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Shi-pi-xiao-ji formula suppresses hepatocellular carcinoma by reducing cellular stiffness through upregulation of acetyl-coA acetyltransferase 1

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2727-2741页

作者： Hui-Ying Jian zi-Cheng liang Huan Wen Zhen Zhang Pu-Hua Zeng Graduate School Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Hunan Provincial Hospital of Integrated Traditional Chinese and Western Cancer Research Institute of Hunan Academy of Traditional Chinese MedicineHunan Academy of Chinese MedicineChangsha 410006Hunan ProvinceChina

BACKGROUND Previous studies have shown that the Shi-pi-xiao-ji(SPXJ)herbal decoction formula is effective in suppressing hepatocellular carcinoma(HCC),but the underlying mechanisms are not ***,this study investigated whether the antitumor effects of the SPXJ formula in treating HCC were mediated by acetyl-coA acetyltransferase 1(ACAT1)-regulated cellular *** a series of experiments,we concluded that SPXJ inhibits the progression of HCC by upregulating the expression level of ACAT1,lowering the level of cholesterol in the cell membrane,and altering the cellular stiffness,which provides a new idea for the research of traditional Chinese medicine against *** To investigate the anti-tumor effects of the SPXJ formula on the malignant progression of *** HCC cells were cultured in vitro with SPXJ-containing serum prepared by injecting SPXJ formula into wild-type *** apoptotic rate and proliferative,invasive,and migratory abilities of control and SPXJ-treated HCC cells were *** force microscopy was used to determine the cell surface morphology and the Young’s modulus values of the control and SPXJ-treated HCC *** membrane cholesterol levels in HCC cells were detected using the Amplex Red cholesterol detection ***1 protein levels were estimated using western *** Compared with the vehicle group,SPXJ serum considerably reduced proliferation of HCC cells,increased stiffness and apoptosis of HCC cells,inhibited migration and invasion of HCC cells,decreased plasma membrane cholesterol levels,and upregulated ACAT1 protein ***,treatment of HCC cells with the water-soluble cholesterol promoted proliferation,migration,and invasion of HCC cells as well as decreased cell stiffness and plasma membrane cholesterol levels,but did not alter the apoptotic rate and ACAT1 protein expression levels compared with the vehicle *** SPXJ formula inhibited proliferation,invasion,and migration

关键词： Shi-pi-xiao-ji formula Hepatocellular carcinoma Cellular stiffness Plasma membrane cholesterol level AcetylcoA acetyltransferase 1

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Effects of certain phenolic acids on advanced glycation end products formation in glucose-lysine Maillard reaction models

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Food Science and Human Wellness 2024年

作者： He Li Meng-Yao Jin zi-Ze liang Dan Li Jia-Hao Ji Lin Kong zi-Qing Zhao Rui-Jie Wu School of Chemistry and Chemical Engineering， North University of China Shanxi Jinshuo Biomedical Technology Co.Ltd.

Advanced glycation end products (AGEs)， a group of complex compounds generated by nonenzymatic interactions between amino acids， proteins and reducing sugars or lipids， accumulate in vivo and activate various signaling pathways closely related to the occurrence of various chronic metabolic diseases. This study aims to explore the structure-activity relationship between phenolic acids with different structure and affecting the AGEs generation， and to provide data support for AGEs control. Phenolic acids (4-hydroxybenzoic， protocatechuic， gallic， ρ-coumaric， caffeic， ferulic and sinapic acids) were employed to indicate the AGEs formation condition in Maillard reaction performed in the glucose-lysine model system. Three 1，2-dicarbonyl compounds were reacted with phenolic acids and then tested by liquid chromatography-mass spectrometry. The results showed that Nε-carboxy-methyl-lysine (CML)， Nε-carboxy-ethyl-lysine (CEL)， and pyrraline formation inhibited by phenolic acids varied from (8.7 ± 2.5)% to (33.2 ± 2.5)%， (10.5 ± 0.8)% to (57.1 ± 3.2)% and (1.3 ± 0.3)% to (23.3 ± 0.8)%， respectively. The ρ-coumaric acid has no inhibitory effect on CML and CEL formation. Gallic acid shows the best inhibitory effect on CML formation due to its strong antioxidant activity. Sinapic acid showed the best glyoxal (GO) trapping rate and thus had the stronger inhibitory effect on CML formation. Ferulic acid can react with mono-， di- tri-methylglyoxal (MGO) to form adduct products， showing the best MGO scavenging rate and a good inhibitory effect on CEL formation. The main role of phenolic acid is an antioxidant agent to inhibit pyrraline formation. The glucose itself or ammonia-induced degradation and ARP oxidation were lowered by protocatechuic， gallic and caffeic acids due to their antioxidant activities to form AGEs， while AGEs inhibited by ferulic and sinapic acids were mainly dependent on their trapping ability on 1，2-dicarbonyl compounds.

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不依赖观测器的不确定性系统输出反馈鲁棒控制

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吉林大学学报（工学版） 2024年第3期54卷 828-835页

作者：赵军赵子亮朱庆林郭斌山东科技大学机械电子工程学院山东青岛266590 山东科技大学交通学院山东青岛266590

针对非匹配不确定性系统的静态输出反馈鲁棒控制问题在线求解难的难题,提出了一种基于数据驱动学习的自适应学习算法。首先,将不确定性系统的鲁棒控制问题转化为具有性能指标函数的标称系统的最优控制问题。其次,为实现输出反馈最优控制... 详细信息

针对非匹配不确定性系统的静态输出反馈鲁棒控制问题在线求解难的难题,提出了一种基于数据驱动学习的自适应学习算法。首先,将不确定性系统的鲁棒控制问题转化为具有性能指标函数的标称系统的最优控制问题。其次,为实现输出反馈最优控制,根据状态反馈控制项构造了输出反馈黎卡提方程。再次,为实现该输出反馈黎卡提方程的在线求解,使用克罗内克积和向量化操作重构输出反馈黎卡提方程,进而设计了基于输入/输出数据的自适应学习算法,摒弃了传统观测器的使用,实现可一步求解的输出反馈鲁棒控制。最后,为实现被估参数的快速收敛,进一步放松了所要求的持续激励条件。仿真结果验证了本文控制方法和学习算法的有效性。

关键词：控制理论与控制工程数据驱动学习鲁棒控制最优控制持续激励条件

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Eikenella corrodens isolated from pleural effusion:A case report

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World Journal of Clinical Cases 2024年第18期12卷 3596-3602页

作者： zi-Cong liang Hao Ouyang Xue-Jing Song Jian-Xin liang Wei-Hua Zheng Jian-Jun Chen Zheng-Gang Yin Sha-Yan Chen Department of Laboratory Science Binhaiwan Central Hospital of DongguanDongguan 523905Guangdong ProvinceChina Key Laboratory of accurately etiological research on the pathogenesis of inflammation and cancer Dongguan 523905Guangdong ProvinceChina Central Laboratory Binhaiwan Central Hospital of DongguanDongguan 523905Guangdong ProvinceChina

BACKGROUND The bacterium Eikenella,classified as a gram-negative member of the phylum Proteobacteria,is distinguished by its rarity,corrosive nature,facultative anaerobic properties,and conditional *** represents the sole species within its genus-Eikenella corrodens(***)-and can be found colonizing both human and animal oral and nasopharyngeal ***,it occasionally inhabits the gastrointestinal or urogenital ***,its slow growth rate can be attributed to its high nutritional ***,there is an uneven distribution of construction and diagnostic capacity in China which poses undeniable challenges for the clinical examination and analysis of this case,especially in the basic *** SUMMARY Here we presented a case of empyema associated with *** infection in a 67-year-old male patient without any previous history of infectious diseases in our primary hospital in Dongguan district of *** patient was admitted due to recurrent worsening cough,sputum production,and dyspnea for 3 d,which had persisted for over 20 ***,the patient experienced a onehour episode of *** admission,immediate comprehensive examinations were conducted on the patient which subsequently led to his admission to the intensive care ***,the patient presented with drowsiness and profuse sweating along with bilateral conjunctival edema observed during initiation of non-invasive ventilation,suggesting empyema.A significant amount of coffee-colored malodorous pleural fluid was drained during the procedure above and sent to the laboratory department for ***,laboratory culture results confirmed the presence of *** infection in the pleural fluid *** patient received antimicrobial therapy until died on day 22 in the *** In this report,we presented a case of empyema associated with *** *** courses of morphological examination,vi

关键词： Eikenella corrodens Pleural fluid Morphology Viable culture Biochemical identification Case report

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Combination of p-Coumaric acid and lactoferrin ameliorates cognitive deficits through suppressing C/EBPβ/AEP pathway and modulating intestinal flora in APP/PS1 mice

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Food Science and Human Wellness 2024年

作者： Yan Zhou Yi-Tian Sun Hui Guo Yan-zi liang Si-Yuan Zhu Yu Sha Zhong-Xiao Wan Jia-Ying Xu Jian-Rong Jiang Li-Qiang Qin Yun-Hong Li Department of Nutrition and Food Hygiene， School of Public Health， Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases， MOE Key Laboratory of Geriatric Diseases and Immunology， Suzhou Medical college of Soochow University Department of Medical Technology， Suzhou Vocational Health College State Key Laboratory of Radiation Medicine and Protection， School of Radiation Medicine and Protection， Suzhou Medical college of Soochow University Suzhou Municipal Center for Disease Control and Prevention

Alzheimer's disease （AD） has become an important public health issue worldwide. P-Coumaric acid （CA） and lactoferrin （Lf） possessed antioxidant， anti-inflammatory， and anti-AD activities. Herein， we hypothesized that a combination treatment of CA and Lf would synergistically improve AD symptoms and studied its mechanisms. Twelve-week-old APP/PS1 mice were treated with CA， Lf， or both CA and Lf for 8 weeks. Results showed that individual and combined treatments could ameliorate cognitive deficits to varying degrees， with stronger effects for combined intervention than for CA or Lf alone. Specifically， combined treatment was most effective in improving nesting ability and reducing Aβ1-42deposition in mice. Moreover， combined treatment was more effective in suppressing APP， BACE1， and inflammation; it inhibited the CCAAT-enhancer-binding protein （C/EBPβ）/asparagine endopeptidase （AEP） signaling pathway in the hippocampus and colon and upregulated the expression of tight junction protein ZO-1 in the colon; it also decreased the F/B ratio at the phylum level and increased the relative abundance of Prevotellaceae， Lachnospira， and Eubacterium at the genus level. Overall， the combination of CA and Lf may ameliorate cognitive deficits in APP/PS1 mice by improving inflammation and inhibiting the C/EBPβ/AEP signaling pathway via modulating gut microbiome.

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Efficacy of budesonide/formoterol inhalation powder in treating viral pneumonia in children

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World Journal of Clinical Cases 2024年第21期12卷 4469-4475页

作者： zi-liang Lin Xu Xu Jiao-Jiao Yang Li-Qiang Lu Heng Huang Xiao-Zhen Hua Li-Dang Lu Department of Pediatrics Cangnan Hospital Affiliated to Wenzhou Medical UniversityWenzhou 325800Zhejiang ProvinceChina

BACKGROUND Respiratory viruses are increasingly detected in children with communityacquired *** strategies to limit antibiotic use in children with viral pneumonia are *** To explore clinical efficacy of budesonide/formoterol inhalation powder for viral pneumonia in children and its impact on cellular immunity and inflammatory factor *** A total of 60 children with viral pneumonia were recruited:30 receiving budesonide/formoterol inhalation powder and 30 conventional symptomatic *** measures included peripheral blood levels of inflammatory cytokines,CD4^(+),CD8^(+),Th1,Th2,Th17 and Treg,clinical efficacy,and incidence of adverse *** Compared with the control group,the observation group showed a significant reduction in interleukin-6 and high-sensitivity C-reactive protein levels after *** with the control group,the observation group showed a significant increase in CD4^(+)/CD8^(+)and Th1/Th2 levels,and a decrease in Th17/Treg levels after *** total effective rates in the observation group and the control group were 93.75%and 85.00%,respectively,which was a significant difference(P=0.003).CONCLUSION Budesonide/formoterol inhalation powder significantly improved therapeutic efficacy for viral pneumonia in *** mechanism of action may be related to downregulation of the inflammatory response and improved cellular immune function.

关键词： Budesonide/Formoterol inhalation powder Viral pneumonia Immunity CD4^(+)/CD8^(+) Th1/Th2 Th17/Treg

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人工智能辅助的MRI影像组学在前列腺癌诊疗中的进展

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中华男科学杂志 2024年第1期30卷 60-65页

作者：梁梓淳(综述) 孙超(审校) 陈明(审校) 东南大学附属中大医院泌尿外科江苏南京210096

前列腺癌(PCa)目前是全球男性第2大常见癌症,也是导致男性癌症死亡的第5大原因。MRI在检测PCa方面具有很高的灵敏度和特异性,是目前用于肿瘤定位和癌症分期最广泛的成像技术。MRI在新发肿瘤患者的风险分层、低风险患者的主动监测以及治... 详细信息

前列腺癌(PCa)目前是全球男性第2大常见癌症,也是导致男性癌症死亡的第5大原因。MRI在检测PCa方面具有很高的灵敏度和特异性,是目前用于肿瘤定位和癌症分期最广泛的成像技术。MRI在新发肿瘤患者的风险分层、低风险患者的主动监测以及治疗后的复发监测方面发挥着关键作用。影像组学是一种新兴的、前景广阔的工具,通过将数字图像转换为可挖掘的高维数据,可对图像中的肿瘤进行定量评估。影像组学的目的是增加可用于检测PCa的特征、避免不必要的活检、确定肿瘤的侵袭性以及监测治疗后的复发。利用人工智能(AI)整合影像组学数据,包括不同的成像模式(如PET-CT)以及其他临床和组织病理学数据,可提高对肿瘤侵袭性的预测并指导临床决策和患者管理。本综述旨在介绍目前AI辅助下的影像组学在PCa MRI图像上的研究应用。

关键词：前列腺癌 MRI 影像组学人工智能

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附着于木拱架的超大LED拉索式网屏建造技术

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建筑技术 2024年第18期55卷 2230-2233页

作者：苗子良北京城建集团有限责任公司北京100088

基于中国天府农业博览园主展馆LED拉索式网屏工程,索网上部承载结构为木拱架,形成了一项附着于木拱架的超大LED拉索式网屏建造技术。在缺乏木结构与索结构组合作用的变形机理、破坏模式的情形下,通过有针对性的节点设计,对桁架拱和索网... 详细信息

基于中国天府农业博览园主展馆LED拉索式网屏工程,索网上部承载结构为木拱架,形成了一项附着于木拱架的超大LED拉索式网屏建造技术。在缺乏木结构与索结构组合作用的变形机理、破坏模式的情形下,通过有针对性的节点设计,对桁架拱和索网进行整体建模计算,利用施工仿真技术及自动化变形监测技术分析桁架拱及索网结构各阶段的受力及变形,取得在外力作用下桁架拱结构本身变形及索网内力之间的互相影响关系,可实现整体建造过程的安全可控及各工序间的无缝衔接。

关键词：木拱架 LED 拉索式网屏模拟计算

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数字化平台应用下智慧建筑施工成本多方协同管理研究

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建筑技术 2024年第18期55卷 2280-2283页

作者：吴量子东南大学南京210096 金地(集团)股份有限公司广东深圳518026

智慧建筑施工成本管理过程中涉及的主体较多,复杂且过多的成本信息导致协同管理效率低下。针对这一情况,对数字化平台应用下智慧建筑施工成本多方协同管理方法进行了研究。在数字化平台的支持下,从空间和时间两方面构建建筑模型信息,确... 详细信息

智慧建筑施工成本管理过程中涉及的主体较多,复杂且过多的成本信息导致协同管理效率低下。针对这一情况,对数字化平台应用下智慧建筑施工成本多方协同管理方法进行了研究。在数字化平台的支持下,从空间和时间两方面构建建筑模型信息,确定成本管理的最小单元和施工成本协同管理的参与主体。结合所获取的信息设计施工成本多方协同管理机制,以数字化平台作为载体实现施工成本多方协同管理。考虑分叉等情况修正协同管理状态,使其保持稳定的协同管理状态,以此保证管理质量与效率。结果表明,提出的数字化平台应用下的协同管理方法协同效应比较高,多方主体信息交流顺畅,管理效率有显著提高。

关键词：数字化平台智慧建筑施工成本多方协同管理机制建筑信息

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基于斜温层等效容积的大型蓄热罐动态特性分析

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科学技术与工程 2024年第4期24卷 1496-1504页

作者：王子杰陆树银赵梓良顾煜炯华北电力大学能源动力与机械工程学院北京102206 华北电力大学国家火力发电工程技术研究中心北京102206

斜温层蓄热罐可以提高热电联产(combined heat and power,CHP)机组在供热期间的调峰能力,因此逐渐向大型化发展,但设计参数对蓄热罐的性能影响较大,且采用目前的性能评估方法效率较低。为此,建立大型蓄热罐的物理模型及数学模型,研究蓄... 详细信息

斜温层蓄热罐可以提高热电联产(combined heat and power,CHP)机组在供热期间的调峰能力,因此逐渐向大型化发展,但设计参数对蓄热罐的性能影响较大,且采用目前的性能评估方法效率较低。为此,建立大型蓄热罐的物理模型及数学模型,研究蓄热过程中斜温层的形成及变化过程,提出斜温层等效容积的概念,同时分析结构参数及运行参数对斜温层等效容积的影响。结果表明:形成稳定斜温层后,随着蓄热量的增加,斜温层厚度变化不大,采用斜温层等效容积可以更高效的评估蓄热罐的性能。比较不同工况下蓄热罐等效容积的相对变化量可知,不同影响因素对斜温层等效容积的影响从高到低排序依次为布水器布置、蓄热流量、高径比和冷热水温差。研究成果为大型蓄热罐的性能评估提供了一种新参考。

关键词：热电联产(CHP) 斜温层蓄热罐等效容积结构参数运行参数

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