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A compensation circuit for the gain temperature drift of silicon photomultiplier tube

Radiation Detection Technology and Methods 2023年第4期7卷 571-577页

作者： Chang-ge zi Jin-fan Chang Ming-jie Yang Feng-fan Yang Yu-Sheng Wang Institute of High Energy Physics Chinese Academy of SciencesBeijing100049China University of Chinese Academy of Sciences Beijing100049China State Key Laboratory of Particle Detection and Electronics of China Beijing100049China Key Laboratory of Particle Astrophysics&Experimental Physics Division&Computing Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing100049China TIANFU Cosmic Ray Research Center Chengdu610213SichuanChina

Background Silicon photomultiplier tube(SiPM)has been widely applied in high energy physics *** wide field of view Cherenkov telescope array of Large High Altitude Air Shower Observatory(LHAASO)consists of 12 arrays of *** of the array includes 32*32 *** Array of imaging atmospheric Cherenkov Telescopes(LACT),the next generation of particle astrophysics experiment,will also adopt SiPM *** LACT will located at a high altitude,leading to a significant operating temperature variation of the *** the gain of SiPM is temperature-sensitive,in order to keep it stable,compensation for the gain is necessary by adjusting the bias voltage of *** The compensation circuit provides the bias voltage of SiPM by using a high-voltage output Digital-to-Analog Converter and several high-voltage output *** reduce the temperature drift of the gain,the compensation circuit adjust the bias voltage of SiPM according to the operating *** The compensation circuit supplies SiPM with an adjustable bias voltage from 0 to 80 V,and the adjustment step is 1.22 *** the output voltage of the compensation circuit is 64 V,the voltage ripple is 2.59 mV,and the temperature drift is 0.17 mV/℃.In the temperature range from−20 to 30℃,the compensation circuit reduces the gain temperature drift of SiPM to within 2%.

关键词： SiPM Gain Compensation LACT

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A SURVEY OF THE THIRD WFAS WORLD CONFERENCE

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World Journal of Acupuncture-Moxibustion 1993年第4期3卷 52-53,42页

作者： ge zi Secretariat of WFAS

There were about 3000 delegates,from 39countries and regions,attending this confer-ence,held at Kyoto International ConferenceHall, Kyoto,Japan,20-23,Nov.,*** 407 lectures and papers in total,involv-ing therapeutic mechanism,basic theories,meridian and acupoint exploration *** ex-changed in oral presentation,video and *** the symposium,invited lectures

关键词： acupoint meridian Kyoto presentation symposium confer involv attending intro needle

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A new class of HIV-1 inhibitors and the target identification via proteomic profiling

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Science China Chemistry 2018年第11期61卷 1430-1439页

作者： Ying-zi ge Bin Zhou Ruo-Xuan Xiao Xiao-Jing Yuan Hu Zhou Ye-Chun Xu Mark A.Wainberg Ying-Shan Han Jian-Min Yue State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Chinese Academy of Sciences McGill University AIDS Centre Lady Davis Institute for Medical Research Jewish General Hospital

Anti-HIV screening with the MT-4/MTT assay on a focused library of structurally diverse natural products has led to the discovery of a group of steroids with potent activities, which include four new ergostane-type steroids, named amotsterols A-D （1-4）, together with two known analogs. Among them, the most potent amotsterol D （4） exhibited anti-HIV activity against wild- type and some clinically relevant multidrug resistant HIV-I strains. Subsequent studies on its target identification through a proteomic approach found that compound 4 might target PKM2, a rate limiting enzyme ofglycolysis, in host cells to restrict HIV replication. The docking model of compound 4 to PKM2 showed that the two hydroxyl groups of 4 form hydrogen bonds with the two parallel Y390 in each subunit of PKM2 separately, and the ring C of 4 is sandwiched between the two parallel aromatic rings ofF26. The identified hit compound may have the potential to be further developed as a novel anti-HIVagent. These results demonstrated that an integrated approach, which combines new chemical structures and phenotypic screening with a proteomic approach, could not only identify novel HIV-1 inhibitors, but also elucidate the unknown targets of compound interactions in antiviral drug discovery.

关键词： ergostane-type steroids anti-HIV target identification PKM2

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Characterization of human primary chondrocytes of osteoarthritic cartilage at varying severity

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Chinese Medical Journal 2011年第24期000卷 4245-4253页

作者： YIN Jing YANG Zheng CAO Yong-ping ge zi-gang Department of Biomedical Engineering College of EngineeringPeking University Beijing 100871 China Department of Orthopaedic Surgery Yong Loo Lin School ofMedicine NUS Tissue Engineering Program National Universityof Singapore 119260 Singapore Department of Orthopaedics Peking University First Hospital Beijing 100034 China Center for Biomaterials and Tissue Engineering Academy for Advanced Interdisciplinary Studies Peking University Beijing 100871 China

Background There is a difficulty in evaluating the in heterogeneity among cartilage affected by osteoarthritis vivo functionality of individual chondrocytes, and there is much （OA）. In this study, in vitro cultured chondrocytes harvested from varying stages of degeneration were studied as a projective model to further understand the pathogenesis of osteoarthritis. Methods Cartilage of varying degeneration of end-stage OA was harvested, while cell yield and matrix glycosaminoglycan （GAG） content were measured. Cell morphology, proliferation, and gene expression of collagen type 1,‘11, and X, aggrecan, matrix metalloproteinase 13 （MMP-13）, and ADAMTS5 of the acquired chondrocytes were measured during subsequent in vitro culture. Results Both the number of cells and the GAG content increased with increasing severity of OA. Cell spreading area increased and gradually showed spindle-like morphology during in vitro culture. gene expression of collagen type II, collagen type X as well as GAG decreased with severity of cartilage degeneration, while expression of collagen type I increased. Expression of MMP-13 increased with severity of cartilage degeneration, while expression of ADAMTS-5 remained stable. Expression of collagen type II, X, GAG, and MMP-13 substantially decreased with in vitro culture. Expression of collagen type I increased with in vitro cultures, while expression of ADAMTS 5 remained stable. Conclusions Expression of functional genes such as collagen type Ⅱ and GAG decreased during severe degeneration of OA cartilage and in vitro dedifferentiation. gene expression of collagen I and MMP-13 increased with severity of cartilage degeneration.

关键词： osteoarthritis chondroeyte differentiation

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THE COMPARISON OF THE EFFECT BETWEEN THE ORIGINAL AND ELECTRICAL ACUPUNCTURE ON SOME CYTOCHEMICALCOMPONENTS OF MEDIAN EMINENTIA AND SUPRAOPTIC NUCLEUS

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针刺研究 1989年第Z1期 107-108页

作者： ge zi Wang ziying Jia Lin Institute of Acupuncture and Moxibustion, China Academy of TCM

The effects of original and clectroacupuncture (OA, EA) upon hypothalamo pituitarysystem was made for providing the theoratical basis in further wideapplication of acupuncture treatment. 246 healthy, adult and male rats were selected in this experiments. Itwas divided into OA, EA and control at random. The painthreshold were me-asured 30 minutes after both kinds of acupuncture, they were elevated signifi-cantly than that of the control.

关键词： THE COMPARISON OF THE EFFECT BETWEEN THE ORIGINAL AND ELECTRICAL ACUPUNCTURE ON SOME CYTOCHEMICALCOMPONENTS OF MEDIAN EMINENTIA AND SUPRAOPTIC NUCLEUS OA than

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Anthropogenic influence on the extreme drought in eastern China in 2022 and its future risk

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Atmospheric and Oceanic Science Letters 2024年第1期17卷 21-27页

作者： Yinjun Zhang Lin Chen Yuqing Li zi-an ge Key Laboratory of Meteorological Disaster Ministry of Education(KLME)/Joint International Research Laboratory of Climate and Environmental Change(ILCEC)/Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters(CIC-FEMD)Nanjing University of Information Science and TechnologyNanjingChina

2022年夏季中国东部地区遭遇了一次持续性极端高温干旱事件.本文利用CMIP6检测归因比较计划(DAMIP)数据,量化了人为强迫对类2022年极端干旱事件发生概率的影响,并基于未来不同增暖情景试验给出了此类极端干旱事件的未来变化预估.通过分... 详细信息

2022年夏季中国东部地区遭遇了一次持续性极端高温干旱事件.本文利用CMIP6检测归因比较计划(DAMIP)数据,量化了人为强迫对类2022年极端干旱事件发生概率的影响,并基于未来不同增暖情景试验给出了此类极端干旱事件的未来变化预估.通过分析不同外强迫因子作用下此类极端干旱事件的发生概率变化,发现人为强迫使此类极端干旱事件的发生概率提高约56%,这主要与人为强迫下中国东部平均水汽减少和平均上升运动减弱有关.进一步通过分析此类极端干旱事件对不同温室气体排放情景(SSP1-2.6,SSP2-4.5,SSP5-8.5)的响应,发现在低排放情景下类2022年极端干旱事件的发生概率较当今气候显著下降,这主要与中国东部平均水汽的增加和平均环流的变化有关,而在高排放情景(SSP5-8.5)下,此类极端干旱事件的发生概率较当今气候增加约79%,这主要与高排放情景下平均下沉运动增强有关.该研究表明,人为强迫通过调制气候平均背景场从而引起极端事件发生频次的变化是人类活动影响极端气候事件的重要途径之一,极端干旱事件对温室气体排放量的响应可能是非线性的.

关键词：极端干旱中国东部归因分析人为强迫未来预估

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风积沙特性及筑路施工应用

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辽宁工程技术大学学报（自然科学版） 2005年第3期24卷 372-374页

作者：葛新葛自强杨威阜新市公路工程质量监督站辽宁阜新123000 阜新市高级路面工程处辽宁阜新123000 新民市勘察设计院辽宁新民110300

论述了风积砂的化学特性和工程特性,通过对风积沙物理化学特性及工程特性的实验研究和分析,风积砂作为盐渍土翻浆和无砂石等地区的路基是一种良好筑路材料。并且用大量试验数据全面阐述风积沙基层的施工工艺及病害处理,只要充分认识和... 详细信息

论述了风积砂的化学特性和工程特性,通过对风积沙物理化学特性及工程特性的实验研究和分析,风积砂作为盐渍土翻浆和无砂石等地区的路基是一种良好筑路材料。并且用大量试验数据全面阐述风积沙基层的施工工艺及病害处理,只要充分认识和利用风积沙的各种特性,采取有效的加固和压实等技术,就能发挥其经济和社会效益。

关键词：风积沙振动压实弹性模量参数E值

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Possible aerosol transmission of COVID-19 and special precautions in dentistry

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2020年第5期21卷 361-368页

作者： zi-yu ge Lu-ming YANG Jia-jia XIA Xiao-hui FU Yan-zhen ZHANG Department of general Dentistry the Second Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310009China

Since its emergence in December 2019,corona virus disease 2019(COVID-19)has impacted several countries,affecting more than 90 thousand patients and making it a global public *** routes of transmission are direct contact,and droplet and possible aerosol *** to the unique nature of dentistry,most dental procedures generate significant amounts of droplets and aerosols,posing potential risks of infection *** the significance of aerosol transmission and its implications in dentistry can facilitate the identification and correction of negligence in daily dental *** addition to the standard precautions,some special precautions that should be implemented during an outbreak have been raised in this review.

关键词： Corona virus disease 2019(COVID-19) Aerosol Infection control

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量子模拟器中规范理论的热化动力学

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科学通报 2022年第25期67卷 2971-2973页

作者：葛自勇范桁 RIKEN Cluster for Pioneering Research Wako-shiSaitama 351-0198Japan 中国科学院物理研究所北京100190

规范理论是现代物理学中描述基本粒子相互作用的基本语言,是标准模型等理论的基石,也和量子叠加、量子纠缠概念密切相关.人们熟知时空对称性,例如在比萨斜塔做质量不等物体的自由落体实验,与在不同时间不同地点做类似实验所得到的结论... 详细信息

规范理论是现代物理学中描述基本粒子相互作用的基本语言,是标准模型等理论的基石,也和量子叠加、量子纠缠概念密切相关.人们熟知时空对称性,例如在比萨斜塔做质量不等物体的自由落体实验,与在不同时间不同地点做类似实验所得到的结论会完全相同.

关键词：现代物理学时空对称性比萨斜塔量子纠缠标准模型动力学基本粒子规范理论

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Integrated emergency department and general intensive care unit management on health outcomes

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Chinese Medical Journal 2021年第21期134卷 2553-2555页

作者： Shan-Lin Mao zi ge Hui Zhao Yan-Xue Wang Jun Cao Zhi-Jie Xia Emergency and Acute Critical Care Department Huashan Hospital NorthFudan UniversityShanghai 201907China

The emergency department(ED)should reliably provide the required medical treatment to patients who are in an emergency or are critically ***,the ED faced two challenges in China.

关键词： China department critically

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