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A novel function of p53 in TR3-MDM2 cross-talk

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Cell Research 2007年第4期17卷 293-294页

作者： Hang-zi Chen~1 Qiao wu ~1Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering School of Life Sciences,Xiamen University,Fujian 361005,China Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering School of Life Sciences Xiamen University Fujian 361005 China

TR3(also known as Nur77,or NGFI-B)belongs tothe steroid/thyroid/retinoid receptor superfamily,and isclassified as an orphan receptor because its specific ligandhas not been identified[1].Originally,TR3 was identifiedas a growth factor-inducible gene[2].The role of TR3 inapoptosis was first reported in 1994,where TR3 expres-sion was shown to be induced by T-cell receptor signalingand required for T-cell receptor-mediated apoptosis[3,4].Rapid induction of TR3 is also observed in different typesof cancer cells after stimulation by apoptosis-inducingagents[5-7],indicating that induction of TR3 contributesto the apoptotic ***3 also functions as a transcription factor which posi-tively or negatively regulates gene *** previousstudy revealed that TR3 heterodimerizes with the retinoid Xreceptor α(RXRα),and binds to the retinoic acid responseelement in the retinoic acid receptor β(RARβ)promoter,thereby promoting RARβ expression which contributesto apoptosis induction in breast cancer cells[8].TR3 alsoheterodimerizes with another orphan receptor,COUP-TF,to regulate the expression of RARβ in lung cancer cells

关键词： TR A novel function of p53 in TR3-MDM2 cross-talk MDM

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带缝钢板阻尼器受力性能试验研究

土木工程学报 2015年第9期48卷 11-22页

作者：孔子昂王涛施唯中国地震局工程力学研究所黑龙江哈尔滨150080 中国地震局地震工程与工程振动部门重点实验室黑龙江哈尔滨150080

对4组弯曲单元宽厚比小于5的带缝钢板阻尼器进行了低周往复拟静力试验，研究其力学特性和耗能能力，利用试验结果检验了现有阻尼器的刚度和强度设计公式。建立有限元模型模拟阻尼器破坏的全过程，通过参数分析研究了带缝钢板阻尼器的延... 详细信息

对4组弯曲单元宽厚比小于5的带缝钢板阻尼器进行了低周往复拟静力试验，研究其力学特性和耗能能力，利用试验结果检验了现有阻尼器的刚度和强度设计公式。建立有限元模型模拟阻尼器破坏的全过程，通过参数分析研究了带缝钢板阻尼器的延性系数、损伤发展机制、超强系数及累积耗能和累积塑性变形。研究表明：带缝钢板阻尼器具有稳定的平面内力学性能、低周疲劳性能和较强的耗能能力，等效黏滞阻尼系数约为0．5；阻尼器延性较好，当弯曲单元高宽比“不小于4时，延性系数受其影响较小，因此不应采用α小于4的阻尼器；带缝钢板阻尼器的超强系数在2．30～2．96之间；累积塑性变形角与d成正比、标准累积塑性耗能率与α成反比，提出的公式可用于指导消能减霹结构设计和阳屁器诜利．

关键词：带缝钢板阻尼器延性系数超强系数累积塑性变形标准累积塑性耗能率

气相色谱-静电场轨道阱质谱在食品和药品分析中的研究进展

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药物分析杂志 2024年第1期44卷 1-10页

作者：吴炎培原文鹏胡新华聂黎行黄烈岩邢江涛于健东魏锋马双成中国食品药品检定研究院北京100050 深圳市人民医院(暨南大学第二临床医学院南方科技大学第一附属医院)药学部深圳518020 赛默飞世尔科技(中国)有限公司北京100013 国家药典委员会北京100061

气相色谱-静电场轨道阱质谱(gas chromatography-Orbitrap mass spectrometry,GC-Orbitrap/MS)作为新兴的高分辨气质联用技术,可实现挥发性成分的精确质量检测和高通量定性定量分析,具有灵敏度高,选择性强,线性动态范围宽等优点,能够很... 详细信息

气相色谱-静电场轨道阱质谱(gas chromatography-Orbitrap mass spectrometry,GC-Orbitrap/MS)作为新兴的高分辨气质联用技术,可实现挥发性成分的精确质量检测和高通量定性定量分析,具有灵敏度高,选择性强,线性动态范围宽等优点,能够很好地应对复杂基质中多种痕量物质分析带来的挑战,近年已开始应用于环境、工业、食品、制药、司法、临床等领域。本文对GC-Orbitrap/MS技术进行全面综述,阐述其基本原理及技术特点,介绍该技术在食品与药品分析研究中的应用进展,包括食品中农药残留检查、持久性有机物检测、香气物质分析和化学药品杂质分析与中药质量评价,并重点分析在超痕量成分测定和未知化合物鉴别方面的优势。最后,从高分辨率标准数据库的建立、可变电子电压技术的应用、样品前处理方式的选择开发与优化、二维GC-Orbitrap/MS串联等角度,提出GC-Orbitrap/MS未来发展方向并展望其应用前景。

关键词：气相色谱-静电场轨道阱质谱高分辨质谱食品药品农药残留持久性有机物香气物质杂质分析中药质量评价综述

Interpeduncular cistern intrathecal targeted drug delivery for intractable postherpetic neuralgia: A case report

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World Journal of Clinical Cases 2023年第30期11卷 7380-7385页

作者： Feng Fu Xian-Feng Jiang Jing-Jing Wang Lei Gong Chen Yun Hong-tao Sun Feng-wu Tang Departments of Pain Medicine Characteristic Medical Center of People’s Armed Police ForcesTianjin 300162China Tianjin Key Laboratory of Neurotrauma Repair Institute of Neurotrauma RepairCharacteristic Medical Center of People’s Armed Police ForcesTianjin 300162China Department of Neurotrauma Repair Characteristic Medical Center of People’s Armed Police ForcesTianjin 300162China

BACKGROUND Intractable postherpetic neuralgia(PHN)can be difficult to manage even with aggressive multimodal *** who experience uncontrolled refractory cranial PHN despite conservative treatment may benefit from an intrathecal drug delivery system(IDDS).For craniofacial neuropathic pain,the traditional approach has been to place the intrathecal catheter tip below the level of the cranial nerve root entry zones,which may lead to insufficient *** SUMMARY We describe a 69-year-old man with a 1-year history of PHN after developing a vesicular rash in the ophthalmic division of cranial nerve V(trigeminal nerve)*** pain was rated 7-8 at rest and 9-10 at breakthrough pain(BTP)on a numeric rating *** receiving aggressive multimodal therapies including large doses of oral analgesics(gabapentin 150 mg q12 h,oxycodone 5 mg/acetaminophen 325 mg q6 h,and lidocaine 5%patch 700 mg q12 h)and sphenopalatine ganglion block,there was no relief of ***,the patient elected to have an implantable IDDS with the catheter tip placed at the interpeduncular *** frequency of BTP episodes *** patient’s continuous daily dose was adjusted to 0.032 mg/d after 3 mo of follow-up and stopped 5 mo *** did not report pain or other discomfort at outpatient follow-up 6 mo and 1 year after stopping intracisternal *** The use of interpeduncular cistern intrathecal infusion with low-dose hydromorphone by IDDS may be effective for severe craniofacial PHN.

关键词： Postherpetic neuralgia Intrathecal drug delivery Interpeduncular cistern Craniofacial pain Opioids Case report

Establishment of the Method of Immunohistochemistry Assay for the Detection of Scrapie in Chinese Short-Tailed Han Sheep by Monoclonal Antibody

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Agricultural Sciences in China 2008年第12期7卷 1516-1523页

作者： ZHANG Yong-qiang WANG Zhi-liang wu Xiao-dong LIU Yu-tian ZHANG Hai-tao BAO En-dong National Diagnostic Center for Exotic Animal Disease/China Animal Health and Epidemiology Center Qingdao 266032 P.R.China College of Veterinary Medicine Nanjing Agricultural University Nanjing 210095 P.R.China

The method of immunohistochemistry assay for the detection of scrapie in Chinese Short-tailed Han sheep was established using monoclonal antibody. Genomic DNA was isolated from Chinese Short-tailed Hart sheep blood. Using the polymerase chain reaction technique, PrP27-30 gene sequence was amplified from Chinese Short-tailed Han sheep genomic DNA. By recombinant DNA technology, the recombinant protein of Chinese Short-tailed Han sheep PrP27-30 was obtained. Then, using standard methodology of myeloma cell fusion, a panel of monoclonal antibodies was generated. With mAbs, scrapie in Chinese Short-tailed Han sheep was detected by immunohistochemistry assay. The recombinant protein of Chinese Short-tailed Han sheep PrP27-30 was obtained and a panel of six hybridoma cell lines secreting specific antibodies to Chinese Short-tailed Han sheep PrP27-30 related to scrapie was obtained with one fusion between myeloma Sp2/0 and spleen ceils from mice immunized with the purified recombinant protein. Four hybridoma cell lines can be used in immunohistochemistry assay for the detection of scrapie in Chinese Short-tailed Han sheep. So that the special monoclonal antibody developed in author＇s institute can be used to detect PrP^sc of scrapie in Chinese Short-tailed Han sheep by immunohistochemistry in China.

关键词： Chinese Short-tailed Han sheep PrP27-30 scrapie monoclonal antibody immunohistochemistry assay

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柔性筛板上黏湿煤团解聚及透筛特性研究

煤炭技术 2024年第2期43卷 217-221页

作者：张家康宫三朋高有进吴涛杨洋董玉杰河南理工大学机械与动力工程学院河南焦作454000 郑州煤矿机械集团股份有限公司郑州450000

振动弛张筛在黏湿细粒煤炭干法筛分领域应用广泛。采用离散元中的API技术,在EDEM软件中构建了一种新型柔性筛面模型,并利用数学理论模型进行验证,此外探究了筛面振幅参数和颗粒表面能大小对黏湿颗粒运动特性的影响规律。结果表明:随着... 详细信息

振动弛张筛在黏湿细粒煤炭干法筛分领域应用广泛。采用离散元中的API技术,在EDEM软件中构建了一种新型柔性筛面模型,并利用数学理论模型进行验证,此外探究了筛面振幅参数和颗粒表面能大小对黏湿颗粒运动特性的影响规律。结果表明:随着表面能的增大,煤团与筛面碰撞后形成的二次团聚体越大,筛下颗粒数越少,一定范围内,随振幅的增大解聚后的颗粒平均法向速度越大。研究成果为离散元法研究黏湿煤炭筛分提供理论基础。

关键词：黏湿煤团表面能离散元法二次团聚柔性筛板

Evolvable Hardware Based Software-Hardware Co-Designing Platform ECDP

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wuhan University Journal of Natural Sciences 2005年第6期10卷 977-982页

作者： TU Hang wu tao-jun LI Yuan-xiang State Key Laboratory of Software Engineering Wuhan University Wuhan 430072 Hubei China School of Computer Wuhan University Wuhan 430072 Hubei China

Based on the theories of EA （Evolutionary Algorithm） and EHW （Evolvable Hardware）, we devise an EHW based software-hardware co designing platform ECDP, on which we provided standards for hardware system encoding and evolving operation designing, as well as circuit emulating tools. The major features of this system are： two layer-encoding of circuit structure, off-line evolving with software cmulation and the evolving of genetic program designing. With this system, we implemented the auto designing of sonic software-hardware systems, like the random number generator.

关键词： EHW(Evolvable Hardware) EA(Evolutionary Algorithm) ECDP

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药师参与下的碘克沙醇不良反应监测与分析

海峡药学 2024年第7期36卷 98-101页

作者：马曾庆李素素吴连平赵欣赵建国陶洋南京市高淳人民医院药学部江苏南京211300

目的监测并分析碘克沙醇不良反应(Adverse Drug Reaction,ADR)的发生、特点和影响因素,为碘克沙醇安全用药提供保障。方法通过药学查房,对2022年1月至2023年8月在我院使用碘克沙醇的患者进行监测,收集患者的人口学和临床信息,结合患者的... 详细信息

目的监测并分析碘克沙醇不良反应(Adverse Drug Reaction,ADR)的发生、特点和影响因素,为碘克沙醇安全用药提供保障。方法通过药学查房,对2022年1月至2023年8月在我院使用碘克沙醇的患者进行监测,收集患者的人口学和临床信息,结合患者的ADR发生情况和用药情况等,对发生ADR的风险因素、ADR的分类和转归情况进行统计并分析。结果在1961例患者中,累计24例患者发生ADR,发生率为1.22%。ADR主要涉及消化系统、皮肤系统和体温调节系统,其中发生率最高的为恶心呕吐(14,0.71%)、发热(4,0.20%)和皮肤瘙痒(3,0.15%)。ADR的发生与患者年龄超过75岁有统计学差异(P<0.05),而和性别、给药途径、用量以及是否合并慢性病无关。结论药师主动参与碘克沙醇ADR监测,能够做到早期干预,保障患者安全用药。

关键词：碘克沙醇药物不良反应临床药师监测

First reference genome assembly of the Indochinese silvered langur(Trachypithecus germaini)

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Zoological Research 2022年第4期43卷 604-607页

作者： Jin-Wei wu Ru Zhang Ya-Lin Qin Li Wang Ming-Bo Han zi-Fan Zhao Pei Jing Hai-Lu Sun Song Wang Ning Huang Bao-Guo Li Dong-Dong wu Chi Zhang Xiao-Guang Qi College of Life Sciences Northwest UniversityXi’anShaanxi 710069China BGI-Shenzhen ShenzhenGuangdong 518083China Nanning Zoo NanningGuangxi 450107China Kunming Institute of Zoology Chinese Academy of SciencesKunmingYunnan 650223China Key Laboratory of Adaptation and Evolution of Plateau Biota Northwest Institute of Plateau BiologyChinese Academy of SciencesXiningQinghai 810008China

DEAR EDITOR,Of the seven genera recognized in Asian colobines,Trachypithecus is the only genus that contains species *** with the species groups characterized by calcium tolerance(*** species group),multi-male,multi-female society(*** species group),and impressive hybridization(*** species group),the *** species group is distinguished by its southernmost distribution and silvery ***,Trachypithecus is an excellent model for investigating evolutionary radiation and behavioral adaptation in Asian ***,comprehensive comparison of species groups remains difficult due to the lack of a reference genome for the *** species group.

关键词： Trachypithecus silver evolutionary