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Journal of Iron and Steel Research International 2010年第7期17卷 44-50页

作者： ZHANG zi-cheng zhu Fu-xian LI Yan-mei State Key Laboratory of Rolling and Automation Northeastern University Shenyang 110004 Liaoning China

The effect of thermomechanical control processing（TMCP）on microstructure and mechanical properties of Fe-0.2C-1.44Si-1.32Mn hot rolled TRIP steel was investigated through ***-induced transformation and transformation-induced plasticity behavior of retained austenite were *** results show that with multipass deformation,reduction per pass of more than critical deformation in austenite recrystallization region and total reduction of more than 58% in non-recrystallization region and high temperature section of two-phase region,austenite can be refined before γ→α *** is beneficial to obtain refined ferrite grain in final *** obtain fine and uniform microstructure and excellent strength-ductility balance,a three-stage cooling process（laminar cooling-air cooling-ultra-fast cooling）after hot rolling was *** ultimate tensile strength and elongation of the investigated steel can reach 663 MPa and 41%,respectively.

关键词： hot rolled TRIP steel TRIP effect retained austenite transformation-induced plasticity mechanical property

Dynamic changes of activator protein 1 and collagen I expression in the sclera of myopia guinea pigs

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International Journal of Ophthalmology(English edition) 2019年第8期12卷 1272-1276页

作者： Xin Zhan zi-cheng zhu Si-Qin Sun Yue-Chun Wen Department of Ophthalmology Anhui Provincial Hospital of Anhui Medical University

AIM: To investigate the dynamic changes of activator protein 1(AP1) and collagen I expression in the sclera of form-deprivation myopic model in guinea pigs. METHODS: A form-deprivation myopic model in guinea pigs were established with the left eye covered for 2 to 6 wk(FDM group). Normal control group(n=25) were untreated. Changes in refractive power and axial length(AL) were measured and recorded at different time points. Expressions of AP1 and collagen 1 of the sclera were measured with Western blotting and reverse transcription-polymerase chain reaction(RT-PCR). The relationship between AP1 and collagen I levels was analyzed. RESULTS: After 0, 2, 4, 6 wk, and 4/-1 wk of form-deprivation, the diopter in the FDM group was gradually changed(2.08±0.31,-1.23±0.68,-4.17±0.58,-7.07±0.55, and-2.67±0.59 D, respectively, P0.05). CONCLUSION: AP1 may be an important transcription factor involved in the regulation of collagen I synthesis and degradation during myopic scleral remodeling.

关键词： sclera remodeling activator protein 1 collagen I form deprivation myopia guinea pig

Effects of scleral encircling surgery on vitreous cavity length and diopter

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International Journal of Ophthalmology(English edition) 2016年第4期9卷 572-574页

作者： zi-cheng zhu Gen-Jie Ke Yue-Chun Wen Zhang-You Wu Department of Ophthalmology Anhui Provincial HospitalAnhui Medical University

AIM： To observe the changes of vitreous cavity length and diopter after scleral encircling（SE） produce.·METHODS： This prospective study included 68 eyes of68 non-consecutive patients with macula-off retinal detachment who were operated by SE surgery. The corneal refractive power, ocular axial length and diopter were measured by keratometer, A-mode ultrasonic meter and computed dioptometer.· RESULTS： There was no significant difference in corneal refractive power among preoperative and post operative 1, 3 and 6mo（0.57±0.54 D at pre-surgery; 0.72±0.26 D at 1mo; 0.71 ±0.34 D at 3mo; 0.69 ±0.31 D at 6mo;all P 〉0.05）. Axial lengths were obviously lengthened,especially in vitreous cavity length（17.87 ±3.09 mm,19.69 ±3.12 mm, 18.97 ±3.56 mm, 18.76 ±3.47 mm, 18.68 ±3.42 mm at pre-surgery, 1wk, 1, 3 and 6mo postoperatively,P 〈0.05） and diopter also increased at beginning and then recovered gradually. After 1 and 3 mo, axial length（vitreous cavity length） and myopia were more and in higher degree than before surgery.·CONCLUSION： The change of postoperative vitreous cavity length is the main factor that results in the changes of axial length and then makes the change of diopter.

关键词： sclera encircling vitreous cavity length diopter axial length

Simultaneous determination of active ingredients in blueberry wine by CE-AD

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Chinese Chemical Letters 2011年第10期22卷 1237-1240页

作者： zi cheng Li Lang zhu Chi Jin Kun zhu Yin Yan Zhang Qing Jiang Wang Pin Gang He Yu Zhi Fang Department of Chemistry East China Normal University Shanghai 200062 China

A method based on capillary electrophoresis coupled with amperometric detection（CE-AD） has been developed for the separation and determination of kaempferol,ferulic acid,vanillic acid,caffeic acid,gallic acid and protocatechuic acid in blueberry wine for the first *** order to get the optimum conditions of separation,the effects of working electrode potential,pH value and concentration of running buffer,separation voltage and injection time on CE-AD were *** the optimum conditions, the analytes could be separated in Na_2B_4O_7-KH_2PO_4 buffer at pH 7.8 within 18 min.A 300μm diameter carbon disk electrode had good current responses at ＋0.95 V（***） for all *** responses were linear with concentrations over three orders of magnitude with detection limits（S/N = 3） at 10^（-8） g/mL magnitude for the analytes and the recoveries were in the range of 95.8- 106.7%.The method could be successfully applied to the analysis of real sample with satisfactory results and therefore recommended for use by the quality control departments of fruit wine producers.

关键词： Application Capillary electrophoresis Amperometric detection Blueberry wine

Activation of autophagy in photoreceptor necroptosis after experimental retinal detachment

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International Journal of Ophthalmology(English edition) 2014年第5期7卷 745-752页

作者： Kai Dong zi-cheng zhu Feng-Hua Wang Gen-Jie Ke Zhang Yu Xun Xu Department of Ophthalmology Anhui Provincial HospitalAnhui Medical University Department of Ophthalmology Shanghai First People's HospitalSchool of MedicineShanghai Jiaotong University Eye Research Institute of Shanghai Jiaotong University Department of Morphology Fudan University Shanghai Medical College Department of Ophthalmology Shanghai First People's HospitalSchool of Medicine Shanghai Jiaotong University Shanghai Key Laboratory of Fundus Disease

AIM:To investigate whether photoreceptor necroptosis induced by z-VAD-FMK(pan caspase inhibitor) was involved the activation of autophagy and whether Necrostatin-1, a specific necroptosis inhibitor, could inhibit this induction of autophagy after experimental retinal ***:Experimental retinal detachment models were created in Sprague-Dawley rats by subretinal injection of sodium hyaluronate and subretinal injections of z-VAD-FMK, vehicle or z-VAD-FMK plus *** days after retinal detachment, morphologic changes were observed by transmission electron microscopy. In other animals, retinas were subjected to immunoprecipitation and Western Blotting, then probed with anti-RIP1, phosphoserine, LC-3II or caspase ***:It was proved by immunoprecipitation and western blotting, that photoreceptor necroptosis was mediated by caspase-8 inhibition and receptor interacting protein kinase(RIP1) phosphorylation activation. Transmission electron microscope and western blotting results indicated that photoreceptornecroptosis was involved the LC-3II and autophagosomes induction. We also discovered Necrostatin-1 could inhibit RIP1 phosphorylation and LC-3II ***:These data firstly indicate photoreceptor necroptosis is associated with the activation of autophagy. Necrostatin-1 protects photoreceptors from necroptosis and autophagy by down-regulation of RIP1 phosphorylation and LC-3II.

关键词： retinal detachment autophagy necroptosis

Expression and role of specificity protein 1 in the sclera remodeling of experimental myopia in guinea pigs

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International Journal of Ophthalmology(English edition) 2017年第4期10卷 550-554页

作者： Bo Jiang Zhang-You Wu zi-cheng zhu Gen-Jie Ke Yue-Chun Wen Si-Qin Sun Department of Ophthalmology Anhui Provincial HospitalAnhui Medical University

AIM：To study the expression of collagen I and transcription factor specificity protein 1（Sp1）,a transforming growth factor-β1（TGF-β1） downstream target,and reveal the impact of the TGF-β1-Sp1 signaling pathway on collagen remodeling in myopic ***：Seventy-five 1-week-old guinea pigs were randomly divided into normal control,form deprivation myopia（FDM）,and self-control *** was induced for different times using coverage with translucent latex balloons and FDM recovery was performed for 1wk after 4wk treatment;then,changes in refractive power and axial length were *** and reverse transcription-polymerase chain reaction were used to evaluate dynamic changes in collagen I and Sp1 expression in the sclera of guinea pigs with emmetropia and experimental myopia,and the relationship between collagen I and Sp1 levels was ***：In the FDM group,the refractive power was gradually changed（from 2.09±0.30 D at week 0 to-1.23±0.69 D,-4.17±0.59 D,-7.07±0.56 D,and-4.30±0.58 D at weeks 2,4,6,and 1wk after 4wk,respectively;P〈0.05）,indicating deepening of *** axial length was increased（from 5.92±0.39 mm at week 0 to 6.62±0.36 mm,7.30±0.34 mm,7.99±0.32 mm,and 7.41±0.36 mm at weeks 2,4,6,and 1wk after 4wk;P〈0.05）.The m RNA and protein expression of Sp1 and collagen I in the sclera of the FDM group was lower than that of the control groups（P〈0.05）,and the reduction was eye-coverage ***,correlation between Sp1 and collagen I down-regulation in the myopic sclera was ***：Our data indicate that transcription factor Sp1 may be involved in the regulation of type I collagensynthesis/degradation during myopic sclera remodeling,suggesting that TGF-β1 signaling plays a role in the development and progression of myopia.

关键词： form-deprivation myopia sclera remodeling transforming growth factor-β1 specificity protein 1 collagen I

Intervention effects and related mechanisms of glycyrrhizic acid on zebrafish with Hirschsprung-associated enterocolitis

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World Journal of Gastrointestinal Surgery 2023年第7期15卷 1317-1330页

作者： Ming-Kun Liu Ying-Jian Chen Fei Chen Zhi-Xiong Lin zi-cheng zhu Yu Lin Yi-Fan Fang Dian-Ming Wu Department of Pediatric Surgery Fujian Maternity and Child Health HospitalCollege of Clinical Medicine for Obstetrics&Gynecology and PediatricsFujian Medical UniversityFuzhou 350001Fujian ProvinceChina Department of Pediatric Surgery Fujian Children’s Hospital(Fujian Branch of Shanghai Children’s Medical Center)College of Clinical Medicine for Obstetrics&Gynecology and PediatricsFujian Medical UniversityFuzhou 350000Fujian ProvinceChina Department of Pediatric Surgery Fujian Children’s HospitalFuzhou 350001Fujian ProvinceChina Department of Clinical Medicine Fujian Medical UniversityFuzhou 350001Fujian ProvinceChina

BACKGROUND The prevention and treatment of Hirschsprung-associated enterocolitis(HAEC)is a serious challenge in pediatric *** the mechanism of HAEC is conducive to the prevention of this *** To explore the possible mechanism of glycyrrhizic acid(GA)and its therapeutic effect on *** We developed a model of enteritis induced by trinitrobenzenesulfonic acid(TNBS)in zebrafish,and treated it with different concentrations of *** analyzed the effect of GA on the phenotype and inflammation of *** After treatment with TNBS,the area of the intestinal lumen in zebrafish was significantly increased,but the number of goblet cells in the intestinal lumen was significantly reduced,but these did not increase the mortality of zebrafish,indicating that the zebrafish enteritis model was successfully *** concentrations of GA protected zebrafish with *** particular,high concentrations of GA were important for the prevention and control of HAEC because it significantly reduced the intestinal luminal area,increased the number of goblet cells in the intestinal lumen,and reduced the levels of interleukin(IL)-1βand *** GA significantly reduced the intestinal luminal area,increased the number of intestinal goblet cells,and decreased IL-1βand IL-8 in zebrafish,and is important for prevention and control of HAEC.

关键词： Hirschsprung-associated enterocolitis High mobility group box 1 protein Toll-like receptor 4 Interleukin-1β Interleukin-8 Glycyrrhizic acid

Sub-object Vertex Modifying Method of Scene Model in Virtual Training System

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Sub-object Vertex Modifying Method of Scene Model in Virtual...

Colonoscopic screening and follow-up for coiorectal cancer in the elderly

作者： Wei-jun CHU zi-cheng zhu Army Engineering University of PLA China Heavy Truck Group Co. Ltd

Vertex Modifying is a key problem in sub-object modeling. Facing local special structures such as convex peaks, pits, step surfaces, slopes, terraces, cliff collapses, landslides, steep cliffs, and gully in scene models, vertex creating process and its definition are illustrated. The modeling method by vertex Modifying and the mutual relation with other sub-objects are analyzed, and the use of repetitive triangulation algorithm and chamfering algorithm based on vertex are further discussed. Vertex control method based on neighborhood factor is expounded, and the influence of its parameters is compared by value and model. The analysis indicates that vertex modification provides flexible modeling method for scene modeling in virtual training system, and the result is anticipative and satisfactory.

关键词： Vertex Modifying Scene model Neighborhood factor Virtual training system

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World Journal of Gastroenterology 2002年第2期8卷 267-269页

作者： Jun Wan zi-Qi Zhang cheng zhu Meng-Wei Wang Dong-Hai Zhao Yong-He Fu Jian-Ping Zhang Ya-Hong Wang Ben-Yan Wu,Department of Gastroenterology,General Hospital of the Chinese PLA,Beijing 100853,China

AIM: To improve the prevention and treatment of senile patients with colorectal cancer by evaluating the importance of colonoscopy in clinical screening and follow-up. METHODS: Clinical screening of colonoscopy was performed for 2196 patients aged 60-90 years old according to the protocol,and 1740 of them (79.2%) were followed-up. RESULTS: Colorectal cancer was found in 52 patients, and the detectable rate was 2.4%. Among them, 19 were diagnosed as early colorectal cancer, accounting for 36.5% of the detected colorectal cancer. Among the followed-up patients, early colorectal cancer was found in 9, accounting for 45.0% of the detected colorectal cancer. The resectable rate and 5 years survival rate of colorectal cancer were 97.7% and 80.9% respectively. The incidence of complication was 0.05%, and the successful rate of cecum intubation was 98.9%. CONCLUSION: Colonoscopic screening and follow-up of the elderly for colorectal cancer and pre-cancerous lesion (adenomatoid polyp) can increase the detectable rate of early colorectal cancer and improve its prevention and treatment.

关键词： Colonoscopy Mass Screening Aged Aged, 80 and over Colorectal Neoplasms Humans Middle Aged Survival Rate

Van Herick法及河南眼科研究所改进法检查前房深度估测房角关闭的准确性研究

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国际眼科杂志 2020年第3期20卷 529-532页

作者：张楚朱子诚应充慧安徽医科大学附属省立医院眼科

目的:研究Van Herick法及河南眼科研究所改进法检查前房深度估测房角关闭的准确性。方法:随机选取2018-06/2019-01于我院门诊就诊的40岁及以上患者52例100眼分别行Van Herick法和河南眼科研究所改进法检查前房深度,筛选出周边前房深度≤... 详细信息

目的:研究Van Herick法及河南眼科研究所改进法检查前房深度估测房角关闭的准确性。方法:随机选取2018-06/2019-01于我院门诊就诊的40岁及以上患者52例100眼分别行Van Herick法和河南眼科研究所改进法检查前房深度,筛选出周边前房深度≤1/3 CT且>1/4 CT与周边前房深度≤1/4 CT人群,对Van Herick法与河南研究所改进法前房检查法结果进行一致性检验,再行房角镜检查与暗室下UBM检查分别检查周边房角是否关闭。结果:在Van Herick法估测周边前房深度≤1/3 CT且>1/4 CT的患眼中,行房角镜检查与UBM检查结果房角关闭的阳性率分别为39%与43%,在河南眼科研究所改进法估测周边前房深度≤1/3 CT且>1/4 CT的患眼中,行房角镜检查与UBM检查结果房角关闭的阳性率分别为46%与42%;在Van Herick法估测周边前房深度≤1/4 CT的患眼中,行房角镜检查与UBM检查结果房角关闭的阳性率分别为67%与89%;在河南眼科研究所改进法估测周边前房深度≤1/4 CT的患眼中,行房角镜检查与UBM检查结果房角关闭的阳性率分别为70%与100%;对Van Herick法与河南眼科研究所改进法进行一致性检验,在估测周边前房深度≤1/3CT且>1/4 CT时,Kappa值为0.85,一致性较好,在估测周边前房深度≤1/4 CT时,Kappa值为0.83,一致性较好;对房角镜检查结果及UBM检查结果进行一致性检验,在Van Herick法估测周边前房深度≤1/3 CT且>1/4 CT时,Kappa值为0.73,一致性一般,在Van Herick法估测周边前房深度≤1/4 CT时,Kappa值为0.40,一致性一般。对房角镜检查结果及UBM检查结果进行一致性检验,在河南眼科研究所改进法估测周边前房深度≤1/3 CT且>1/4 CT时,Kappa值为0.75,一致性较好,在河南眼科研究所改进法估测周边前房深度≤1/4 CT时,Kappa值为0,一致性较差。结论:Van Herick法及河南眼科研究所改进法前房深度检查在测量人群中房角关闭的具有一定的假阴性率,但准确性较高,仍适合作为估测房角关闭的初步检查方式。

关键词：裂隙灯法前房深度检查房角镜检查超声生物显微镜房角关闭