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Characteristics of traumatic brain injury models:from macroscopic blood flow changes to microscopic mitochondrial changes

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Neural Regeneration Research 2023年第10期18卷 2268-2277页

作者： Ding-Ding yang Xiang-Dong Wan An-Di Chen zi-qian yan Yi-Fan Lu Jun-Chen Liu Ya-Zhou Wang Jing Wang yan Zhao Sheng-Xi Wu Guo-Hong Cai Department of Neurobiology School of Basic MedicineForth Military Medical UniversityXi’anShaanxi ProvinceChina Hebei Medical University ShijiazhuangHebei ProvinceChina College of Life Sciences&Research Center for Resource Peptide Drugs Yan’an UniversityYan’anShaanxi ProvinceChina Department of Nuclear Medicine First Affiliated Hospital of Forth Military Medical UniversityXi’anShaanxi ProvinceChina Department of Gastroenterology First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi ProvinceChina

Controlled cortical impingement is a widely accepted method to induce traumatic brain injury to establish a traumatic brain injury animal model.A strike depth of 1 mm at a certain speed is recommended for a moderate brain injury and a depth of>2 mm is used to induce severe brain ***,the different effects and underlying mechanisms of these two model types have not been *** study investigated the changes in cerebral blood flow,differences in the degree of cortical damage,and differences in motor function under different injury parameters of 1 and 2 mm at injury speeds of 3,4,and 5 m/*** also explored the functional changes and mitochondrial damage between the 1 and 2 mm groups in the acute(7 days)and chronic phases(30 days).The results showed that the cerebral blood flow in the injured area of the 1 mm group was significantly increased,and swelling and bulging of brain tissue,increased vascular permeability,and large-scale exudation *** the 2 mm group,the main pathological changes were decreased cerebral blood flow,brain tissue loss,and cerebral vasospasm occlusion in the injured *** motor and cognitive impairments were found on day 7 after injury in the 2 mm group;at 30 days after injury,the motor function of the 2 mm group mice recovered significantly while cognitive impairment *** sequencing showed that compared with the 1 mm group,the 2 mm group expressed more ferroptosis-related *** changes of mitochondria in the two groups on days 7 and 30 using transmission electron microscopy revealed that on day 7,the mitochondria in both groups shrank and the vacuoles became larger;on day 30,the mitochondria in the 1 mm group became larger,and the vacuoles in the 2 mm group remained *** analyzing the proportion of mitochondrial subgroups in different groups,we found that the model mice had different patterns of mitochondrial composition at different time periods,suggesting that the differenc

关键词： cerebral blood flow cognitive impairments controlled cortical impingement ferroptosis mitochondrial dysfunction motor impairments mouse model traumatic brain injury

Arsenic availability and transportation in soil-rice system affected by iron-modified biochar

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Journal of Central South University 2021年第6期28卷 1901-1918页

作者： qian zi-yan XUE Sheng-guo CUI Meng-qian WU Chuan LI Wai-chin School of Metallurgy and Environment Central South UniversityChangsha 410083China Department of Science and Environmental Studies the Education University of Hong KongTai PoHong KongChina

Iron-modified biochar(FeOS)is known to be effective at immobilization of arsenic(As)in soils.A pot experiment was conducted to investigate the effects of FeOS on As availability and ttransportation in the soil-rice system at different growth stages of rice with different pollution *** results showed that Fe concentration decreased and As concentration increased in paddy soils with the FeOS addition,especially in 120 mg/kg As treatment,the As concentration decreased by 16.46%and 30.56%at the maturity stage with 0.5%and 1%FeOS additions,*** with the control,the application of FeOS reduced the arsenic content in rice tissues and increased the biomass,with the root biomass increased by 12.68%and the shoot biomass was increased by 8.94%with the addition of 1%*** may be related to the promotion of iron plaque formation and the transformation of microbial community structure in FeOS treatments,in accordance with the result of gene abundance and Fe/As contents of iron plaque in the *** study is expected to provide further support and theoretical basis for the application of FeOS in the remediation of As contaminated paddy soil.

关键词： arsenic rice iron-modified biochar(FeOS) iron plaque speciation uptake

Discovery of a new family member of arsenic–vanadium polyoxometalates with high catalytic performance for one-pot coupling of CO2, epoxides and amines

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Tungsten 2025年第1期7卷 80-87页

作者： Fang-qian Wang Yin Zhang Wei-Wei Wang Mei-qian Fu Hong-Bing Mo Wei-Dong Yu Chao Liu Jun yan College of Chemistry and Chemical Engineering Central South University Junior Education Department Changsha Normal University School of Science Hunan University of Technology and Business

Arsenic-vanadium polyoxometalates（POMs） represent a family of tremendous potential catalysts owing to their peculiar physical and chemical *** in CO2conversion,using POMs to catalyze the conversion of CO2and epoxide into chemical intermediates is the research ***,A new family number of arsenic-vanadium POMs,[N（CH3）4]4[As8V12O38（H2O）]·2H2O({As8V12O38}),was reported and characterized by single-crystal X-ray diffraction,fourier transform infrared spectroscopy,X-ray photoelectron spectroscopy,*** from other allotropicity,{As8V12O38}shows a different structure pattern with an I-43d *** obtained {As8V12O38} was employed as a catalyst for the *** initial catalytic reaction confirmed that {As8V12O38} can catalyze the formation of epoxy carbonate by using 1.01 kPa CO2and epoxide at 70℃.Furtherly,when added amine in the catalytic system,oxazolidinone could be obtained by high yields,which provides an efficient way to convert CO2into profitable ***,a possible catalytic reaction mechanism was proposed by using different characterization analyses.{As8V12O38} first catalyzes the epoxide and CO2to form an epoxy carbonate and then catalyzes epoxy carbonate and benzylamine into oxazolidinone.

关键词： Arsenic CO2 conversion Oxazolidinone Polyoxometalates Vanadium

Multifunctional Nacre‑Like Nanocomposite Papers for Electromagnetic Interference Shielding via Heterocyclic Aramid/MXene Template‑Assisted In‑Situ Polypyrrole Assembly

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Nano-Micro Letters 2025年第3期17卷 37-54页

作者： Jinhua Xiong Xu Zhao Zonglin Liu He Chen qian yan Huanxin Lian Yunxiang Chen Qingyu Peng Xiaodong He National Key Laboratory of Science and Technology On Advanced Composites in Special Environments Center for Composite Materials and StructuresHarbin Institute of TechnologyHarbin 150080People’s Republic of China

Robust, ultra-flexible, and multifunctional MXene-basedelectromagnetic interference (EMI) shielding nanocomposite filmsexhibit enormous potential for applications in artificial intelligence,wireless telecommunication, and portable/wearable electronic *** this work, a nacre-inspired multifunctional heterocyclic aramid(HA)/MXene@polypyrrole (PPy) (HMP) nanocomposite paper withlarge-scale, high strength, super toughness, and excellent tolerance tocomplex conditions is fabricated through the strategy of HA/MXenehydrogel template-assisted in-situ assembly of PPy. Benefiting from the"brick-and-mortar" layered structure and the strong hydrogen-bondinginteractions among MXene, HA, and PPy, the paper exhibits remarkable mechanical performances, including high tensile strength (309.7 MPa),outstanding toughness (57.6 MJ m−3), exceptional foldability, and structural stability against ultrasonication. By using the template effect ofHA/MXene to guide the assembly of conductive polymers, the synthesized paper obtains excellent electronic conductivity. More importantly,the highly continuous conductive path enables the nanocomposite paper to achieve a splendid EMI shielding effectiveness (EMI SE) of 54.1 dBat an ultra-thin thickness (25.4 μm) and a high specific EMI SE of 17,204.7 dB cm2g−1. In addition, the papers also have excellent applicationsin electromagnetic protection, electro-/photothermal de-icing, thermal therapy, and fire safety. These findings broaden the ideas for developinghigh-performance and multifunctional MXene-based films with enormous application potential in EMI shielding and thermal management.

关键词： MXene Remarkable mechanical properties Heterocyclic aramid Electromagnetic interference shielding Polypyrrole Multifunctionality

土壤-水稻系统砷的生物地球化学过程研究进展

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农业环境科学学报 2019年第7期38卷 1429-1439页

作者：吴川安文慧薛生国江星星崔梦倩钱子妍中南大学冶金与环境学院

本文综述了具有不同渗氧能力基因型水稻对土壤砷结合形态、水稻根表铁膜、砷吸收的影响以及不同根际氧化还原条件对土壤砷形态、水稻砷积累、砷转运载体表达的影响,分析了硅的不同施加量对水稻砷吸收的研究进展及其作用机制,从土壤铁矿... 详细信息

本文综述了具有不同渗氧能力基因型水稻对土壤砷结合形态、水稻根表铁膜、砷吸收的影响以及不同根际氧化还原条件对土壤砷形态、水稻砷积累、砷转运载体表达的影响,分析了硅的不同施加量对水稻砷吸收的研究进展及其作用机制,从土壤铁矿物氧化和还原两个方面总结了根际铁循环对砷环境行为的影响以及对砷污染土壤修复的潜在价值,以期为最终降低水稻砷吸收提供理论参考。微生物介导的铁氧化还原对砷的环境行为如砷的溶解释放、吸附沉淀、形态转化等有重要影响,而铁细菌的胞外电子传递过程促进了铁的矿物相转化并耦合砷的钝化,在未来工作中值得进一步关注和研究。

关键词：水稻砷土壤硅铁循环

miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong Jing-Jing Hu yan Yu Xiao-Li Li Xiao-Ting Sun Li-Ting Wang Xia Wu Ling-Jie Zhu Xiao-Jia yang qian-Ru He Fei Ding Hai-yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

A monolithic 3D IGZO-RRAM-SRAM-integrated architecture for robust and efficient compute-in-memory enabling equivalent-ideal device metrics

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Science China(Information Sciences) 2025年

作者： Shengzhe yan Zhaori CONG zi WANG Zhuoyu DAI Zeyu GUO Zhihang qian Xufan LI Xu ZHENG Chuanke CHEN Nianduan LU Chunmeng DOU Guanhua yanG Xiaoxin XU Di GENG Jinshan YUE Lingfei WANG Ling LI Ming LIU Institute of Microelectronics of the Chinese Academy of Sciences University of Chinese Academy of Sciences

Abstract Compute-in-memory (CIM) based on various devices such as static random access memory (SRAM) and resistive random access memory (RRAM) and other emerging devices such as indium-gallium-zinc-oxide (IGZO) transistor, magnetoresistive RAM (MRAM), and ferroelectric RAM (FeRAM) has been explored for better performance and energy efficiency on neural networks applications. However, CIM based on a single-type device suffers a variety of non-ideal metrics to reach the simultaneous optimal accuracy, density, and energy efficiency. This work presents equivalent-ideal CIM (Eq-CIM), a monolithic 3D(M3D) IGZO-RRAM-SRAM integrated architecture for robust and efficient compute-in-memory enabling equivalent-ideal device metrics. To overcome the non-ideality (variation, endurance, temperature, etc.) of the single-type devices, system-technology co-optimization (STCO) is performed. This work highlights the non-ideality-aware functionality breakdown for robust high accuracy and simultaneous high density/efficiency, by utilizing 2T0C IGZO for temporal activation storage, RRAM for high-density weight storage, and SRAM for accurate CIM. Device-to-algorithm variation transfer is applied to analyze the system-level accuracy. We benchmark Eq-CIM architecture on CIFAR-10/ImageNet, with 5.06×storage density and 5.05×/2.45×area/energy efficiency compared with single-type-device-based CIM, and high robustness (<0.27%accuracy loss) from-40℃ to 120℃.

关键词：

带拼接板螺栓连接耗能梁段的可恢复功能钢框筒结构抗震性能研究

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调整细胞培养条件提高间充质干细胞外泌体治疗骨关节炎的潜能

工程力学 2025年第1期42卷 83-102页

作者：连鸣戴子琳程倩倩西安建筑科技大学土木工程学院西安710055 西安建筑科技大学结构工程与抗震教育部重点实验室西安710055 中国建筑西北设计研究院有限公司西安710018

为了提升传统钢框筒结构的延性和耗能能力，提出采用拼接板螺栓连接的可恢复功能剪切耗能型钢框筒结构(FTS-SRSL)，该结构结合了可更换剪切型耗能梁段和钢框筒结构具有良好的抗震性能。该文对一个2/3缩尺的单层单跨FTS-SRSL子结构试件... 详细信息

为了提升传统钢框筒结构的延性和耗能能力，提出采用拼接板螺栓连接的可恢复功能剪切耗能型钢框筒结构(FTS-SRSL)，该结构结合了可更换剪切型耗能梁段和钢框筒结构具有良好的抗震性能。该文对一个2/3缩尺的单层单跨FTS-SRSL子结构试件进行了往复加载试验，试验结果表明，FTS-SRSL子结构试件具有良好的抗震性能，结构损伤集中于耗能梁段，且耗能梁段可实现更换。在试验的基础上，以耗能梁段长度比、耗能梁段腹板加劲肋间距、螺栓直径、翼缘拼接板和腹板拼接板厚度为参数，利用ABAQUS建立了15个足尺的单层单跨FTS-SRSL有限元模型，探究各模型的抗震性能，包括承载力、刚度、耗能以及塑性变形能力。有限元分析结果表明：改变拼接板螺栓连接的剪切型耗能梁段长度比会显著影响结构的承载力、刚度及耗能，建议FTS-SRSL中的拼接板螺栓连接剪切型耗能梁段长度比取0.73~1.09;改变耗能梁段腹板加劲肋间距对结构的承载力、刚度和耗能影响较小，基于该文的分析结果，建议FTS-SRSL中的拼接板螺栓连接剪切型耗能梁段腹板加劲肋间距取e/4~e/3(e为耗能梁段长度)，且间距应满足我国抗规的规定;改变翼缘拼接板和腹板拼接板厚度对结构的承载力、刚度及耗能基本无影响;改变螺栓直径对结构承载力、刚度及耗能影响较小。

关键词：可更换耗能梁段拼接板螺栓连接钢框筒结构抗震性能参数分析

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中国组织工程研究 2025年第1期29卷 164-174页

作者：钱燕刘启颂深圳国家感染性疾病临床医学研究中心南方科技大学深圳市第三人民医院广东省深圳市518112

背景:间充质干细胞外泌体有望发展成为治疗骨关节炎的无细胞疗法,而通过调整细胞培养条件,可以进一步提高其治疗活性和临床转化潜能。目的:综述分析细胞培养条件对外泌体活性的影响,分析其临床转化潜力。方法:查阅国内外有关骨关节炎/... 详细信息

背景:间充质干细胞外泌体有望发展成为治疗骨关节炎的无细胞疗法,而通过调整细胞培养条件,可以进一步提高其治疗活性和临床转化潜能。目的:综述分析细胞培养条件对外泌体活性的影响,分析其临床转化潜力。方法:查阅国内外有关骨关节炎/软骨损伤修复与间充质干细胞来源外泌体的文献。检索词分别为“外泌体,间充质干细胞,骨关节炎,软骨修复”和“exosomes,extracellular vesicles,mesenchymal stem cells,osteoarthritis,cartilage repair”,检索数据库分别为PubMed和中国知网数据库,检索时限为2010-2023年,最后纳入100篇文献进行总结和分析。结果与结论:(1)在间充质干细胞的培养过程中,提供有利于软骨细胞生长的物理环境,或添加软骨保护小分子、成软骨诱导因子和炎症因子等刺激细胞,可以进一步提高间充质干细胞外泌体在维持软骨细胞表型、促进软骨再生和免疫抑制等方面的调控活性;因此,其他具有相似特征的物理或化学因素,也有可能提升间充质干细胞外泌体治疗骨关节炎的疗效。(2)低氧诱导、脉冲电磁场刺激、生物反应器及软骨保护分子(如人甲状旁腺素1-34)刺激等细胞培养方案具有安全、可规模化生产等优点,可用于制备临床用途的、疗效好的间充质干细胞外泌体。(3)间充质干细胞外泌体有望实现骨关节炎的修正治疗,通过调整细胞培养方案提升治疗活性,可进一步提高其临床转化的可行性。

关键词：间充质干细胞外泌体骨关节炎软骨修复细胞培养低氧诱导预处理三维培养软骨保护因子炎症因子