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Effects of ulinastatin on renal ischemia-reperfusion injury in rats

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Acta Pharmacologica Sinica 2004年第10期 94-100页

作者： Cong-cong CHEN, zi-ming liu, hui-hua WANG, Wei HE, Yi WANG, Wei-dong WUDepartment of Anesthesiology, Second Affiliated Hospital, Medical College of Zhejiang University, Hangzhou 310009,China

AIM: To investigate the effect and possible mechanism of ulinastatin on renal ischemia-reperfusion injury in rats. METHODS: Male Sprague-Dawley rats were subjected to 45-min bilateral renal ischemia, treated with intravenously 12 500 U ulinastatin at 30 min prior to ischemia and at the beginning of reperfusion, compared with a nontreated group without ulinastatin and a sham-operation group without bilateral renal ischemia. After 0 h, 2 h, 6 h, 12 h, and 24 h of reperfusion, serum creatinine and blood urea nitrogen were measured for the assessment of renal function, renal sections were used for histologic grading of renal injury, for immunohistochemical localization of Bcl-2 and heat shock protein 70. Renal ultrastructure was observed through a transmission electron microscope. RESULTS: Ulinastatin significantly reduced the increase in blood urea nitrogen and creatinine produced by renal ischemia-reperfusion, suggesting an improvement in renal function. Ulinastatin reduced the histologic evidence of renal

关键词： reperfusion injury urinastatin immunohistochemistry ultrastructure

人力资本与家庭消费——基于CFPS数据的实证分析

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山西财经大学学报 2018年第4期40卷 17-35页

作者：刘子兰刘辉袁礼湖南师范大学商学院

采用三期CFPS混合截面数据,选取受教育年限、技能培训和健康作为人力资本的测量指标,考察了人力资本对家庭消费的影响。研究发现：户主人力资本水平的提升能够有效提高家庭消费水平,人力资本对家庭消费的影响存在较明显的年龄效应和代... 详细信息

采用三期CFPS混合截面数据,选取受教育年限、技能培训和健康作为人力资本的测量指标,考察了人力资本对家庭消费的影响。研究发现：户主人力资本水平的提升能够有效提高家庭消费水平,人力资本对家庭消费的影响存在较明显的年龄效应和代际效应;从技能培训和健康水平来看,技能培训能够有效提升家庭消费水平,而健康水平对家庭消费具有显著的负向影响;分位数回归表明,受教育年限和健康水平对家庭消费的边际效应随着消费水平的提高而逐渐降低,技能培训对家庭不同类型消费的边际效应则存在不同的变化趋势。

关键词：人力资本家庭消费年龄效应代际效应分位数回归

Advances in the exploration of adjuvant therapy of colon cancer with Chinese medicine

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Cancer Advances 2022年第10期5卷 1-6页

作者： Yu-Xin Wei Bing-Lin Shi Huai-Yuan Zheng An Yan Xue-Hai Wei Shi-Bo Zhao zi-hui liu College of clinical YoujiangMedical University for NationalitiesBaise 533000China General Surgery First People's Hospital of FangchenggangFangchenggang 538000China College of Nursing Youjiang Medical University for NationalitiesBaise 533000China College of Clinical Medicine Guilin Medical UniversityGuilin 541000China Hematology First People's Hospital of FangchenggangFangchenggang 538000China

Colon cancer is currently a highly prevalent cancer with a high mortality rate *** medical technology provides a range of treatments for colon cancer through different means,and research on the modulating adjuvant treatment of colon cancer with Chinese medicine is currently undergoing continuous theoretical and practical exploration to find highly effective herbal remedies to modulate,alleviate or treat the *** present study reviews different aspects of colon cancer in relation to different factors and the modulating adjuvant treatment of colon cancer with Chinese medicine.

关键词： Chinese medicine gene adjuvant therapy review

The potential of complementary and alternative medicine combination chemotherapy in the treatment of non-small cell lung cancer

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Drug Combination Therapy 2022年第2期4卷 25-27页

作者： An Yan Xiu-Ling Wei Huai-Yuan Zheng Kai-Ren Xie Xu Yan Shi-Bo Zhao zi-hui liu College of Clinical Medicine Youjiang Medical University for NationalitiesBaise 533000China Obstetrics and Gynecology Southwest Hospital Affiliated to Youjiang Medical College for NationalitiesBaise 533000China College of Graduate Youjiang Medical University for NationalitiesBaise 533000China College of Pharmacy Hubei University of Chinese MedicineWuhan 430065China General Surgery Fangchenggang First People's HospitalFangchenggang 538000China College of Clinical Medicine Guilin Medical CollegeGuilin 541000China Hematology Fangchenggang First People's HospitalFangchenggang 538000China

The most common cytotoxic effects of chemotherapy drugs alone include bone marrow suppression,gastrointestinal symptoms,and liver and kidney function *** the continuous research on non-small cell lung cancer(NSCLC),various treatment modalities such as targeted therapy and immunotherapy have emerged in recent years,but there is no denying that chemotherapy remains one of the most basic treatment *** Jia et al.,in exploring the efficacy of detoxification and yin clearing soup(Astragalus membranaceus(Fisch.)Bunge,Atractylodes macrocephala Koidz,et al.),found that the addition of the soup treatment significantly reduced the number of adverse reactions such as bone marrow suppression,nausea and vomiting,and abnormal liver and kidney function,and the incidence of adverse reactions was also significantly lower than that of the group with chemotherapy drugs alone[1].

关键词： chemotherapy drugs treatment alone

Rational modulation of fluorophosphate cathode by anionic groups to reduce the polarization behavior for fast-charging sodium-ion batteries

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Journal of Energy Chemistry 2025年第1期100卷 509-521页

作者： Xinyuan Wang Fan Zhang Xingyu Zhou Qian Wang Changyu liu Yangyang liu hui Wang Xiaojie liu Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education College of Chemistry & Materials Science Northwest University

Na3V2（PO4）2O2F （VP） is recognized as a promising cathode material for sodium-ion batteries due to its stable structural framework and high specific *** functional theory （DFT） and finite element simulations show that incorporating SO42-into VP decreases its band gap,lowers the migration energy barrier,and ensures a uniform Na+concentration gradient and stress distribution during charge and discharge ***,the average Na+diffusion coefficient of Na3V2（PO4）1.95（SO4）0.05O2F（VPS-1） is roughly double that of VP,leading to enhanced rate capability (80 C,75.5 mAh g-1) and cycling stability (111.0 mAh g-1capacity after 1000 cycles at 10 C current density) for ***-1 exhibits outstanding fast-charging capabilities,achieving an 80%state of charge in just 8.1 *** assembled VPS-1//SbSn/NPC full cell demonstrated stable cycling over 200 cycles at a high 5 C current,maintaining an average coulombic efficiency of 95.35%.

关键词： Anionic group modulation Polarization behavior Fast-charging Sodium-ion battery Fluorophosphate Cathode

Advances in Mig6 gene in tumor research

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Precision Medicine Research 2022年第1期4卷 32-34页

作者： Ye-Min-Xiao Zeng An Yan Zhong-Gang wu Wen-Jie Zeng Huai-Yuan Zheng Xiu-Ling Wei Shi-Bo Zhao zi-hui liu College of clinical Youjiang Medical University for NationalitiesBaise 533000China College of Medical Laboratory Youjiang Medical University for NationalitiesBaise 533000China Obstetrics and Gynecology Southwest Hospital Affiliated to Youjiang Medical College for Nationalities/People's Hospital ofBaiseBaise 533000China Graduate School Youjang Medical University for NationalitiesBaise 533000China General Surgery First People's Hospital of FangchenggangFangchenggang 538000China College of Clinical Medicine Guilin Medical UniversityGuilin 541000China Hematology First People's Hospital of FangchenggangFangchenggang 538000China

Background Mitogen-inducible gene 6(Mig6),also known as RALT or gene 33,is a multiadaptive protein implicated in the regulation of RTK and stress signaling *** recent years,the negative control of RTK signaling has piqued the interest of *** an increasing number of negative feedback regulators of tyrosine kinase(Receptor Protein Tyrosine Kinase,RTK).Although several commonly used inhibitors have been identified at this stage,this merely emphasizes the significance of signal attenuation and regulation for proper signal ***,the mechanisms of their action are not well understood,especially those in vivo function and metabolic expression.

关键词： RTK action Mig

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印染企业实施清洁生产的环境与经济效益探讨

染整技术 2006年第7期28卷 25-27页

作者：蔡焕兴刘子辉常州市环境监测中心站江苏常州213001 常州市环境保护研究所江苏常州213001

结合我国现状,论述了印染行业实施清洁生产的紧迫性与必要性,并以常州市几家印染企业为例,就运用酶处理技术、丝光淡碱回收技术及涂料染色/印花新工艺等清洁生产典型案例,阐述了将这些清洁生产工艺有机结合起来,实现环境保护与经济效益... 详细信息

结合我国现状,论述了印染行业实施清洁生产的紧迫性与必要性,并以常州市几家印染企业为例,就运用酶处理技术、丝光淡碱回收技术及涂料染色/印花新工艺等清洁生产典型案例,阐述了将这些清洁生产工艺有机结合起来,实现环境保护与经济效益双赢、提高市场竞争能力、提升国内印染业抗击国际市场风险能力的可行性。

关键词：清洁生产环境保护经济效益

Unraveling brain aging through the lens of oral microbiota

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Neural Regeneration Research 2025年第7期20卷 1930-1943页

作者： Qinchao Hu Si Wang Weiqi Zhang Jing Qu Guang-hui liu State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijingChina Hospital of Stomatology Guanghua School of StomatologyGuangdong Provincial Key Laboratory of StomatologySun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Advanced Innovation Center for Human Brain Protection and National Clinical Research Center for Geriatric Disorders Xuanwu HospitalCapital Medical UniversityBeijingChina Aging Translational Medicine Center International Center for Aging and CancerBeijing Municipal Geriatric Medical Research CenterXuanwu HospitalCapital Medical UniversityBeijingChina CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijingChina University of Chinese Academy of Sciences BeijingChina Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijingChina Aging Biomarker Consortium BeijingChina State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijingChina Beijing Institute for Stem Cell and Regenerative Medicine BeijingChina

The oral cavity is a complex physiological community encompassing a wide range of *** of oral microbiota can lead to various oral infectious diseases,such as periodontitis and tooth decay,and even affect systemic health,including brain aging and neurodegenerative *** studies have highlighted how oral microbes might be involved in brain aging and neurodegeneration,indicating potential avenues for intervention *** this review,we summarize clinical evidence demonstrating a link between oral microbes/oral infectious diseases and brain aging/neurodegenerative diseases,and dissect potential mechanisms by which oral microbes contribute to brain aging and *** also highlight advances in therapeutic development grounded in the realm of oral microbes,with the goal of advancing brain health and promoting healthy aging.

关键词： Alzheimer's disease brain aging multiple sclerosis neurodegeneration neurodegenerative diseases oral microbiota Parkinson's disease periodontitis bacteria Porphyromonas gingivalis

Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

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Neural Regeneration Research 2025年第1期20卷 6-20页

作者： Xiu-Yun Zhao De-En Xu Ming-Lei Wu Ji-Chuan liu zi-Ling Shi Quan-Hong Ma Department of Neurology and Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular *** reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and *** this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular *** also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative *** summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve *** review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.

关键词： autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response