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Molecular mechanism and research progress of traditional Chinese medicine in the treatment of prostate cancer

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Traditional Medicine Research 2025年第1期10卷 62-72页

作者： Hai-Luo Wang Ruo-Ran Zhang Hao Wang Peng Xu jing-Kai Wang Bo Chen Hao Xu Deng Pan yu-Yang Ma Kun Pang Department of Urology Xuzhou Central HospitalXuzhou Clinical School of Xuzhou Medical CollegeXuzhou 221009China Graduate School Jiangsu UniversityZhenjiang 212013China Graduate School Bengbu Medical UniversityBengbu 233040China Department of Urology The Peixian People’s HospitalXuzhou 221699China.

Prostate cancer(PCa)is one of the most common malignant tumors in the male genitourinary system,ranking second in incidence *** Chinese medicine(TCM),as an important component of complementary and alternative medicine,shows unique advantages in cancer *** herbal medicine is usually composed of multiple ingredients and involves multiple signaling pathways,which showed function of inducing apoptosis of cancer cells,arresting the cell cycle,inhibiting invasion and metastasis,reducing drug resistance,and regulating immune *** therapy is also an important treatment of ***,Physical therapy such as acupuncture or Tai Chi and Qigong are gaining increased recognition in the management of PCa,particularly in addressing issues like urinary incontinence and bone metastasis-related *** article reviews the TCM treatment and therapy of PCa,in order to provide new research avenues and treatment options for the treatment of PCa with TCM and improve the quality of life of patients.

关键词： traditional Chinese medicine prostate cancer Chinese herbal medicine physical therapy

Amethod for sharing dynamic geometry information in studies on liquid-based detectors

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Nuclear Science and Techniques 2021年第2期32卷 101-111页

作者： Shu Zhang jing-Shu Li Yang-Jie Su yu-Mei Zhang zi-yuan Li Zheng-yun You School of Physics Sun Yat-Sen UniversityGuangzhou 510275China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Sino-French Institute of Nuclear Engineering and Technology Sun Yat-Sen UniversityZhuhai 519082China

Liquid-based detectors are widely used in particle and nuclear physics *** fixed method is used to construct the geometry in detector simulations such as Geant4,it is usually difficult to describe the non-uniformity of the liquid in a *** propose a method based on geometry description markup language and a tessellated detector description to share the detector geometry information between computational fluid dynamics simulation software and detector simulation *** method makes it possible to study the impact of a liquid flow and non-uniformity on the key performance of a liquid-based detector,such as the event vertex reconstruction *** will also be helpful in the detector design and performance optimization.

关键词： Liquid-based detector Geometry Simulation Geant4 Computational fluid dynamics

Effective suppression of beta oscillation in Parkinsonian state via a noisy direct delayed feedback control scheme

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Chinese Physics B 2021年第3期30卷 555-563页

作者： Hai-Tao yu zi-Han Meng Chen Liu Jiang Wang jing Liu School of Electrical and Information Engineering Tianjin UniversityTianjin 300072China Department of Neurology Tangshan Gongren HospitalTangshan 063000China

This work explores the function of the noisy direct delayed feedback(NDDF)control strategy in suppressing the pathological oscillations in the basal ganglia(BG)with Parkinson’s disease(PD).Deep brain stimulation(DBS)alleviates the PD state ***,due to its unclear mechanism and open-loop characteristic,it is challenging to further improve its effects with lower energy *** noise stimulus performs competitively in alleviating the PD state theoretically,but it cannot adapt to the neural condition timely and automatically due to its open-loop control *** direct delayed feedback(DDF)control strategy is able to disturb excessive synchronous ***,the NDDF control strategy is proposed and researched based on a BG computational model,which can reflect the intrinsic properties of the BG neurons and their connections with thalamic *** results show that the NDDF control strategy with optimal parameters is effective in removing the pathological beta *** comparison,we find the NDDF control strategy performs more excellent than DDF in alleviating PD ***,we define the multiple-NDDF control strategy and find that the multiple-NDDF with appropriate parameters performs better than *** obtained results contribute to the cure for PD symptoms by optimizing the noise-induced improvement of the BG dysfunction.

关键词： basal ganglia neural networks Parkinsonian state noise delayed feedback

Molecular phylogeny and morphology reveal a new wood-rotting fungal species,Cyathus wenshanensis *** the yunnan-Guizhou Plateau

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Studies in Fungi 2022年第1期7卷 58-67页

作者： zi-Yan Duan jing yu Chang-Lin Zhao College of Biodiversity Conservation Southwest Forestry UniversityKunming 650224P.R.China yunnan Key Laboratory for Fungal Diversity and Green Development Kunming Institute of BotanyChinese Academy of ScienceKunming 650201P.R.China

A new species of bird's nest fungus,Cyathus wenshanensis is proposed based on a combination of the morphological and molecular *** is characterised by the obconical to cupulate basidiomata covered with hirsute hairs,striations on the outer and inner surface of the peridium,funicular peridioles,a trimitic hyphal system of peridium with generative hyphae having clamp connections,a dimitic hyphal system of peridiole middle,and subglobose,elliptical to ellipsoid-elongate,thick-walled *** of the internal transcribed spacers(ITS)gene region was generated,and the phylogenetic analysis was performed with maximum likelihood,maximum parsimony and Bayesian inference *** phylogenetic analyses inferred from ITS dataset indicated that *** nested within the genus Cyathus,in which it formed a monophyletic lineage and grouped with ***,***,***,***,*** and ***.

关键词： phylogeny Plateau Guizhou

Multi-Physics Modeling of Solid Oxide Fuel Cell Fueled by Methane and Analysis of Carbon Deposition

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Chinese Journal of Chemical Physics 2015年第3期28卷 299-307,I0001页

作者： Bao-xuan Wang Jiang Zhu zi-jing Lin Hefei National Laboratory for Physical Sciences at the Microscale & Collaborative Innovation Center of Suzhou Nano Science and Technology University of Science and Technology of China Hefei 230025 China Key Laboratory of Strongly-Coupled Quantum Matter Physics Chinese Academy of Sciences and Department of Physics University of Science and Technology of China Hefei 230025 China

Internal reformation of low steam methane fuel is important for the high efficiency and low cost operation of solid oxide fuel cell. Understanding and overcoming carbon deposition is crucial for the technology development. Here a multi-physics model is established for the relevant experimental cells. Balance of electrochemical potentials for the electrochemical reactions, generic rate expression for the methane steam reforming, dusty gas model in a form of Fick＇s model for anode gas transport are used in the model. Excellent agreement between the theoretical and experimental current-voltage relations is obtained, demonstrating the validity of the proposed theoretical model. The steam reaction order in low steam methane reforming reaction is found to be 1. Detailed information about the distributions of physical quantities is obtained by the numerical simulation. Carbon deposition is analyzed in detail and the mechanism for the coking inhibition by operating current is illustrated clearly. Two expressions of carbon activity are analyzed and found to be correct qualitatively, but not quantitatively. The role of anode diffusion layer on reducing the current threshold for carbon removal is also explained. It is noted that the current threshold reduction may be explained quantitatively with the carbon activity models that are only qualitatively correct.

关键词： Numerical model Methane reforming kinetics Current-voltage relation Carbon activity Diffusion barrier layer

Relation Between the Eventual Continuity and the E-property for Markov-Feller Semigroups

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Acta Mathematicae Applicatae Sinica 2024年第1期40卷 1-16页

作者： Yong Liu zi-yu Liu LMAM School of Mathematical SciencePeking UniversityBeijing100871China

We investigate some relations between two kinds of semigroup regularities, namely the e-property and the eventual continuity, both of which contribute to the ergodicity for Markov processes on Polish *** precisely, we prove that for Markov-Feller semigroup in discrete time and stochastically continuous MarkovFeller semigroup in continuous time, if there exists an ergodic measure whose support has a nonempty interior,then the e-property is satisfied on the interior of the support. In particular, it implies that, restricted on the support of each ergodic measure, the e-property and the eventual continuity are equivalent for the discrete-time and the stochastically continuous continuous-time Markov-Feller semigroups.

关键词： Markov-Feller semigroup ergodicity e-property eventual continuity

Local Structures and Chemical Properties of Deprotonated Arginine

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Chinese Journal of Chemical Physics 2012年第6期25卷 681-686,I0003,I0004页

作者： Hong-bao Li zi-jing Lin Yi Luo Hefei National Laboratory for Physical Sciences at the Microscale and Department of Physics University of Science and Technolo&y of China Hefei 230025 China Department of Theoretical Chemistry and Biology School of BiotechnoloEy Royal Institute ofTechnoloEy S-106 91 Stockholm Sweden

The potential energy surface of gaseous deprotonated arginine has been systematically in- vestigated by first principles calculations. At the B3LYP/6-31G（d） level, apart from the identification of several stable local structures, a new global minimum is located which is about 6.56 k J/tool more stable than what has been reported. The deprotonated arginine molecule has two distinct forms with the deprotonation at the carboxylate group （COO-）. These two forms are bridged by a very high energy barrier and possess very different IR spectral profiles. Our calculated proton dissociation energy and gas-phase acidity of argi- nine molecule are found to be in good agreement with the corresponding experimental results. The predicted geometries, dipole moments, rotational constants, vertical ionization energies and IR spectra of low energy conformers will be useful for future experimental measurements.

关键词： Deprotonated arginine Energy barrier IR spectrum Gas-phase acidity

Simple PSF based method for pupil phase mask’s optimization in wavefront coding system

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第2期8卷 180-185页

作者： ZHANG Wen-zi CHEN Yan-ping ZHAO Ting-yu YE zi yu Fei-hong State Key Laboratory of Modern Optical Instrumentation Optical Engineering Department Zhejiang University Hangzhou 310027 China

By applying the wavefront coding technique to an optical system, the depth of focus can be greatly increased. Several complicated methods, such as Fisher Information based method, have already been taken to optimize for the best pupil phase mask in ideal condition. Here one simple point spread function (PSF) based method with only the standard deviation method used to evaluate the PSF stability over the depth of focus is taken to optimize for the best coefficients of pupil phase mask in practical optical systems. Results of imaging simulations for optical systems with and without pupil phase mask are presented, and the sharpness of image is calculated for comparison. The optimized results showed better and much more stable imaging quality over the original system without changing the position of the image plane.

关键词： Wavefront coding Pupil phase mask Depth of focus PSF stability Optimization Sharpness Imaging simulation

Illumination system with compound parabolic retro-reflector for single LCOS panel projection display

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第12期8卷 2021-2026页

作者： ZHEN Yan-kun YE zi ZHANG Wen-zi ZHAO Ting-yu yu Fei-hong State Key Lab. of Modern Optical Instrumentation Zhejiang University Hangzhou 310027 China

In this paper, a new illumination system with ultra high performance (UHP) lamp is proposed for projection display. Parabolic reflector (PR) and compound parabolic retro-reflector (CPR) were jointly used to collect and collimate the light generated from UHP lamp. A polarization converter system (PCS) was used to increase the light efficiency of the projection display system. A beam transformer between PCS and 2f imaging systems was directly used to make the illumination meet the requirement of projection display system. With the consideration of the loss of reflection, the light efficiency in this projection display system was estimated to be 15.6%.

关键词： Compound parabolic retro-reflector (CPR) Uniformity Light efficiency Etendue