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Rare Metals 2024年第8期43卷 3702-3712页

作者： zi-jie mu Yan-Jun Gao Wen-Shuai Dong Zong-You Li Qing-Yi Song Han-Jiao Huang Li-Dong Xing Jian-Guo Zhang Wei Wang Qi-Yao Yu State Key Laboratory of Explosion Science and Technology School of Mechatronical EngineeringBeijing Institute of TechnologyBeijing 100081China School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China

The highly reversible insertion/extraction of large-radius K^+into electrode materials remains a tough goal,especially for con version-type ***,we design a current collector-integrated electrode(N-CoSe/CoSe_(2)-C@Cu) as an advanced anode for potassium-ion battery(PIBs).The conductive CoSe/CoSe_(2) heterojunction with rich Se vacancy defects,conductive sp^2 N-doped carbon layer,and the elastic copper foil matrix can greatly accelerate the electron transfer and enhance the structural ***,the well-designed N-CoSe/CoSe_(2)-C@Cu current collector-integrated electrode displays enhanced potassium storage performance with regard to a high capacity(325.1 mAh·g^(-1) at 0.1 A·g^(-1) after 200cycles),an exceptional rate capability(223.5 mAh·g^(-1) at2000 mA·g^(-1)),and an extraordinary long-term cycle stability(a capacity fading of only 0.019% per cycle over1200 cycles at 2000 mA·g^(-1)).Impressively,ex situ scanning electron microscopy(SEM) characterizations prove that the elastic structure of copper foil is merged into the cleverly designed N-CoSe/CoSe_(2)-C@Cu heterostructure,which buffers the deformation of structure and volume and greatly promotes the cycle life during the potassium/depotassium process.

关键词： Potassium-ion battery Integrated collector electrode CoSe CoSe_2 Heterojunction Copper foil matrix N-doped carbon

CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

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Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： Lin Yin Yalan Xu jie mu Yu Leng Lei Ma Yu Zheng Ruizhi Li Yin Wang Peifeng Li Hai Zhu Dong Wang Jing Li Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of Life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions

A semi-analytical method to compute acoustic nonlinearity parameter of Cu,Ag and Au

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Rare Metals 2023年第3期42卷 1050-1055页

作者： zi-mu Chen Zheng Zhang School of Materials Science and Engineering Beihang UniversityBeijing 100191China

In this paper,a semi-analytical method was proposed to evaluate the acoustic nonlinearity parameter for single crystals of Cu,Ag and *** acoustic nonlinearity parameter can be derived analytically by general expressions in terms of the interatomic potentials with the distances between each pair of atoms in these transition *** evaluate the acoustic nonlinearity parameter,one needs to conduct one step molecular static simulation and obtain the equilibrium positions of all the ***,based on this method,numerical experiments with molecular dynamic code LAMMPS were given to compute the acoustic nonlinearity parameter of Cu,Ag and *** illustrate the validity of these expressions,comparison was made between calculation results and data in the *** agreement is *** of the analytical nature of this method,it provides a fundamental understanding of the nonlinear elastic behavior of these transition metals.

关键词： Nondestructive testing Semi-analytical Acoustic nonlinearity parameter Molecular static simulation

Cloning and characterization of the gene encoding an ubiquitin-activating enzyme E1 domain-containing protein of silkworm, Bombyx moil

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Insect Science 2010年第2期17卷 75-83页

作者： Ping Wu mu-Wang Li Yun-Feng Jiang zi-Sheng Wang Xi-jie Guo Sericultural Research Institute Chinese Academy of Agricultural Sciences College of Biotechnology and Environmental Engineering Jiangsu University of Science and Technology Zhenjiang Jiangsu Province China

Bombyx mori cytoplasmic polyhedrosis virus （BmCPV） is one of the major viral pathogens for the silkworm. To date, the molecular mechanism of BmCPV invasion has been unclear. We cloned the full length complementary （c）DNA which encodes the ubiquitin-activating enzyme El-domain containing proteinl （UbE1DC1） ofBombyx mori by using suppression subtraefive hybridization （SSH） and rapid amplification of com- plementary （c）DNA ends （RACE）. The full-length eDNA of UbE1DClgene is 1 919 bp, consisting of a 100 bp 5＇ untranslated region, a 637 bp 3＇ untranslated region and an 1 182 bp open reading frame （ORF）, encoding a 393 amino acid protein. The protein contained the THiF_MoeB_hesA_family domain, an adenosine triphosphate binding site, which belongs to the family of ubiquitin-activating enzyme El. Reverse transcription - polymerase chain reaction analysis from the silkworm tissues, namely silk gland, hemo- cyte, fat body, gonad and midgut revealed that UbE1DC1 was expressed in all the five tissues. The real-time quantitative polymerase chain reaction analysis indicated that the relative expression of UbE1DC1 in the normal midgut was approximately 9.78-fold of that in the BmCPV-infected midgut. It is implicated that UbEIDCI may play an important role in the interaction between the host and BmCPV invasion.

关键词： Bombyx mori Cytoplasmic polyhedrosis virus midgut quantitative real-time PCR rapid amplification of eDNA ends suppression subtractive hybridization

Cardioneuroablation for the treatment of symptomatic bradycardia mediated by the cardiac autonomic nervous

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Journal of Geriatric Cardiology 2023年第9期20卷 615-617页

作者： zi-Liang SONG mu QIN Xu LIU Department of Cardiology Shanghai Chest HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina

Sinus bradycardia is a common clinical problem with a population prevalence of approximately 4/1000.[1]Most patients are asymptomatic,but some patients experience symptoms such as fatigue,dizziness,exercise intolerance,syncope,or pre-syncope,worsening of angina symptoms,worsening of heart failure,or cognitive *** both European and American guidelines recommend cardiac pacing for patients with severe symptoms of sinus bradycardia,there are problems such as infection,electrode detachment,perforation,and pacemaker replacement.

关键词： cardiac cardia angina

Three-Dimensional Structure of Optimal Nonlinear Excitation for Decadal Variability of the Thermohaline Circulation

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Atmospheric and Oceanic Science Letters 2013年第6期6卷 410-416页

作者： ZU zi-Qing mu mu Henk A.DIJKSTRA State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics (LASG) Institute of Atmospheric Physics Chinese Academy of Sciences University of Chinese Academy of Sciences Key Laboratory of Ocean Circulation and Wave Institute of Oceanology Chinese Academy of Sciences Institute for Marine and Atmospheric Research Utrecht Department of Physics and Astronomy Utrecht University

The decadal variability of the North Atlantic thermohaline circulation(THC) is investigated within a three-dimensional ocean circulation model using the conditional nonlinear optimal perturbation method. The results show that the optimal initial perturbations of temperature and salinity exciting the strongest decadal THC variations have similar structures: the perturbations are mainly in the northwestern basin at a depth ranging from 1500 to 3000 m. These temperature and salinity perturbations act as the optimal precursors for future modifications of the THC, highlighting the importance of observations in the northwestern basin to monitor the variations of temperature and salinity at depth. The decadal THC variation in the nonlinear model initialized by the optimal salinity perturbations is much stronger than that caused by the optimal temperature perturbations, indicating that salinity variations might play a relatively important role in exciting the decadal THC variability. Moreover, the decadal THC variations in the tangent linear and nonlinear models show remarkably different characteristics, suggesting the importance of nonlinear processes in the decadal variability of the THC.

关键词： thermohaline circulation decadal variability conditional nonlinear optimal perturbation optimal precursor nonlinear processes

Novel Poly(thienylene Ethynylene)s with Electron-accepting Groups

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Chinese Chemical Letters 2006年第10期17卷 1381-1384页

作者： mu jie YANG Kuan LIU Key Laboratory of Macromolecular Synthesis and Functionalization Ministry of Education Department of Polymer Science and Engineering Zhejiang University Hangzhou 310027

Novel n-conjugated polymers constituted of 2,1,3-benzothiadiazole or cyano-containing unit copolymers were synthesized and characterized by UV-Vis, IR and PL.

关键词： Poly(thienylene ethynylene)s synthesis characterization.

Bayesian inference of the crust–core transition density via the neutron-star radius and neutron-skin thickness data

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Nuclear Science and Techniques 2023年第6期34卷 125-133页

作者： Wen-jie Xie zi-Wei Ma Jun-Hua Guo Department of Physics Yuncheng UniversityYuncheng044000China

In this work,we perform a Bayesian inference of the crust-core transition density ρ_(t) of neutron stars based on the neutron-star radius and neutron-skin thickness data using a thermodynamical *** and Gaussian distributions for the ρ_(t) prior were adopted in the Bayesian *** has a larger probability of having values higher than 0.1 fm^(−3) for ρ_(t) as the uniform prior and neutron-star radius data were *** was found to be controlled by the curvature K_(sym) of the nuclear symmetry *** phenomenon did not occur if K_(sym) was not extremely negative,namely,K_(sym)>−200 *** value ofρ_(t) obtained was 0.075_(−0.01)^(+0.005) fm^(−3) at a confidence level of 68%when both the neutron-star radius and neutron-skin thickness data were *** anti-correlations were observed between ρ_(t),slope L,and curvature of the nuclear symmetry *** dependence of the three L-K_(sym) correlations predicted in the literature on crust-core density and pressure was quantitatively *** most probable value of 0.08 fm^(−3) for ρ_(t) was obtained from the L-K_(sym) relationship proposed by Holt et *** larger values were preferred for the other two relationships.

关键词： Crust–core transition density of neutron stars Neutron-star radius Neutron-skin thickness Bayesian inference approach L–K_(sym)

A Novel Thin Film Resistive Humidity Sensor Based on SolubleConjugated Polymer:(propionic acid)-co-(propargyl alcohol)

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Chinese Chemical Letters 2001年第8期12卷 701-702页

作者： Yang LI mu jie YANG Department of Polymer Science and Engineering Zhejiang UniversiryHangzhou 310027

A novel soluble conjugated copolymer (propionic acid)-co-(propargyl alcohol) (PA-co-OHP) has been synthesized for the first time using a new palladium acetylide catalyst Pd(PPh3)(2)(C=CC(CH3)(2)OH)(2)(PPB). Thin film resistive humidity sensor based oil the copolymer doped with HClO4 was prepared. The impedance of the sensor changed from 10(3)similar to 10(7) Omega in 95%similar to 30%RH, and the response of that is very quick (<6 sec.). Preliminary results show the copolymer is a promising humidity sensitive material.

关键词： Humidity sensor conjugated polymer propiolinc acid propargyl alcohol

POST1/C12ORF49 regulates the SREBP pathway by promoting site-1 protease maturation

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Protein & Cell 2021年第4期12卷 279-296页

作者： Jian Xiao Yanni Xiong Liu-Ting Yang Ju-Qiong Wang zi-mu Zhou Le-Wei Dong Xiong-jie Shi Xiaolu Zhao jie Luo Bao-Liang Song Hubei Key Laboratory of Cell Homeostasis College of Life SciencesFrontier Science Center for Immunology and MetabolismWuhan UniversityWuhan 430072China

Sterol-regulatory element binding proteins(SREBPs)are the key transcriptional regulators of lipid *** activation of SREBP requires translocation of the SREBP precursor from the endoplasmic reticulum to the Golgi,where it is sequentially cleaved by site-1 protease(S1P)and site-2 protease and releases a nuclear form to modulate gene *** search for new genes regulating cholesterol metabolism,we perform a genome-wide CRISPR/Cas9 knockout screen and find that partner of site-1 protease(POSH),encoded by C120RF49,is critically involved in the SREBP *** of POSH decreases the generation of nuclear SREBP and reduces the expression of SREBP target *** binds S1P,which is synthesized as an inactive protease(form A)and becomes fully mature via a two-step autocatalytic process involving forms B/B and C/*** promotes the generation of the functional S1P-C/C from S1P-B/B(canonical cleavage)and,notably,from S1P-A directly(non-canonical cleavage)as *** POSH-mediated S1P activation is also essential for the cleavages of other S1P substrates including ATF6,CREB3 family members and the a/p-subunit precursor of ***,we demonstrate that POSH is a cofactor controlling S1P maturation and plays important roles in lipid homeostasis,unfolded protein response,lipoprotein metabolism and lysosome biogenesis.

关键词： SREBP site-1 protease proteolytic activation unfolded protein response activating transcription factor 6 mannose-6-phosphate