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Ferricyanide-Promoted Oxidative Activation and ligation of Protein Thioacids in Neutral Aqueous Media

CCS Chemistry 2024年第8期6卷 2031-2043页

作者： Guo-Chao Chu Lu-Jun liang Rui Zhao Yan-Yan Guo Chun-Tong li Chong Zuo Huasong Ai Xiao Hua zi-chen li Yi-Ming li Lei liu NewCornerstone Science Laboratory Tsinghua-Peking Center for Life SciencesMinistry of Education Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical BiologyCenter for Synthetic and Systems BiologyDepartment of ChemistryTsinghua UniversityBeijing 100084 School of Food and Biological Engineering Hefei University of TechnologyHefei 230009 Center for BioAnalytical Chemistry Hefei National Laboratory of Physical Science at MicroscaleUniversity of Science and Technology of ChinaHefei 230026 Department of Chemistry University of Science and Technology of ChinaHefei 230026

Ferricyanide-promoted oxidative activation of Nacylatedα-aminothioacids for amide bond formation withα-aminonitriles was recently shown to be a plausible pathway for prebiotic peptide *** we describe the finding that by adding sodium azide and thiols,ferricyanide oxidation can elicit highly efficient and clean conversion of fully unprotected peptide or protein thioacids in neutral aqueous media to the corresponding *** transformation enables the development of ferricyanide-promoted thioacid-based native chemical ligation(NCL)as a new redox-based method for chemical protein synthesis,which does not need to change pH and is therefore operationally easy for ligation at small *** effectiveness of the ferricyanide-promoted thioacid-based NCL was illustrated by synthesis of an ISG15-modified MDA5 segment under nondenaturing conditions and synthesis of an acetylated ubiquitin(Ub)-modified histone H2A through an N-to-C sequential *** work broadens the concept of on-demand oxidative activation strategy for protein ligation and provides a new useful supplement to the repertoire of methods for chemical protein synthesis,particularly for studies on proteins carrying Ub family modifications.

关键词： chemical protein synthesis protein thioacid ferricyanide oxidation native chemical ligation ubiquitin family modifications

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胎膜早破合并绒毛膜羊膜炎血清NLRP3、sTNFR-Ⅰ、miR-182水平及其预测价值

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中华医院感染学杂志 2024年第13期34卷 2041-2045页

作者：李海园陈自力孙艳李浩明王彦锦天津市第五中心医院妇产科天津300450 天津医科大学总医院妇产科天津300052 天津滨海新区塘沽妇产医院妇产科天津300450 天津北大医疗海洋石油医院妇产科天津300452

目的为探究胎膜早破(PROM)合并绒毛膜羊膜炎(CA)血清NOD样受体热蛋白结构域相关蛋白3(NLRP3)、可溶性肿瘤坏死因子受体-Ⅰ(sTNFR-Ⅰ)、微小核糖核酸(miR)-182水平及其预测价值。方法选取2019年1月-2023年6月天津市第五中心医院收治的PRO... 详细信息

目的为探究胎膜早破(PROM)合并绒毛膜羊膜炎(CA)血清NOD样受体热蛋白结构域相关蛋白3(NLRP3)、可溶性肿瘤坏死因子受体-Ⅰ(sTNFR-Ⅰ)、微小核糖核酸(miR)-182水平及其预测价值。方法选取2019年1月-2023年6月天津市第五中心医院收治的PROM合并CA产妇52例为研究组,另选同期收治的PROM未合并CA产妇54例为对照组,研究组根据CA分期分为I期组25例和Ⅱ~Ⅲ期组27例。比较研究组和对照组、不同CA分期血清NLRP3、sTNFR-Ⅰ、miR-182水平;Spearman分析PROM产妇血清NLRP3、sTNFR-Ⅰ、miR-182水平与CA分期的相关性,受试者工作特征(ROC)曲线分析三指标对PROM合并CA的预测价值。结果与对照组相比,研究组血清NLRP3、sTNFR-Ⅰ、miR-182水平升高(P<0.05);与Ⅰ期组相比,Ⅱ~Ⅲ期组血清NLRP3、sTNFR-Ⅰ、miR-182水平升高(P<0.05);血清NLRP3、sTNFR-Ⅰ、miR-182水平与CA分期呈正相关(P<0.05);血清NLRP3、sTNFR-Ⅰ、miR-182联合检测诊断PROM合并CA的曲线下面积(AUC)比单个指标检测值高(P<0.05),且联合检测的敏感度、特异度为86.54%、90.74%。结论PROM产妇合并CA血清NLRP3、sTNFR-Ⅰ、miR-182水平呈高表达,三指标与CA分期呈正相关,且三指标联合检测可提高PROM产妇合并CA的预测价值。

关键词：胎膜早破绒毛膜羊膜炎 NOD样受体热蛋白结构域相关蛋白3 可溶性肿瘤坏死因子受体-Ⅰ 微小核糖核酸-182 受试者工作特征曲线预测价值

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Special Issue:In Memory of Professor Fosong Wang

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Chinese Journal of Polymer Science 2023年第5期41卷 605-606,I0005页

作者： zi-chen li li-Xiang Wang State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun China

Professor Fosong Wang was a leading polymer chemist and made great contributions in polymer science including synthetic rubber,stereospecific polymerization,conjugated polymers and biodegradable *** was also a highly respected educator in the field of *** was not only a professor,a mentor,but also an academic father to many students.

关键词： rubber professor father

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外周血sTREM-1联合MIP-1α预测胎膜早破孕妇急性宫内感染中的价值

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中华医院感染学杂志 2024年第15期34卷 2368-2371页

作者：杨莉莉陈自力张永展刘蓝泽陈静李艳梅陈红晓卢慧天津市第五中心医院(北京大学滨海医院)妇产科天津300450

目的分析外周血可溶性髓样细胞触发受体-1(sTREM-1)联合巨噬细胞炎性蛋白-1α(MIP-1α)预测胎膜早破孕妇急性宫内感染中的价值.方法回顾性分析2020年2月—2023年2月天津市第五中心医院产科92例胎膜早破孕妇的临床资料,根据患儿是否合并... 详细信息

目的分析外周血可溶性髓样细胞触发受体-1(sTREM-1)联合巨噬细胞炎性蛋白-1α(MIP-1α)预测胎膜早破孕妇急性宫内感染中的价值.方法回顾性分析2020年2月—2023年2月天津市第五中心医院产科92例胎膜早破孕妇的临床资料,根据患儿是否合并宫内感染分为宫内感染组36例与非宫内感染组56例;统计宫内感染组宫颈分泌物病原学分布特点,分析宫内感染组与非宫内感染组血清sTREM-1及MIP-1α水平差异,并利用受试者工作特征(ROC)曲线分析sTREM-1及MIP-1α诊断宫内感染的临床价值.结果36例宫内感染组孕妇宫颈分泌物共检测出35株病原菌,其中革兰阴性菌20株占57.14%,革兰阳性菌13株占37.14%,真菌2株占5.71%;宫内感染组血清sTREM-1及MIP-1α水平高于非宫内感染组(P<0.05);ROC曲线分析结果血清sTREM-1、MIP-1α对宫内感染均具有较高诊断价值[曲线下面积(AUC)=0.840、0.911],二指标联合诊断价值更高(AUC=0.938).结论血清sTREM-1和MIP-1α水平预测胎膜早破孕妇是否发生宫内感染具有较高的灵敏性和特异性,可为早期诊断提供参考价值.

关键词：可溶性髓样细胞触发受体-1 巨噬细胞炎性蛋白-1α 胎膜早破宫内感染预测价值

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企业寻租、高压反腐与企业创新

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软科学 2024年第3期38卷 93-98页

作者：陈字理马文聪张光宇陈修德华南理工大学工商管理学院广州510630 广东工业大学管理学院广州510520

利用2008—2020年中国A股上市企业数据,探讨企业寻租、高压反腐与企业创新三者之间的关系以及关系机制。研究发现:(1)企业层面的寻租能够促进创新活动的开展,但行业层面的寻租会抑制该行业的创新;(2)寻租能够通过保护创新成果免受掠夺... 详细信息

利用2008—2020年中国A股上市企业数据,探讨企业寻租、高压反腐与企业创新三者之间的关系以及关系机制。研究发现:(1)企业层面的寻租能够促进创新活动的开展,但行业层面的寻租会抑制该行业的创新;(2)寻租能够通过保护创新成果免受掠夺的“保护费”功能与获得资源的“润滑剂”功能促进创新;(3)高压反腐能够有效抑制寻租“润滑剂”与“保护费”功能的发挥,从而一定程度上消除寻租对创新的扭曲效应;(4)相对利用式创新,寻租对创新的扭曲效应以及高压反腐的修正作用在探索式创新活动当中更加明显。

关键词：企业寻租企业创新高压反腐

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The Order Properties of r-compact Operators on Banach Lattices

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Acta Mathematica Sinica,English Series 2007年第3期23卷 457-466页

作者： zi li chen A. W. WICKSTEAD Department of Mathematics Southwest Jiaotong University Chengdu 610031 P. R. China Department of Pure Mathematics The Queen's University of Belfast Belfast BT71NN Northern Ireland UK

We present here that F（E,F）, the space of all r-compact operators from E into F, is a generalised sublattice of L^r（E, F） for arbitary Banach lattices E and F, and that the characterization of the regular norm on F（E, F） is order continuous. Some conditions for F（E, F） to be a KB-space or a band in .L（E, F） are also provided.

关键词： Banach lattice KB-space regular norm order continuous norm r-compact operator

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Ring-opening Polymerization of 2-Oxabicyclo[2.2.2]octan-3-one and the Influence of Stereochemistry on the Thermal Properties of the Polyesters

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Chinese Journal of Polymer Science 2022年第10期40卷 1173-1182,I0008页

作者： Tong Zhou Yu-Ting Guo Fu-Sheng Du zi-chen li Beijing National Laboratory for Molecular Sciences(BNLMS) Key Laboratory of Polym.Chem.&Physics of Ministry of EducationDepartment of Polymer Science&EngineeringCollege of Chemistry and Molecular EngineeringCenter for Soft Matter Science and EngineeringPeking UniversityBeijing 100871China

Polyesters with cyclic structures in the main chain typically possess superior mechanical and thermal properties together with chemical ***-opening polymerization(ROP)of bridged or fused bicyclic lactones is a simple,and in most cases controlled method to synthesize polyesters with alicyclic moieties in the polymer *** stereochemistry of the alicyclic structures has a great effect on the polymer properties,which can be regulated by varying the polymerization ***,we report a systematic investigation on the ROP of 2-oxabicyclo[2.2.2]octan-3-one([2.2.2]VL)under different *** initiated byn-butyl lithium(n-Buli)or catalyzed by trifluoromethanesulfonic acid(TfOH)in the presence of benzyl alcohol,P[2.2.2]VLs containing all cis^(-1),4 disubstituted cyclohexane ring were ***,P[2.2.2]VLs initiated by sodium methoxide(MeONa)or catalyzed by organic superbase contained both cis and trans isomeric structural *** cis to trans transformation mechanism under these conditions was manifested,and the effect of stereochemical variations on the properties ofP[2.2.2]VLwas *** stereoregularP[2.2.2]VLs,bothcisandtrans,exhibited higher crystallinity and melting temperatures(Tm)than those of the stereoirregular ***,the degradation of P[2.2.2]VL with acid at high temperature could recover 3-cyclohexenecarboxylic acid.

关键词： 2-Oxabicyclo[2.2.2]octan-3-one Ring-opening polymerization Stereochemistry Polyester Thermal properties

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Dynamic Ring-chain Equilibrium of Nucleophilic Thiol-yne "Click" Polyaddition for Recyclable Poly(dithioacetal)s

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Chinese Journal of Polymer Science 2021年第9期39卷 1146-1154页

作者： Jin-Xia Lei Qi-Yuan Wang Fu-Sheng Du zi-chen li Beijing National Laboratory for Molecular Sciences(BNLMS) Key Laboratory of Polym.Chem.&Physics of Ministry of EducationDepartment of Polymer Science&EngineeringCollege of Chemistry and Molecular EngineeringCenter for Soft Matter Science and EngineeringPeking UniversityBeijing 100871China

We report a dynamic polymerization system based on the reversible nucleophilic Michael polyaddition of activated alkynes and *** poly(dithioacetal)s(P1-P4)were prepared via the base-catalyzed thiol-yne"click"polyaddition of two dithiols(1,4-butanedithiol(4S)and 1,5-pentanedithiol(5S))and two alkynones(3-butyn-2-one(Y1)and 1-phenyl-2-propyn-1-one(Y2))at high *** systematically investigated the base-catalyzed polymerization of 4S and Y1(for polymer PI)under different conditions,and found that this polymerization was a highly concentration-dependent dynamic system:polymer PI was formed at high concentration,while seven-membered dithioacetal,1-(1,3-dithiepan-2-yl)propan-2-one(C1),was obtained at low *** polymerization of 4S and Y2(for polymer P4)displayed similar polymerization behavior,generating 2-(1,3-dithiepan-2-yl)-1-phenylethanone(C4)at low *** the contrary,polymer P2(from Y1 and 5S)was exclusively obtained with no formation of eight-membered *** polymerizations of Y1 with 1,2-ethanedithiol(2S)and 1,3-dimercaptopropane(3S)only afforded corresponding five-and six-membered dithioacetals,1-(1,3-dithiolan-2-yl)propan-2-one(C2)and 1-(1,3-dithian-2-yl)propan-2-one(C3).This dynamic behavior of PI and P4 was attributed to the concentration-dependent retro-Michael addition reaction between a thiol and a β-sulfido-α,β-unsaturated carbonyl compound catalyzed by ***,polymers P1 and P4 could be depolymerized into Cl and C4 in yields of 58% and 95%,*** ring-opening polymerization of Cl at high concentration could successfully regenerate polymer ***,a new type of closed-loop recyclable poly(dithioacetal)s was developed.

关键词： Poly(dithioacetal)s Nucleophilic thiol-yne"click"polyaddition Chemical recycling Ring-chain equilibrium

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A Practical Quantum Network Coding Protocol Based on Non-Maximally Entangled State

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Computers, Materials & Continua 2021年第8期68卷 2651-2663页

作者： Zhen-Zhen li zi-chen li Xiu-Bo chen Zhiguo Qu Xiaojun Wang Haizhu Pan School of Information Engineering Beijing Institute of Graphic CommunicationBeijing102600China Information Security Center State Key Laboratory of Networking and Switching TechnologyBeijing University of Posts and TelecommunicationsBeijing100876China Jiangsu Collaborative Innovation Center of Atmospheric Environment and Equipment Technology Nanjing University of Information Science and TechnologyNanjing210044China School of Electronic Engineering Dublin City UniversityDublin9Ireland College of Computer and Control Engineering Qiqihar UniversityQiqihar161006China

In many earlier works,perfect quantum state transmission over the butterfly network can be achieved via quantum network coding protocols with the assist of maximally entangled ***,in actual quantum networks,a maximally entangled state as auxiliary resource is hard to be obtained or easily turned into a non-maximally entangled state subject to all kinds of environmental ***,we propose a more practical quantum network coding scheme with the assist of non-maximally entangled *** this paper,a practical quantum network coding protocol over grail network is proposed,in which the non-maximally entangled resource is assisted and even the desired quantum state can be perfectly *** achievable rate region,security and practicability of the proposed protocol are discussed and *** practical quantum network coding protocol proposed over the grail network can be regarded as a useful attempt to help move the theory of quantum network coding towards practicability.

关键词： Quantum network coding non-maximally entangled state quantum grail network practical protocol

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Quantum Remote State Preparation Based on Quantum Network Coding

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Computers, Materials & Continua 2022年第10期73卷 119-132页

作者： Zhen-Zhen li zi-chen li Yi-Ru Sun Haseeb Ahmad Gang Xu Xiu-Bo chen School of Information Engineering Beijing Institute of Graphic CommunicationBeijing102600China School of Computer Science and Information Engineering Zhejiang Gongshang UniversityHangzhou310018China Information Security Center State key Laboratory of Networking and Switching TechnologyBeijing University of Posts and TelecommunicationsBeijing100876China Department of Computer Science National Textile UniversityFaisalabad37610Pakistan School of Information Science and Technology North China University of TechnologyBeijing100144China Advanced Cryptography and System Security Key Laboratory of Sichuan Province China

As an innovative theory and technology,quantum network coding has become the research hotspot in quantum network *** this paper,a quantum remote state preparation scheme based on quantum network coding is *** with the general quantum remote state preparation schemes,our proposed scheme brings an arbitrary unknown quantum state finally prepared remotely through the quantum network,by designing the appropriate encoding and decoding steps for quantum network *** is worth mentioning,from the network model,this scheme is built on the quantum k-pair network which is the expansion of the typical bottleneck network—butterfly ***,it can be treated as an efficient quantum network preparation scheme due to the characteristics of network coding,and it also makes the proposed scheme more applicable to the large-scale quantum *** addition,the fact of an arbitrary unknown quantum state remotely prepared means that the senders do not need to know the desired quantum ***,the security of the proposed scheme is ***,this scheme can always achieve the success probability of 1 and 1-max flow of value ***,the communication efficiency of the proposed scheme is ***,the proposed scheme turns out to be practicable,secure and efficient,which helps to effectively enrich the theory of quantum remote state preparation.

关键词： Quantum remote state preparation quantum network coding quantum k-pair network

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