检索结果-南通市图书馆

Chinese Chemical Letters 2014年第3期25卷 474-478页

作者： tao You Ke Chen Fei-Hai Wang Pi-Hong Li Li-Yi Li Zhi-Hao wu Kong-Hai Ni Zhi-Qiang Zheng Department of General Surgery The Second Affiliated HospitalWenzhou Medical University School of Clinical Medicine Wenzhou Medical University

Novel histone deacetylase （HDAC） inhibitors 9a-1 were designed and synthesized by coupling the carboxyl group of salicylic acid （SA） with N-hydroxycinnamamides through various alkylol amines, and their in vitro biological activities were evaluated. The N-hydroxycinnamamide/SA hybrids 9b-f and 9h showed good to moderate anti-tumor activities. Notably, compound 9e had a greater potency, comparable to vorinostat （SAHA）, in human colon carcinoma cells, which was probably, or at least partially, attributable to the positive effects of the chain length noted in allojlol amines. Furthermore, the HDAC inhibitory activities of 9e against Hela cell nuclear were also similar to that of vorinostat （SAHA）, while the tested compounds 9c-f did not exhibit any isoform selectivity in the inhibition of HDACs. In addition, compound 9e could selectively inhibit tumor cells, but not inhibit non-tumor cell proliferation in vitro. Our findings suggest that the N-hydroxycinnamamide/SA hybrids may hold significant promise as therapeutic a^ents for the intervention of human cancers.

关键词： SynthesisAnti-tumor agentsHistone deacetylase inhibitorsN-HydroxycinnamamidesSalicylic acid

Research on Water Resources Conservation of Mountain River Based on the Concept of Region Partition

在线全文

学校读者我要写书评

暂无评论

Journal of Mountain Science 2011年第4期8卷 582-591页

作者： LIU Yubang tao Qingyu LIANG Chuan wu Yong State Key Laboratory of Geohazard Prevention and Geoenvironment Protection Chengdu University of Technology Chengdu 61o059 China State Key Laboratory of Hydraulics and Mountain River Engineering College of Water Resource & Hydropower Sichuan University Chengdu 61oo65 China Academic Journal Center of Chengdu University of Technology Chengdu 61oo59 China

Presently concepts and methods related to water resources conservation of mountain rivers are seriously insufficient,and its level is far from being adaptable to the development of a harmonious *** mountain ecosystems play a key role in water resources conservation of mountain rivers,and the characteristics of mountain ecosystems and hydrologic features of mountain river follow strong temporal and spatial distribution,partition theory can be applied to the water resources conservation of mountain *** theory observes the following partition principles:regional relativity,spatial continuity,integralcounty,meeting management needs,hierarchical principle,and comparability *** it lays equal emphasis on both water resources conservation and environmental protection,on both water quality conservation and water quantity protection,on the combination of water features,water cycle and water *** the partition methods,index method and map superposition method will be applied in region *** example of region partition of water resources conservation in the upper reaches of the Yangtze River shows that the partition theory is practicable in water resources conservation of mountain rivers,and it provides a platform for future study in water resources conservation.

关键词： Water resources conservation Mountain river Region partition Mountain ecosystems

在线全文

学校读者我要写书评

暂无评论

职业本科背景下创新型技能人才培养路径研究

承德石油高等专科学校学报 2024年第2期26卷 5-8页

作者：邱亚雷杨威吴二刚王翊康王艺博郭霄柳子辰河北体育学院纪检监察室河北石家庄050000 河北石油职业技术大学办公室河北承德067000 河北铁路运输学校学生处河北石家庄050000 河北医科大学后勤处河北石家庄050000 石家庄珍爱网高级网络数据分析室河北石家庄050000

中国职业本科教育作为培养创新型技能人才而言,具有远大的发展前途和美好的发展前景,当前我国大力倡导建设创新型国家和培养创新型人才,职业本科教育作为一个重要载体具有不可替代的作用。着重从培养创新型技能人才的培养路径入手,通过... 详细信息

中国职业本科教育作为培养创新型技能人才而言,具有远大的发展前途和美好的发展前景,当前我国大力倡导建设创新型国家和培养创新型人才,职业本科教育作为一个重要载体具有不可替代的作用。着重从培养创新型技能人才的培养路径入手,通过建立相应的指标评价体系,提供了目前阶段切实可行的创新型技能人才培养方法。

关键词：职业本科教育创新型技能人才评价体系培养方法

2818例未产女性孕前体成分特点的现况分析

在线全文

学校读者我要写书评

暂无评论

生殖医学杂志 2024年第3期33卷 337-343页

作者：贺宇恒谭容容刘莉莉陶新城浦丹华吴洁南京医科大学第一附属医院江苏省人民医院南京210029

目的了解未产女性孕前体成分的分布特征,为孕前女性优生保健提供指导。方法选取2020年1月至2023年8月于我院就诊的2818例孕前未产女性作为研究对象,采用生物电阻抗的方法进行体成分检测。结果2818例孕前未产女性平均年龄(28.55±3.27)岁... 详细信息

目的了解未产女性孕前体成分的分布特征,为孕前女性优生保健提供指导。方法选取2020年1月至2023年8月于我院就诊的2818例孕前未产女性作为研究对象,采用生物电阻抗的方法进行体成分检测。结果2818例孕前未产女性平均年龄(28.55±3.27)岁,平均体质量指数(BMI)(22.46±3.59)kg/m^(2)。高达70.09%(1975例)的孕前女性体脂百分比高于正常值,体脂百分比正常者仅占28.57%(805例)。根据体成分特征进行分型,高体脂正常肌肉型占比最高为39.78%(1121/2818),其次为高体脂低肌肉型24.80%(700/2818),而正常体脂正常肌肉型仅占14.02%(395/2818)。按年龄分组分析,肥胖相关指标(BMI、内脏脂肪面积、腰围、臂围)在不同年龄组间有显著差异(P0.80,P<0.001)。结论孕前未产女性主要表现为高体脂百分比体型,尤其年龄≥35岁的女性,以腹型肥胖为主。积极开展孕前女性体成分分析有助于更精准地识别潜在肥胖人群、降低超重/肥胖对育龄期女性健康以及母婴健康的远期影响,便于为孕前优生保健提供指导。

关键词：孕前未产女性体成分体质量指数体脂百分比

腹腔镜胃底折叠术治疗质子泵抑制剂依赖性胃食管反流病10年疗效:单中心160例报道

在线全文

学校读者我要写书评

暂无评论

中华普通外科杂志 2024年第6期39卷 423-429页

作者：胡志伟吴继敏李萌刘健男邓昌荣战秀岚纪涛王峰田书瑞张玉陈冬中国人民解放军火箭军特色医学中心胃食管外科北京100088

目的探讨腹腔镜胃底折叠术治疗质子泵抑制剂(PPI)依赖性胃食管反流病(GERD)的长期疗效。方法回顾性分析2012年1至6月于中国人民解放军火箭军特色医学中心接受腹腔镜胃底折叠术的PPI依赖性GERD患者的临床资料。研究指标包括GERD症状评分... 详细信息

目的探讨腹腔镜胃底折叠术治疗质子泵抑制剂(PPI)依赖性胃食管反流病(GERD)的长期疗效。方法回顾性分析2012年1至6月于中国人民解放军火箭军特色医学中心接受腹腔镜胃底折叠术的PPI依赖性GERD患者的临床资料。研究指标包括GERD症状评分、症状主观缓解率、PPI停药率和手术满意度,以及复发和并发症等。结果本研究共纳入GERD患者160例,其中64%的患者合并呼吸道症状,行Nissen和Toupet胃底折叠术分别为43和117例,平均随访时间为(127±3)个月。患者术后各GERD相关症状评分均显著低于治疗前(均P<0.001);消化道和呼吸道总体症状主观缓解程度分别为90%(80%,100%)和100%,PPI停药率为86%,疗效总满意率为92%,其中合并呼吸道症状患者的满意率为89%。7%患者出现不同程度的症状复发,4%的患者再次接受内镜下治疗和(或)腹腔镜胃底折叠术,6/7患者再次取得满意疗效。术后长期吞咽困难、腹胀、嗳气、排气增多、腹痛、腹泻和便秘发生率分别为11.3%、16.9%、0、1.3%、0、2.5%和5.6%。结论腹腔镜胃底折叠术治疗GERD具有良好的长期疗效,少数患者术后可出现复发以及吞咽困难和腹胀等并发症,复发患者可通过内镜下治疗或二次手术重新取得满意疗效。

关键词：胃食管反流胃底折叠术质子泵抑制剂疝,食管裂孔食管炎,消化性

Induction of Lung Injury by Cooking Oil Fumes in Mice and the Protective Effects of Vitamin C

在线全文

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2021年第11期34卷 916-919页

作者： LI Xiao Hong YU Xiao Li ZHOU Jian SHAN Hui OUYANG Chuan KE Hong Yang wu tao Jin LI Wan Wei School of Public Health Weifang Medical UniversityWeifang 261053ShandongChina Public Health Testing Center School of Public Health and ManagementWeifang Medical UniversityWeifang 261053ShandongChina Weifang Key Laboratory of Health Inspetion and Quarantine Weifang 261053ShandongChina

Cooking oil fumes(COF)are one of the most common air pollutants in indoor living environments in *** oil is heated above 250°C,at least220 types of products are produced in the lampblack,including carcinogenic hetero... 详细信息

关键词： Cook heated heterocyclic

Molecular diagnosis of phenylketonuria in 157 Chinese families and the results of prenatal diagnosis in these families

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2021年第13期134卷 1626-1628页

作者： Yang Xiao Qiang Gu Hai-Rong wu Song-tao Wang Pei Pei Xue-Fei Zheng Hong Pan Yi-Nan Ma Department of Central Laboratory Peking University First HospitalBeijing 100034China Department of Pediatrics Peking University First HospitalBeijing 100034China

To the Editor:Phenylketonuria(PKU)is an autosomal recessive genetic disease caused by pathogenic variants in the phenylalanine hydroxylase(PAH)gene encoding phenylalanine hydroxylase,a key enzyme in the metabo-lism of *** low-phenylalanine diet improves most of the neuropsychological disorders,but it is difficult to be maintained for a long period of time.

关键词： diagnosis hydroxylase maintained

Research on magnetic centermeasurement of quadrupole and sextupole using vibrating wire alignment technique in HEPS-TF

在线全文

学校读者我要写书评

暂无评论

Radiation Detection Technology and Methods 2018年第2期2卷 140-147页

作者： Lei wu Xiao-long Wang Chun-hua Li Hua-min Qu zi-hao Wang Min-xian Li Ling-ling Gong Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Dongguan Institute of Neutron Sciences Dongguan 523808China University of Chinese Academy of Sciences Beijing 100049China

Purpose In order to meet the extremely low emittance requirement,the magnets in the storage ring of high-energy photon source(HEPS)need to have a stable support and precise *** HEPS-TF,the key and difficult technologies of HEPS should be researched and *** wire alignment technique is one important project of *** can be used to pre-align the quadrupoles and sextupoles on one girder with high precision.A vibrating wire measurement system was set up and tested to verify the magnetic center measurement precision and the magnet adjustment *** There are one sextupole and one quadrupole installed on a multipole *** wire is stretched through mechanical center of the magnet apertures and supported by the test benches on the two sides.A single conducting wire is stretched through themagnet aperture and electrified by alternating *** wire will vibrate for a period of Lorentz *** matching the current frequency to one mode of natural frequency of the wire,the vibrating amplitude will be *** by measuring the vibrating amplitude,the magnetic field at the wire position can be *** the wire across the magnet aperture in the transversal or vertical direction,the distribution of magnetic field and magnetic center position can be *** to the magnetic center position error to adjust the *** the magnetic center of all magnets installed on the multipole girder one by one,and adjust their magnetic center to a *** The magnetic center measurement precision is better than±3μm,and the magnet adjustment error is less than 6μ*** The vibrating wire system design and a series of magnetic center measurement experiments have gained good *** has been proved the vibrating wire system is designed reasonable and using the vibrating wire to align the magnets installed on a multipole girder is feasible and can reach a high precision.

关键词： Vibrating wire Magnetic center Measurement precision Magnet adjustment

Genome-wide analysis of expression quantitative trait loci(eQTLs)reveals the regulatory architecture of gene expression variation in the storage roots of sweet potato

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Horticulture Research 2020年第1期7卷 1713-1724页

作者： Lei Zhang Yicheng Yu Tianye Shi Meng Kou Jian Sun tao Xu Qiang Li Shaoyuan wu Qinghe Cao Wenqian Hou Zongyun Li Jiangsu Key Laboratory of Phylogenomics and Comparative Genomics School of Life SciencesJiangsu Normal UniversityXuzhou 221116 Jiangsu ProvincePeople’s Republic of China Xuzhou Academy of Agricultural Sciences/Sweet Potato Research Institute CAASXuzhou 221121 Jiangsu ProvincePeople’s Republic of China

Dissecting the genetic regulation of gene expression is critical for understanding phenotypic variation and species ***,our understanding of the transcriptional variability in sweet potato remains ***,we analyzed two publicly available datasets to explore the landscape of transcriptomic variations and its genetic basis in the storage roots of sweet *** comprehensive analysis identified a total of 724,438 high-confidence single nucleotide polymorphisms(SNPs)and 26,026 expressed *** quantitative trait locus(eQTL)analysis revealed 4408 eQTLs regulating the expression of 3646 genes,including 2261 local eQTLs and 2147 distant *** distant eQTL hotspots were found with target genes significantly enriched in specific functional *** combining the information from regulatory network analyses,eQTLs and association mapping,we found that IbMYB1-2 acts as a master regulator and is the major gene responsible for the activation of anthocyanin biosynthesis in the storage roots of sweet *** study provides the first insight into the genetic architecture of genome-wide expression variation in sweet potato and can be used to investigate the potential effects of genetic variants on key agronomic traits in sweet potato.

关键词： roots analysis sweet

以伪装热为表现的儿童孟乔森综合征10例病例系列报告

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国循证儿科杂志 2024年第2期19卷 137-140页

作者：朱国琴薛莉莎何孝亮刘靖高雨彤吴晴沈杨胡容萱徐达良李涛李国民江南大学附属儿童医院肾脏风湿免疫科无锡214023 湖北医药学院附属太和医院儿童医疗中心十堰442000 安徽省立儿童医院风湿科合肥230051

背景以伪装热为表现的儿童孟乔森综合征病例常就诊于精神科、心理科以外的其他科室,这些科室医生对该病认识不足,患儿很难得到及时和正确的诊治,发病率可能被低估。目的总结以伪装热为表现的孟乔森综合征儿童的临床资料,提高对该病的... 详细信息

背景以伪装热为表现的儿童孟乔森综合征病例常就诊于精神科、心理科以外的其他科室,这些科室医生对该病认识不足,患儿很难得到及时和正确的诊治,发病率可能被低估。目的总结以伪装热为表现的孟乔森综合征儿童的临床资料,提高对该病的认识。设计病例系列报告。方法回顾性纳入2022年1月至2024年1月在3个医院诊断以伪装热为表现的孟乔森综合征的连续住院病例。通过各医院管理信息系统采集病例性别、发病年龄、病程,就诊经历及治疗史,发热特征,体格检查,辅助检查等临床资料。主要结局指标发热特征。结果 10例患儿进入本文分析,均为女童,起病年龄12(10~14)岁,病程6.3(1~18)个月。门诊频次平均8(4~12)次,住院频次平均3.5(2~5)次,就诊医院数平均3.5(3~5)家。均有反复行糖皮质激素、抗菌药物治疗史且均无疗效。均在短时间内体温达到高热(39.0~40.2℃),约5 min内体温恢复正常;6例偶有头晕,其中伴头痛2例,伴腹痛1例;发热前均无畏寒及寒战,时间无规律性;体温恢复正常时无出汗反应。发热前后皮肤体感温度、脉搏、心率、呼吸频次均未见变化。精神和食欲均正常;体重轻度增加3例,余病例均未见下降;均无阳性体征。辅助检查均未见异常。单亲家庭环境4例,父母长期争执、吵闹5例,留守儿童1例。均转至心理科进行干预,随访时间8(5~12)个月,未见类似发热发作,也无因其他症状就诊者。结论以伪装热为表现的儿童孟乔森综合征好发于女性儿童/青少年,多次反复求治于不同医院,体温可在3~8 min内达到高热,约5 min内恢复正常,发作时无发热时典型病理生理过程变化,实验室检验和辅助检查结果无异常;虽然病程较长,但无疾病状态改变。

关键词：不明原因发热做作性障碍伪装热病态表现儿童孟乔森综合征