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A breathing A4 paper by in situ growth of green metal-organic frameworks for air freshening and cleaning

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Chinese Journal of Chemical Engineering 2022年第12期52卷 95-102页

作者： Bo Zhang Hongwen Chen Liming Jiang Youqing Shen Dan Zhao zhuxian zhou Key Laboratory of Biomass Chemical Engineering of Ministry of Education and Zhejiang Key Laboratory of Smart Biomaterials College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310027China Department of Polymer Science and Engineering Zhejiang UniversityHangzhou 310027China Department of Chemical&Biomolecular Engineering National University of Singapore117585Singapore Hangzhou Global Scientific and Technological Innovation Center Zhejiang UniversityHangzhou 311215China

Surface modification of natural cellulose fibers with nanomaterials is an effective strategy for producing functional textiles for multiple applications.A4-sized printing paper is a commonly used,cheap,and easily acquirable office supply which is mainly made of cellulose ***,we report green and simple nanofabrication of A4 paper to endow it with high capability for fragrance encapsulation and sustained release,and strong adsorption to indoor air *** method utilizes the sugar molecule of cellulose for in-situ growth ofγ-cyclodextrin(γ-CD)metal-organic frameworks(MOFs)on A4 *** obtainedγ-CD-MOF/A4 nanocomposites have superior specific surface area and high porous ***γ-CD-MOF/A4 nanocomposites can effectively encapsulate fragrant molecules through host-guest ***γ-CD-MOF/A4 nanocomposites also show strong absorption capability to formaldehyde and carbon dioxide through the formation of hydrogen bonding and chemical ***γ-CD-MOF/A4nanocomposites combine the advantages of both A4 paper andγ-CD-MOF,which can be used in indoor air freshening and cleaning.

关键词： Metal-organic frameworks A4 printing paper In situ synthesis Fragrance encapsulation Formaldehyde removal Carbon dioxide capture

“One-for-All”approach:a black technology for nanomedicine development?

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Medical Review 2023年第2期3卷 184-187页

作者： Jiajia Xiang Shiqun Shao zhuxian zhou Youqing Shen Zhejiang Key Laboratory of Smart Biomaterials and Center for Bionanoengineering College of Chemical and Biological EngineeringZhejiang UniversityHangzhouZhejiang ProvinceChina ZJU-Hangzhou Global Scientific and Technological Innovation Center Zhejiang UniversityHangzhouZhejiang ProvinceChina Zhejiang Key Laboratory of Smart Biomaterials and Center for Bionanoengineering College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310027Zhejiang ProvinceChina

Cancer nanomedicines require different,even opposite,properties to voyage the cascade drug delivery process involving a series of biological *** nanomedicines can only alleviate adverse effects but cannot improve patient survival because they fail to meet all the ***,nanocarriers with synchronized functions are highly requisite to capacitate efficient drug delivery and enhanced therapeutic *** perspective article summarizes recent advances in the two main strategies for nanomedicine design,the All-in-One approach(integration of all the functions in one system)and the One-for-All approach(one functional group with proper affinity enables all the functions),and presents our views on future nanomedicine development.

关键词： cell membrane affinity clinical translation nanomedicine One-for-All transcytosis

Synthesis and evaluation of a paclitaxel-binding polymeric micelle for efficient breast cancer therapy

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Science China(Life Sciences) 2018年第4期61卷 436-447页

作者： Jiajia Xiang Bihan Wu zhuxian zhou Shiqi Hu Ying Piao Quan zhou Guowei Wang Jianbin Tang Xiangrui Liu Youqing Shen Key Laboratory of Biomass Chemical Engineering of Ministry of Education Center for Bionanoengineering and College of Chemical and Biological Engineering Zhejiang University

Paclitaxel(PTX) is one of the most effective anticancer drugs for the treatment of various solid tumors, but its clinical use is limited by its poor solubility, low bioavailability, and severe systemic toxicity. Encapsulation of PTX in polymeric nanoparticles is used to overcome these problems but these micelles still need improvements in stability, pharmacokinetics, therapeutic efficacy, and safety profiles. In this study, we demonstrate a facile fabrication of a stable PTX-binding micelle made from poly(ethylene glycol)-block-dendritic polylysine, whose primary amines were reacted with phenethyl isothiocyanate(PEITC), a hydrophobic anticancer agent under clinical study. The amphiphilic conjugate(PEG-Gx-PEITC; Gx, the generation of the polylysine dendron) formed well-defined micelles whose core was composed of phenyl groups and thiourea groups binding PTX via π-π stacking and hydrogen bonding. Compared with the PTX-loaded poly(ethylene glycol)-block-poly(D,L-lactide)(PEGPDLLA/PTX) micelles in clinical use, PTX-loaded PEG-Gx-PEITC third-generation(PEG-G3-PEITC/PTX) micelles showed slowed blood clearance, enhanced tumor accumulation, and thus much improved in vivo therapeutic efficacy in both subcutaneous and orthotopic human breast cancer xenografts. Therefore, PEG-G3-PEITC is a promising drug delivery system for PTX in the treatment of breast cancer.

关键词： paclitaxel delivery paclitaxel-binding phenethyl isothiocyanate dendritic polylysine polymeric micelles cancer drugdelivery enhanced stability prolonged blood circulation

Tuning the release rate of volatile molecules by pore surface engineering in metal-organic frameworks

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Chinese Chemical Letters 2021年第6期32卷 1988-1992页

作者： Hongwen Chen Huaqiang Chen Bo Zhang Liming Jiang Youqing Shen Engang Fu Dan Zhao zhuxian zhou Key Laboratory of Biomass Chemical Engineering of Ministry of Education and Center for Bionanoengineering College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310027China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Key Laboratory of Macromolecular Synthesis and Functionalization of Ministry of Education Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China Department of Chemical&Biomolecular Engineering National University of SingaporeSingapore 117585Singapore

Encapsulation and controlled release of volatile molecules such as fragrances in a designed manner is important but challenging for the flavor and fragrance ***,we report the tuning release of volatile molecules by postsynthetic modification of an amine-terminated metal-organic framework(MOF)MIL-101-NH_(2).By amidation,we obtained three MIL-101 MOFs,the trimethylacetamideterminated TC-MIL-101,the benzamide-terminated BC-MIL-101,and the oxalic acid monoamideterminated *** the MOFs can efficiently encapsulate volatile ***,we demonstrate that the release profile of volatiles can be widely tuned to sustain the release in several days to months and even over a year using different modified MIL-101 *** show that the release profiles are correlated with the binding energies between the guest volatiles and pores in *** pore diffusion and the synergistic transport are the rate-limiting step of the guest molecules from the modified MOFs.

关键词： Metal-organic frameworks(MOFs) Postsynthetic modification Encapsulation and sustained-release Fragrances Host-guest interaction

氨基修饰的锆基金属有机框架材料对香料的吸附和缓控释

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中国科学：化学 2019年第4期49卷 607-612页

作者：刘宇航周珠贤江黎明申有青浙江大学化学工程与生物工程学院生物质化工教育部重点实验室杭州310027 浙江大学高分子科学与工程学系高分子合成与功能构造教育部重点实验室杭州310027

本文以氨基修饰的锆基金属有机框架材料(MOF) UiO-66-NH_2为香料载体,研究了其对一系列香料分子的吸附和释放行为.我们发现UiO-66-NH_2对非极性的萜类香料吸附几乎无差别,而在极性香料的酯类吸附上差异较大.我们通过扫描电子显微镜(SEM)... 详细信息

本文以氨基修饰的锆基金属有机框架材料(MOF) UiO-66-NH_2为香料载体,研究了其对一系列香料分子的吸附和释放行为.我们发现UiO-66-NH_2对非极性的萜类香料吸附几乎无差别,而在极性香料的酯类吸附上差异较大.我们通过扫描电子显微镜(SEM)、X射线衍射仪(XRD)和红外光谱(FTIR)等对UiO-66-NH_2吸附香料后的样品进行表征,结果表明MOF材料吸附香料后不会造成结构坍塌和晶型变化, UiO-66-NH_2中的氨基与不同的酯类香料可形成氢键,对提高吸附量和延长缓释效果起到积极促进作用.与传统吸附材料活性炭相比, MOF对香料有更好的吸附效果.我们使用顶空-气相色谱对酯类香料的释放进行检测,结合释放动力学模型分析,发现其释放行为符合Korsmeyer-Peppas模型,孔道扩散是其释放的限速性环节.

关键词：有机金属框架材料香料吸附控释

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纳米香料技术的现状与发展

中国科学：化学 2019年第4期49卷 575-580页

作者：周珠贤胡静江黎明朱为宏张欣肖作兵申有青浙江大学化学工程与生物工程学院生物质化工教育部重点实验室杭州310027 上海应用技术大学香料香精技术与工程学院上海200235 浙江大学高分子科学与工程学系高分子合成与功能构造教育部重点实验室杭州310027 华东理工大学化学与分子工程学院精细化工研究所结构可控先进功能材料及其制备教育部重点实验室上海200237 中国科学院过程工程研究所生化工程国家重点实验室北京100190

纳米加香技术可以提高香料在基材内的负载并实现可控释放,从而提高芳香产品质量,增加产品对消费者的吸引力.本文对国内外的纳米加香技术的当前状况和研究进展进行了评述,指出了当前香精加香技术存在的问题,提出了基于基材纳米结构的直... 详细信息

纳米加香技术可以提高香料在基材内的负载并实现可控释放,从而提高芳香产品质量,增加产品对消费者的吸引力.本文对国内外的纳米加香技术的当前状况和研究进展进行了评述,指出了当前香精加香技术存在的问题,提出了基于基材纳米结构的直接纳米加香技术具有的发展潜力和优势,并讨论了实现该技术在芳香高端产品的大规模应用上仍需解决的关键科学问题.

关键词：香料纳米技术微胶囊加香技术纳米加香技术

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抗肿瘤纳米药物递送系统的研究现状与展望

中国基础科学 2022年第1期24卷 25-36页

作者：周珠贤申有青赵宇亮浙江大学化学工程与生物工程学院浙江省智能生物材料重点实验室杭州310027 国家纳米科学中心中国科学院纳米生物效应与安全性重点实验室北京100190

纳米药物递送系统通过纳米技术制备功能化纳米载体对传统药物进行靶向输送和可控释放,以提高药物的疗效,减少对健康组织的伤害。目前,纳米递送系统已在疾病的预防、精准诊断和高效治疗等方面获得了令人振奋的进展,如2019年针对新型冠状... 详细信息

纳米药物递送系统通过纳米技术制备功能化纳米载体对传统药物进行靶向输送和可控释放,以提高药物的疗效,减少对健康组织的伤害。目前,纳米递送系统已在疾病的预防、精准诊断和高效治疗等方面获得了令人振奋的进展,如2019年针对新型冠状病毒m RNA疫苗的快速开发正是基于几十年来脂质纳米粒递送技术的研究。尤其是在癌症的诊断与治疗方面,抗肿瘤纳米药物递送系统已取得了巨大的进展,广泛用于抗癌药物的递送,已有几十种纳米制剂实现临床应用,另有数百种纳米药物处于各临床试验阶段。但是,目前临床应用以及临床试验中的纳米药物递送系统,都仅仅能够降低药物毒副作用,没能显著提高药物疗效,导致了许多纳米药物在临床试验中最终失败。近年来,国内外学者分析了抗肿瘤药物递送过程的低靶向性、渗透难等关键瓶颈问题,通过设计一系列新型纳米药物载体,如智能纳米机器人型药物递送系统,极大地提升了药物的输送效率和疗效。本文综述纳米药物递送过程的关键问题和临床转化瓶颈,介绍智能型抗肿瘤纳米药物递送系统的最新设计与进展,并对当前纳米药物临床应用前景进行展望。

关键词：智能纳米药物纳米药物递送瓶颈主动渗透肿瘤渗透 EPR效应

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学科交叉型实验室的运行与管理

实验技术与管理 2019年第1期36卷 262-265,277页

作者：朴莹唐建斌刘祥瑞周珠贤段真申有青浙江大学化学工程与生物工程学院浙江杭州310012

随着交叉学科研究的蓬勃发展,交叉学科实验室管理方法有待提升。以浙江大学生物纳米工程中心生物与化学交叉学科实验室为例,归纳学科交叉型实验室特点,并结合企业微信管理工具总结学科交叉型实验室在安全、采购核算、仪器方面的管理经验... 详细信息

随着交叉学科研究的蓬勃发展,交叉学科实验室管理方法有待提升。以浙江大学生物纳米工程中心生物与化学交叉学科实验室为例,归纳学科交叉型实验室特点,并结合企业微信管理工具总结学科交叉型实验室在安全、采购核算、仪器方面的管理经验,对交叉学科实验室管理中存在的若干问题提出解决对策。

关键词：学科交叉实验室管理企业微信采购核算仪器管理

基于SF_(6)气体温度迟滞模型的密度监测失效判定策略

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中国电力 2024年第5期57卷 200-210页

作者：朱榜超商琼玲黄珠羡广西电网有限责任公司百色供电局广西百色533000

气体绝缘开关(gas insulated switchgear,GIS)设备SF_(6)气体密度监测失效可能会导致泄漏状态误判断,威胁电网安全运行。为此,针对数字式SF_(6)气体密度监测装置特点,构建并优化了基于热力学的SF_(6)气体温度迟滞模型。通过温度迟滞实验... 详细信息

气体绝缘开关(gas insulated switchgear,GIS)设备SF_(6)气体密度监测失效可能会导致泄漏状态误判断,威胁电网安全运行。为此,针对数字式SF_(6)气体密度监测装置特点,构建并优化了基于热力学的SF_(6)气体温度迟滞模型。通过温度迟滞实验,获取了模型中未知参数。模拟实验表明,SF_(6)气体温度迟滞模型温度补偿偏差为±0.6℃,基于补偿后温度的计算压力与压力传感器检测压力偏差为±0.002 MPa。设计基于计算压力与检测压力相互验证的密度监测失效判定策略,结合某220 kV变电站中试点设备数据进行验证,经SF_(6)气体温度迟滞模型温度补偿并归算至20℃下的压力与实际值均不超过0.002 MPa,验证了该模型的准确度以及SF_(6)气体密度监测失效判定策略现场应用的可行性。

关键词： SF6气体数字式SF_(6)气体密度监测装置监测失效判定温度迟滞模型