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Rare Metals 2024年第5期43卷 2230-2240页

作者： Ping Zhao Hai-Fa Zheng Ju Peng Xing-long Li Fazal Raziq Xiao-Jun Liu Hao-Quan Yu Jin-Lu tang Yi-Fan Kang Wen-Huan Huang School of Chemistry and Chemical Engineering Guangdong Pharmaceutical UniversityGuangzhou 510006China KAUST Catalysis Center King Abdullah University of Science and Technology23955-6900 ThuwalKingdom of Saudi Arabia Key Laboratory of Chemical Additives for China National Light Industry College of Chemistry and Chemical EngineeringShaanxi University of Science and TechnologyXi'an 710021China

Although chemotherapy has been intensively applied in cancer treatments,its inadequate therapeutic efficacy and severe side effects are still under constant *** used as anti-tumor drug delivery system(DDS)have attracted tremendous attentions owing to their various intriguing ***,Mn-doped MoO_(2)nanoparticles coated with ZrO_(2)and capped with Bi_(2)O_(3)have been designed as a DDS,namely *** possesses good magnetic properties,great photothermal conversion ability,sensitive tumor microenvironment(TME)responsiveness,and good biocompatibility in hemocompatibility in ***,MMZB has been utilized to load the chemotherapeutic agent daunomycin(DNM)(MMZB@DNM)for chemo-photothermal combined ***@DNM demonstrates a more impressive anti-cancer effect than the individual photothermal or chemotherapy both in vitro and in ***,the analysis of tumor specimen sections and serum levels after the treatment indicates negligible side effects for MMZB@DNM in *** contribution provides a valuable concept in designing therapeutic agents for achieving significantly enhanced tumor treatments,which benefits from the synergistic combination of chemotherapy and photothermal therapy in one single nanoagent.

关键词： Mn-doped MoO_(2) Bi_(2)O_(3) Nanocarrier Photothermal Chemotherapy

Single-atom sites regulation by the second-shell doping for efficient electrochemical CO_(2)reduction

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Chinese Chemical Letters 2024年第9期35卷 360-363页

作者： Qian-Qian tang Li-Fang Feng Zhi-Peng Li Shi-Hao Wu long-Shuai Zhang Qing Sun Mei-Feng Wu Jian-Ping Zou Key Laboratory of Jiangxi Province for Persistent Pollutants Control and Resources Recycle Nanchang Hangkong UniversityNanchang 330063China National-Local Joint Engineering Research Center of Heavy Metals Pollutants Control and Resource Utilization Nanchang Hangkong UniversityNanchang 330063China

Nitrogen-doped carbon loaded single-atom catalysts(SACs)are promising candidates for electrocatalytic conversion of CO_(2)into high-valuable chemicals,and the modification of catalysts by heteroatom-doping strategy is an effective approach to enhance the CO_(2)reduction ***,the large difference exists in atomic radius between nitrogen atoms and the doped heteroatoms may lead to the poor stability of active *** this study,we have synthesized a Ni single atom catalyst with S doping at the secondshell on the ultrathin carbon nanosheets support(Ni-N_(4)-SC)by solid-phase *** S atom in the second-shell contributes to the higher efficiency of CO_(2)conversion at lower potentials while the Ni-N_(4)-SC can be more *** experimental results and theoretical calculations indicate that the S atom in second-shell breaks the uniform charge distribution and reduces the free energy of hydrogenation,which can increase the adsorption of CO_(2),accelerate charge transfer,and reduce the reaction energy *** work reveals the close relationship between the second-shell and the electrocatalytic activity of single atom sites,which also provides a new perspective to design efficient single atom catalysts.

关键词： Single-atom catalyst Heteroatom-doping Second shell CO_(2)electroreduction Electronic structure regulation

Protein tyrosine phosphatase non-receptor Ⅱ:A possible biomarker of poor prognosis and mediator of immune evasion in hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2024年第9期16卷 3913-3931页

作者： Hui-Yuan Li Yi-Ming Jing Xue Shen Ming-Yue tang Hong-Hong Shen Xin-Wei Li zi-Shu Wang Fang Su Department of Medical Oncology The First Affiliated Hospital of Bengbu Medical UniversityBengbu 233000Anhui ProvinceChina Department of Neurology The First Affiliated Hospital of Bengbu Medical UniversityBengbu 233000Anhui ProvinceChina

BACKGROUND The incidence of primary liver cancer is increasing year by *** 2022 alone,more than 900000 people were diagnosed with liver cancer worldwide,with hepatocellular carcinoma(HCC)accounting for 75%-85%of *** is the most common primary liver *** has the highest incidence and mortality rate of HCC in the world,and it is one of the malignant tumors that seriously threaten the health of Chinese *** onset of liver cancer is occult,the early cases lack typical clinical symptoms,and most of the patients are already in the middle and late stage when ***,it is very important to find new markers for the early detection and diagnosis of liver cancer,improve the therapeutic effect,and improve the prognosis of *** tyrosine phosphatase non-receptor 2(PTPN2)has been shown to be associated with colorectal cancer,triple-negative breast cancer,non-small cell lung cancer,and prostate cancer,but its biological role and function in tumors remain to be further *** To combine the results of relevant data obtained from The Cancer Genome Atlas(TCGA)to provide the first in-depth analysis of the biological role of PTPN2 in *** The expression of PTPN2 in HCC was first analyzed based on the TCGA database,and the findings were then verified by immunohistochemical staining,quantitative real-time polymerase chain reaction(qRT-PCR),and *** value of PTPN2 in predicting the survival of patients with HCC was assessed by analyzing the relationship between PTPN2 expression in HCC tissues and clinicopathological ***,the potential of PTPN2 affecting immune escape of liver cancer was evaluated by tumor immune dysfunction and exclusion and immunohistochemical *** The results of immunohistochemical staining,qRT-PCR,and immunoblotting in combination with TCGA database analysis showed that PTPN2 was highly expressed and associated with a poor prognosis in HCC *** Encyclopedia of Ge

关键词： Protein tyrosine phosphatase non-receptor 2 Hepatocellular carcinoma Immune evasion Biomarker Immunotherapy Prognosis

Comparative Evaluation of Antitumor Chinese Patent Medicine Injections Based on Evidence-Based Medicine and Markov Model

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World Journal of Traditional Chinese Medicine 2024年第2期10卷 220-229页

作者： Jing Yang Yan-Peng Wang Wen-Gong Yu Yu-Yao Guan Prince Emmanuel Opoku Amponsah Xian-Shuai tang Ying-zi Sun Lei Zheng School of Medicine and Pharmacy Ocean University of ChinaQingdaoChina Department of Pharmacy Shandong Medical CollegeJinanChina Department of Pharmacy Cheeloo College of MedicineShandong Provincial Third HospitalShandong UniversityJinanChina Biomedical Engineering Graduate School University of ArizonaTucsonAZUSA

Objective: The objective of this study was to explore the safety, efficacy, economy, and other aspects of frequently-used antitumor Chinese patent medicine injections through a comprehensive evaluation of evidence-based medical research to provide scientific information and decision-making basis for drug selection, rational drug use, public awareness of safe drug use, and medical insurance. Materials and Methods: The names of five frequently used antitumor Chinese patent medicine injections were used as search terms, including the compound Sophora flavescens injection, Kangai injection, Aidi injection, Kanglaite injection, and Brucea javanica oil emulsion injection. Relevant evidence-based medical research was extracted from the databases. A descriptive evaluation was conducted, and the Markov model was used for the cost-benefit analysis. Finally, the above injections are ranked by comprehensive scores using the multi-criteria decision analysis and Delphi method. Results: The five injections had their own advantages in enhancing the effectiveness of anti-tumor treatments, improving the quality of life for cancer patients, and reducing the incidence of adverse reactions. From the perspective of economy and other attributes, compound S. flavescens was superior to B. javanica oil, Aidi, Kangai, and Kanglaite. After a comprehensive evaluation of the above five injections, the compound S. flavescens injection received the highest score. Conclusions: Compound S. flavescens, Kangai, Aidi, B. javanica oil, and Kanglaite have their own advantages in effectiveness and no significant difference in safety. Compound S. flavescens injection has the highest comprehensive score. Clinical attention should be paid to monitoring the initial stage of medication and special groups.

关键词： Anti-tumor Chinese patent medicine comprehensive evaluation medication safety pharmacoeconomics rational drug use

Characteristic Analysis of Power Oscillations Caused by Disharmony Among Voltage-source-controlled Units in Three-terminal Local Power Grid

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Journal of Modern Power Systems and Clean Energy 2024年第4期12卷 1295-1308页

作者： Qiyi Yu Yi tang School of Electrical Engineering Southeast UniversityNanjing 210018China

Previous studies have demonstrated that disharmo-ny among voltage-source-controlled units(VSCUs)may occur on an alternating current(AC)transmission or distribution line under steady-state operating conditions(SSOCs)or quasi-static operating conditions(QSSOCs).As the studies on frequency dis-harmony have been expanded to multiple disharmonized vS-CUs in the local power grid,its adverse effects on AC lines and equivalent load(EL)at the bus without active voltage control ability(non-active bus)need to be investigated ***-ering the locality of disharmony and common topological con-nections among VSCUs,this paper adopts a Y-type three-termi-nal local power grid(LPG)as the research *** dishar-mony among the three VSCUs is ***,for the load at non-active bus,the formulas for single-phase instantaneous voltage,load current,load power,as well as average power un-der disharmony operating conditions(DOCs)are *** characteristic indicators of the above electrical quantities are defined,which can measure the amplification and reduction de-grees of the above electrical quantities before and after ***,for the line directly connected to VSCUs,the formulas for single-phase instantaneous line current and power and the average power under DOCs are *** character-istic indicators of power flow are defined,which can be used to quantify the peak amplification impact of oscillation before and after ***,the case study on the Y-type three-terminal LPG under the single-disharmony and the multi-dis-harmony switching scenarios indicates that the long-period pow-er oscillation caused by disharmony may occur in the load flow at the non-active bus and the line *** oscillation causes a serious decrease in load capability and a significant amplifica-tion of the peak of line power oscillation.

关键词： New power system power oscillation disharmony voltage-source-controlled unit(VSCU) characteristic analysis

Hybrid pseudocapacitance/co-intercalation mechanisms of TiO2/graphite anodes for rapid sodium-ion storage

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Rare Metals 2024年第10期43卷 5427-5434页

作者： Ze-Rui Yan Da-Fu tang Bin-Hao Wang Xiao-Juan Huang Xia Zou Si-Cheng Fan Yan Wu Tong Shu Qiu-long Wei Department of Materials Science and Engineering College of MaterialsFujian Key Laboratory of Surface and Interface Engineering for High Performance MaterialsXiamen University

Developing anode materials with high specific/volumetric capacities,high-rate capability,long-term cycles and low cost is significant for advanced sodium-ion ***,we report the hybrid TiO2/graphite （TiO2/G） anodes for fast （dis）charging sodium-ion *** advantage of the rapid pseudocapacitive surface-redox on anatase TiO2nanoparticles （NPs） and fast[Na（diglyme）x]+co-intercalation into graphite,the hybrid anodes display excellent rate ***,the TiO2NPs are able to fill into the interspaces among graphite flakes and the graphite provides continuous electron pathways,which largely boosts the volumetric capacities and rate *** from the synergistic effects,

关键词： Titanium dioxide

Performance of water-coupled charge blasting under different in-situ stresses

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Journal of Central South University 2024年第7期31卷 2300-2320页

作者： ZHOU zi-long WANG Zhen CHENG Rui-shan CAI Xin LAN Ri-yan School of Resources and Safety Engineering Central South UniversityChangsha 410083China Center for Infrastructural Monitoring and Protection School of Civil and Mechanical EngineeringCurtin UniversityBentleyAustralia Guangxi Xinfazhan Communication Group Co. Ltd.Nanning 530000China

Water-coupled charge blasting is a promising technique to efficiently break rock *** this study,numerical models of double boreholes with water-coupled charge are established using LS-DYNA and are calibrated by the tests of rock masses subjected to explosion loads to examine its *** crack levels of rock mass induced by water-coupled charge blasting and air-coupled charge blasting are first *** is found that water-coupled charge blasting is more appropriate to fracture deep rock mass than air-coupled charge *** addition,the effects of rock properties,water-coupled charge coefficients,and borehole connection angles on the performance of water-coupled charge blasting are *** results show that rock properties and water-coupled charge coefficients can greatly influence the crack and fragmentation levels of rock mass induced by water-coupled charge blasting under uniform and non-uniform in-situ ***,changing borehole-connection angles can only affect crack and fragmentation levels of rock mass under non-uniform in-situ stresses but barely affect those under uniform in-situ stresses.A formula is finally proposed by considering the above-mentioned factors to provide the design suggestion of water-coupled charge blasting to fracture rock mass with different in-situ stresses.

关键词： water-coupled blasting in-situ stress water-coupled charge coefficient rock type borehole-connection angle

Coupling N-doping and confined Co_(3)O_(4) on carbon nanotubes by polydopamine coating strategy for pleiotropic water purification

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Rare Metals 2024年第7期43卷 3146-3160页

作者： Wen-long Tu Gang Wang Yue Zhang Hong-Yang Zhu Rong-Rong Du Hong-Yao Zhao Sheng tang Zeng-Jing Guo Jun Yang Fu Yang Cheng-Zhang Zhu School of Environmental and Chemical Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China School of Chemistry and Chemical Engineering Liaocheng UniversityLiaocheng 252000China School of Material Science and Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China School of Environmental Science and Engineering Nanjing Tech UniversityNanjing 211816China

The development of effective and sustainable solutions for pleiotropic water purification becomes urgent and *** Fenton-like catalysts for activation of peroxymonosulfate(PMS)to purify organic wastewater show great *** this work,by tuning metal loading with an in-situ polydopamine coating strategy,oxygen vacancy-enriched Co_(3)O_(4) loading on N-doped carbon nanotubes(CNTs)were constructed to enhance PMS activation efficiency for pollutants ***,the obtained modified CNTs afford a well-developed N-containing network structure,which is further endowed with abundant Co(Ⅱ)/Co(Ⅲ)redox cycles and significant metal-carbon *** particular,the surface N doping in CNTs might induce the oriented enrichment of pollutants around the catalyst,which reduces the migration distance and correspondingly improves the utilization of reactive oxidative *** electron transfer efficiency of the catalyst can be further improved by incorporating oxygen vacancy-enriched Co_(3)O_(4).The performance results show that the optimal NC/Co-1 could mineralize 20×10^(-6)of bisphenol A(BPA)by almost 98%in 8 min.A low reaction activation energy(26.05 kJ·mol^(-1))in BPA degradation was demonstrated by the NC/*** importantly,NC/Co-1 can inherit excellent degradation performance towards oxytetracycline,2,4-dichlorophenol,and tetracycline,showing wide practical *** addition,by virtue of the photothermal conversion property,NC/Co-1 achieves an additive function for interfacial solar water evaporation(1.84 kg·m^(-2)·h^(-1),112.51%),showing impressive potential for clean water recovery under complicated environmental pollution conditions.

关键词： Carbon nanotube Advanced oxidation process Co_(3)O_(4) Photothermal conversion Solar water evaporation

Transition-Metal-Free Allylic Defluorination Cross-Electrophile Coupling Employing Rongalite

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Chinese Journal of Chemistry 2024年第12期42卷 1360-1366页

作者： Xiang-long Chen Chun-Yan Wu Dong-Sheng Yang Bo-Cheng tang Huai-Yu Wang Zhi-Cheng Yu Anling Li Yan-Dong Wu An-Xin Wu National Key Laboratory of Green Pesticide International Joint Research Center for Intelligent Biosensor Technology and HealthCollege of ChemistryCentral China Normal UniversityWuhanHubei 430079China state Key Laboratory of Chemical Biology and Drug Discovery Department of Applied Biology and Chemical Technology The HongKong Polytechnic UniversityKowloonHong Kong SARChina Department of Clinical Laboratory Center for Gene Diagnosisand Program of Clinical Laboratory MedicineZhongnan Hospital of Wuhan UniversityWuhanHubei 430062China

Comprehensive Summary The conversion of CF3-alkenes to gem-difluoroalkenes using reductive cross-coupling strategy has received much attention in recent years,however,the use of green and readily available reducing salt to mediate these reactions remains to be *** this work,a concise construction of gem-difluoroalkenes,which requires neither a catalyst nor a metal reducing agent,was ***,a safe and inexpensive industrial product,was employed as both a radical initiator and *** procedure was compatible with both linear and cyclic diaryliodonium salts,enabling a wide variety of substrates(>70 examples).The utility of this approach was demonstrated through gram-scale synthesis and efficient late-stage functionalizations of anti-inflammatory drugs.

关键词： Defluoroarylation Transition metal free gem-Difluoroalkenes Rongalite Single electron transfer C-C coupling Redox reactions Cross-coupling