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Primary early-stage intestinal and colonic non-Hodgkin's lymphoma: Clinical features, management, and outcome of 37 patients

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World Journal of Gastroenterology 2005年第37期11卷 5905-5909页

作者： Shu-Lian Wang Zhong-Xing Liao Xin-Fan Liu zi-hao yu Da-Zhong Gu Tu-Nan Qian Yong-Wen Song Jing Jin Wei-Hu Wang Ye-Xiong Li Department of Radiation Oncology Cancer HospitalPeking Union Medical College and Chinese Academy of Medical Sciences Beijing 100021 China Department of Radiation Oncology The University of Texas MD Anderson Cancer Center Houston 77030 TX USA

AIM： To analyze the clinical features, management, and outcome of treatment of patients with primary intestinal and colonic non-Hodgkin＇s lymphoma （PICL）. METHODS： A retrospective study was performed in 37 patients with early-stage PICL who were treated in our hospital from 1958 to 1998. Their clinical features, management, and outcome were assessed. Prognostic factors for survival were analyzed by univariate analysis using the Kaplan-Meier product-limit method and log-rank test. RESULTS： Twenty-five patients presented with Ann Arbor stage Ⅰ PICL and 12 with Ann Arbor stage Ⅱ PICL. Thirty-five patients underwent surgery （including 31 with complete resection）, 22 received postoperative chemotherapy or radiotherapy or both. Two patients with rectal tumors underwent biopsy and chemotherapy with or without radiotherapy. The 5- and 10-year overall survival （OS） rates were 51.9% and 44.5%. The corresponding diseasefree survival （DIS） rates were 42.4% and 37.7%. In univariate analysis, multiple-modality treatment was associated with a better DFS rate compared to single treatment （P= 0.001）. While age, tumor size, tumor site, stage, histology, or extent of surgery were not associated with OS and DFS, use of adjuvant chemotherapy significantly improved DFS （P = 0.031） for the 31 patients who underwent complete resection. Additional radiotherapy combined with chemotherapy led to a longer survival than chemotherapy alone in six patients with gross residual disease after surgery or ***： Combined surgery and chemotherapy is recommended for treatment of patients with PICL, Additional radiotherapy is needed to improve the outcome of patients who have gross residual disease after surgery.

关键词： Intestinal neoplasm Colonic neoplasm Non-Hodgkin's lymphoma Surgery Chemotherapy Radiotherapy

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Abnormal resting-state functional connectivity of hippocampal subfields in patients with major depressive disorder

Abnormal resting-state functional connectivity of hippocampa...

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第二十二届全国心理学学术会议

作者： zi yu hao yuan Zhong Ning Zhang Chun Wang School of Psychology Nanjing Normal University Jiangsu Key Laboratory of Mental Health and Cognitive Science Nanjing Normal University Nanjing Brain Hospital Affiliated to Nanjing Medical University Functional Brain Imaging Institute of Nanjing Medical University Cognitive Behavioral Therapy Institute of Nanjing Medical University

Background: Many studies have found that the hippocampus plays a very important role in major depressive disorder(MDD). The hippocampus can be divided into three subfields: the cornu ammonis(CA), dentate gyrus(DG) and subiculum. Each subfield of the hippocampus has a unique function and are differentially associated with the pathological mechanisms of MDD. However, no research exists to describe the resting state functional connectivity of each hippocampal subfield in MDD. Methods: 55 patients with MDD and 25 healthy controls(HCs) matched for gender, age and years of education were obtained. A seed-based method that imposed a template on the whole brain was used to assess the resting-state functional connectivity(rsFC) of each hippocampal subfield. Results: Patients with MDD demonstrated increased connectivity in the left premotor cortex(PMC) and reduced connectivity in the right insula with the CA seed region. Increased connectivity was reported in the left orbitofrontal cortex(OFC) and left ventrolateral prefrontal cortex(vlPFC) with the DG seed region. The subiculum seed region revealed increased connectivity with the left premotor cortex(PMC), the right middle frontal gyrus(MFG), the left ventrolateral prefrontal cortex(vlPFC) and reduced connectivity with the right insula. ROC curves confirmed that the differences between groups were statistically significant. Conclusion: The results suggest that the CA, DG and subiculum have significant involvement with MDD. Specifically, the abnormal functional connectivity of the CA may be related to bias of coding and integration of information in patients with MDD. The abnormal functional connectivity of the DG may be related to the impairment of working memory in patients with MDD, and the abnormal functional connectivity of the subiculum may be related to cognitive impairment and negative emotions in patients with MDD.

关键词： major depressive disorder hippocampal subfields cornu ammonis dentate gyrus subiculum resting-state functional connectivity

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Effect of cholesterol metabolism on hepatolithiasis

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World Journal of Gastroenterology 2025年第1期31卷 157-162页

作者： Lin Zheng zi-yu Ye Jun-Ji Ma Department of Gastroenterology The Second Hospital of Hebei Medical UniversityHebei Key Laboratory of GastroenterologyHebei Institute of GastroenterologyHebei Clinical Research Center for Digestive DiseasesNo.215 Heping West RoadShijiazhuang 050000Hebei ProvinceChina

Surgical intervention is currently the primary treatment for hepatolithiasis;how-ever,some patients still experience residual stones and high recurrence rates after *** metabolism seems to play an important role in hepatoli-thiasis pathogenesis.A high cholesterol diet is one of the significant reasons for the increasing incidence of ***,regular diet and appropriate medical intervention are crucial measures to prevent hepatolithiasis and reduce recurrence rate after *** dietary cholesterol and drugs that increase cholesterol stone solubility are key therapeutic approaches in treating *** article discusses the cholesterol metabolic pathways related to the pathogenesis of hepatolithiasis,as well as food intake and targeted therapeutic drugs.

关键词： Hepatolithiasis Cholesterol metabolism High-fat diet 3-hydroxy-3-methylglutaryl-coenzyme A reductase Interlobular bile duct

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循环热冲击后裂隙砂岩力学特性试验研究

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岩土力学 2023年第5期44卷 1260-1270页

作者：李满刘先珊潘玉华乔士豪郝梓宇钱磊罗晓雷重庆大学山地城镇建设与新技术教育部重点实验室重庆400045 重庆大学土木工程学院重庆400045 重庆大学库区环境地质灾害防治国家地方联合工程研究中心重庆400045

砂岩热储层的改造和长期稳定性评价对地热能源开发具有重要意义。研究了裂隙砂岩在0~8次热冲击作用下的力学特性。试验结果表明:随着热冲击次数的增加,两种冷却方式下裂隙砂岩的纵波波速、单轴抗压强度和弹性模量均逐渐减小。与水冷却相... 详细信息

砂岩热储层的改造和长期稳定性评价对地热能源开发具有重要意义。研究了裂隙砂岩在0~8次热冲击作用下的力学特性。试验结果表明:随着热冲击次数的增加,两种冷却方式下裂隙砂岩的纵波波速、单轴抗压强度和弹性模量均逐渐减小。与水冷却相比,空气冷却对裂隙砂岩物理力学特性的劣化较弱,单轴抗压强度和弹性模量与热冲击次数呈现较好的指数函数关系。纵波波速和弹性模量均能很好地表征裂隙砂岩随热冲击次数的损伤,其中首次热冲击对裂隙砂岩力学性能的损伤最为严重,且当热冲击次数超过4次时,热冲击对裂隙砂岩力学特性的损伤显著减缓。此外,裂隙砂岩单轴抗压强度和弹性模量与纵波波速具有很好的指数函数关系。最后,在COMSOL Multiphysics中模拟了砂岩试样热冲击过程,并讨论了对流换热系数和预制裂纹对砂岩内部温度场和应力场的影响,揭示了热冲击作用下砂岩产生热裂纹的机制。

关键词：砂岩预制裂纹循环热冲击损伤演化热破裂

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二阶锥线性互补问题的低阶罚函数算法

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数学杂志 2017年第2期37卷 427-438页

作者：赵雯宇郝自军余国林北方民族大学数学与信息科学学院宁夏银川750021

本文研究了二阶锥线性互补问题的低阶罚函数算法.利用低阶罚函数算法将二阶锥线性互补问题转化为低阶罚函数方程组,获得了低阶罚函数方程组的解序列在特定条件下以指数速度收敛于二阶锥线性互补问题解的结果,推广了二阶锥线性互补问题... 详细信息

本文研究了二阶锥线性互补问题的低阶罚函数算法.利用低阶罚函数算法将二阶锥线性互补问题转化为低阶罚函数方程组,获得了低阶罚函数方程组的解序列在特定条件下以指数速度收敛于二阶锥线性互补问题解的结果,推广了二阶锥线性互补问题的幂罚函数算法.数值实验结果验证了算法的有效性.

关键词：二阶锥线性互补问题低阶罚函数算法指数收敛速度

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Functional Verification for Agile Processor Development: A Case for Workflow Integration

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Journal of Computer Science & Technology 2023年第4期38卷 737-753页

作者：徐易难余子濠王凯帆王华强蔺嘉炜金越张林隽张紫飞唐丹王卅石侃孙凝晖包云岗 State Key Lab of Processors Institute of Computing TechnologyChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Beijing Institute of Open Source Chip Beijing 100080China

Agile hardware development methodology has been widely adopted over the past *** the research progress,the industry still doubts its applicability,especially for the functional verification of complicated processor *** verification commonly employs a simulation-based method of co-simulating the design under test with a reference model and checking the consistency of their outcomes given the same input *** observe limited collaboration and information exchange through the design and verification processes,dramatically leading to inefficiencies when applying the conventional functional verification workflow to agile *** this paper,we propose workflow integration with collaborative task delegation and dynamic information exchange as the design principles to effectively address the challenges on functional verification under the agile development *** on workflow integration,we enhance the functional verification workflows with a series of novel methodologies and *** diff-rule based agile verification methodology(DRAV)reduces the overhead of building reference models with runtime execution information from designs under *** present the RISC-V implementation for DRAV,DiffTest,which adopts information probes to extract internal design behaviors for co-simulation and *** further integrates two plugins,namely XFUZZ for effective test generation guided by design coverage metrics and LightSSS for efficient fault analysis triggered by co-simulation *** present the integrated workflows for agile hardware development and demonstrate their effectiveness in designing and verifying RISC-V processors with 33 functional bugs found in *** also illustrate the efficiency of the proposed toolchains with a case study on a functional bug in the L2 cache of XiangShan.

关键词： functional verification agile development open-source hardware workflow integration

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零级指令缓存研究综述

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计算机工程与科学 2017年第3期39卷 405-412页

作者：张昆郝子宇郑方谢向辉数学工程与先进计算国家重点实验室江苏无锡214125

高效能是处理器设计的重要指标。由于指令部件在处理器芯片中开始占据越来越多的芯片面积,消耗了较多的芯片功耗,研究人员提出了零级指令缓存设计。零级指令缓存容量小、访问耗能低,与流水线紧密耦合、取指命中时可以门控流水线部分逻... 详细信息

高效能是处理器设计的重要指标。由于指令部件在处理器芯片中开始占据越来越多的芯片面积,消耗了较多的芯片功耗,研究人员提出了零级指令缓存设计。零级指令缓存容量小、访问耗能低,与流水线紧密耦合、取指命中时可以门控流水线部分逻辑。因此,零级指令缓存可以有效提高流水线指令部件的能效比。综述了现有的零级指令缓存的不同结构、各结构的发展与应用情况;展望了零级指令缓存设计的未来研究思路。

关键词：高效能零级缓存指令缓存微体系结构设计

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抑郁症自杀未遂者静息态脑功能连接改变及其与心理痛苦的关系

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中国临床心理学杂志 2021年第5期29卷 891-896页

作者：甄子昂李欢欢郝子雨蒋松源王湘中国人民大学心理学系北京100872 中南大学湘雅二医院医学心理研究中心长沙410011

目的:考察抑郁症自杀未遂者静息态下痛苦加工环路的脑功能连接变化,探索三维心理痛苦模型,尤其是痛苦逃避动机预测抑郁症自杀未遂的潜在脑影像学指标。方法:对60名抑郁症患者和32名健康对照组(HC)进行临床量表评估和静息态磁共振扫描。... 详细信息

目的:考察抑郁症自杀未遂者静息态下痛苦加工环路的脑功能连接变化,探索三维心理痛苦模型,尤其是痛苦逃避动机预测抑郁症自杀未遂的潜在脑影像学指标。方法:对60名抑郁症患者和32名健康对照组(HC)进行临床量表评估和静息态磁共振扫描。其中,依据有无自杀未遂史,病例组分为抑郁自杀未遂组(DSA,n=23)和抑郁自杀意念组(DSI,n=37)。运用基于感兴趣区域(ROI-wise)功能连接方法计算痛苦加工环路内各节点间功能连接系数的组间差异,进一步分析脑功能连接系数与抑郁、自杀意念、自杀未遂和心理痛苦三维量表得分之间的关系。结果:①DSA组的自杀意念、痛苦逃避得分显著高于DSI组和HC组;②与DSI组和HC组相比,DSA组左内侧眶额皮层与左侧脑岛的功能连接减弱;③与HC组相比,DSA组和DSI组右外侧眶额皮层与右侧丘脑的功能连接增强,左外侧眶额皮层与左侧杏仁核的功能连接增强;④左内侧眶额皮层与左侧脑岛的功能连接系数与自杀意念、痛苦逃避得分呈显著正相关。结论:三维心理痛苦模型中的痛苦逃避维度是区分有无自杀未遂史抑郁症患者的敏感行为学指标。静息态下左内侧眶额皮层与左侧脑岛的功能连接减弱作为痛苦加工环路异常的脑区特征,可能是自杀脑的神经基础。

关键词：三维心理痛苦抑郁症自杀未遂静息态功能连接

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广东番茄曲叶病毒G2分离物基因组DNA-A的分子特征

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微生物学报 2005年第1期45卷 48-52页

作者：何自福虞皓罗方芳广东省农业科学院植物保护研究所

从采集于广东的番茄曲叶病病株上分离到病毒分离物G2 ,序列分析结果表明 ,其DNA_A为单链环状 ,全长2 74 4nt,共有 6个ORF ,其中病毒链上编码AV1(CP)、AV2 ,互补链上编码AC1、AC2、AC3和AC4。BLAST结果显示 ,与G2基因组有同源关系的病毒... 详细信息

从采集于广东的番茄曲叶病病株上分离到病毒分离物G2 ,序列分析结果表明 ,其DNA_A为单链环状 ,全长2 74 4nt,共有 6个ORF ,其中病毒链上编码AV1(CP)、AV2 ,互补链上编码AC1、AC2、AC3和AC4。BLAST结果显示 ,与G2基因组有同源关系的病毒均属双生病毒科菜豆金色花叶病毒属。序列比较结果显示 ,G2与菜豆金色花叶病毒属病毒的DNA_A序列同源率均不超过 83% ,其中同源率最高的是PaLCuCNV_[G10 ](82 8% )。进一步比较发现 ,它们的基因间隔区 (IR)变异最大 (同源率为 30 9%～ 81 8% ) ;CP氨基酸序列的同源率较高 (77 6 %～ 99 2 % ) ,AC4蛋白氨基酸序列的同源率较低 (4 3 5 %～ 78 8% )。系统进化关系分析结果也显示 ,G2与已报道的菜豆金色花叶病毒属病毒的亲缘关系均较远。因此 ,G2可能是双生病毒科菜豆金色花叶病毒属中一个未报道的新种 ,命名为广东番茄曲叶病毒 (TomatoleafcurlGuangdongVirus ,ToLCGDV)

关键词：广东番茄曲叶病毒 DNA-A 序列分析分子特征

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Phase Ⅰ study of postoperative radiotherapy combined with capecitabine for gastric cancer

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World Journal of Gastroenterology 2014年第4期20卷 1067-1073页

作者： Xin Wang Jing Jin Ye-Xiong Li Hua Ren Hui Fang Shu-Lian Wang yue-Ping Liu Wei-Hu Wang zi-hao yu Yong-Wen Song Xin-Fan Liu Department of Radiation Oncology Cancer Hospital National Cancer Center Chinese Academy of Medical Sciences and Peking Union Medical College

AIM: To determine the maximum tolerated dose (MTD) and dose-limiting toxicity (DLT) of capecitabine combined with postoperative radiotherapy for gastric cancer.

关键词： Radiotherapy Capecitabine Gastric cancer Maximum tolerated dose Dose-limiting toxicity

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