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Regenerating gene 4 promotes chemoresistance of colorectal cancer by affecting lipid droplet synthesis and assembly

World Journal of Gastroenterology 2023年第35期29卷 5104-5124页

作者： Cong-Yu Zhang Rui Zhang Li Zhang zi-mo wang Hong-Zhi Sun Zheng-Guo Cui Hua-Chuan Zheng Cancer Center The First Affiliated Hospital of Jinzhou Medical UniversityJinzhou 121001Liaoning ProvinceChina Department of Colorectal Surgery Liaoning Cancer HospitalShenyang 110042Liaoning ProvinceChina Department of Oncology The Affiliated Hospital of Chengde Medical UniversityChengde 067000Hebei ProvinceChina Department of Environmental Health University of Fukui School of Medical SciencesFukui 910-1193Japan

BACKGROUND Regenerating gene 4(REG4)has been proved to be carcinogenic in some cancers,but its manifestation and possible carcinogenic mechanisms in colorectal cancer(CRC)have not yet been *** previous study found that the drug resistance of CRC cells may be closely linked to their fat *** To explore the role of REG4 in CRC and its association with lipid droplet formation and *** We conducted a meta-analysis and bioinformatics and pathological analyses of REG4 expression in *** effects of REG4 on the phenotypes and related protein expression were also investigated in CRC *** detected the impacts of REG4 on the chemoresistance and lipid droplet formation in CRC ***,we analyzed how REG4 regulated the transcription and proteasomal degradation of lipogenic enzymes in CRC *** Compared to normal mucosa,REG4 mRNA expression was high in CRC(Pmor-node-metastasis staging or short overall survival and REG4 mRNA overexpression(Pmokine activity;taste receptors;protein-DNA and DNA packing complexes;nucleosomes and chromatin;generation of second messenger molecules;programmed cell death signals;epigenetic regulation and DNA methylation;transcription repression and activation by DNA binding;insulin signaling pathway;sugar metabolism and transfer;and neurotransmitter receptors(Pmoted proliferation,antiapoptosis,migration,and invasion of DLD-1 cells in an autocrine or paracrine manner by activating the epidermal growth factor receptor-phosphoinositide 3-kinase-Akt-nuclear factor-κB ***4 was involved in chemoresistance not through de novo lipogenesis,but lipid droplet ***4 inhibited the transcription of acetyl-CoA carboxylase 1(ACC1)and ATP-citrate lyase(ACLY)by disas

关键词： Colorectal cancer Regenerating gene 4 Aggressive behavior Prognosis Chemoresistance Lipid droplet formation Epidermal growth factor receptor signal

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基于色散效应的光纤光栅高速高精度解调方法研究

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物理学报 2017年第1期66卷 112-120页

作者：李政颖周磊孙文丰李子墨王加琪郭会勇王洪海武汉理工大学光纤传感技术与信息处理教育部重点实验室武汉430070 武汉理工大学光纤传感技术国家工程实验室武汉430070

利用普通单模光纤(SMF)与色散补偿光纤(DCF)分别具有正色散和负色散系数特性,实现光纤光栅阵列的高速高精度解调.系统采用全光纤结构,仅需发出单一高速光脉冲,即可根据反射光脉冲时延差同时获取各个光栅的波长与位置信息,大幅提高了光... 详细信息

利用普通单模光纤(SMF)与色散补偿光纤(DCF)分别具有正色散和负色散系数特性,实现光纤光栅阵列的高速高精度解调.系统采用全光纤结构,仅需发出单一高速光脉冲,即可根据反射光脉冲时延差同时获取各个光栅的波长与位置信息,大幅提高了光纤光栅解调速度;通过建立DCF-SMF双通道和色散差矫正模型,削弱了温度变化及色散值误差对系统解调精度的影响.实验表明,本方法解调速率可达1 MHz,解调过程受传感网络光纤及双通道温变影响较小,具有良好稳定性及高精度;5—75?C温度扰动实验中,传感网络传输光纤温变时系统解调均方差16.8 pm,DCF-SMF双通道受温度扰动时系统解调均方差为11.9 pm,恒温下系统长时间解调时均方差为6.4 pm;应力实验中,解调线性度可达0.9998,解调精度约为8.5 pm.

关键词：光纤传感普通单模光纤色散补偿光纤高速高精度

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纳米流体基本性能研究进展

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功能材料与器件学报 2016年第4期22卷 1-5页

作者：吴张永刘霖霖宋铮铮莫子勇王娴王娟昆明理工大学机电工程学院昆明650500

纳米流体应用于强化传热领域具有良好的换热之后，成为材料、物理、化学、传热学等众多领域的研究热点。本文从纳米流体的制备及分散稳定性、热物性与流变学物性、防锈抗磨性能等方面总结了纳米流体基本性能的研究进展。指出纳米流体的... 详细信息

纳米流体应用于强化传热领域具有良好的换热之后，成为材料、物理、化学、传热学等众多领域的研究热点。本文从纳米流体的制备及分散稳定性、热物性与流变学物性、防锈抗磨性能等方面总结了纳米流体基本性能的研究进展。指出纳米流体的研究尚处在实验研究阶段，只能通过实验来研究纳米流体的基本性能，在实验的基础上只提出了相关的假设机理，并没有形成完善的理论体系来对纳米流体相关的性能做出总结。还需对其进行更深入的研究，从而形成一套相对完善的纳米流体基本性能的理论体系。

关键词：纳米流体稳定性导热系数流变学腐蚀磨损

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Manufacturing process and microstructure of copper-coated aluminum wires

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International Journal of Minerals,Metallurgy and Materials 2015年第2期22卷 190-196页

作者： Xiao-hua Chen Xin Tang zi-dong wang Xi-dong Hui mo Li Yong-wei wang State Key Laboratory for Advanced Metals and Materials University of Science and Technology Beijing School of Materials Science and Engineering Georgia Institute of Technology School of Materials Science and Engineering University of Science and Technology Beijing School of Mechanical Engineering University of Science and Technology Beijing

Copper-coated aluminum wires exhibit good electrical conductivity, high thermal conductivity, low contact resistance of copper and low density, and provide economic advantages over aluminum. However, there are some problems in the manufacring processes of hot-dip copper-coated aluminum wires, such as the difficulties in controlling coating process. In this work, the hot-dip copper-coating method of aluminum wires was investigated for producing copper-coated aluminum wire composites. The interface microstructure between the aluminum wire and the copper coating layer was analyzed by scanning electron microscopy （SEM） and energy-dispersive X-ray spec- trometry （EDS）. Five different fluxing agents were tested. Experimental results show that appropriate conditions for the hot-dip process are determined as the liquid copper temperature of 1085℃ and the treatment time less than 1 s. A success in hot-dip copper-coated aluminum wires is achieved by hot-dipping a low-melting-point metal into a high-melting-point metal liquid, which is significant for the further devel- opment and application of copper-coated aluminum wire composites.

关键词： bimetallic composites copper aluminum hot dip coating interfaces

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Mandelbrot Law of Evolving Networks

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Chinese Physics Letters 2012年第3期29卷 275-278页

作者： REN Xue-Zao YANG zi-mo wang Bing-Hong ZHOU Tao School of Science Southwest University of Science and TechnologyMianyang 621010 Web Sciences Center University of Electronic Science and Technology of ChinaChengdu 610054 Department of modern Physics University of Science and Technology of ChinaHefei 230026

We show that the degree distribution of a growing network with linear preferential attachment approximately follows the Mandelbrot law,and propose an analytical method based on a recursive formula that can be used to obtain a more accurate expression of the shifting *** demonstrate the advantages of our *** work provides a possible mechanism leading to the Mandelbrot law of evolving networks,and refines the mainstream analytical methods for the shifting coefficient.

关键词： coefficient network shifting

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Insufficient application of estimation equations of glomerular filtration rate:a survey of 1009 Chinese pediatricians

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World Journal of Pediatrics 2022年第5期18卷 368-372页

作者： zi-mo Sun Nan Zhou Xiao-Xia Peng Hui wang Ying Shen Center for Clinical Epidemiology and Evidence-Based Medicine Beijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijing 100045China Department of Nephrology Beijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijing 100045China

The cur re nt high prevalence of kidney disease and kidney injury in children represents a significant public health *** incidence of chronic kidney disease(CKD)is 3.0-17.5 per million children,and the prevalence is 14.9-118.8 per million children,with an increasing trend[1].CKD can progress to end-stage renal disease and cause complications,including dysplasia and cardiovascular disease,thus causing more significant health problems[2].

关键词： kidney prevalence cardiovascular

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Comparative study on the passivation layers of copper sulphide minerals during bioleaching

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International Journal of Minerals,Metallurgy and Materials 2012年第10期19卷 886-892页

作者： Kai-bin Fu Hai Lin Xiao-lan mo Han wang Hong-wei Wen zi-long Wen School of Civil and Environmental Engineering University of Science and Technology Beijing Beijing 100083 China Key Laboratory of Solid Waste Treatment and Resource Recycle (Ministry of Education) Southwest University of Science and Technology Mianyang 621010 China

The bioleaching of copper sulphide minerals was investigated by using A. ferrooxidans ATF6. The result shows the preferential order of the minerals bioleaching as djurleite〉bomite〉pyritic chalcopyrite〉covellite〉porphyry chalcopyfite. The residues were characterized by X-ray diffraction （XRD） and scanning electron microscopy （SEM）. It is indicated that jarosite may not be responsible for hindered disso- lution. The elemental sulfur layer on the surface of pyritic chalcopyrite residues is cracked. The compact surface layer of porphyry chalcopy- rite may strongly hinder copper extraction. X-ray photoelectron spectroscopy （XPS） further confirms that the passivation layers of covellite, pyritic chalcopyrite, and porphyry chalcopyrite are copper-depleted sulphide Cu4S11, S8, and copper-rich iron-deficient polysulphide CtuFe2S9, resoectivelv. The ability of these oassivation layers was found as Cu4Fe2S9〉Cu4S11〉S8〉iarosite.

关键词： copper ore treatment copper sulphide bioleaching passivation

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Photodynamic therapy regulates fate of cancer stem cells through reactive oxygen species

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World Journal of Stem Cells 2020年第7期12卷 562-584页

作者： zi-Jian Zhang Kun-Peng wang Jing-Gang mo Li Xiong Yu Wen Department of General Surgery Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina Department of General Surgery Taizhou Central Hospital(Taizhou University Hospital)Taizhou 318000Zhejiang ProvinceChina

Photodynamic therapy(PDT)is an effective and promising cancer *** directly generates reactive oxygen species(ROS)through photochemical *** oxygen-dependent exogenous ROS has anti-cancer stem cell(CSC)*** addition,PDT may also increase ROS production by altering metabolism,endoplasmic reticulum stress,or potential of mitochondrial *** is known that the half-life of ROS in PDT is short,with high reactivity and limited diffusion ***,the main targeting position of PDT is often the subcellular localization of photosensitizers,which is helpful for us to explain how PDT affects CSC characteristics,including differentiation,selfrenewal,apoptosis,autophagy,and *** speaking,excess ROS will damage the redox system and cause oxidative damage to molecules such as DNA,change mitochondrial permeability,activate unfolded protein response,autophagy,and CSC resting ***,understanding the molecular mechanism by which ROS affect CSCs is beneficial to improve the efficiency of PDT and prevent tumor recurrence and *** this article,we review the effects of two types of photochemical reactions on PDT,the metabolic processes,and the biological effects of ROS in different subcellular locations on CSCs.

关键词： Cancer stem cells Photodynamic therapy Reactive oxygen species Photosensitizer Mitochondrial Endoplasmic reticulum

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Experimental and Numerical Studies on Sea Sand Concrete Filled Stainless Steel Tube with Inner FRP Tube Subjected to Axial Compression

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China Ocean Engineering 2023年第2期37卷 272-287页

作者： ZENG Lan YU Wen-lan mo zi-yong HUANG Shi-qing YUAN Hong moE Key Laboratory of Disaster Forecast and Control in Engineering School of Mechanics and Construction EngineeringJinan UniversityGuangzhou 510632China Construction Engineering Quality and Safety Supervision Station of Renshou County Meishan 620500China School of Architectural Engineering Guangzhou Institute of Science and TechnologyGuangzhou 510540China

Since fibre-reinforced polymer(FRP) and stainless steel(SS) offer advantages of corrosion resistance and hybrid confinement, this study proposed a new type of composite column: sea sand concrete(SSC)-filled SS tubular columns with an inner FRP tube(CFSTFs) to help exploit abundant ocean resources in marine engineering. To study compressive behaviours of these novel members, eight CFSTFs and two SSC-filled SS tubular columns(CFSTs)were tested under axial compression. Their axial load-displacement curves, axial load-strain curves in SS or FRP tubes were obtained, and influences of key test parameters(the existence of glass FRP(GFRP) tubes, steel tube shapes, and GFRP tube thicknesses and diameters) were discussed. Further, specimen failure mechanism was analyzed employing the finite element method using ABAQUS software. Test results confirmed the excellent ductility and load-bearing capacity of CFSTFs. The existence of GFRP tubes inside can postpone SS tube buckling, and the content of inner FRP tubes, particularly increasing diameters, was found to improve compressive behaviours. GFRP contents helped develop the second elastic-plastic stage of the load-displacement curves. Furthermore, the bearing capacity of CFSTFs with a circular cross-section was approximately 26% higher than that with a square cross-section, and this difference narrowed with the increase in GFRP ratios.

关键词： sea-sand concrete(SSC) confined concrete column fibre-reinforced polymer(FRP)tube stainless steel tube axial compression

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Dual-property blue and red emission carbon dots for Fe(Ⅲ)ions detection and cellular imaging

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Rare Metals 2021年第7期40卷 1957-1965页

作者： Yin-Long Xu Rui-Xue mo Cai-Yu Qi Zeng Ren Xiu-Zhi Jia zi-Gui Kan Cao-Long Li Fei wang Key Laboratory of Biomedical Functional Materials School of Basic ScienceChina Pharmaceutical UniversityNanjing 211198China Tibetan Medicine Research Institute Tibetan Traditional Medical CollegeLasa 850000China School of Basic Medical Science Harbin Medical UniversityHarbin 150081China

The excitation wavelength-dependent and-independent emissions are two crucial fluorescent properties of carbon dots(CDs).However,CDs reported till date exhibit only one of these properties,which limits their practical ***,dual-property carbon dots(DCDs)with both the excitation wavelength-dependent and-independent emissions were synthesized via a facile onestep solvothermal method using 4-(2-pyridylazo)-resorcinol as the carbon *** multi-functional applications of the resulting DCDs were also *** asprepared DCDs exhibited not only excellent monodispersity,high photostability,and storage stability,but also low toxicity,good biocompatibility,and cellular bioimaging *** addition,the DCDs exhibited excitation-dependent emission photoluminescence under low excitation *** DCDs exhibited good Fe3+detection by quenching the blue emission fluorescence and showed a relatively low Fe3+detection limit of 0.067 lmol·L-1 based on three times signal-to-noise criteria(R2=0.99).Furthermore,the DCDs showed excitation-independent emission at low excitation wavelengths and exhibited red emission at about 598 nm to avoid damage to the *** results demonstrate the excellent bioimaging properties of the *** to their dual PL properties,the as-prepared DCDs exhibited multi-functional applications:Fe3+detection and A549 cell *** results will be helpful in developing novel CDs for applications in various fields.

关键词： Carbon dots Solvothermal Dual properties Fe3+ions detection Bioimaging

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