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Bullous pemphigoid associated with acquired hemophilia A: A case report

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World Journal of Clinical Cases 2025年第4期13卷 28-33页

作者： Su-Ye Hu Meng-Can li zi-Jia Hao Xu-Ya Chai Pei-Sai li Yang liu li-Xia liu Ying Xu Pan-Pan Yang ling-E li Department of Dermatology Shijiazhuang Traditional Chinese Medicine HospitalShijiazhuang 050051Hebei ProvinceChina Graduate School Hebei University of Traditional Chinese MedicineShijiazhuang 050051Hebei ProvinceChina Department of Pathology Shijiazhuang Traditional Chinese Medicine HospitalShijiazhuang 050051Hebei ProvinceChina

BACKGROUND Acquired hemophilia A (AHA) is a rare and potentially severe bleeding disordercaused by circulating autoantibodies against factor Ⅷ (FⅧ). In approximately50% of the patients, the condition is associated with autoimmune diseases,cancers, medication use, pregnancy, and the post-partum period. Bullous pemphigoid(BP) is a chronic autoimmune subepidermal blistering disease associatedwith tissue-bound and circulating autoantibodies against BP antigens 180 (BP180)and 230 (BP230). AHA-associated BP has a high mortality rate;hence, the understandingof this disease must *** SUMMARY A 69-year-old man presented with erythema, blisters, blood blisters, and crustsaccompanied by severe pruritus for more than 20 days, and ecchymosis andswelling on his left upper arm for 3 days. Pathological examination revealed asubepidermal blister that contained eosinophils. Laboratory tests showed that theBP180 autoantibody levels had increased, isolated activated partial thromboplastintime was notably prolonged (115.6 s), and coagulation FⅧ activity wasextremely low (lity rate. Therefore, its timely diagnosis and effectivetreatment are necessary.

关键词： Bullous pemphigoid Acquired hemophilia A Acquired hemophilia A FactorⅧ Case report

Endoplasmic reticulum stress and autophagy in cerebral ischemia/reperfusion injury:PERK as a potential target for intervention

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Neural Regeneration Research 2025年第5期20卷 1455-1466页

作者： Ju Zheng Yixin li Ting Zhang Yanlin Fu Peiyan Long Xiao Gao Zhengwei Wang Zhizhong Guan Xiaolan qi Wei Hong Yan Xiao Key Laboratory of Endemic and Ethnic Diseases Ministry of Education&Key Laboratory of Medical Molecular Biology of Guizhou ProvinceGuizhou Medical UniversityGuiyangGuizhou ProvinceChina Guizhou Center for Disease Control and Prevention GuiyangGuizhou ProvinceChina Department of Histology and Embryology Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Collaborative Innovation Center for Prevention and Control of Endemic and Ethnic Regional Diseases Co-constructed by the Province and Ministry GuiyangGuizhou ProvinceChina

Several studies have shown that activation of unfolded protein response and endoplasmic reticulum(ER)stress plays a crucial role in severe cerebral ischemia/reperfusion *** occurs within hours after cerebral ischemia,but the relationship between ER stress and autophagy remains *** this study,we established experimental models using oxygen-glucose deprivation/reoxygenation in PC12 cells and primary neurons to simulate cerebral ischemia/reperfusion *** found that prolongation of oxygen-glucose deprivation activated the ER stress pathway protein kinase-like endoplasmic reticulum kinase(PERK)/eukaryotic translation initiation factor 2 subunit alpha(e IF2α)-activating transcription factor 4(ATF4)-C/EBP homologous protein(CHOP),increased neuronal apoptosis,and induced ***,inhibition of ER stress using inhibitors or by si RNA knockdown of the PERK gene significantly attenuated excessive autophagy and neuronal apoptosis,indicating an interaction between autophagy and ER stress and suggesting PERK as an essential target for regulating *** autophagy with chloroquine exacerbated ER stress-induced apoptosis,indicating that normal levels of autophagy play a protective role in neuronal injury following cerebral ischemia/reperfusion *** from this study indicate that cerebral ischemia/reperfusion injury can trigger neuronal ER stress and promote autophagy,and suggest that PERK is a possible target for inhibiting excessive autophagy in cerebral ischemia/reperfusion injury.

关键词： apoptosis ATF4 autophagy C/EBP homologous protein cerebral ischemia/reperfusion injury eIF2α endoplasmic reticulum stress PERK

High-order harmonic generations in tilted Weyl semimetals

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Chinese Physics B 2022年第12期31卷 242-251页

作者： zi-Yuan li qi li Zhou li GBA Branch of Aerospace Information Research Institute Chinese Academy of SciencesGuangzhou 510700China

We investigate high-order harmonic generations(HHGs)under comparison of Weyl cones in two *** to the hyperboloidal electron pocket structure,strong noncentrosymmetrical generations in high orders are observed around a single type-ⅡWeyl point,especially at zero *** a remarkable DC signal is proved to have attributions from the intraband transition after spectral *** weak pulse electric field,the linear optical response of a nontilted Weyl cone is consistent with the Kubo *** extensive numerical simulations,we conclude that the non-zero chemical potential can enhance the even-order generations,from the slightly tilted system to the over-tilted *** consideration of dynamical symmetries,type-Ⅰand type-ⅡWeyl cones also show different selective responses under the circularly polarized ***,using a more realistic model containing two pairs of Weyl points,we demonstrate that paired Weyl points with opposite chirality can suppress the overall even-order generations.

关键词： high order harmonic generation nonlinear optics Weyl semimetals

Kalb-Ramond field localization on a thick de Sitter brane

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Communications in Theoretical Physics 2020年第7期72卷 123-131页

作者： Chen Yang zi-qi Chen li Zhao Institute of Theoretical Physics Lanzhou University222 South Tianshui RoadLanzhou 730000China Research Center of Gravitation Lanzhou University222 South Tianshui RoadLanzhou 730000China

In this paper,we explore the localization condition of Kalb-Ramond(KR)tensorial gauge field on a thick de Sitter(dS)*** the localization mechanism in the work by Chumbes et al(2012 ***.D 85085003),we analyze the localization of KR tensorial gauge field on a non-flat *** propose three kinds of coupling methods and two of them support the localization of zero *** addition,there exist resonant Kaluza-Klein modes on the thick dS *** effects of three parameters on the localization and the resonant mode for the KR field are also discussed.

关键词： Kalb–Ramond field localization braneworld

黄芪对老年肺心病者电镜下血小板形态变化的影响

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实用老年医学 1997年第4期11卷 160-161页

作者：范蓉杨百理漆自立四川省人民医院

目的肺心病患者血小板聚集和释放功能增加，肺小动脉血栓形成；黄芪则有改善血液流变学异常，抑制亢进的血小板功能。本文观测黄芪对肺心病血小板形态的影响。方法选择老年肺心病４０例，随机分成２组，各２０例。对照组：采用常规治疗... 详细信息

目的肺心病患者血小板聚集和释放功能增加，肺小动脉血栓形成；黄芪则有改善血液流变学异常，抑制亢进的血小板功能。本文观测黄芪对肺心病血小板形态的影响。方法选择老年肺心病４０例，随机分成２组，各２０例。对照组：采用常规治疗，实验组则在此基础上加黄芪静滴。在治疗前、后分别于对照组和实验组抽血，观测电镜下血小板分类计数，用ｔ检验和相关分析行统计学处理。结果肺心病患者聚集型血小板明显增多（３８．５±９．８％，２５．９±１０．４９％），聚集型血小板与氧分压呈负相关（ｒ＝０．５５，Ｐ＜０．０５）。黄芪治疗后，聚集型血小板减少（３８±２％，２２±１．４％）病程亦短于对照组（２８±１１天，２１±９天，Ｐ＜０．０５）。结论提示黄芪可抑制亢进的血小板功能，可促进肺心病患者康复，缩短病程。

关键词：黄芪肺心病血小板老年人中医药疗法

Copper-catalyzed 1,4-protosilylation and 1,4-protoborylation of enynic orthoesters for synthesis of functionalized 2,3-allenoates

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Chinese Chemical Letters 2023年第9期34卷 151-155页

作者： qi li zi-Lu Wang Yun-He Xu Department of Chemistry University of Science and Technology of ChinaHefei 230026China

Herein,copper-catalyzed 1,4-protosilylation and 1,4-protoborylation of enynic orthoesters have been *** enynic orthoesters as precursors of unstable enynic esters were applied to produce the functionalized 2,3-allenoate ***,the asymmetric 1,4-protosilylation of enynic orthoesters with Ph Me2Si-Bpin was also *** chiral monopyridine imidazoline ligand was efficient to provide the asymmetric 1,4-protosilylation products with high enantioselectivity.

关键词： Copper-catalyzed 1,4-Protosilylation 1,4-Protoborylation 2,3-Allenoate Enynic orthoesters

硫醇吸附挥发性有机气体(VOCs)的气敏机理

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原子与分子物理学报 2025年第3期42卷 35-44页

作者：张海燕李琦王梓臻文豪刘丹凤中国环境科学研究院北京100012 中国汽车工程研究院股份有限公司重庆401122 中国科学院微电子研究所北京100029

化学电阻气体传感器对于空气质量、食品检测和人体呼吸有着重要作用.传感器上修饰物硫醇与待测的VOCs之间吸附的气敏机理分析是选择硫醇、预测吸附能力与特异性的重要手段.本文选取了11-巯基-1-十一醇(MUD)和4-甲氧基苄硫醇(MTT)两种常... 详细信息

化学电阻气体传感器对于空气质量、食品检测和人体呼吸有着重要作用.传感器上修饰物硫醇与待测的VOCs之间吸附的气敏机理分析是选择硫醇、预测吸附能力与特异性的重要手段.本文选取了11-巯基-1-十一醇(MUD)和4-甲氧基苄硫醇(MTT)两种常见的硫醇与六种典型的VOCs(乙醇ETN、异丙醇IPA、丙酮ACN、正己烷HXN、甲苯TLN、苯甲醛BND),基于密度泛函理论(DFT),计算其表面静电势(ESP)并建立气体吸附模型.在气体吸附模型的基础上计算其吸附能,并分析其弱相互作用,从微观角度解释气体吸附的作用机理.实验结果表明,具有羟基的MUD分子对同样有羟基的气体(如ETN、IPA)能够以氢键的方式吸附,具有较强的选择效果;具有苯环的MTT分子与具有苯环结构的气体分子(如TLN、BND)吸附时会在苯环之间形成π-π堆积,基于色散作用进行吸附,这表明MTT分子对具有苯环结构的气体有着较强的吸附作用.研究发现其色散作用吸附的强弱与分子的表面ESP绝对值有关.本文对于传感器表面修饰物吸附气体的气敏机理进行了探究,并对表面修饰物的选择和实验结果预测提供了理论指导.

关键词：硫醇 VOCs DFT 表面静电势气体吸附模型弱相互作用分析

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Experimental study on the relation between the water content of surface soil and the acoustic wave

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Acta Seismologica Sinica(English Edition) 2001年第5期14卷 571-576页

作者： GUO zi-qi 1. Institute of Remote Sensing Application Chinese Academy of Sciences 100101 Beijing China 2. Institute of Geophysics China Seismological Bureau 100081 Beijing China

In order to investigate the relation between the water content changing of surface soil and micro-quake recorded before earthquakes, we carried out a simulation experiment in laboratory. Its purpose is to explore whether the acoustic wave generated by micro-fracturing before earthquake are able to change water content of surface soil, so as to understand the relation between thermal anomaly in the remote sensing image got from the seismogenic area and the coming earthquake. The result of the experiment shows that when the acoustic wave enters into the surface soil the water content here increases on the background of decreasing due to natural evaporation. In the meantime, temperature here decreases.

关键词： acoustic wave remote sensing water content in soil micro-fracturing

Laser direct writing of flexible multifunctional airflow sensors on the Kevlar fabric

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Nano Research 2025年第1期18卷 443-454页

作者： Wei Wang zi-qing Chen Yong-qi li Yu-Long Wang Mei-Chen liu Yun-Bo Ruan Yang Zhang Shu-Juan liu qiang Zhao College of Electronic and Optical Engineering and College of Flexible Electronics(Future Technology) Nanjing University of Posts and TelecommunicationsNanjing 210023China State Key Laboratory of Organic Electronics and Information Displays and Jiangsu Key Laboratory for Biosensors Institute of Advanced Materials(IAM)Nanjing University of Posts and TelecommunicationsNanjing 210023China Zhe Jiang Topsun Logistic Control CO. LTD.Yuhuan 317600China Department of Rehabilitation Medicine School of Acupuncture-Moxibustion and Tuina and School of Health Preservation and RehabilitationNanjing University of Chinese MedicineNanjing 210023China

The growing interest in flexible devices has emerged as a global trend due to their advantages in flexibility,lightweight structure,and wearability,addressing the limitations of traditional *** wearable airflow sensors have been previously reported,the development of flexible fabric-based airflow sensors capable of functioning in environments with open flames—critical for fire rescue operations—has yet to be explored,largely due to the poor fire resistance of conventional *** this work,we first present a flexible,wearable,and multifunctional airflow sensor with excellent fire-resistant properties,fabricated through a simple direct laser writing *** sensor maintains airflow detection capabilities even in the presence of open ***,the fabrication of fabric-based sensors involves complex procedures such as carbon materials doping or vapor-phase deposition,leading to lengthy preparation cycles and high ***,fabric-based devices are inherently prone to *** address these challenges,we introduce twice-vertical laser-induced graphene(TVliG)as a sensitive and reliable component for fire-resistant airflow *** resulting TVliG/Kevlar fabric can be integrated into various garments,particularly protective suits,to form sensitive and fire-resistant airflow sensors capable of detecting airflow velocity and direction in both two-dimensional(2D)and three-dimensional(3D)spaces during fire ***,the TVliG patterns can be expanded to multifunctional platforms,such as glucose detection for injured individuals,offering further applications in rescue *** functional expansion reduces the burden on rescue personnel and streamlines device *** its outstanding sensing capabilities,fire resistance,and expandability,the developed flexible airflow sensor shows great potential for various real-world rescue scenarios,promising advancements in wearable sensing technology for rescue enginee

关键词： flexible airflow sensor direct laser writing twice-vertical laser-induced graphene fire accident rescue Kevlar fabric