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Surgical treatment for proliferative diabetic retinopathy with ocular albinism

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International Journal of Ophthalmology(English edition) 2023年第3期16卷 479-482页

作者： zi-jing huang Ding-Guo huang Wei-Qi Chen Joint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong Shantou 515041Guangdong ProvinceChina

Dear Editor,We are writing to present an uncommon case of a45-year-old woman with bilateral proliferative diabetic retinopathy (PDR) and ocular albinism (OA).Albinism is a group of inherited disorders of tyrosinase ac... 详细信息

关键词： ocular proliferative diabetic

Pediatric episcleral osseous choristomas:a case report

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International Journal of Ophthalmology(English edition) 2020年第10期13卷 1671-1674页

作者： zi-jing huang Jian-Long Zheng De-Zhi Zheng Ding-Guo huang Dong-Ping Tian Wei-Qi Chen Joint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong Shantou 515041Guangdong ProvinceChina Department of Pathology Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina

Dear Editor,We are writing to present a rare episcleral osseous choristomas in a 12-year-old *** are congenital benign mass composed of normal tissue located in an abnormal site[1].Ocular choristomas can be categorize... 详细信息

关键词： congenital epi ler

Evolution of helium bubbles in FeCoNiCr-based high-entropy alloys containing γ′ nanoprecipitates

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Chinese Physics B 2024年第7期33卷 491-500页

作者：冯婷蒋胜明胡潇天张子骏黄子敬董士刚张建 College of Energy Xiamen UniversityXiamen 361005China16

A series of high-entropy alloys(HEAs) containing nanoprecipitates of varying sizes is successfully prepared by a non-consuming vacuum arc melting *** order to study the irradiation evolution of helium bubbles in the FeCoNiCrbased HE As with γ' precipitates,these samples are irradiated by 100-keV helium ions with a fluence of 5 × 10^(20) ions/m^(2) at 293 K and 673 K,*** the samples irradiated at room temperature are annealed at different temperatures to examine the diffusion behavior of helium *** electron microscope(TEM) is employed to characterize the structural morphology of precipitated nanoparticles and the evolution of helium *** results reveal that nanosized,spherical,dispersed,coherent,and ordered L1_(2)-type Ni_(3)Ti γ' precipitations are introduced into FeCoNiCr(Ni_(3)Ti)_(0.1) HEAs by means of ageing treatments at temperatures between 1073 K and 1123 *** the ageing treatment conditions adopted in this work,γ' nanoparticles are precipitated in FeCoNiCr(Ni_(3)Ti)_(0.1) HE As,with average diameters of 15.80 nm,37.09 nm,and 62.50 nm,*** average sizes of helium bubbles observed in samples after 673-K irradiation are 1.46 nm,1.65 nm,and 1.58 nm,*** improvement in the irradiation resistance of FeCoNiCr(Ni_(3)Ti)_(0.1) HEAs is evidenced by the diminution in bubbles ***,the FeCoNiCr(Ni_(3)Ti)_(0.1) HEAs containing γ' precipitates of 15.8 nm exhibits the minimum size and density of helium bubbles,which can be ascribed to the considerable helium trapping effects of heterogeneous coherent phase ***,annealing experiments conducted after 293-K irradiation indicate that HEAs containing precipitated phases exhibits smaller apparent activation energy(E_(a)) for helium bubbles,resulting in larger helium bubble *** study provides guidance for improving the irradiation resistance of L1_(2)-strengthened high-entropy alloy.

关键词： high-entropy alloys irradiation resistance coherent precipitates helium bubbles

Nrf2和NF-κB通路在药源性肝损伤中交互的分子机制

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中国药学杂志 2018年第9期53卷 666-670页

作者：李紫薇黄菁菁杨婉花上海交通大学医学院附属瑞金医院药剂科上海200025

核因子E2相关因子2(nuclear factor erythroid 2-related factor 2,Nrf2)是应对氧化应激的敏感因子,通过调控体内的抗氧化酶和解毒酶,降低有毒物质对机体的损伤。核因子κB(nuclear factor-kappa light chain enhancer of B cells,NF-κB)是调节炎症反应和免疫应答的关键因子。生理条件下,两个转录因子相互制约共同维持细胞内氧化还原平衡。功能水平分析Nrf2缺失小鼠,NF-κB的诱导明显增强,相反地,NF-κB也可抑制Nrf2的活性。研究表明,药源性肝损伤(drug induced liver injury,DILI)的分子机制是扰乱了Nrf2和NF-κB通路之间的平衡。近年来,发现许多天然活性物质同时具有激活Nrf2和抑制NF-κB的药理效应。因此,这两条通路中的交互环节有望成为治疗和预防DILI的靶点。笔者旨在阐述Nrf2和NF-κB在DILI中交互的分子机制以及探究天然药理活性物质如何调节Nrf2和NF-κB通路。

关键词：药源性肝损伤核因子E2相关因子2 核因子-κB 氧化应激炎症反应

Plasmon-induced local electric field improved hydrogen evolution reaction on Ag/Mo_(2)C nanosheets

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Nano Research 2025年第1期18卷 270-277页

作者： huangjingWei Li Xin zi Jun Wu Xinli Wang Li Zhu Qiyou Wang Jianfu Han Junwei Fu Hongmei Li Kai huang Yu Chen Min Liu School of Physics State Key Laboratory of Powder MetallurgyHunan Joint International Research Center for Carbon Dioxide Resource UtilizationCentral South UniversityChangsha 410083China School of Metallurgy and Environment Central South UniversityChangsha 410083China Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Nano-Institute Munich Faculty of PhysicsLudwig-Maxilimians-Universität MünchenMünchen 80539Germany Hunan Institute of Advanced Sensing and Information Technology Xiangtan UniversityXiangtan 411105China

Electrocatalytic water splitting offers a promising way for hydrogen production with near-zero ***,such as molybdenum carbides(Mo_(2)C),are promising materials for hydrogen evolution reaction(HER)but still suffer from poor intrinsic water activation ***,we developed a plasmon-induced local electric field(PILEF)strategy to solve this ***(Ag)nanoparticles decorated Mo_(2)C nanosheets(Ag/Mo_(2)C)were successfully prepared by electrostatic *** visible light excited the PILEF on Ag/Mo_(2)C remarkably reducing the activation energy by 92.7 kJ·mol^(-1)from 147.3 kJ·mol^(-1)of Mo_(2)C to 54.6 kJ·mol^(-1).As a result,the plasmonic Ag/Mo_(2)C significantly enhances~2.3-fold of the current density from 2.8 mA·cm^(-2)of Mo_(2)C to 6.5 mA·cm^(-2)at-3 V *** and reduces the overpotential by 104 mV from 403 mV of dark state to 299 mV of light state at the current density of 10 mA·cm^(-2),achieving better performance than reported *** research demonstrates that PILEF enhances HER activities,offering a potential strategy for boosting the intrinsic activities of catalysts.

关键词： sliver particles plasmon effect field effect hydrogen evolution reaction(HER) electrocatalysis

β-Phase Crystallization of Poly(vinylidene fluoride) in Poly(vinylidene fluoride)/Poly(ethyl methacrylate) Blends

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Chinese Journal of Polymer Science 2019年第1期37卷 94-100,4-7页

作者： zi-Jie huang jing Jiang Gi Xue Dong-Shan Zhou Department of Polymer Science and Engineering School of Chemistry and Chemical Engineering Key Laboratory of High Performance Polymer Materials and Technology and The State Key Laboratory of Coordination Chemistry Nanjing University School of Physical Science and Technology Xinjiang Key Laboratory and Phase Transitions and Microstructures in Condensed Matters Yili Normal University

The nature of the crystalline phase of poly(vinylidene fluoride)(PVDF) in compatible blends with poly(ethyl methacrylate)(PEMA) was investigated by using X-ray diffraction(XRD), infrared microscopy(IR) and differential scanning calorimetry(DSC). The βphase of PVDF was observed after quenching from the melt and further annealing above the glass transition temperature over a composition range. The PVDF/PEMA blend with weight ratio of 3:2 has formed higher content of PVDF β crystals than others. By taking advantage of fast cooling rate of ultrafast differential scanning calorimeter(UFDSC), the quenching process of blends was modeled and tested simultaneously, and the melting behavior of β crystals in all blends was investigated. Three types of crystallization behavior of βphase PVDF in blends were found after quenching-annealing at different temperatures.

关键词： β-Crystal of PVDF Mesophase PVDF/PEMA blend Ultra-fast scanning calorimetry

光照不均匀条件下无人机航拍低照度图像增强方法

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现代电子技术 2025年第1期48卷 55-59页

作者：黄静欧余韬桂林电子科技大学计算机工程学院广西北海536000

增强图像时高低频参数未增强,没有更好地保留图像的细节和平衡图像的亮度,因此,提出一种光照不均匀条件下无人机航拍低照度图像增强方法。首先通过高斯滤波预处理无人机航拍图像,实现无人机航拍图像中的噪声抑制,将预处理后的图像通过... 详细信息

增强图像时高低频参数未增强,没有更好地保留图像的细节和平衡图像的亮度,因此,提出一种光照不均匀条件下无人机航拍低照度图像增强方法。首先通过高斯滤波预处理无人机航拍图像,实现无人机航拍图像中的噪声抑制,将预处理后的图像通过小波分解得到图像的高频参数和低频参数,分别通过双边滤波算法、软阈值方法和直方图对图像的低频参数和高频参数进行增强,采用小波重构对增强后的图像高频参数和低频参数进行重构,得到增强后的无人机航拍图像。通过实验验证,该方法能够实现一种效果较好的图像增强,在原始图像基础上,通过文中方法增强原始亮度8.14%、对比度提高了37.90%以及清晰度增加了31.01%,使得图像的整体质量得到了显著提升,为后续的图像分析、处理提供了更加准确、丰富的信息。

关键词：无人机航拍低照度图像增强高斯滤波小波分解与重构双边滤波算法软阈值方法

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Photocaged activity-based probes for improved monitoring of protein S-sulfenylation in living cells

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Chinese Chemical Letters 2024年第2期35卷 451-454页

作者： Jiahao Zhang Haiyue Peng zi'an Chen Guorui Li jing huang State Key Laboratory of Chemo/Biosensing and Chemometrics Hunan Provincial Key Laboratory of Animal Models and Molecular MedicineSchool of Biomedical SciencesHunan UniversityChangsha 410082China

Protein S-sulfenylation(protein sulfenic acid),as one of the most significant oxidative post-translational modifications(OxiPTMs),plays a vital role in regulating protein function.A variety of activity-based probes have been developed to profile sulfenic acid in living ***,due to the transient presence and low content of sulfenic acid in living cell,high doses of probes are needed to achieve efficient *** importantly,current probes have no temporal control over sulfenic acid *** overcome these limitations,two caged cysteine sulfenic acid probes DYn-2-ONB and DYn-2-Cou with either an o-nitrobenzyl or coumarin protecting group were developed in this *** probes can be efficiently uncaged via irradiation to produce the active C-nucleophile probe *** assay in living cells demonstrated DYn-2-ONB exhibited better labeling capacity compared with DYn-2,providing it as a powerful tool for improved monitoring of protein S-sulfenylation in living cells.

关键词： Cysteine Sulfenic acid Activity-based probe Photocage Light activation Protein S-sulfenylation

Inhibitory effects of patchouli alcohol on stress-induced diarrhea-predominant irritable bowel syndrome

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World Journal of Gastroenterology 2018年第6期24卷 693-705页

作者： Tian-Ran Zhou jing-jing huang zi-Tong huang Hong-Ying Cao Bo Tan The Research Center for Integrative Medicine School of Basic Medical Sciences Guangzhou University of Chinese Medicine School of Chinese Materia Medica Guangzhou University of Chinese Medicine

AIM To elucidate the mechanism of patchouli alcohol(PA) in treatment of rat models of diarrhea-predominant irritable bowel syndrome(IBS-D).METHODS We studied the effects of PA on colonic spontaneous motility using its cumulative log concentration(3 × 10^(-7) mol/L to 1 × 10^(-4)mol/L). We then determined the responses of the proximal and distal colon segments of rats to the folowing stimuli:(1) carbachol(1 × 10^(-9) mol/L to 1 × 10^(-5) mol/L);(2) neurotransmitter antagonists including N~ω-nitro-l-arginine methyl ester hydrochloride(10μmol/L) and(1 R~*, 2 S~*)-4-[2-Iodo-6-(methylamino)-9 Hpurin-9-yl]-2-(phosphonooxy)bicyclo[3.1.0]hexane-1-methanol dihydrogen phosphate ester tetraammonium salt(1 μmol/L);(3) agonist α,β-methyleneadenosine 5′-triphosphate trisodium salt(100 μmol/L); and(4) single KCl doses(120 mmol/L). The effects of blockers against antagonist responses were also assessed by pretreatment with PA(100 μmol/L) for 1 min. Electrical-field stimulation(40 V, 2-30 Hz, 0.5 ms pulse duration, and 10 s) was performed to observe nonadrenergic, noncholinergic neurotransmitter release in IBS-D rat colon. The ATP level of Kreb's solution was also *** PA exerted a concentration-dependent inhibitory effect on the spontaneous contraction of the colonic longitudinal smooth muscle, and the half maximal effective concentration(EC_(50)) was 41.9 μmol/L. In comparison with the KCl-treated IBS-D group, the contractile response(mg contractions) in the PA + KCl-treated IBS-D group(11.87 ± 3.34) was significantly decreased in the peak tension(P < 0.01). Compared with CCh-treated IBS-D rat colon, the cholinergic contractile response of IBS-D rat colonic smooth muscle(EC_(50) = 0.94 μmol/L) was significantly decreased by PA(EC_(50) = 37.43 μmol/L)(P < 0.05). Lack of nitrergic neurotransmitter release in stress-induced IBS-D rats showed contraction effects on colonic smooth muscle. Pretreatment with PA resulted in inhibitory effect on l-NAME-induced(10 μmol/L) con

关键词： Patchouli alcohol Colonic longitudinal smooth muscles Diarrhea-predominant irritable bowel syndrome Enteric nervous system Cholinergic nerves Non-adrenergic non-cholinergic Potassium channel