high-order poles under the nonzero boundary conditions is first investigated via developing a Riemann-Hilbert(RH)*** begin with the asymptotic property,symmetry and analyticity of the Jost solutions,and successfully construct the RH problem of the focusing mKdV *** solve the RH problem when 1/S_(11)(k)has a single highorder pole and multiple high-order ***,we derive the soliton solutions of the focusing mKdV equation which corresponding with a single high-order pole and multiple high-order poles,***,the dynamics of one-and two-soliton solutions are graphically discussed.

关键词： Riemann-Hilbert approach focusing mKdV equation nonzero boundary conditions multiple high-order poles soliton solutions

DI-YOLOv5:An Improved Dual-Wavelet-Based YOLOv5 for Dense Small Object Detection

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IEEE/CAA Journal of Automatica Sinica 2025年第2期12卷 457-459页

作者： zi-Xin Li Yu-Long wang Fei wang the Shanghai Key Laboratory of Power Station Automation Technology Shanghai University the School of Mechatronic Engineering and Automation Shanghai University IEEE the TAIHU Laboratory of Deepsea Technological Science China Ship Scientific Research Center

Dear Editor,This letter focuses on the fact that small objects with few pixels disappear in feature maps with large receptive fields, as the network deepens, in object detection tasks. Therefore, the detection of dens...

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Spatiotemporal evolution of wildfire activity during the Paleocene-Eocene Thermal Maximum in China

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Science China Earth Sciences 2025年第2期68卷 509-522页

作者： Xue-ting wang Zuoling CHEN Linlin CUI Xu wang State Key Laboratory of Lithospheric and Environmental Coevolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China University of Chinese Academy of Sciences College of Earth and Planetary SciencesBeijing 100049China Institute of Geology and Geophysics Chinese Academy of SciencesBeijing 100029China

The Paleocene-Eocene Thermal Maximum(PETM)was the most prominent warming event in the Cenozoic and serves as a geological analog for the current global warming driven by anthropogenic CO_(2)emissions from burning fossil *** a primary disruptor of Earth's ecosystems,wildfire activity affects the balance of ecosystems,the global carbon cycle,and climate ***,studying the evolution and driving mechanisms of wildfires during the PETM is essential for predicting wildfire activity under global warming scenarios and for understanding the carbon cycle in the context of wildfire *** research on wildfires during the PETM has mainly focused on the Northern Hemisphere,particularly Europe and North America,whereas studies on Chinese mainland remain *** this study,we analyzed black carbon(BC)concentration and carbon isotope(δ13C)in the Beigou section of the Nanyang Basin and the Xilutian section of the Fushun Basin to reconstruct the spatiotemporal evolution of wildfires in arid/semi-arid and humid *** integrated these findings with those of previous studies on the paleoclimate of the research area to elucidate the driving mechanisms behind wildfire *** results indicate that wildfire activity weakened at the onset of the PETM,with the negative carbon isotope period characterized by low wildfire activity,except for a brief resurgence in the Nanyang *** the recovery phase of the PETM,wildfire activity gradually increased,returning to the pre-PETM *** prolonged low wildfire state was likely caused by extremely high temperatures and precipitation as well as the resulting vegetation *** the PETM recovery phase,increased wildfire activity transformed“short-term carbon sinks”of the biological-atmospheric carbon cycle into“long-term carbon sinks”through the burial of *** process of carbon sink conversion may have acted as a negative feedback mechanism,contributing to carbon sequestration and the e

关键词： PETM Wildfire Carbon cycle Nanyang Basin Fushun Basin

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Critical station identification of metro networks based on the integrated topological-functional algorithm:A case study of Chengdu

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Chinese Physics B 2025年第2期34卷 509-520页

作者： zi-Qiang Zeng Sheng-Jie He wang Tian Business School Sichuan UniversityChengdu 610065China

As a key mode of transportation, urban metro networks have significantly enhanced urban traffic environments and travel efficiency, making the identification of critical stations within these networks increasingly essential. This study presents a novel integrated topological-functional(ITF) algorithm for identifying critical nodes, combining topological metrics such as K-shell decomposition, node information entropy, and neighbor overlapping interaction with the functional attributes of passenger flow operations, while also considering the coupling effects between metro and bus networks. Using the Chengdu metro network as a case study, the effectiveness of the algorithm under different conditions is *** results indicate significant differences in passenger flow patterns between working and non-working days, leading to varying sets of critical nodes across these scenarios. Moreover, the ITF algorithm demonstrates a marked improvement in the accuracy of critical node identification compared to existing methods. This conclusion is supported by the analysis of changes in the overall network structure and relative global operational efficiency following targeted attacks on the identified critical nodes. The findings provide valuable insight into urban transportation planning, offering theoretical and practical guidance for improving metro network safety and resilience.

关键词： critical node metro network topological structure functional operation