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ADAR1 Inhibits Macrophage Apoptosis and Alleviates Sepsis-induced Liver Injury Through miR-122/BCL2A1 Signaling

Journal of Clinical and Translational Hepatology 2024年第2期12卷 134-150页

作者： Shanshou Liu Jiangang Xie Chujun Duan Xiaojun Zhao zhusheng feng Zheng Dai Xu Luo Yu Li Minghe Yang Ran Zhuang Junjie Li Wen Yin Emergency Department Xijing HospitalFourth Military Medical UniversityXi’anShaanxiChina Emergency Department Tangdu HospitalFourth Military Medical UniversityXi’anShaanxiChina Third Student Brigade School of Basic Medical ScienceFourth Military Medical UniversityXi’anShaanxiChina Department of Immunology Fourth Military Medical UniversityXi’anShaanxiChina

apoptosis plays regulatory roles in the pathogenesis of immunosuppression and organ *** previously reported that adenosine deaminases acting on RNA-1(ADAR1)reduced intestinal and splenic inflammatory damage during ***,the roles and mechanism of ADAR1 in sepsis-induced liver injury remain ***:We performed transcriptome and single-cell RNA sequencing of peripheral blood mononuclear cells(PBMCs)from patients with sepsis to investigate the effects of ADAR1 on immune cell *** also employed a cecal ligation and puncture(CLP)sepsis mouse model to evaluate the roles of ADAR1 in sepsisinduced liver ***,we treated murine RAW 264.7 macrophages with lipopolysaccharide to explore the underlying ADAR1-mediated mechanisms in ***:PBMCs from patients with sepsis had obvious apoptotic morphological ***-cell RNA sequencing indicated that apoptosis-related pathways were enriched in monocytes,with significantly elevated ADAR1 and BCL2A1 expression in severe ***-induced septic mice had aggravated liver injury and Kupffer cell apoptosis that were largely alleviated by ADAR1 ***1 directly bound to premiR-122 to modulate miR-122 ***-122 was an upstream regulator of ***,ADAR1 also reduced macrophage apoptosis in mice with CLP-induced sepsis through the miR-122/BCL2A1 signaling pathway and protected against sepsis-induced liver ***:The findings show that ADAR1 alleviates macrophage apoptosis and sepsis-induced liver damage through the miR-122/BCL2A1 signaling *** study provides novel insights into the development of therapeutic interventions in sepsis.

关键词： Sepsis Macrophage ADAR1 microRNA122 BCL2A1 Apoptosis

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医疗救援领域的无人机应用:SWOT分析

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中国急救复苏与灾害医学杂志 2024年第10期19卷 1280-1283页

作者：范颖楠史小飞赵威王倩梅尹文叶玉勤冯筑生空军军医大学第一附属医院急诊科陕西西安710032 西安交通大学附属红会医院急诊科陕西西安710054 空军军医大学第一附属医院神经外科陕西西安710032

目的探索医疗救援无人驾驶飞机(UAVs)的使用现状以及需要改进的方面,为UAVs在医疗救援领域的应用提供参考。方法通过跨数据库联合检索,采用优势、劣势、机会和威胁(SWOT)分析方法对医疗救援UAVs的相关文献进行评估。结果当前在医疗救援... 详细信息

目的探索医疗救援无人驾驶飞机(UAVs)的使用现状以及需要改进的方面,为UAVs在医疗救援领域的应用提供参考。方法通过跨数据库联合检索,采用优势、劣势、机会和威胁(SWOT)分析方法对医疗救援UAVs的相关文献进行评估。结果当前在医疗救援过程中应用UAVs相较于传统救援方式具有诸多优势,并在血液制品运输、特殊疾病诊治、现场急救以及器官移植等领域的应用取得长足进步,但也存在一定限制条件和安全风险。结论UAVs在医疗救援领域的应用扩展和功能优化值得继续探索和研究,未来发展具有较大潜力,应用前景较好。

关键词：医疗救援无人机 SWOT分析

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血栓弹力图在创伤领域的应用进展

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中华急诊医学杂志 2016年第5期25卷 563-567页

作者：冯筑生李俊杰尹文第四军医大学西京医院急诊科西安710032

创伤系45岁以下人群死亡的主要原因，全球范围内有1／10的死亡由创伤造成，每年创伤相关性死亡超过六百万并造成大量患者残疾，给社会和家庭造成了巨大的医疗经济负担。近年来，创伤相关研究领域取得了一系列进展，涌现出了许多新的诊... 详细信息

创伤系45岁以下人群死亡的主要原因，全球范围内有1／10的死亡由创伤造成，每年创伤相关性死亡超过六百万并造成大量患者残疾，给社会和家庭造成了巨大的医疗经济负担。近年来，创伤相关研究领域取得了一系列进展，涌现出了许多新的诊治手段和方法，致力于提高患者生存率和降低创伤相关并发症的发生风险。

关键词：血栓弹力图创伤应用相关并发症经济负担发生风险死亡相关性

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系统性内皮病在创伤性休克领域研究

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创伤外科杂志 2021年第11期23卷 801-804页

作者：尹文冯筑生空军军医大学第一附属医院急诊科西安710032

创伤导致的出血和组织损伤会引发休克,而休克所造成的组织灌注不足会进一步引起交感肾上腺素系统激活、炎症、内皮糖萼(EG)脱落、血小板激活和功能紊乱、内源性肝素化、凝血因子活性降低和纤溶亢进等一系列综合的病理生理反应,这些反应... 详细信息

创伤导致的出血和组织损伤会引发休克,而休克所造成的组织灌注不足会进一步引起交感肾上腺素系统激活、炎症、内皮糖萼(EG)脱落、血小板激活和功能紊乱、内源性肝素化、凝血因子活性降低和纤溶亢进等一系列综合的病理生理反应,这些反应统称为系统性内皮病(SE),SE在创伤相关因素和复苏相关因素的影响下会进一步发展为创伤性凝血病(TC)。因此探寻SE相关病理生理机制和诊断治疗进展,对于早期阻断TC的发生发展,改善创伤患者预后具有重要意义。

关键词：系统性内皮病创伤性凝血病病理生理诊断与治疗

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A novel method for AFRPs burrs removal:Principle of mechanochemo-induced fiber fracture

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Chinese Journal of Aeronautics 2024年第7期37卷 522-538页

作者： Jie XU Bo LI Pingfa feng Qiang WANG feng feng Division of Advanced Manufacturing Tsinghua Shenzhen International Graduate SchoolTsinghua UniversityShenzhen 518055China Department of Mechanical Engineering Tsinghua UniversityBeijing 100084China Changhe Aircraft Industry(Group)Co.Ltd Jingdezhen 333000China

Burrs generated during the machining of Aramid-Fiber-Reinforced Composites(AFRPs)pose a challenge for the production efficiency of aircraft and helicopter housing *** studies have generally attempted to suppress burrs by referring to delamination suppression *** contrast to stratification,burrs are remediable machining *** such,a mechanochemical method with burrs trimming technological strategy are implemented to effectively combat ***,we clarify the mechanism by which aramid fibers cannot be cut off using analytical and numerical *** addition,the mechanism of fiber fracture with Modified Polyurethane Reactive Polymer(M-PUR),and development of anti-burr devices(thermostatic adhesive sealed generator)are ***,the experimental results show that the reduction rate in burr length is 87%-91%through the mechanochemical *** method not only opens a new avenue to solve the burr problem of aramid fibers but also builds an interdisciplinary bridge between polymer science and composite machining.

关键词： Mechanochemical method Burrs Orthogonal cutting Aramid fiber-reinforced composites Milling

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低压复苏治疗创伤失血性休克的系统评价

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中华急诊医学杂志 2016年第5期25卷 605-609页

作者：冯筑生范颖楠李俊杰王倩梅尹文第四军医大学西京医院急诊科西安710032

目的系统评价低压复苏治疗创伤失血性休克的有效性。方法计算机检索Pubmed、Embase和The Corchrane Library等数据库，纳入低压复苏治疗创伤失血性休克的随机对照试验或半随机对照试验，检索时间均为从建库至2015年8月。由2位研究者独... 详细信息

目的系统评价低压复苏治疗创伤失血性休克的有效性。方法计算机检索Pubmed、Embase和The Corchrane Library等数据库，纳入低压复苏治疗创伤失血性休克的随机对照试验或半随机对照试验，检索时间均为从建库至2015年8月。由2位研究者独立进行资料提取和质量评价，采用Rev Man5．3软件进行Meta分析，计数资料使用相对危险度（risk ratio，RR）及其95％可信区间（confidence interval，CI）进行评估，并采用GRADE5．6．1软件对证据质量进行分级。结果纳入4项研究，Meta分析及GRADE评级结果显示：与常规复苏比较，低压复苏有较低的总病死率[RR=0．77，95％CI：0．62～0．95，P=0．01；n=984，GRADE评级：中]及24h病死率[RR=0．47，95％CI：0．24—0．91，P=0．03；n=281，GRADE评级：中]；但总病死率的亚组分析结果显示：在钝挫伤或穿透伤亚组以及穿透伤亚组，两组差异无统计学意义。结论低压复苏能够降低创伤失血性休克患者的总病死率及24h病死率，证据质量为中级。未来研究应该着力于低压复苏对于不同创伤类型患者的疗效进行进一步探索。

关键词：低压复苏创伤休克系统评价 GRADE系统

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Record-high efficiency perovskite LEDs achieved by accelerating radiative recombination

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Science China Materials 2024年第9期67卷 3039-3040页

作者： feng Gao Department of Physics Chemistry and BiologyLinköping UniversityLinköping58183Sweden

Light-emitting diodes(LEDs)have revolutionized the lighting and displays due to their superior energy *** increasing demand for more efficient and brighter thin-film LEDs in flat-panel displays and solid-state lighting applications has driven extensive research into perovskite materials,which show great promise for high brightness and efficiency.

关键词： lighting radiative high

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Derivation of Expanded Isospectral-Nonisospectral Integrable Hierarchies via the Column-vector Loop Algebra

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Acta Mathematicae Applicatae Sinica 2024年第3期40卷 778-800页

作者： Hai-feng WANG Yu-feng ZHANG School of Science Jimei UniversityXiamen 361021China School of Mathematics China University of Mining and TechnologyXuzhou 221116China

A scheme for generating nonisospectral integrable hierarchies is *** on the method,we deduce a nonisospectral hierarchy of soliton equations by considering a linear spectral *** follows that the corresponding expanded isospectral and nonisospectral integrable hierarchies are deduced based on a 6 dimensional complex linear space ■.By reducing these integrable hierarchies,we obtain the expanded isospectral and nonisospectral derivative nonlinear Schr?dinger *** using the trace identity,the biHamiltonian structure of these two hierarchies are also ***,some symmetries and conserved quantities of the resulting hierarchy are discussed.

关键词： expanded isospectral-nonisospectral integrable hierarchies column-vector loop algebra bi-Hamiltonian structure symmetry

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Carbon-based materials with combined functions of thermal management and electromagnetic protection: Preparation, mechanisms, properties, and applications

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Nano Research 2024年第3期17卷 883-903页

作者： Junwei Yue Yiyu feng Mengmeng Qin Wei feng School of Materials Science and Engineering and Tianjin Key Laboratory of Composite and Functional Materials Tianjin UniversityTianjin 300350China

The proliferation of high-power,highly informationized,and highly integrated electronic devices and weapons equipment has given rise to increasingly conspicuous issues about electromagnetic(EM)pollution and thermal *** issues,in turn,impose constraints on the performance of such equipment and jeopardize personnel *** materials,owing to their diverse and modifiable structures,offer adjustable thermal and electric conductivity,rendering them highly promising for applications in fields such as thermal management and EM protection which have garnered extensive research and *** pursuit of integrated device and equipment development has elevated the demand for multifunctional materials,prompting significant research into carbon-based composite materials that include both thermal management and EM protection ***,there are no relevant reviews on this topic at ***,this work consolidates research findings from recent years on carbon matrix composites exhibiting dual attributes of thermal management and EM *** attributes include thermally conductive electromagnetic interference(EMI)shielding materials,thermally insulating EMI shielding materials,thermally conductive EM wave(EMW)absorbing materials,and thermally insulating EMW absorbing *** paper elucidates the fundamental principles underpinning thermal conduction,thermal insulation,EMW absorbing,and EMI ***,it engages in discussions surrounding areas of contention,design strategies,and the functional properties of various material ***,the paper concludes by presenting the challenges encountered and potential research strategies about composites endowed with both thermal management and EM protection functionalities,while also envisaging the development of novel multifunctional EM protection materials.

关键词： carbon-based composites electromagnetic interference shielding microwave absorption thermal conduction thermal insulation

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Design and identification of a double-acting piezoelectric-hydraulic hybrid actuator

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Chinese Journal of Aeronautics 2024年第3期37卷 456-467页

作者： Junjian ZHANG Zhihua feng Key Laboratory of Precision Scientific Instrumentation of Anhui Higher Education Institutes University of Science and Technology of ChinaHefei 230026China

Traditional single-acting piezoelectric-hydraulic hybrid actuators usually have the problem of inertial force caused by flow pulsation of the liquid,which degrades their output *** suppress or solve the associated inertial force and enhance its output capabilities,this paper proposes a new type of double-acting piezoelectric-hydraulic hybrid actuator with four check valves acting as mechanical *** new hybrid actuator was fabricated and its output performance was *** the voltage is 700 Vp-pand the bias pressure is 2 MPa,the pulsation ratesδof the new actuator at 400 Hz,500 Hz and 600 Hz are 2.29,2.08 and 1.78,respectively,whileδof the single-acting hybrid actuator under the same conditions are 10.98,11.05 and ***,the liquid pulsation rate of the new hybrid actuator is significantly reduced,which is beneficial for improving the flow uniformity and weakening the influence of inertial force on the hybrid *** strategy ultimately leads to a maximum no-load velocity of 168.1 mm/s at 600 Hz and a maximum blocking force of 141 N at 450 Hz for the new hybrid *** addition,this strategy has the potential to be used in other electrohydrostatic actuators to improve their performance.

关键词： Double-acting Flow pulsation Inertial force Piezoelectric actuators Piezoelectric devices Piezoelectric hydraulic actuation Piezoelectric pump

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