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Current opinions on the mechanism,classification,imaging diagnosis and treatment of post-traumatic osteomyelitis

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Chinese Journal of Traumatology 2021年第6期24卷 320-327页

作者： Jian Yang Jiang-Ling Yao zi-quan wu De-Lu Zeng Lin-Yang Zheng Dong Chen Zheng-Dong Guo Lei Peng Trauma Center the First Affiliated Hospital of Hainan Medical UniversityHainan Medical UniversityHaikou570100China Key Laboratory of Emergency and Trauma Ministry of EducationHainan Medical UniveristyHaikou571199China Hainan Provincial Key Laboratory Hainan Medical UniversityHaikou571199China Hainan Provincial Biomaterials and Medical Device Engineering Technology Research Center Hainan Medical UniversityHaikou571199China

Post-traumatic osteomyelitis(PTO)is a worldwide problem in the field of orthopaedic *** far,there is no ideal treatment or consensus-based gold standard for its *** paper reviews the representative literature focusing on PTO,mainly from the following four aspects:(1)the pathophysiological mechanism of PTO and the interaction mechanism between bacteria and the body,including fracture stress,different components of internal fixation devices,immune response,occurrence and development mechanisms of inflammation in PTO,as well as the occurrence and development mechanisms of PTO in skeletal system;(2)clinical classification,mainly the etiological classification,histological classification,anatomical classification and the newly proposed new classifications(a brief analysis of their scope and limitations);(3)imaging diagnosis,including non-invasive examination and invasive examination(this paper discusses their advantages and disadvantages respectively,and briefly compares the sensitivity and effectiveness of the current examinations);and(4)strategies,including antibiotic administration,surgical choices and other treatment *** on the above-mentioned four aspects,we try to put forward some noteworthy sections,in order to make the existing opinions more specific.

关键词： Osteomyelitis Bone infection Post-traumatic osteomyelitis Pathology Diagnosis Clinical classification Treatment

Bending Stiffness of Concrete-Filled Steel Tube and Its Influence on Concrete Placement Timing of Composite Beam-String Structure

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Structural Durability & Health Monitoring 2025年第1期19卷 55-75页

作者： Zhenyu Zhang quan Jin Haitao Zhang Zhao Liu Yuyang wu Longfei Zhang Renzhang Yan CCCC Third Highway Engineering Co. Ltd.Beijing101300China School of Civil Engineering Chongqing Jiaotong UniversityChongqing400074China

When the upper chord beam of the beam-string structure(BSS)is made of concrete-filled steel tube(CFST),its overall stiffness will change greatly with the construction of concrete placement,which will have an impact on the design of the tensioning plans and selection of control measures for the *** order to accurately obtain the bending stiffness of CFST beam and clarify its impact on the mechanical properties of composite BSS during construction,the influence of some factors such as height-width ratio,wall thickness of steel tube,elasticity modulus of concrete,and friction coefficient on the bending stiffness are analyzed parametrically by the numerical simulation technology based on an actual *** calculation formula of the equivalent bending stiffness of CFST is also established through mathematical statistical ***,the equivalent bending stiffness is introduced into the construction and use stages of the composite BSS,respectively,and the mechanical properties such as prestress-tensioning control value,structural deformation,and internal force of key members are comparatively analyzed when adopting two different construction ***,the optimal construction plan of concrete placement first and then prestress-tensioning is proposed.

关键词： Concrete panels freeze-thaw damage compression-shear crack tension-shear crack

The cGAS-STING-interferon regulatory factor 7 pathway regulates neuroinflammation in Parkinson's disease

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Neural Regeneration Research 2025年第8期20卷 2361-2372页

作者： Shengyang Zhou Ting Li Wei Zhang Jian wu Hui Hong Wei quan Xinyu Qiao Chun Cui Chenmeng Qiao Weijiang Zhao Yanqin Shen Laboratory of Neurodegenerative and Neuroinjury Diseases Wuxi Medicine SchoolJiangnan UniversityWuxiJiangsu ProvinceChina

Interferon regulatory factor 7 plays a crucial role in the innate immune ***,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains *** we report that interferon regulatory factor 7 is markedly up-regulated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease and co-localizes with microglial *** the selective cyclic guanosine monophosphate adenosine monophosphate synthase inhibitor RU.521 and the stimulator of interferon genes inhibitor H151 effectively suppressed interferon regulatory factor 7 activation in BV2 microglia exposed to 1-methyl-4-phenylpyridinium and inhibited transformation of mouse BV2 microglia into the neurotoxic M1 *** addition,si RNA-mediated knockdown of interferon regulatory factor 7 expression in BV2 microglia reduced the expression of inducible nitric oxide synthase,tumor necrosis factorα,CD16,CD32,and CD86 and increased the expression of the anti-inflammatory markers ARG1 and *** together,our findings indicate that the cyclic guanosine monophosphate adenosine monophosphate synthase-stimulator of interferon genes-interferon regulatory factor 7 pathway plays a crucial role in the pathogenesis of Parkinson's disease.

关键词： cyclic guanosine monophosphate adenosine monophosphate synthase H151 interferon regulatory factor 7 M1 phenotype neurodegenerative disease neuroinflammation Parkinson’s disease RU521 STING type I interferon

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三基色白光LED的司辰节律因子研究

发光学报 2016年第11期37卷 1384-1389页

作者：郑莉莉郭自泉严威吴挺竹吕毅军高玉琳史园陈忠厦门大学电子科学系福建省半导体照明工程技术研究中心福建厦门361005 厦门市产品质量监督检验院国家半导体发光器件(LED)应用产品质量监督检验中心福建厦门361004

采用司辰节律因子模型,通过计算三基色白光LED光源在不同工作电流下的司辰节律因子,对可调色温的三基色白光LED光源进行非视觉效应研究。为了获取与自然光非视觉效应类似的LED白光,建立了司辰节律因子和相关色温分别相对于工作电流的关... 详细信息

采用司辰节律因子模型,通过计算三基色白光LED光源在不同工作电流下的司辰节律因子,对可调色温的三基色白光LED光源进行非视觉效应研究。为了获取与自然光非视觉效应类似的LED白光,建立了司辰节律因子和相关色温分别相对于工作电流的关系模型,从而已知自然光的司辰节律因子和相关色温,就可以确定三基色LED的工作电流。通过测试一天内不同时刻的自然光光谱,根据上述模型推算出了三基色LED的工作电流。在所推算的三基色电流下,测试了白光LED光谱参数并计算了相应的司辰节律因子。与自然光司辰节律因子的对比结果表明,理论值和实验值的误差在1.1%以内,证实该方法具有可行性。本文所呈现的方法对于利用三基色白光LED模拟自然光具有一定的指导意义。

关键词：非视觉效应三基色白光LED 司辰节律因子自然光

[Determination of eight phthalate metabolites in urine of pregnant women and evaluation of neonatal birth outcomes based on solid-phase extraction-high performance liquid chromatography-tandem mass spectrometry]

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Se pu = Chinese journal of chromatography 2025年第1期43卷 60-67页

作者： zi-Hao Wang Meng-Fei Xu Bei-Ni Li Ping wu Wei wu Hubei University of Chinese Medicine Wuhan 430065 China.

Phthalates (PAEs) are endocrine-disrupting chemicals that are widely present in everyday life and enter the human body through various pathways. The release of PAEs into the environment through pathways that include leaching, evaporation, abrasion, and the use of personal care products exposes humans to PAEs via ingestion, inhalation, and dermal absorption. Pregnant women, as a particularly vulnerable population, risk adverse newborn growth and development when exposed to PAEs. While the concentrations of PAEs in urine reflect recent exposure levels in humans, urinary levels of phthalate metabolites (mPAEs) are commonly used as biomarkers of internal exposure owing to the relatively short biological half-lives of PAEs (quantification performed using the internal-standard method. Good linearities were obtained in the range of 0.1-200 ng/mL for the eight mPAEs, with limits of detection (LODs) and quantification (LOQs) of 0.015-0.048 and 0.050-0.160 ng/mL, respectively. The eight mPAEs exhibited recoveries of 80.2%-99.7% at three spiked levels (1, 10, and 50 ng/mL). This method was subsequently used to analyze the eight mPAEs levels in urine samples of 497 pregnant women from the Ezhou Maternity and Child Health Care Hospital. The participants exhibited widespread exposure t

关键词： birth outcomes high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) phthalate metabolites (mPAEs) urine samples of pregnant women

基于机器学习筛选猪活体肌内脂肪含量间接选育和构建预测模型的关键性状

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南京农业大学学报 2025年第1期48卷 161-170页

作者：吴建杨文孟孜查成万吴望军南京农业大学动物科技学院江苏南京210095

[目的]本研究旨在探究猪断奶重、屠宰前活体重、背膘厚等性状因素对猪肌内脂肪(intramuscular fat,IMF)含量的影响,确定影响猪IMF含量的关键性状因素。[方法]以805头皮特兰×[杜洛克×(长白×大白)]四元商品猪群为试验对象,记录性别,测... 详细信息

[目的]本研究旨在探究猪断奶重、屠宰前活体重、背膘厚等性状因素对猪肌内脂肪(intramuscular fat,IMF)含量的影响,确定影响猪IMF含量的关键性状因素。[方法]以805头皮特兰×[杜洛克×(长白×大白)]四元商品猪群为试验对象,记录性别,测定初生重、断奶重、屠宰前活体重和IMF含量等14个性状,然后通过相关性分析从14个性状中初步筛选出影响IMF含量的性状因素,再通过随机森林模型评估各性状因素对IMF含量影响的重要性,进一步通过LASSO回归和逐步回归筛选出影响IMF含量的关键性状因素;在此基础上,利用广义线性模型(generalized linear model,GLM)分析关键性状因素不同水平对IMF含量的影响。[结果]相关性分析结果显示,猪IMF含量与断奶重(r=0.13, P0.05)。胸腰椎结合处背膘厚大于26 mm组的平均IMF含量(2.73%)显著高于其他背膘厚组(P0.05)。[结论]本研究通过机器学习确定了性别、断奶重、屠宰前活体重和胸腰椎结合处背膘厚4个与IMF含量显著相关的活体可测定性状,并发现平均IMF含量随着屠宰前活体重和胸腰椎结合处背膘厚的增加呈明显的上升趋势。

关键词：猪肌内脂肪间接选择模型构建机器学习活体可测定性状

The asymptotic relation between the first crossing point and the last exit time of Gaussian order statistics sequences

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Applied Mathematics(A Journal of Chinese Universities) 2023年第4期38卷 545-561页

作者： NING zi-jun TAN Zhong-quan College of Data Science Jiaxing UniversityJiaxing 314001China

In this paper,we study the asymptotic relation between the first crossing point and the last exit time for Gaussian order statistics which are generated by stationary weakly and strongly dependent Gaussian *** is shown that the first crossing point and the last exit time are asymptotically independent and dependent for weakly and strongly dependent cases,*** asymptotic relations between the first crossing point and the last exit time for stationary weakly and strongly dependent Gaussian sequences are also obtained.

关键词： rst crossing point last exit time stationary Gaussian sequences Gaussian order statistic se-quences

Asymptotic Behavior of Soliton Solutions with a Double Spectral Parameter for Principal Chiral Field

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Communications in Theoretical Physics 2005年第6X期44卷 977-980页

作者： SONG quan-Fu ZHOU zi-Xiang School of Mathematical Sciences Fudan University Shanghai 200433 China

The soliton solutions with a double spectral parameter for the principal chiral field are derived by Darboux transformation. The asymptotic behavior of the solutions as time tends to infinity is obtained and the speed... 详细信息

关键词： principal chiral field asymptotic solutions

Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

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Science China Chemistry 2025年第01期 288-296页

作者： Shuai Liu Wen-Qiang Xu Ying-Tong Di Man-Cheng Tang Ding-Kang Chen Ming-Ming Cao Yao-Wen Chang Hong-Yu Tang Chun-Mao Yuan Jun-Bo Yang Zhi-Li Zuo Han Guo zi-Fei Xu Ying Zeng Yun-Dong wu Xiao-Jiang Hao Key Laboratory of Phytochemistry and Natural Medicines (Chinese Academy of Sciences) Kunming Institute of Botany Chinese Academy of Sciences University of Chinese Academy of Sciences Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical Oncogenomics Peking University Shenzhen Graduate School Shenzhen Bay Laboratory State Key Laboratory of Microbial Metabolism School of Life Sciences & Biotechnology Shanghai Jiao Tong University State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University Molecular Biology Experimental Center Germplasm Bank of Wild Species in Southwest China Kunming Institute of Botany Chinese Academy of Sciences Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of Botany Chinese Academy of Sciences Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical Sciences

In the intricate process of natural product biosynthesis, a metabolon can enhance metabolic flux by associating sequential enzymes. A fungal metabolon, comprising of flavin-dependent monooxygenase Spe F and P450 monooxygenase Spe G, is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide B. Using notoamide E as a substance, Spe F/Spe G metabolon can control the stereoselectivity of its 2,3-epoxidation, followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-m A with dienyl iminium unit. Subsequently,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol rearrangement. This provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

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