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Development and validation of a web-based calculator to predict individualized conditional risk of site-specific recurrence in nasopharyngeal carcinoma: Analysis of 10,058 endemic cases

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Cancer Communications 2021年第1期41卷 37-50页

作者： Chen-Fei Wu Jia-Wei Lv Li Lin Yan-Ping Mao Bin Deng Wei-Hong zheng Dan-Wan Wen Yue Chen Jia Kou Fo-Ping Chen Xing-Li Yang zi-qi zheng Zhi-Xuan Li Si-Si Xu Jun Ma Ying Sun Department of Radiation Oncology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapyGuangzhouGuangdong 510060P.R.China Department of Radiation Oncology Wuzhou Red Cross HospitalWuzhouGuangxi 543002P.R.China

Background:Conditional survival(CS)provides dynamic prognostic estimates by considering the patients existing survival *** CS for endemic nasopharyngeal carcinoma(NPC)is lacking,we aimed to assess the CS of endemic NPC and establish a web-based calculator to predict individualized,conditional sitespecific recurrence ***:Using an NPC-specific database with a big-data intelligence platform,10,058 endemic patients with non-metastatic stage I–IVA NPC receiving intensity-modulated radiotherapy with or without chemotherapy between April 2009 and December 2015 were *** CS estimates of conditional overall survival(COS),conditional disease-free survival(CDFS),conditional locoregional relapse-free survival(CLRRFS),conditional distant metastasis-free survival(CDMFS),and conditional NPC-specific survival(CNPC-SS)were ***-adjusted CS estimates were generated using inverse probability weighting.A prediction model was established using competing risk models and was externally validated with an independent,non-metastatic stage I–IVA NPC cohort undergoing intensity-modulated radiotherapy with or without chemotherapy(n=601)at another ***:The median follow-up of the primary cohort was 67.2 *** 5-year COS,CDFS,CLRRFS,CDMFS,and CNPC-SS increased from 86.2%,78.1%,89.8%,87.3%,and 87.6%at diagnosis to 87.3%,87.7%,94.4%,96.0%,and 90.1%,respectively,for an existing survival time of 3 years since *** in CS estimates between prognostic factor subgroups of each endpoint were noticeable at diagnosis but diminished with time,whereas an ever-increasing disparity in CS between different age subgroups was observed over ***,the prognoses of patients that were poor at diagnosis improved greatly as patients survived *** individualized CS predictions,we developed a web-based model to estimate the conditional risk of local(C-index,0.656),regional(0.667),bone(0.742),lung(0.681),and liver(0.711)recurren

关键词： endemic nasopharyngeal carcinoma conditional survival big data web-based individualized prediction model overall survival disease-free survival locoregional relapse-free survival distant metastasis-free survival NPC-specific survival

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巩固、发展与抗日:中央红军东征期间与各方势力之周旋

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河北学刊 2025年第1期45卷 218-224页

作者：郑康奇南开大学历史学院

1935年底,红军在陕北会师后积极进行扩红与筹粮运动。与此同时,中共中央审时度势决定进行东征,以图缓解陕北地区兵员、粮源的紧张局面。1936年2至5月,中央红军东渡黄河与阎锡山部作战,蒋介石也借机派兵进入山西。在红军东征的过程中,双... 详细信息

1935年底,红军在陕北会师后积极进行扩红与筹粮运动。与此同时,中共中央审时度势决定进行东征,以图缓解陕北地区兵员、粮源的紧张局面。1936年2至5月,中央红军东渡黄河与阎锡山部作战,蒋介石也借机派兵进入山西。在红军东征的过程中,双方高层展开了一系列的斗争与博弈。中共在东征中积极争取张学良与杨虎城部,统一战线策略取得了成功。这一时期,国际政治局势变幻莫测,中国共产党与共产国际的关系也产生了一些微妙变化。在与国际国内各方的政治博弈中,中共的政策逐渐走向成熟,为第二次国共合作奠定了重要基础。

关键词：红军东征扩红政治势力抗日战争

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Endoplasmic reticulum stress and autophagy in cerebral ischemia/reperfusion injury:PERK as a potential target for intervention

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Neural Regeneration Research 2025年第5期20卷 1455-1466页

作者： Ju zheng Yixin Li Ting Zhang Yanlin Fu Peiyan Long Xiao Gao zhengwei Wang Zhizhong Guan Xiaolan qi Wei Hong Yan Xiao Key Laboratory of Endemic and Ethnic Diseases Ministry of Education&Key Laboratory of Medical Molecular Biology of Guizhou ProvinceGuizhou Medical UniversityGuiyangGuizhou ProvinceChina Guizhou Center for Disease Control and Prevention GuiyangGuizhou ProvinceChina Department of Histology and Embryology Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Collaborative Innovation Center for Prevention and Control of Endemic and Ethnic Regional Diseases Co-constructed by the Province and Ministry GuiyangGuizhou ProvinceChina

Several studies have shown that activation of unfolded protein response and endoplasmic reticulum(ER)stress plays a crucial role in severe cerebral ischemia/reperfusion *** occurs within hours after cerebral ischemia,but the relationship between ER stress and autophagy remains *** this study,we established experimental models using oxygen-glucose deprivation/reoxygenation in PC12 cells and primary neurons to simulate cerebral ischemia/reperfusion *** found that prolongation of oxygen-glucose deprivation activated the ER stress pathway protein kinase-like endoplasmic reticulum kinase(PERK)/eukaryotic translation initiation factor 2 subunit alpha(e IF2α)-activating transcription factor 4(ATF4)-C/EBP homologous protein(CHOP),increased neuronal apoptosis,and induced ***,inhibition of ER stress using inhibitors or by si RNA knockdown of the PERK gene significantly attenuated excessive autophagy and neuronal apoptosis,indicating an interaction between autophagy and ER stress and suggesting PERK as an essential target for regulating *** autophagy with chloroquine exacerbated ER stress-induced apoptosis,indicating that normal levels of autophagy play a protective role in neuronal injury following cerebral ischemia/reperfusion *** from this study indicate that cerebral ischemia/reperfusion injury can trigger neuronal ER stress and promote autophagy,and suggest that PERK is a possible target for inhibiting excessive autophagy in cerebral ischemia/reperfusion injury.

关键词： apoptosis ATF4 autophagy C/EBP homologous protein cerebral ischemia/reperfusion injury eIF2α endoplasmic reticulum stress PERK

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菝葜皂苷对胃癌BGC-823细胞Bcl-2、Bax凋亡蛋白表达影响的实验研究

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中国医药指南 2018年第18期16卷 1-2页

作者：廖子君郑琪赵征孙海凤龙婧陈勇西安交通大学医学院附属陕西省肿瘤医院陕西西安710061

目的观察不同浓度菝葜皂苷元对体外培养的胃癌BGC-823细胞凋亡相关蛋白Bax、Bcl-2表达的影响。方法采用免疫组化方法,检测BGC-823细胞经不同浓度(12.5、25、50μg/mL)的菝葜皂苷元处理后Bcl-2、Bax的表达情况。结果随着菝葜皂苷元浓度... 详细信息

目的观察不同浓度菝葜皂苷元对体外培养的胃癌BGC-823细胞凋亡相关蛋白Bax、Bcl-2表达的影响。方法采用免疫组化方法,检测BGC-823细胞经不同浓度(12.5、25、50μg/mL)的菝葜皂苷元处理后Bcl-2、Bax的表达情况。结果随着菝葜皂苷元浓度的增加,与对照组比较,BGC-823细胞Bax表达逐渐增加,不同浓度组之间差异有统计学差异(P<0.05),而Bcl-2表达逐渐减少(P<0.05)。结论菝葜皂苷元可诱导BGC-823细胞凋亡,上调Bax蛋白水平与下调Bcl-2蛋白水平。

关键词：菝葜皂苷元细胞株BGC-823 凋亡相关蛋白

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Integration of perioperative features and intragraft TCF7L2 expression to predict lipid metabolic disorder in liver transplant recipients

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Science China Life Sciences 2025年第1期 297-299页

作者： Junbin Zhou Rongli Wei Guanghan Fan zhengxing Lian Xuanyu Zhang Linsong Tang Zhetuo qi Haiyang Xie Shusen zheng qiang Wei Xiao Xu Department of Hepatobiliary and Pancreatic Surgery People's Hospital of LishuiAffiliated Lishui Hospital of Wenzhou Medical UniversityThe First Affiliated Hospital of Lishui University NHFPC Key Laboratory of Combined Multi-Organ Transplantation Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province Department of Hepatobiliary and Pancreatic SurgeryHangzhou First People's Hospital Department of Hepatobiliary and Pancreatic Surgery The First Affiliated HospitalZhejiang University School of Medicine Department of Urology The Second Affiliated HospitalZhejiang University School of Medicine Department of Hepatobiliary and Pancreatic Surgery Department of Liver TransplantationShulan (Hangzhou) Hospital Hangzhou Medical College Zhejiang University School of Medicine

Dear Editor, Liver transplantation(LT) is the only curative therapy for patients with endstage liver disease(He et al., 2023; Ling et al., 2022). Post-transplant hypertriglyceridemia(PTHT), which has an incidence of up to 32.8% in 6 months after LT, is one of the major post-transplant complications(Toshima et al., 2020).

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Study of thermal decoherence of harmonic oscillators

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原子与分子物理学报 2025年第5期42卷 108-114页

作者： LI Jian ZHOU Gao-Liang YAN zheng-Xin LIU Wei WANG Zhao-qi College of Science Xi’an University of Science and TechnologyXi’an 710054China

The thermal decoherence of harmonic oscillators is investigated *** quantum system presented here is a one-dimensional oscillator with angular frequency,which is surrounded by a thermal bath of environmental *** are various environmental oscillators with different angular frequency(below an ultraviolet cutoff).At the beginning,the quantum system is a pure state and the environmental oscillators are in thermodynamic equilibrium with *** a period,the system-environment interactions inspire significant decoherence of the quantum *** decoherence is displayed by explicit calculations of the purity and von Neumann entropy of the quantum *** is worth noting that the decoherence could be significant even in the weak coupling and low temperature case due to the large amount of environmental degrees of *** the decoherence process is inspired between the quantum system and an ordinary thermal environment here,the thermal decoherence result is quite general.

关键词： Quantum decoherence Grand canonical ensemble Oscillators

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Experimental study on the relation between the water content of surface soil and the acoustic wave

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Acta Seismologica Sinica(English Edition) 2001年第5期14卷 571-576页

作者： GUO zi-qi 1. Institute of Remote Sensing Application Chinese Academy of Sciences 100101 Beijing China 2. Institute of Geophysics China Seismological Bureau 100081 Beijing China

In order to investigate the relation between the water content changing of surface soil and micro-quake recorded before earthquakes, we carried out a simulation experiment in laboratory. Its purpose is to explore whether the acoustic wave generated by micro-fracturing before earthquake are able to change water content of surface soil, so as to understand the relation between thermal anomaly in the remote sensing image got from the seismogenic area and the coming earthquake. The result of the experiment shows that when the acoustic wave enters into the surface soil the water content here increases on the background of decreasing due to natural evaporation. In the meantime, temperature here decreases.

关键词： acoustic wave remote sensing water content in soil micro-fracturing

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Fe_(n)Mo_(38-n)(n=0-38)及Fe_(n)Mo_(55-n)(n=0-55)双金属团簇的结构演化和基态能量

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原子与分子物理学报 2025年第3期42卷 85-93页

作者：郑琪琪陈轩程彪段海明新疆大学物理科学与技术学院乌鲁木齐830017

基于半经验的Gupta多体势,采用遗传算法及分子动力学淬火算法,系统研究了(FeMo)m(m=38及55)双金属团簇的基态结构及其能量.结果表明:对于Fe_(n)Mo_(38-n)(n=0-38)团簇,随Fe原子数的增加,Fe原子优先占据团簇表面再占据内部,其基态构型存... 详细信息

基于半经验的Gupta多体势,采用遗传算法及分子动力学淬火算法,系统研究了(FeMo)m(m=38及55)双金属团簇的基态结构及其能量.结果表明:对于Fe_(n)Mo_(38-n)(n=0-38)团簇,随Fe原子数的增加,Fe原子优先占据团簇表面再占据内部,其基态构型存在类O_(h)结构、类I_(h)结构和无序结构间的竞争.对于Fe_(n)Mo_(55-n)(n=0-55)团簇,随Fe原子数的增加,Fe原子优先占据团簇中心位置,再依次占据表面顶点、棱边和次外层,双金属团簇基态构型主要体现为在Mackay二十面体基础上的结构畸变.Fe_(24)Mo_(14),Fe_(13)Mo_(42)和Fe_(43)Mo_(12)为幻数结构团簇,研究发现双金属团簇幻数成因不能通过单质团簇常用的平均配位数和平均键长模型解释,它更多的归咎于组分效应导致的结构高对称性.

关键词：双金属团簇结构和能量淬火算法遗传算法

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Fe_(n)Co_(55-n)与Co_(n)Mo_(55-n)(n=0~55)团簇基态的能量与结构演化

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原子与分子物理学报 2025年第5期42卷 57-66页

作者：程彪郑琪琪陈轩段海明新疆大学物理科学与技术学院乌鲁木齐830049

采用半经验的Gupta多体势函数结合遗传算法及分子动力学淬火算法,系统研究了Co_(n)Mo_(55-n)(n=0~55)与Fe_(n)Co_(55-n)(n=0~55)团簇的基态结构与能量.通过分析基态结构的相似函数、质心间距、平均键长、平均原子配位数、平均结合能、... 详细信息

采用半经验的Gupta多体势函数结合遗传算法及分子动力学淬火算法,系统研究了Co_(n)Mo_(55-n)(n=0~55)与Fe_(n)Co_(55-n)(n=0~55)团簇的基态结构与能量.通过分析基态结构的相似函数、质心间距、平均键长、平均原子配位数、平均结合能、混合能与二阶差分能.探究了团簇基态的结构特征及稳定性与团簇所含元素种类及组分的关联.结果表明:对Co-Mo混合团簇,随Co原子数目增加,Co原子依次占据团簇中心与最外层顶点,混合团簇逐渐出现组分偏析与无序现象;对Fe-Co混合团簇,基态结构主体上均体现为围绕Mackay二十面体构型的结构畸变,随Fe原子含量增加,Fe原子先占据团簇外表面顶点位置直到全部包裹Co原子,逐渐形成核壳式结构;Co_(13)Mo_(42)与Fe_(42)Co_(13)是幻数结构团簇,研究发现组分效应导致的团簇高对称性相比团簇平均键长与平均原子配位数更能解释幻数结构的成因.

关键词：遗传算法淬火算法双金属团簇基态结构

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Further developments of a multi-phase transport model for relativistic nuclear collisions

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Nuclear Science and Techniques 2021年第10期32卷 110-142页

作者： zi-Wei Lin Liang zheng Department of Physics East Carolina UniversityGreenvilleNC 27858USA School of Mathematics and Physics China University of Geosciences(Wuhan)Wuhan 430074China

A multi-phase transport(AMPT)model was constructed as a self-contained kinetic theory-based description of relativistic nuclear collisions as it contains four main components:the fluctuating initial condition,a parton cascade,hadronization,and a hadron ***,we review the main developments after the first public release of the AMPT source code in 2004 and the corre-sponding publication that described the physics details of the model at that *** also discuss possible directions for future developments of the AMPT model to better study the properties of the dense matter created in relativistic collisions of small or large systems.

关键词： QGP Transport model Heavy-ion collisions

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