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Understanding Mass Dependence of Glass Formation in Ring Polymers

Chinese Journal of Polymer Science 2023年第9期41卷 1447-1461,I0008页

作者： Xiang-Yu Song Zhen-Yue Yang Qi-Lu Yuan Shang-Wei Li zi-qiang tang Yue-Tong Dong Shi-Chun Jiang Wen-Sheng Xu State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei230026China School of Materials Science and Engineering Tianjin UniversityTianjin300072China

Having highly tunable molecular topology is one of the most important characteristics of polymers that provides these materials with a wide range of interesting and unique *** particular,ring polymers exhibit a number of properties that are markedly distinct from their linear ***,we compare and contrast the glass formation of unknotted,nonconcatenated ring and linear polymer melts having variable molecular mass based on molecular dynamics simulations of a coarse-grained *** revealing an unusual property in the structure of small rings,we discuss the mass dependence of the structural relaxation time determined from the self-intermediate scattering function over a wide range of temperatures in both ring and linear *** a general trend,we find that the characteristic temperatures(e.g.,the glass transition temperature)and fragility of glass formation increase with increasing molecular mass in linear polymers,but the mass dependences of these properties are rather weak in the family of ring polymer models considered,in broad accord with experimental ***,we show that the glass formation of ring polymers can quantitatively be described by the string model,a model that is broadly consistent with the entropy theory of glass formation and that takes the mass of string-like clusters as a molecular realization of the abstract cooperatively rearranging *** opens the possibility of applying the configurational entropy-based theories to describe the glass formation of ring polymers,once the ring topology is taken into account.

关键词： Ring polymers Glass formation String model Molecular dynamics simulation

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BIBR1532 inhibits proliferation and metastasis of esophageal squamous cancer cells by inducing telomere dysregulation

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 214-225页

作者： Qin Wang Qing-Rong Li Lei Xu zi-Chun Yuan Xiao Liu Mao-Ju tang Man Luo Xiao-Wu Zhong qiang Ma Xiao-Lan Guo Department of Clinical Laboratory Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina School of Laboratory Medicine&Translational Medicine Research Center North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina

BACKGROUND Esophageal squamous cell carcinoma(ESCC)is a malignant tumor with high morbidity and mortality,and easy to develop resistance to chemotherapeutic *** are DNA-protein complexes located at the termini of chro-mosomes in eukaryotic cells,which are unreplaceable in maintaining the stability and integrity of ***,an RNA-dependent DNA polymerase,play vital role in telomere length maintain,targeting telomerase is a promising therapeutic strategy for ***150 and KYSE410 cells were cultured and exposed to various concentrations of *** viability was assessed at 48 hours and 72 hours to determine the IC50 *** effects of BIBR1532 on ESCC cell proliferation,migration,and cellular senescence were evaluated using the cell counting kit-8 assay,plate colony formation assay,scratch assay,transwell assay,andβ-galactosidase staining,*** blotting was performed to detect the expression of RESULTS The IC50 values for KYSE150 and KYSE410 cells after 48 hours of BIBR1532 exposure were 48.53μM and 39.59μM,*** values decreased to 37.22μM and 22.71μM,respectively,following a longer exposure of 72 ***1532 exhibited dose-dependent effects on KYSE150 and KYSE410 cells,including decreased hTERT expression,inhibition of proliferation and metastasis,and induction of cellular ***,BIBR1532 upregulated the expression of the DDR protein,γ-H2AX,and activated the ataxia telangiectasia and Rad3-related protein(ATR)/check point kinase 1(CHK-1)and ataxia-telangiectasia mutated gene(ATM)/CHK2 ***1532 downregulated the expression of telomere-binding proteins,including telomeric-repeat binding factor 1(TRF1),TRF2,protection of telomeres 1,and TIN2-interacting protein *** a nude mouse xenograft model,BIBR1532 significantly suppressed tumor growth,reduced hTERT expression,and increasedγ-H2AX protein *** and eosin staining of various organs,including the heart,liver,s

关键词： Esophageal squamous cell carcinoma BIBR1532 Human telomerase reverse transcriptase DNA damage response Telomere-binding proteins

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用穆斯堡尔效应研究YBa_2Cu_3O_(7-δ)中的磁有序

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物理学报 1990年第3期39卷 472-478页

作者：都有为邱子强唐焕 J.C.Walker 南京大学固体物理研究所 The Johns Hopkins University BaltimoreMD 21218 U.S.A.

以^(57)Fe作为探针,用穆斯堡尔效应研究YBa_2Cu_3O_(7-8)的磁有序与超导电性的关系。实验结果可以用非声子超导机制进行定性解释。

关键词：穆斯堡尔效应 YBa2Cu3O7-8 磁有序

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Activin A receptor type 1C single nucleotide polymorphisms associated with esophageal squamous cell carcinoma risk in Chinese population

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 39-51页

作者： Si-Yun Lin Hou Huang Jin-Jie Yu Feng Su Tian Jiang Shao-Yuan Zhang Lu Lv Tao Long Hui-Wen Pan Jun-Qing Qi qiang Zhou Wei-Feng tang Guo-Wen Ding Li-Ming Wang Li-Jie Tan Jun Yin Department of Thoracic Surgery Zhongshan Hospital Affiliated to Fudan UniversityShanghai 200032China Shanghai Key Laboratory of Clinical Geriatric Medicine Huadong Hospital Affiliated to Fudan UniversityShanghai 200040China Department of Cardiothoracic Surgery The Affiliated People's Hospital of Jiangsu UniversityZhenjiang 212002Jiangsu ProvinceChina Department of Thoracic Surgery Sichuan Cancer Hospital&InstituteChengdu 610042Sichuan ProvinceChina Department of Cardiothoracic Surgery Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210000Jiangsu ProvinceChina Department of Respiratory and Critical Care Medicine Shanghai Xuhui Central HospitalShanghai 200032China

BACKGROUND Transforming growth factor-β(TGF-β)superfamily plays an important role in tumor progression and *** A receptor type 1C(ACVR1C)is a TGF-βtype I receptor that is involved in tumorigenesis through binding to dif-ferent *** To evaluate the correlation between single nucleotide polymorphisms(SNPs)of ACVR1C and susceptibility to esophageal squamous cell carcinoma(ESCC)in Chinese Han *** In this hospital-based cohort study,1043 ESCC patients and 1143 healthy controls were *** SNPs(rs4664229,rs4556933,rs77886248,rs77263459,rs6734630)of ACVR1C were assessed by the ligation detection reaction ***-Weinberg equilibrium test,genetic model analysis,stratified analysis,linkage disequi-librium test,and haplotype analysis were *** Participants carrying ACVR1C rs4556933 GA mutant had significantly decreased risk of ESCC,and those with rs77886248 TA mutant were related with higher risk,especially in older male *** the haplotype analysis,ACVR1C Trs4664229Ars4556933Trs77886248Crs77263459Ars6734630 increased risk of ESCC,while Trs4664229Grs4556933Trs77886248Crs77263459Ars6734630 was associated with lower susceptibility to *** ACVR1C rs4556933 and rs77886248 SNPs were associated with the susceptibility to ESCC,which could provide a potential target for early diagnosis and treatment of ESCC in Chinese Han population.

关键词： Activin A receptor type 1C Single nucleotide polymorphisms Esophageal squamous cell carcinoma Genetic susceptibility Hospital-based cohort study

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Design of a 162.5 MHz continuous-wave normal-conducting radiofrequency electron gun

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Nuclear Science and Techniques 2020年第11期31卷 50-59页

作者： Cheng Wang zi-Han Zhu Zeng-Gong Jiang Qi-Sheng tang Zhen-tang Zhao qiang Gu Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201210China

A high-gradient radiofrequency(RF)gun operated in continuous-wave(CW)mode is required in various accelerating *** to the high RF power loss,a traditional normal-conducting(NC)RF electron gun has difficulty meeting the requirement of generating a high-repetition-rate electron *** development of a scheme for a CW NC-RF gun is urgently *** as a photoinjector of a high-repetition-rate free-electron laser(FEL),an electron gun operated in CW mode and the VHF band is *** analysis of the reentrant gun cavity is presented in this paper to increase the gradient and decrease the power density and power *** to the analysis results,the design of a162.5 MHz gun cavity is optimized by a multi-objective evolutionary algorithm to achieve better performance in CW *** and thermal analyses are also deliberated in the design to coordinate with RF and mechanical *** optimized 162.5 MHz gun cavity can be operated in CW mode to generate a high-repetition-rate beam with voltage up to 1 MV and gradient up to 32.75 MV/m at the cathode.

关键词： High-repetition-rate beam Radiofrequency gun Continuous-wave mode Multi-objective evolutionary algorithm

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On K_2-group of a Formal Matrix Ring

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Acta Mathematica Sinica,English Series 2012年第9期28卷 1897-1906页

作者： zi qiang FAN Zhi Xiang YIN Department of Mathematics Anhui University of Science and Technology

Let S be a formal matrix ring, T the subring consisting of all diagonal elements, I the set consisting of all off-diagonal elements. Then I is a split radical ideal under certain conditions. In this paper, we show tha... 详细信息

关键词： K2 group relative K2 group extension of groups

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Simulations of a two-stream backward-wave oscillator with a slot-hole structure

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Chinese Physics B 2012年第1期21卷 518-523页

作者： Shi Zong-Jun tang Xiao-Pin Yang zi-qiang Lan Feng Liang Zheng Terahertz Research Centre School of Physical ElectronicsUniversity of Electronic Science and Technology of ChinaChengdu 610054China

We study a two-stream backward-wave oscillator with a slot-hole structure at short millimeter waves with the help of a three-dimensional particle-in-cell simulation. In order to increase the interaction region of the electron beam, the efficiency and the output power, a slot-hole loaded rectangular waveguide structure used as the high-frequency system is proposed. Based on the mechanism of the backward-wave oscillator, a slow-wave oscillator with a frequency of 0.14 THz is designed. The simulations show that the output power and the efficiency of the oscillator can be enhanced due to the coupling between the two beams through the slot holes. The interaction efficiency is 5.18%, and the starting current density is below 5 A. cm^-2 for the two beams. These attractive results indicate that, based on the two-stream backward-wave oscillator, we can get short millimeter wave sources with high power and low current density.

关键词： slot-hole structure short millimeter wave two-stream backward-wave oscillator

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Arbitrary-oriented target detection in large scene sar images

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Defence Technology（防务技术） 2020年第4期16卷 933-946页

作者： zi-shuo Han Chun-ping Wang qiang Fu Shijiazhuang Campus Army Engineering UniversityShijiazhuang050003China

Target detection in the field of synthetic aperture radar(SAR) has attracted considerable attention of researchers in national defense technology worldwide,owing to its unique advantages like high resolution and large scene image acquisition capabilities of ***,due to strong speckle noise and low signal-to-noise ratio,it is difficult to extract representative features of target from SAR images,which greatly inhibits the effectiveness of traditional *** order to address the above problems,a framework called contextual rotation region-based convolutional neural network(RCNN) with multilayer fusion is proposed in this ***,aimed to enable RCNN to perform target detection in large scene SAR images efficiently,maximum sliding strategy is applied to crop the large scene image into a series of sub-images before *** of using the highest-layer output for proposal generation and target detection,fusion feature maps with high resolution and rich semantic information are constructed by multilayer fusion ***,we put forwards rotation anchors to predict the minimum circumscribed rectangle of targets to reduce redundant detection ***,shadow areas serve as contextual features to provide extraneous information for the detector identify and locate targets *** results on the simulated large scene SAR image dataset show that the proposed method achieves a satisfactory performance in large scene SAR target detection.

关键词： Target detection Convolutional neural network Multilayer fusion Context information Synthetic aperture radar

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Microbial D-amino acids and marine carbon storage

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Science China Earth Sciences 2016年第1期59卷 17-24页

作者： ZHANG zi Lian ZHENG qiang JIAO Nian Zhi State Key Laboratory of Marine Environmental Science Institute of Marine Microbes and EcospheresXiamen University

In nature, there are two conformational types of amino acids: L- and D-isomers. The L-amino acids are the predominant form and are used mainly for protein synthesis, while the D-amino acids are few in quantity but more diverse in terms of their biological functions. D-amino acids are produced by many marine microbes, which are important players in carbon and energy cycles in the ocean. As the major constituent of the marine organic carbon pool, D-amino acids can persist in the water column for a long time before being further transformed by chemical or biological processes or transported through physical processes(such as absorption and aggregation). This article reviews the microbial synthesis of D-amino acids, their physiological function and metabolism in microbes, and the contribution of D-amino acids as a carbon source to the oceanic carbon reservoir.

关键词： Microbe D-amino acid Dissolved organic carbon Marine carbon storage

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Review:Advances in research of stress-assisted corrosion fatigue problem

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第2期8卷 221-227页

作者： tang Zhi-bo LI qiang Division of Engineering Zhejiang Ocean University Zhoushan 316004 China

Ceramic materials are notable for their rigidity, insulation and resistance to hostile environment, Nevertheless, if a stressed ceramic component is exposed to chemical attack, it may suffer from a form of delayed fracture known as static fatigue. From the point of view of a designer, it is clearly desirable to determine the behavior of sub-critical crack growth; the crack path and crack growth rate, as a function of material properties and loading conditions are of particular interest. This paper presents a review of advances in stress assisted corrosion problem in history and its corresponding numerical approaches in the last decades, and finally, comes uo with consideration and crucial suggestions for future work.

关键词： Stress corrosion Finite element method (FEM) Fracture Static fatigue Meshless local Petrov-Galerkin (MLPG)

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