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基于时间序列分解的京津冀区域PM_(2.5)和O_(3)空间分布特征

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环境科学 2024年第5期45卷 2487-2496页

作者：姚青丁净杨旭蔡子颖韩素芹天津市环境气象中心中国气象局‐南开大学大气环境与健康研究联合实验室天津300074

京津冀区域大气污染分布呈现明显的空间差异,厘清不同时间尺度下PM_(2.5)和O_(3)浓度分布有助于制定科学有效的污染防控措施.采用STL方法分解PM_(2.5)和O_(3)浓度,获取长期分量、季节分量和短期分量,研究其变化趋势与空间分布特征.结果... 详细信息

京津冀区域大气污染分布呈现明显的空间差异,厘清不同时间尺度下PM_(2.5)和O_(3)浓度分布有助于制定科学有效的污染防控措施.采用STL方法分解PM_(2.5)和O_(3)浓度,获取长期分量、季节分量和短期分量,研究其变化趋势与空间分布特征.结果表明,2017~2021年京津冀区域PM_(2.5)浓度下降幅度高于O_(3),春、夏季PM_(2.5)和O_(3)浓度呈正相关,秋、冬季呈现负相关,短期分量和季节分量分别对PM_(2.5)和O_(3)浓度的贡献最大.PM_(2.5)的季节分量、短期分量以及O_(3)的长期分量和短期分量均存在2个主成分,对应河北省中南部和京津冀区域北部,在不同时间尺度上京津冀区域PM_(2.5)和O_(3)均存在次区域分布.与原始序列相比,长期分量能够更好地反映PM_(2.5)和O_(3)浓度的演变趋势;季节分量和短期分量的标准差可用于衡量各城市PM_(2.5)和O_(3)浓度波动情况,太行山前各城市PM_(2.5)浓度季节分量和短期分量标准差较高,唐山的O_(3)浓度短期分量的标准差最高.

关键词：时间序列分解 PM_(2.5) 臭氧(O_(3)) 京津冀区域空间分布

WavEnhancer: Unifying Wavelet and Transformer for Image Enhancement

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Journal of Computer Science & Technology 2024年第2期39卷 336-345页

作者：李梓诺陈绪行郭淑娜王书强潘治文 Department of Computer and Information Science University of MacaoMacao 999078China Research Center for Biomedical Information Technology Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China

Image enhancement is a widely used technique in digital image processing that aims to improve image aesthetics and visual quality. However, traditional methods of enhancement based on pixel-level or global-level modifications have limited effectiveness. Recently, as learning-based techniques gain popularity, various studies are now focusing on utilizing networks for image enhancement. However, these techniques often fail to optimize image frequency domains. This study addresses this gap by introducing a transformer-based model for improving images in the wavelet domain. The proposed model refines various frequency bands of an image and prioritizes local details and high-level features. Consequently, the proposed technique produces superior enhancement results. The proposed model’s performance was assessed through comprehensive benchmark evaluations, and the results suggest it outperforms the state-of-the-art techniques.

关键词： transformer wavelet transform image enhancement

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间充质干细胞对肺内皮细胞的保护作用及机制

生物化学与生物物理进展 2024年第8期51卷 1822-1833页

作者：孟子烨姜淼高敏赵自刚许袖赵振奥河北北方学院微循环研究所张家口075000 河北北方学院基础医学院张家口075000 河北医科大学基础医学院石家庄050017 河北省急危重症发病机制及干预重点实验室张家口075000

急性呼吸窘迫综合征(acute respiratory distress syndrome,ARDS)是临床上常见的严重的呼吸衰竭,死亡率高达40%。毛细血管内皮细胞通透性增加和肺水肿是ARDS的重要特征,修复肺微血管内皮屏障是阻止液体和蛋白质进入肺间质和肺泡腔的关... 详细信息

急性呼吸窘迫综合征(acute respiratory distress syndrome,ARDS)是临床上常见的严重的呼吸衰竭,死亡率高达40%。毛细血管内皮细胞通透性增加和肺水肿是ARDS的重要特征,修复肺微血管内皮屏障是阻止液体和蛋白质进入肺间质和肺泡腔的关键。动物实验和临床试验中发现,间充质干细胞移植可明显改善ARDS,减少炎症反应,降低内皮通透性。静脉移植的间充质干细胞可直接接触内皮细胞,在肺内皮损伤治疗方面可能有独特的优势,其主要通过旁分泌和免疫调节起作用。以往综述大多聚焦间充质干细胞对肺泡上皮的保护作用,本文聚焦肺内皮细胞,综述了间充质干细胞通过旁分泌细胞因子、细胞外囊泡等对内皮的直接保护作用和机制,并分析了间充质干细胞可能通过调节免疫细胞间接保护肺内皮细胞的机制。

关键词：内皮损伤急性呼吸窘迫综合征间充质干细胞肺微血管内皮细胞

Analysis of status and influencing factors of mental health in patients with systemic lupus erythematosus

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World Journal of Psychiatry 2024年第6期14卷 829-837页

作者： xuan Zhang Zhe Wang Gui-Ling Lin Fang-Zhi Wei Yan-Ping Zhuang Wen-Lu xu Qi Zhang Hui-Tao Wu zi-Man He Xi-Yu Yin Ying Liu Long Mi Ai-Min Gong School of Traditional Chinese Medicine Hainan Medical UniversityHaikou 571101Hainan ProvinceChina Department of Rheumatology and Immunology Hainan General HospitalHainan Affiliated Hospital of Hainan Medical UniversityHaikou 570311Hainan ProvinceChina Department of Radiology The First Affiliated Hospital of Hainan Medical UniversityHainan Medical UniversityHaikou 570100Hainan ProvinceChina

BACKGROUND Systemic lupus erythematosus(SLE)is a heterogeneous autoimmune disorder with varied clinical courses and prognoses,not only did the patients suffer from physical impairment,but also various physical and psychiatric *** evidence have suggested that mental disorders in SLE patients,can lead to various adverse *** To explored the features and influencing factors of mental health in patients with SLE and clarifying the correlations between mental health and personality characteristics and perceived social *** results would provide a basis for psychological intervention in patients with *** The clinical data of 168 patients with SLE admitted at the First Affiliated Hospital of Hainan Medical University between June 2020 and June 2022 were *** assessment and correlation analysis were conducted using the Symptom Checklist-90(SCL-90)and Perceived Social Support Scale,and the collected data were compared with the national norms in *** relevant factors influencing mental health were identified by statistical analysis.A general information questionnaire,the Revised Life Orientation Test,and Short-Form 36-Item Health Survey were employed to assess optimism level and quality of life(QoL),*** Patients with SLE obtained higher scores for the somatization,depression,anxiety,and phobic anxiety subscales than national norms(P<0.05).A correlation was identified between total social support and total SCL-90 score or each subscale(P<0.05).The factors significantly affecting patients’mental health were hormone dosage and disease activity index(DAI)(P<0.05).The average optimism score of patients with SLE was 14.36±4.42,and 30 cases were in the middle and lower levels.A positive correlation was found between optimism level and QoL *** Patients with SLE develop psychological disorders at varying degrees,which are significantly influenced by hormone dosage and ***’menta

关键词： Systemic lupus erythematosus Mental health Quality of life Influencing factors

基于信息调查和高分辨质谱的新污染物筛查研究进展

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环境与健康杂志 2024年第7期41卷 648-653页

作者：齐翠翠金胜许子牧安徽省生态环境科学研究院安徽合肥230071 合肥工业大学资源与环境工程学院

随着各类化学品大量生产和使用,内分泌污染物、全氟化合物、抗生素和微塑料等新污染物在环境中不断检出,不同类别新污染物的排放清单、在环境介质和生物体内的存在形态和浓度水平亟待全面调查研究。为满足摸清新污染物底数的需要,急需... 详细信息

随着各类化学品大量生产和使用,内分泌污染物、全氟化合物、抗生素和微塑料等新污染物在环境中不断检出,不同类别新污染物的排放清单、在环境介质和生物体内的存在形态和浓度水平亟待全面调查研究。为满足摸清新污染物底数的需要,急需突破适于新污染物快速筛查技术瓶颈。笔者综述了基于信息调查和高分辨质谱技术在新污染物筛查领域的应用研究进展,并对今后的研究方向进行了展望。

关键词：新污染物信息调查高分辨质谱筛查

Transcriptomic Landscape Analysis Reveals a Persistent DNA Damage Response in Metabolic Dysfunction-associated Steatohepatitis Post-dietary Intervention

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Journal of Clinical and Translational Hepatology 2024年第9期12卷 765-779页

作者： zi-Yuan Zou Tian-Yi Ren Jia-Qi Li Ting-Ying Jiao Meng-Yu Wang Lei-Jie Huang Shuang-Zhe Lin Yuan-Yang Wang Xiao-Zhen Guo Ye-Yu Song Rui-xu Yang Cen Xie Jian-Gao Fan Center for Fatty Liver Department of GastroenterologyXinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghaiChina University of Chinese Academy of Sciences BeijingChina Human Phenome Institute School of Life SciencesFudan UniversityShanghaiChina Department of Gastroenterology Ningbo No.2 HospitalNingboZhejiangChina Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition ShanghaiChina

Background and Aims:Metabolic dysfunction-associated steatotic liver disease(MASLD)and its more advanced form,metabolic dysfunction-associated steatohepatitis,have emerged as the most prevalent liver diseases ***,lifestyle modification is the foremost guidelinerecommended management strategy for ***,it remains unclear which detrimental signals persist in MASLD even after disease ***,we aimed to examine the persistent changes in liver transcriptomic profiles following this ***:Male C57BL/6J mice were divided into three groups:Western diet(WD)feeding,chow diet(CD)feeding,or diet reversal from WD to *** 16 weeks of feeding,RNA sequencing was performed on the mice’s livers to identify persistent alterations characteristic of ***,RNA sequencing databases containing high-fat diet-fed P53-knockout mice and human MASLD samples were ***:WD-induced MASLD triggered persistent activation of the DNA damage response(DDR)and its primary transcription factor,P53,long after the resolution of the hepatic phenotype through dietary *** levels of P53 might promote apoptosis,thereby exacerbating metabolic dysfunction-associated steatohepatitis,as they strongly correlated with hepatocyte ballooning,an indicator of apoptosis ***,P53 knockout in mice led to downregulated expression of apoptosis signaling in the ***,P53 may regulate apoptosis by transcriptionally activating the expression of apoptosis-enhancing nuclease(AEN).Consistently,P53,AEN,and the apoptosis process all exhibited persistently elevated expression and showed a strong inter-correlation in the liver following dietary ***:The liver demonstrated upregulation of DDR signaling and the P53-AEN-apoptosis axis both during and after exposure to *** findings provide new insights into the mechanisms of MASLD relapse,highlighting DDR signaling as a promising target to prevent MASLD recu

关键词： Apoptosis DNA Damage Metabolic dysfunction-associated steatotic liver disease RNA-Seq Tumor suppressor protein P53 Western Diets

Patient-Reported Outcomes of Postoperative NSCLC Patients with or without Staged Chinese Herb Medicine Therapy during Adjuvant Chemotherapy(NALLC 2): A Randomized, Double-Blind, Placebo-Controlled Trial

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Chinese Journal of Integrative Medicine 2024年第11期30卷 963-973页

作者： ZHANG Yi-lu JIAO Li-jing GONG Ya-bin xu Jian-fang NI Jian SHEN Xiao-yong ZHANG Jie ZHOU Di QIAN Cheng-xin WANG Qin YAO Jia-lin YANG Wen-xiao SU Ling-zi WANG Li-yu LI Jia-qi YAO Yi-qin ZHANG Yuan-hui WANG Yi-chao CHEN Zhi-wei xu Ling Oncology Department Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Shanghai University of Traditional Chinese Medicine Institute of Traditional Chinese Medicine Oncology Shanghai University of Traditional Chinese Medicine Oncology Department Shanghai Pulmonary Hospital Shanghai Tongji University Thoracic Surgery Department Huadong Hospital Shanghai Fudan University Thoracic Surgery Department Shanghai Cancer Hospital Shanghai Fudan University Oncology Department Shanghai Chest Hospital Shanghai Jiao Tong University

Objective:To investigate whether the combination of chemotherapy with staged Chinese herbal medicine(CHM) therapy could enhance health-related quality of life(QoL) in non-small-cell lung cancer(NSCLC)patients and prolong the time before deterioration of lung cancer symptoms,in comparison to chemotherapy ***:A prospective,double-blind,randomized,controlled trial was conducted from December 14,2017 to August 28,2020.A total of 180 patients with stage ⅠB-ⅢA NSCLC from 5 hospitals in Shanghai were randomly divided into chemotherapy combined with CHM(chemo+CHM) group(120 cases) or chemotherapy combined with placebo(chemo+placebo) group(60 cases) using stratified blocking *** European Organization for Research and Treatment of Cancer(EORTC) Quality-of-Life-Core 30 Scale(QLQ-C30) was used to evaluate the patient-reported outcomes(PROs) during postoperative adjuvant chemotherapy in patients with early-stage *** events(AEs) were assessed in the safety ***:Out of the total 180 patients,173 patients(116in the chemo+CHM group and 57 in the chemo+placebo group) were included in the PRO *** initial mean QLQ-C30 Global Health Status(GHS)/QoL scores at baseline were 57.16±1.64 and 57.67±2.25 for the two respective groups(P>0.05).Compared with baseline,the chemo+CHM group had an improvement in QLQ-C30GHS/QoL score at week 18 [least squares mean(LSM) change 17.83,95% confidence interval(CI) 14.29 to 21.38].Conversely,the chemo+placebo group had a decrease in the score(LSM change-13.67,95% CI-22.70 to-4.63).A significant between-group difference in the LSM GHS/QoL score was observed,amounting to 31.63 points(95% CI25.61 to 37.64,P<0.001).The similar trends were observed in physical functioning,fatigue and appetite *** week 18,patients in the chemo+CHM group had a higher proportion of improvement or stabilization in GHS/QoL functional and symptom scores compared to chemo+placebo group(P<0.001).The median time to deterioration

关键词： Chinese herbal medicine adjuvant chemotherapy health-related quality of life non-small-cell lung cancer patient-reported outcome

新媒体与交互方向硕士研究生分类培养模式的探索

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印刷与数字媒体技术研究 2024年第3期 41-47页

作者：许甲子杨静大连工业大学艺术设计学院大连116032 扬州大学美术与设计学院扬州225127

研究生教育肩负着为国家培养高层次学术与应用型人才的崇高使命,学术型与专业型硕、博士的培养同等重要。在研究生分类培养的使命下,新媒体与交互方向的硕士层次人才培养需结合专业特点,构建立体的、复合的培养模式。本文通过分析新媒... 详细信息

研究生教育肩负着为国家培养高层次学术与应用型人才的崇高使命,学术型与专业型硕、博士的培养同等重要。在研究生分类培养的使命下,新媒体与交互方向的硕士层次人才培养需结合专业特点,构建立体的、复合的培养模式。本文通过分析新媒体与交互方向的研究生培养模式的现状及存在的问题,论述研究生分类培养下的人才培养模式改革,从培养理念、培养过程、数字化教育转型、导师队伍建设等几方面,探索专业人才分类培养的策略,以期跟随新时代我国新质生产力的加快发展要求,构建相应的培养路径。

关键词：新媒体与交互研究生分类培养人才培养培养模式

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中国式民族教育现代化三问

民族教育研究 2024年第1期35卷 73-82页

作者：许丽英刘子涵中央民族大学教育学院北京100081

内涵之问、困境之问和破局之问是中国式民族教育现代化必须回答的时代“三问”。在中国式现代化的客观要求下,中国式民族教育现代化的本质是坚持中国共产党的全面领导、坚持中华文明的五个突出特性和坚持人才培养的三个面向,是各民族人... 详细信息

内涵之问、困境之问和破局之问是中国式民族教育现代化必须回答的时代“三问”。在中国式现代化的客观要求下,中国式民族教育现代化的本质是坚持中国共产党的全面领导、坚持中华文明的五个突出特性和坚持人才培养的三个面向,是各民族人民、各地区均衡发展、数字化赋能高质量发展、坚定文化自信自强和推进两个共同体建设的教育现代化。尽管实现中国式民族教育现代化已具备深厚的现实基础,但仍存在人才效能缺位、资源保障失衡、数字化转型遇障、文化功能发挥受限以及内生发展任务艰巨等短板问题。要坚持以提高人才培养质量为着力点、以优化资源配置手段为支撑点、以推进数字化教学实践为突破点、以弘扬中华优秀传统文化为关键点和以打造人类命运共同体为最终愿景,全面推动中国特色的民族教育现代化更快、更好地实现。

关键词：中国式现代化民族教育高质量发展中华文明数字化转型