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Journal of Iron and Steel Research International 2016年第8期23卷 745-755页

作者： zi-qian zhang School of Mechanical Engineering and Automation Northeastern University

Cross-sectional ovalization of thin-walled circular steel tube because of large plastic bending,also known as the Brazier effect,usually occurs during the initial stage of tube′s continuous rotary straightening *** amount of ovalization,defined as maximal cross section flattening,is an important technical parameter in tube′s straightening process to control tube′s bending deformation and prevent ***,for the lack of special analytical model,the maximal section flattening was determined in accordance with the specified charts developed by experienced operators on the basis of experimental data;thus,it was inevitable that the localized buckling might occur during some actual straightening *** normal strain component formulas were derived based on the thin shell ***,strain energy of thin-walled tube（per unit length）was obtained using the elastic-plastic theory.A rational model for predicting the maximal section flattening of the thin-walled circular steel tube under its straightening process was presented by the principle of minimum potential *** new model was validated by experiments and numerical *** results show that the new model agrees well with the experiments and the numerical simulations with error of less than 10%.This new model was expected to find its potential application in thin-walled steel tube straightening machine design.

关键词： walled Rotary bending buckling length maximal radius localized Prediction rotary

Supervised Vessels Classification Based on Feature Selection

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Journal of Computer Science & Technology 2017年第6期32卷 1222-1230页

作者： Bei-Ji Zou Yao Chen Cheng-zhang Zhu Zai-Liang Chen zi-qian zhang School of Information Science and Engineering Central South University Changsha 410083 China ‘Mobile Health' Ministry of Education-China Mobile Joint Laboratory Central South University Changsha 410083 China College of Literature and Journalism Central South University Changsha 410083 China

Arterial-venous classification of retinal blood vessels is important for the automatic detection of cardiovascular diseases such as hypertensive retinopathy and stroke. In this paper, we propose an arterial-venous classification （AVC） method, which focuses on feature extraction and selection from vessel centerline pixels. The vessel centerline is extracted after the preprocessing of vessel segmentation and optic disc （OD） localization. Then, a region of interest （ROI） is extracted around OD, and the most efficient features of each centerline pixel in ROI are selected from the local features, grey-level co-occurrence matrix （GLCM） features, and an adaptive local binary patten （A-LBP） feature by using a max-relevance and min-redundancy （mRMR） scheme. Finally, a feature-weighted K-nearest neighbor （FW-KNN） algorithm is used to classify the arterial-venous vessels. The experimental results on the DRIVE database and INSPIRE-AVR database achieve the high accuracy of 88.65% and 88.51% in ROI, respectively.

关键词： fundus image arterial-venous classification adaptive local binary patten(A-LBP) feature selection feature-weighted K-nearest neighbor(FW-KNN)

Performance of climate reanalyses in the determination of pan-Arctic terrestrial rain-on-snow events

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Advances in Climate Change Research 2023年第4期14卷 522-536页

作者： Jia TAO Xiao CHENG Lei ZHENG Xiong-Xin XIAO Xin-Yue ZHONG Qi LIANG zi-qian zhang Hong LIN School of Geospatial Engineering and Science Sun Yat-sen University and Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)Zhuhai 519082China Key Laboratory of Comprehensive Observation of Polar Environment(Sun Yat-sen University) Ministry of EducationZhuhai 519082China Institute of Geography and Oeschger Center for Climate Change Research University of BernBern 3012Switzerland Key Laboratory of Remote Sensing of Gansu Province Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China

Rain-on-snow(ROS)events can cause rapid snowmelt,leading to flooding and avalanches in the pan-Arctic and can also lead to starvation and the death of massive *** products(e.g.,ERA-I,ERA5-land,JRA55,MERRA2)are the primary source data for the research about ROS events in the large-scale ***,the accuracy and reliability of reanalyses have never been evaluated with respect to the determination of terrestrial ROS *** present study aims to statistically evaluate the performance of reanalysis datasets in identifying ROS events with different criteria based on in-situ rainfall data and MODIS snow cover *** results show that all reanalysis datasets exhibit poor performance(Recall≤0.16,Kappa coefficient≤0.26,F-score≤0.42,MCC≤0.33)in all criteria in the pan-Arctic,mainly due to the low accuracy of rainfall data(r≤0.56).Nevertheless,the spatial distribution pattern and hot spots of ROS from all reanalysis datasets are essentially *** hot spots of ROS are mainly located on the coast of Alaska,Norway,and *** reanalyses demonstrate an increase in rainy days,but there is little overall change in ROS events due to the reduction in snow cover *** work suggests that none of the current reanalyses are reliable in the determination of ROS events due to the poor representation of the rainfall parameterization *** development of alternative strategies that can investigate ROS events at large-scale is urgently needed in a changing Arctic under rapid warming.

关键词： Rain-on-snow Pan-Arctic Reanalysis datasets Rainfall MODIS

zinc-based metal-organic frameworks as efficient carriers for anticancer drug to reduce toxicity and increase efficacy

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Rare Metals 2024年第10期43卷 5152-5163页

作者： Dong-Wei Ma Jing-Sheng Lu Xiang-Xin Cao Yan-Wei Cheng Gang Wang zi-qian zhang Bo-Cheng Chen Ning Lin Qing Chen College of Pharmacy Guangxi Scientific Research Center of Traditional Chinese MedicineGuangxi University of Chinese MedicineNanning 530200China Guangxi Zhuang Yao Medicine Center of Engineering and Technology Nanning 530200China

The rational design of a specific co-drug delivery platform that can address the unavoidable resistance,toxic side effects and low targeting efficiency of traditional cancer treatments is of great ***,Zn-based MOF-zeolitic imidazole framework-90(ziF-90)was selected as the drug delivery carrier,with the cancer therapeutic drug mercaptopurine(6-MP)and glucose oxidase(GOD)as the drug models,hyaluronic acid(HA)was used for protection and targeted delivery,which designed and fabricated an intelligent drug delivery platform(6-MP@ziF-90@GOD@HA).This platform aims to reduce the toxic side effects of 6-MP and enhance its efficacy while improving the targeting ability of GOD,thereby further enhancing the treatment ***,results from both in vitro and in vivo experiments demonstrate that the targeted synergistic chemo/reactive oxygen species(ROS)-mediated/starvation therapy inhibited the cancer cell growth while reducing the chemotherapy toxicity,which provides new possibilities for the development of more precise and effective treatment strategies.

关键词： Metal-organic framework Cancer treatment Combination therapy Drug delivery Reduced toxicity

Homocysteine-Induced Disturbances in DNA Methylation Contribute to Development of Stress-Associated Cognitive Decline in Rats

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Neuroscience Bulletin 2022年第8期38卷 887-900页

作者： Shi-Da Wang Xue Wang Yun Zhao Bing-Hua Xue Xiao-Tian Wang Yu-Xin Chen zi-qian zhang Ying-Rui Tian Fang Xie Ling-Jia qian Institute of Military Cognitive and Brain Sciences Academy of Military Medical SciencesBeijing100850China 8th People’s Hospital of Qingdao Qingdao266041China School of Public Health Lanzhou UniversityLanzhou730000China

Chronic stress is generally accepted as the main risk factor in the development of cognitive decline;however,the underlying mechanisms remain *** data have demonstrated that the levels of homocysteine(Hcy)are significantly elevated in the plasma of stressed animals,which suggests that Hcy is associated with stress and cognitive *** test this hypothesis,we analyzed the cognitive function,plasma concentrations of Hcy,and brain-derived neurotropic factor(BDNF)levels in rats undergoing chronic unpredicted mild stress(CUMS).The results showed that decreased cognitive behavioral performance and decreased BDNF transcription and protein expression were correlated with hyperhomocysteinemia(HHcy)levels in stressed ***-induced HHcy mimicked the cognitive decline and BDNF downregulation in the same manner as CUMS,while Hcy reduction(by means of vitamin B complex supplements)alleviated the cognitive deficits and BDNF reduction in CUMS ***,we also found that both stress and HHcy disturbed the DNA methylation process in the brain and induced DNA hypermethylation in the BDNF *** contrast,control of Hcy blocked BDNF promoter methylation and upregulated BDNF levels in the *** results imply the possibility of a causal role of Hcy in stress-induced cognitive *** also used ten-eleven translocation(TET1),an enzyme that induces DNA demethylation,to verify the involvement of Hcy and DNA methylation in the regulation of BDNF expression and the development of stress-related cognitive *** data showed that TET1-expressing viral injection into the hippocampus inhibited BDNF promoter methylation and significantly mitigated the cognitive decline in HHcy *** together,novel evidence from the present study suggests that Hcy is likely involved in chronic stress-induced BDNF reduction and related cognitive *** addition,the negative side-effects of HHcy may be associated with Hcy-induced DNA hypermethylation in the BDN

关键词： Stress-associated cognitive decline Homocysteine DNA methylation BDNF

Trends of alkaline phosphatase to prealbumin ratio in patients with hepatitis B linked to hepatocellular carcinoma development

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World Journal of Gastroenterology 2025年第2期31卷 42-51页

作者： Wen-Chong Zhen Jing Sun Xue-Ting Bai qian zhang zi-Han Li Yi-Xin zhang Rong-Xuan Xu Wei Wu Zhi-Han Yao Chun-Wen Pu Xiao-Feng Li School of Public Health Dalian Medical UniversityDalian 116044Liaoning ProvinceChina Graduate School Dalian Medical UniversityDalian 116044Liaoning ProvinceChina Dalian Public Health Clinical Center Dalian Municipal Research Institute for Public HealthDalian 116001Liaoning ProvinceChina Department of Epidemiology and Health Statistics Dalian Medical UniversityDalian 116044Liaoning ProvinceChina

BACKGROUND Chronic hepatitis B often progresses silently toward hepatocellular carcinoma(HCC),a leading cause of mortality *** detection of HCC is crucial,yet *** To investigate the role of dynamic changes in alkaline phosphatase to prealbumin ratio(APR)in hepatitis B progression to *** Data from 4843 patients with hepatitis B(January 2015 to January 2024)were *** incidence rates in males and females were compared using the log-rank *** were evaluated using Kaplan–Meier *** Linear Mixed-Effects Model was applied to track the fluctuation of APR levels over ***,Joint Modeling of Longitudinal and Survival data was employed to investigate the temporal relationship between APR and HCC *** The incidence of HCC was higher in *** ensure the model’s normality assumption,this study applied a logarithmic transformation to APR,yielding *** levels were higher in females(t=5.26,P<0.01).A 1-unit increase in ratio correlated with a 2.005-fold higher risk of HCC in males(95%CI:1.653-2.431)and a 2.273-fold higher risk in females(95%CI:1.620-3.190).CONCLUSION Males are more prone to HCC,while females have higher APR *** no baseline APR link,rising APR indicates a higher HCC risk.

关键词： Alkaline phosphatase to prealbumin ratio Chronic hepatitis B patients Hepatocellular carcinoma Retrospective cohort study Linear Mixed-Effect Mode Joint Modelling of Longitudinal and Survival data

Prognosis of critically ILL patients with systemic lupus erythematosus:a retrospective study

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Prognosis of critically ILL patients with systemic lupus ery...

Catalyst–Support Interaction in Polyaniline‑Supported Ni_(3)Fe Oxide to Boost Oxygen Evolution Activities for Rechargeable Zn‑Air Batteries

The 8th International Congress on SLE

作者： Xiao zhang Guang-Fu Dong Wen-Li Chen Guang-Feng zhang zi-qian zhang Yun-Xia Lei Rheumatoiogy & Immunology Department Guang Dong Provincial People’s Hospital the First affiliated Hospital of Southern Medical University Guang Zhou China 510080

＜正＞Objectives:Systemic lupus erythematosus（SLE）is an prototypical autoimmune disease with varying course and ***,there is few clinical study regarding prognosis of the SLE patients admitted to the intensive care unit（ICU）in *** retrospective study aimed to improve our diagnosis and treatment by analyzing outcome and prognostic factors of the critically ill SLE patients.

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Nano-Micro Letters 2025年第1期17卷 176-190页

作者： Xiaohong Zou qian Lu Mingcong Tang Jie Wu Kouer zhang Wenzhi Li Yunxia Hu Xiaomin Xu Xiao zhang Zongping Shao Liang An Department of Mechanical Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control Jiangsu Collaborative Innovation Center of Atmospheric Environment and Equipment TechnologySchool of Environmental Science and TechnologyNanjing University of Information Science and TechnologyNanjing 210044People’s Republic of China Department of Chemistry The Chinese University of Hong KongMa Lin BuildingShatinHong Kong SAR 999077People’s Republic of China WA School of Mines:Minerals Energy and Chemical Engineering(WASM‑MECE)Curtin UniversityPerthWA 6102Australia Research Institute for Advanced Manufacturing The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China Research Institute for Smart Energy The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China

Catalyst–support interaction plays a crucial role in improving the catalytic activity of oxygen evolution reaction(OER).Here we modulate the catalyst–support interaction in polyaniline-supported Ni_(3)Fe oxide(Ni_(3)Fe oxide/PANI)with a robust hetero-interface,which significantly improves oxygen evolution activities with an overpotential of 270 mV at 10 mA cm^(-2)and specific activity of 2.08 mA cm_(ECSA)^(-2)at overpotential of 300 mV,3.84-fold that of Ni_(3)Fe *** is revealed that the catalyst–support interaction between Ni_(3)Fe oxide and PANI support enhances the Ni–O covalency via the interfacial Ni–N bond,thus promoting the charge and mass transfer on Ni_(3)Fe *** the excellent activity and stability,rechargeable Zn-air batteries with optimum Ni_(3)Fe oxide/PANI are assembled,delivering a low charge voltage of 1.95 V to cycle for 400 h at 10 mA cm^(-2).The regulation of the effect of catalyst–support interaction on catalytic activity provides new possibilities for the future design of highly efficient OER catalysts.

关键词： Catalyst-support interaction Supported catalysts Heterointerface Oxygen evolution reaction Zn-air batteries

Nomogram for overall survival in ampullary adenocarcinoma using the surveillance,epidemiology,and end results database and external validation

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World Journal of Clinical Oncology 2025年第2期16卷 36-51页

作者： Jia Yang zi-Yi Wang Jing Chen Yao zhang Lei Chen Department of Gastroenterology The First Affiliated Hospital of Army Medical UniversityChongqing 400038China Department of Epidemiology College of Preventive MedicineArmy Medical UniversityChongqing 400038China

BACKGROUND Ampullary adenocarcinoma is a rare malignant tumor of the gastrointestinal ***,only a few cases have been reported,resulting in limited information on *** To develop a dynamic nomogram using internal and external validation to predict survival in patients with ampullary *** Data were sourced from the surveillance,epidemiology,and end results stat *** patients in the database were randomized in a 7:3 ratio into training and validation *** Cox regression univariate and multivariate analyses in the training group,we identified independent risk factors for overall survival and cancer-specific survival to develop the *** nomogram was validated with a cohort of patients from the First Affiliated Hospital of the Army Medical *** For overall and cancer-specific survival,12(sex,age,race,lymph node ratio,tumor size,chemotherapy,surgical modality,T stage,tumor differentiation,brain metastasis,lung metastasis,and extension)and 6(age;surveillance,epidemiology,and end results stage;lymph node ratio;chemotherapy;surgical modality;and tumor differentiation)independent risk factors,respectively,were incorporated into the *** area under the curve values at 1,3,and 5 years,respectively,were 0.807,0.842,and 0.826 for overall survival and 0.816,0.835,and 0.841 for cancer-specific *** internal and external validation cohorts indicated good consistency of the *** The dynamic nomogram offers robust predictive efficacy for the overall and cancer-specific survival of ampullary adenocarcinoma.

关键词： Ampullary adenocarcinoma Dynamic nomogram Gastrointestinal tract Surveillance Epidemiology End results database Survival rate

Development of a nomogram for overall survival in patients with esophageal carcinoma:A prospective cohort study in China

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 158-168页

作者： Shi-Shi Yu Xi Zheng Xiao-Sheng Li qian-Jie Xu Wei zhang Zhong-Li Liao Hai-Ke Lei Department of Gastroenterology Chongqing University Cancer HospitalChongqing 400030China Chongqing Cancer Multi-omics Big Data Application Engineering Research Center Chongqing University Cancer HospitalChongqing 400030China Department of Health Statistics School of Public HealthChongqing Medical UniversityChongqing 400016China

BACKGROUND Esophageal carcinoma(EC)presents a significant public health issue in China,with its prognosis impacted by myriad *** creation of a reliable prog-nostic model for the overall survival(OS)of EC patients promises to greatly advance the customization of treatment *** To create a more systematic and practical model that incorporates clinically significant indicators to support decision-making in clinical *** This study utilized data from a prospective longitudinal cohort of 3127 EC patients treated at Chongqing University Cancer Hospital between January 1,2018,and December 12,*** the least absolute shrinkage and selection operator regression alongside multivariate Cox regression analyses helped pinpoint pertinent variables for constructing the *** efficacy was assessed by concordance index(C-index),area under the receiver operating characteristic curve(AUC),calibration curves,and decision curve analysis(DCA).RESULTS Nine variables were determined to be significant predictors of OS in EC patients:Body mass index(BMI),Karnofsky performance status,TNM stage,surgery,radiotherapy,chemotherapy,immunotherapy,platelet-to-lymphocyte ratio,and albumin-to-globulin ratio(ALB/GLB).The model demonstrated a C-index of 0.715(95%CI:0.701-0.729)in the training cohort and 0.711(95%CI:0.689-0.732)in the validation *** the training cohort,AUCs for 1-year,3-year,and 5-year OS predictions were 0.773,0.787,and 0.750,respectively;in the validation cohort,they were 0.772,0.768,and 0.723,respectively,illustrating the model's *** curves and DCA verified the model's predictive accuracy and net *** A novel prognostic model for determining the OS of EC patients was successfully developed and validated to help clinicians in devising individualized treatment schemes for EC patients.

关键词： Esophageal carcinoma High-risk factors Prognosis Overall survival Prediction model