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Combination of Chinese and Western Medicine to Prevent and Reverse Resistance of Cancer Cells to Anticancer Drugs

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Chinese Journal of Integrative Medicine 2020年第4期26卷 251-255页

作者： sui Xin-bing XIE Tian Holistic Integrative Pharmacy Institutes and Comprehensive Cancer Diagnosis and Treatment Center the Affiliated Hospital of Hangzhou Normal UniversityCollege of MedicineHangzhou Normal UniversityHangzhou(311121)China Key Laboratory of Elemene Class Anti-cancer Chinese Medicine of Zhejiang Province and Engineering Laboratory of Development and Application of Traditional Chinese Medicine from Zhejiang Province Hangzhou Normal UniversityHangzhou(311121)China

Resista nee to anticancer drugs is a major problem in on cology,which causes the failure of an titumor treatme nt.A variety of factors con tribute to drug resistance,in eluding drug efflux and metabolism,tumor cell heteroge neity,tumor microenvironment stress-induced genetic or epigenetic alterations in the cancer cells and so ***,how to circumvent this resista nee to improve antican cer efficacy remains to be *** circumvent chemotherapeutic resista nee,many reversal agents have been developed,but most of them fail in clinical trials due to severe adverse ***,several natural products have been reported to augme nt sen sitivity or overcome resista nee of an ticancer chemotherapeutic drugs,including elemene,curcumin,Shenqi Fuzheng Injection(参芪扶正注射液),PHY906,***,understand!ng the novel function of Chinese medicine may allow us to develop a promising therapeutic approach to enhance the effects of anticancer strategies and preve nt or overcome their resista nee in the treatment of can cer patie nts.

关键词： Chinese medicine Western medicine integrative Chinese and Western medicine resistance an tica ncer drugs

Effect of the ginsenoside Rb1 on the spontaneous contraction of intestinal smooth muscle in mice

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World Journal of Gastroenterology 2012年第38期18卷 5462-5469页

作者： Lei Xu sui-Ping Huang Scientific Research Station for Post-doctoral Studies Post-doctoral Research Centre Zhongshan Affiliated HospitalGuangzhou University of Traditional Chinese Medicine Zhong-shah 528400 Guangdong Province China Department of Gastroenterology GuangdongProvincial Traditional Chinese Medicine Hospital Ersha IslandBranch Guangzhou 510405 Guangdong Province China

AIM: To investigate the effect and the possible mechanism of ginsenoside Rb1 on small intestinal smooth muscle motility in mice. METHODS: Intestinal smooth muscle strips were isolated from male ICR mice (5 wk old), and the effect of ginsenoside Rb1 on spontaneous contraction was recorded with an electrophysiolograph. The effect of ginsenoside Rb1 on ion channel currents, including the voltage-gated K + channel current (IK V ), calcium-activated potassium channel currents (IK Ca ), spontaneous transient outward currents and ATP-sensitive potassium channel current (IK ATP ), was recorded on freshly isolated single cells using the whole-cell patch clamp technique. RESULTS: Ginsenoside Rb1 dose-dependently inhibited the spontaneous contraction of intestinal smooth muscle by 21.15% ± 3.31%, 42.03% ± 8.23% and 67.23% ± 5.63% at concentrations of 25 μmol/L, 50 μmol/L and 100 μmol/L, respectively (n=5,P<0.05). The inhibitory effect of ginsenoside Rb1 on spontaneous contraction was significantly but incompletely blocked by 10 mmol/L tetraethylammonium or 0.5 mmol/L 4-aminopyridine, respectively (n=5, P<0.05). However, the inhibitory effect of ginsenoside Rb1 on spontaneous contraction was not affected by 10 μmol/L glibenclamide or 0.4 μmol/L tetrodotoxin. At the cell level, ginsenoside Rb1 increased outward potassium currents, and IK V was enhanced from 1137.71 ± 171.62 pA to 1449.73 ± 162.39 pA by 50 μmol/L Rb1 at +60 mV (n=6, P<0.05). Ginsenoside Rb1 increased IK Ca and enhanced the amplitudes of spontaneous transient outward currents from 582.77 ± 179.09 mV to 788.12 ± 278.34 mV (n=5, P<0.05). However, ginsenoside Rb1 (50 μmol/L) had no significant effect on IK ATP (n=3, P<0.05). CONCLUSION: These results suggest that ginsenoside Rb1 has an inhibitory effect on the spontaneous contraction of mouse intestinal smooth muscle mediated by the activation of IK V and IK Ca , but the K ATP channel was not involved in this effect.

关键词： Ginsenoside Rb1 Intestinal smooth muscle Intestinal smooth muscle cell Potassium channel Spontaneous contraction Whole-cell patch clamp technique

A survey of weak stability boundaries in the Sun-Mars system

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Research in Astronomy and Astrophysics 2015年第3期15卷 376-392页

作者： Jian Li Yi-sui Sun School of Astronomy and Space Science & Key Laboratory of Modern Astronomy and Astrophysics in Ministry of Education Nanjing University

We investigate the weak stability boundary （WSB） for a new primary, Mars, in the framework of the planar circular restricted 3-body problem, and also in the pla- nar bicircular restricted 4-body problem by including a perturbation due to Jupiter. For the sake of a simple stability/instability criterion, our computations have been done us- ing the equations of motion in polar coordinates. It is found that the relative size of the weakly stable sets around Mars is much larger than that of the Earth-Moon and the Sun-Jupiter systems, as the mass ratio of the Sun-Mars system is significantly smaller. We propose that this difference could be scaled by the Hill radius. In an enlarged view of the domain close to Mars, the geometry of the WSB has been presented for various parameters and compared to previous works. Our results also show that Jupiter＇s grav- itational force would strongly affect the Martian stable regions and should be taken into account to design a ballistic capture trajectory.

关键词： celestial mechanics

Indelible Rules of Josephson Coupling Energy and Zero-Point Energy in High-Tc Cuprates

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Communications in Theoretical Physics 2004年第4期41卷 629-631页

作者： LIUFu-sui CHENWan-Fang DepartmentofPhysics PekingUniversityBeijing100871China CCAST（WorldLaboratory） P.O.Box8730Beijing100080China

This paper shows that the Josephson coupling energy and the zero-point energy have indelible rules on the superfluid density and the superconductivity in the high-Tc cuprates. This paper also shows that the values of Tc at underdoped and overdoped regions are determined by the damage conditions of the phase coherence in the classical and the quantum XY-models, respectively.

关键词： high-T-c cuprates superfluid density Josephson coupling zero-point energy

Trace Class Toeplitz Operators with Unbounded Symbols on Weighted Bergman Spaces

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Acta Mathematica Sinica,English Series 2010年第8期26卷 1567-1574页

作者： sui HUANG Guang Fu CAO Departement of Mathematics Guangzhou University Guangzhou 510006 P. R. China

In this note we construct a function φ in L2（Bn,dμ） which is unbounded on any neighborhood of each boundary point of Bn such that Tφ is a trace class operator on weighted Bergman space Lα2（Bn,dμ） for several ... 详细信息

关键词： Toeplitz operator unbounded function compact operator

Using the resource-environment-economy coordination degree model to guide China's national blue bay remediation action plan in Qingdao

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Journal of Oceanology and Limnology 2020年第6期38卷 1846-1857页

作者： sui Xiaotong WANG Xiaohua ZHAO Lingdi School of Economics Ocean University of ChinaQingdao 266000China Marine Development Studies Institute of OUC Key Research Institute of Humanities and Social Sciences at UniversitiesMinistry of EducationQingdao 266000China Sino-Australian Research Centre for Coastal Management UNSW CanberraBC 2610Australia

The China National Blue Bay Remediation Action Plan(NBBRAP)is a crucial step towards achieving the overall goal of building a maritime power and a beautiful *** paper presents the resource-environment-economy(REE)composite system from the three-dimensional perspective of ***,through the coordination degree model of the composite system based on the order degree of subsystems,empirical analysis of the coordination degree of the REE composite system in a typical coastal city Qingdao from 2005 to 2016 was carried *** indicate that the degree of coordination and interactive coordination of the REE composite system in Qingdao were in a low-quality ***'s economy development depended largely on the expense of over-exploitation of resources and environmental degradation in *** policy implementation was less persistent in 2009-2010 and *** immediate stimulating effect was significant,making the coordination degree of the REE composite system fluctuate in a volatile *** of the coordination degree of the REE composite system has practical guiding significance for the successful implementation attainment of the NBBRAP target in Qingdao and is conducive to deepening the learning and promotion of this plan in other coastal cities.

关键词： China National Blue Bay Remediation Action Plan resource-environment-economy coordination

Numerical simulation of a horizontal sedimentation tank considering sludge recirculation

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Journal of Environmental Sciences 2010年第10期22卷 1534-1538页

作者： Wei Zhang Zhihong Zou Jun sui School of Economics and Management BeiHang University Beijing 100191 China. Guangzhou Municipal Engineering Design & Research Institute Guangzhou 510060 China

Most research conducted on the concentration distribution of sediment in the sedimentation tank does not consider the role of the suction dredge. To analyze concentration distribution more accurately, a suspended sediment transportation model was constructed and the velocity field in the sedimentation tank was determined based on the influence of the suction dredge. An application model was then used to analyze the concentration distribution in the sedimentation tank when the suction dredge was fixed, with results showing that distribution was in accordance with theoretical analysis. The simulated value of the outlet concentration was similar to the experimental value, and the trends of the isoconcentration distribution curves, as well as the vertical distribution curves of the five monitoring sections acquired through simulations, were almost the same as curves acquired through experimentation. The differences between the simulated values and the experimental values were significant.

关键词： concentration and isoconcentration distribution suspended sediment transportation model velocity field verticaldistribution.

Study of hydro-mechanical behaviours of rough rock fracture with shear dilatancy and asperities using shear-flow model

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第10期16卷 4004-4016页

作者： Luyu Wang Weizhong Chen Qun sui Department of Civil and Environmental Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina Institute of Rock and Soil Mechanics Chinese Academy of SciencesWuhan430071China Changjiang Design Group Co. Ltd.Wuhan430010China

The geometric properties of fracture surfaces significantly influence shear-seepage in rock fractures,introducing complexities to fracture *** present study focuses on the hydro-mechanical behaviours of rough rock fractures during shear-seepage processes to reveal how dilatancy and fracture asperities affect these *** achieve this,an improved shear-flow model(SFM)is proposed with the incorporation of dilatancy effect and *** particular,shear dilatancy is accounted for in both the elastic and plastic stages,in contrast to some existing models that only consider it in the elastic *** on the computation approaches for the peak dilatancy angle,three different versions of the SFM are derived based on Mohr-Coulomb,joint roughness coefficient-joint compressive strength(JRC-JCS),and Grasselli’s ***,this is a new attempt that utilizes Grasselli’s model in shearseepage *** advanced parameter optimization method is introduced to accurately determine model parameters,addressing the issue of local optima inherent in some conventional ***,model performance is evaluated against existing experimental *** findings demonstrate that the SFM effectively reproduces the shear-seepage characteristics of rock fracture across a wide range of stress *** sensitivity analysis reveals how dilatancy and asperity affect hydraulic *** relation between hydro-mechanical properties(dilatancy displacement and hydraulic conductivity)and asperity parameters is *** profound understandings of the shear-seepage process are obtained by exploring the phenomenon under various conditions.

关键词： Rock fracture Stress-seepage coupling Shear-flow model Fracture asperity Shear dilatancy

An Observational Analysis of the Oceanic and Atmospheric Structure of Global-Scale Multi-decadal Variability

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Advances in Atmospheric Sciences 2014年第2期31卷 316-330页

作者： Peng LIU Chung-Hsiung sui Key Laboratory of Meteorological Disaster of Ministry of Education Nanjing University of Information Science & Technology Department of Atmospheric Sciences NTU Taipei 10617

The aim of the present study was to identify multi-decadal variability （MDV） relative to the current centennial global warming trend in available observation *** centennial global wanning trend was first identified in the global mean surface temperature （STgm） *** MDV was identified based on three sets of climate variables,including sea surface temperature （SST）,ocean temperature from the surface to 700 m,and the NCEP and ERA40 reanalysis datasets,*** variables were detrended and low-pass *** three independent EOF analyses of the filtered variables,all results consistently showed two dominant modes,with their respective temporal variability resembling the Pacific Decadal Oscillation/Inter-decadal Pacific Oscillation （PDO/IPO） and the Atlantic Multi-decadal Oscillation （AMO）.The spatial structure of the PDO-like oscillation is characterized by an ENSO-like structure and hemispheric symmetric *** structure associated with the AMO-like oscillation exhibits hemispheric asymmetric features with anomalous warm air over Eurasia and warm SST in the Atlantic and Pacific basin north of 10°S,and cold SST over the southern *** Pacific and Atlantic MDV in upper-ocean temperature suggest that they are mutually *** also found that the PDO-like and AMO-like oscillations are almost equally important in global-scale MDV by EOF *** the period 1975-2005,the evolution of the two oscillations has given rise to strong temperature trends and has contributed almost half of the STgm ***,in the next decade,the two oscillations are expected to slow down the global warming trends.

关键词： global-scale multi-decadal variation global mean surface temperature PDO-like oscillation AMO-like oscillation